Tag: M.W=100-150

Yun, Xue-Jing; Zhu, Jing-Wei; Jin, Yan; Deng, Wei; Yao, Zi-Jian published the artcile< Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process>, Application In Synthesis of 5344-90-1, the main research area is ruthenium half sandwich cyclometalated complex preparation hydrogenation catalyst; amine ketone hydrogenation catalyst ruthenium half sandwich cyclometalated complex.

Four types of half-sandwich ruthenium complexes with an N,O-coordinate mode based on hydroxyindanone-imine ligands have been prepared in good yields. These stable ruthenium complexes exhibited high activity in the catalytic synthesis of quinolines from the reactions of amino alcs. with different types of ketones or secondary alcs. under very mild conditions. Moreover, the methodol. for the direct one-pot synthesis of tetrahydroquinoline derivatives from amino alcs. and ketones has been also developed on the basis of the continuous catalytic activity of this ruthenium catalyst in the selective hydrogenation of the obtained quinoline derivatives with a low catalyst loading. The corresponding products, quinolines and tetrahydroquinoline derivatives, were afforded in good to excellent yields. The efficient and diverse catalytic activity of these ruthenium complexes suggested their potential large-scale application. All of the ruthenium complexes were characterized by various spectroscopies to confirm their structures. Half-sandwich ruthenium complexes based on hydroxyindanone-imine ligands exhibited high activity in the catalytic synthesis of quinoline derivatives starting from amino alcs. and ketones as well as secondary alcs. under very mild conditions. One-pot synthesis of tetrahydroquinoline has been also developed on the basis of the continuous catalytic activity of these ruthenium catalysts in selective hydrogenation.

Inorganic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zewei; Lv, Kang; Yuan, Taoyue; Zhang, Xuguang; Yao, Weiwei; Ma, Mengtao published the artcile< Electrochemical hydroboration of carbonyl compounds>, Computed Properties of 403-41-8, the main research area is aryl alkyl alc preparation; boronic ester preparation regioselective green chem hydrolysis; carbonyl compound tetramethyl dioxaborolane electrochem hydroboration.

A green and sustainable electrochem. hydroboration of carbonyl compounds RC(O)R1 (R = Bu, Ph, cyclohexyl, pyridin-4-yl, etc.; R1 = H, Me, Ph, i-Pr, 2-fluorophenyl) with HBpin has been reported for the first time. Under catalyst-free and additive-free mild reaction conditions the corresponding boronic esters RR1CHOBpin were obtained in excellent yields via the simple electrochem. hydroboration of various aldehydes and ketones with HBpin at room temperature The scale-up reaction demonstrated potential practical applications. A plausible reaction mechanism was proposed based on the corresponding deuterium-labeling, radical inhibition and cyclic voltammetry experiments

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiao, Meng-Jie; Hu, Qiang; Hu, Xiu-Qin; Xu, Peng-Fei published the artcile< Visible-Light-Promoted Multistep Tandem Reaction of Vinyl Azides toward the Formation of 1-Tetralones>, Application of C9H8O, the main research area is tetralone preparation green chem; vinyl azide alkyl bromide tandem cyclization reaction photocatalyst.

A visible-light-driven multistep tandem reaction between vinyl azides 2-R-3-R1-4-R2-C6H2C(=CH2)N3 (R = H, Cl, Me; R1 = H, Me; R2 = H, Br, CN, Ph, etc.) and alkyl bromides R3CH(R4)C((C(O)OCH2CH3)2)Br (R3 = H, prop-1-yn-1-yl, Ph, naphthalen-1-yl, etc.; R4 = H, Me; R3R4 = -(CH2)4-) has been developed leading to the formation of tetralone skeletons I (R5 = H, Me) under mild conditions, which can be easily scaled up to the gram scale. Various 1-tetralone derivatives I are synthesized and transformed into desired products in good to high yields.

Journal of Organic Chemistry published new progress about Azides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei published the artcile< Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water>, SDS of cas: 403-41-8, the main research area is copper triazolylnaphthyridinylpyridine complex preparation catalyst.

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment

Green Chemistry published new progress about Catalysts. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Wei; Zhou, Yiming; He, Yanlin; Huang, You published the artcile< DABCO catalyzed [4+2] annulations of Morita-Baylis-Hillman carbonates with isocyanates>, COA of Formula: C7H9NO, the main research area is alkoxy oxopropenyl dihydroquinazoline carboxylate preparation; MBH carbonate preparation isocyanate DABCO catalyst chemoselective cycloaddition.

