Tag: M.W=100-150

Anandan, Sampath-Kumar; Webb, Heather K.; Do, Zung N.; Gless, Richard D. published the artcile< Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble epoxide hydrolase>, Recommanded Product: 3-Aminocyclohexanol, the main research area is unsym aryl urea derivative preparation soluble epoxide hydrolase inhibitor; aryl amide derivative preparation soluble epoxide hydrolase inhibitor.

Incorporation of an adamantyl group in prototypical soluble epoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. Replacement of the adamantyl group in unsym. ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors, e.g., I and II, is explored. Aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded enzyme IC50 values comparable to the adamantyl compounds in an ether substituted, unsym. N,N’-diaryl urea or amide scaffold.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. Robin published the artcile< Pyrrolizidine alkaloid analogs. Part 2. Further hydroxymethyl-1-methyl-3-pyrrolines (synthanecines), and the preparation and esterification of some hydroxymethylpyrroles>, Related Products of 52160-51-7, the main research area is synthanecine D E total synthesis; esterification hydroxymethylpyrrole hydroxymethylindole; pyrrolizidine alkaloid analog; pyrrole hydroxymethyl esterification; indole hydroxymethyl esterification; alkylation hydroxymethylpyrrole kinetics.