A highly concise method for 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyzed [4+2] annulations of o-amino-acylation of aryl Morita-Baylis-Hillman (MBH) carbonates with isocyanates was developed. For the first time, MBH carbonates served as 1,4-dipoles, providing functionalized 3,4-dihydroquinazolinones in mild conditions with good to excellent yields. The d. functional theory calculations of the mechanism supports this hypothesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takenaka, Ikuo Risa; Fujimura, Koji; Narukami, Shoji; Sasaki, Tomohiro; Maeda, Tsuneaki published the artcile< Quantitative determination of 2-ethyl-1-hexanol, texanol and TXIB in in-door air using a solid-phase extraction-type collection device followed by gas chromatography-mass spectrometry>, Product Details of C8H18O, the main research area is ethyl hexanol texanol TXIB air solid phase extraction GCMS; Semi-volatile organic compounds; gas chromatography–mass spectrometry; sample preparation; sick house syndrome.

In this study, in-door air semi-volatile organic compounds (SVOCs) including 2-ethyl- 1-hexanol, 2,2,4-trimethyl-1,3- pentanediol monoisobutyrate (texanol). and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (T M ), which are scheduled for adding as regulated compounds concerning indoor air reference values in Japan, were quant. extracted using a solid-phase extraction-type collection device, followed by sensitively determined by gas chromatog.-mass spectrometry. The developed method has shown a good extraction recovery up to an air sampling volume of 900 L. The extracted analytes were quant. and rapidly eluted by 7 mL of acetone. The limit of quantification of the analytes were 0.7, 2.1 and 0.2 ng L-1 in air sample at a sampling volume of 300 mL without any concentration of a desorption solvent. The developed method was applied to simultaneous determinations of the investigated target analytes and phthalate esters in real indoor air samples.

Analytical Sciences published new progress about Air analysis. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Waiba, Satyadeep; Jana, Sayan K.; Jati, Ayan; Jana, Akash; Maji, Biplab published the artcile< Manganese complex-catalysed α-alkylation of ketones with secondary alcohols enables the synthesis of β-branched carbonyl compounds>, Computed Properties of 403-41-8, the main research area is aryl ketone secondary alc manganese complex alkylation; carbonyl compound preparation.

Herein, β-branched carbonyl compounds were synthesized via the α-alkylation of ketones with secondary alcs. under “”borrowing hydrogen”” catalysis. A wide range of secondary alcs., including various cyclic, acyclic, sym., and unsym. alcs., was successfully applied under the developed reaction conditions. A manganese(I) complex bearing a phosphine-free multifunctional ligand catalyzed the reaction and produced water as the sole byproduct.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cabeza, Javier A.; Fernandez-Colinas, Jose M.; Garcia-Alvarez, Joaquin; Garcia-Alvarez, Pablo; Laglera-Gandara, Carlos J.; Ramos-Martin, Marina published the artcile< Dipyrromethane-Based PGeP Pincer Germyl Rhodium Complexes>, SDS of cas: 403-41-8, the main research area is crystal structure mol dipyrromethane pincer germyl rhodium complex preparation; dipyrromethane pincer germyl rhodium complex hydroboration catalyst styrene catecholborane; PGeP pincers; germylenes; hydroboration; pincer complexes; rhodium.

A family of germyl rhodium complexes derived from the PGeP germylene 2,2′-bis(di-isopropylphosphinylmethyl)-5,5′-dimethyldipyrromethane-1,1′-diylgermanium(II), Ge(pyrmPiPr2)2CMe2 (1), has been prepared Germylene 1 reacted readily with [RhCl(PPh3)3] and [RhCl(cod)(PPh3)] (cod=1,5-cyclooctadiene) to give, in both cases, the PGeP-pincer chloridogermyl rhodium(I) derivative [Rh{κ3P,Ge,P-GeCl(pyrmPiPr2)2CMe2}(PPh3)] (2). Similarly, the reaction of 1 with [RhCl(cod)(MeCN)] afforded [Rh{κ3P,Ge,P-GeCl(pyrmPiPr2)2CMe2}(MeCN)] (3). The methoxidogermyl and methylgermyl rhodium(I) complexes [Rh{κ3P,Ge,P-GeR(pyrmPiPr2)2CMe2}(PPh3)] (R=OMe, 4; Me, 5) were prepared by treating complex 2 with LiOMe and LiMe, resp. Complex 5 readily reacted with CO to give the carbonyl rhodium(I) derivative [Rh{κ3P,Ge,P-GeR(pyrmPiPr2)2CMe2}(CO)] (6), with HCl, HSnPh3 and Ph2S2 rendering the pentacoordinate methylgermyl rhodium(III) complexes [RhHX{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}] (X=Cl, 7; SnPh3, 8) and [Rh(SPh)2{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}] (9), resp., and with H2 to give the hexacoordinate derivative [RhH2{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}(PPh3)] (10). Complexes 3 and 5 are catalyst precursors for the hydroboration of styrene, 4-vinyltoluene and 4-vinylfluorobenzene with catecholborane under mild conditions.

Chemistry – A European Journal published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Xu; Song, Ning; Saidahmatov, Abdusaid; Wang, Peipei; Wang, Yong; Hu, Xiaobei; Kan, Weijuan; Zhu, Wei; Gao, Lixin; Zeng, Mingjie; Wang, Yujie; Li, Chunpu; Li, Jia; Liu, Hong; Zhou, Yubo; Wang, Jiang published the artcile< Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia>, Recommanded Product: 3-Aminocyclohexanol, the main research area is acute myeloid leukemia CDK9 inhibitors antiproliferative activity bioavailability SAR.

CDK9 is an essential drug target correlated to the development of acute myeloid leukemia (AML). Starting from the hit compound 10, which was discovered through a screening of our inhouse compound library, the structural modifications were carried out based on the bioisosterism and scaffold hopping strategies. Consequently, compound 37 (I) displayed the optimal CDK9 inhibitory activity with an IC50 value of 5.41 nM, which was nearly 1500-fold higher than compound 10. In addition, compound 37 exhibited significant antiproliferative activity in broad cancer cell lines. Further investigation of in vivo properties demonstrated that compound 37 could be orally administrated with an acceptable bioavailability (F = 33.7%). In MV-4-11 s.c. xenograft mouse model, compound 37 (7.5 mg/kg) could significantly suppress the tumor progression with a T/C value of 27.80%. Compound 37 represents a promising lead compound for the development of a novel class of CDK9 inhibitors for the treatment of acute myeloid leukemia.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tsui, Brian T. H.; Sung, Molly M. H.; Kinas, Jenny; Hahn, F. Ekkehardt; Morris, Robert H. published the artcile< A Ruthenium Protic N-Heterocyclic Carbene Complex as a Precatalyst for the Efficient Transfer Hydrogenation of Aryl Ketones>, Reference of 403-41-8, the main research area is bipyridinylimidazolylidene ruthenium pincer complex preparation catalyst reduction aryl ketone; crystal structure bipyridinylimidazolylidene ruthenium pincer complex; mol structure bipyridinylimidazolylidene ruthenium pincer complex.

A neutral azole precursor to a protic N-heterocyclic carbene (pNHC) ligand, 6-((4,5-diphenyl-1H-imidazol-1-yl)methyl)-2,2′-bipyridine (3), was prepared from 6-(bromomethyl)-2,2′-bipyridine (2) and 4,5-diphenylimidazole. [RuCl(pNHC-bpy)(PPh3)2](PF6) (4) bearing a protic, bipyridine-tethered NHC ligand was prepared by refluxing 3 with RuCl2(PPh3)3 and KPF6 in MeOH and was characterized by NMR spectroscopy, mass spectrometry, elemental anal., and a single-crystal x-ray diffraction study. The hydrido complex [RuH(pNHC-bpy)(PPh3)2](PF6) (5) was prepared by reaction of 4 with NaBH4 in EtOH and characterized by NMR and FTIR spectroscopy. Complex 5 was used as the catalyst (0.1 mol % loading) in the transfer hydrogenation of a range of alkyl/aryl ketones in basic iso-PrOH at 60°. Bulky alkyl groups or ortho-substituted aryl groups at the ketones slowed down or inhibited the catalytic transformation. The addition of an excess of PPh3 also slowed the catalysis, providing an indication for a mechanism involving phosphine dissociation, while the addition of an excess of elemental Hg had only a small effect on the conversion. The importance of K cations in the mechanism is consistent with the observation of reduced catalytic conversion when [2,2,2]-cryptand was present or when 1,8-diazabicyclo[5.4.0]undec-7-ene was used as the base. A plausible homogeneous catalysis mechanism involving the innersphere addition of hydride to the substrate in the transition state TS1 is supported by d. functional theory calculations where the K ion has replaced the H atom of the N-H group in a protic NHC.

Organometallics published new progress about Alkylidenes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation) (Ru pincer complexes). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts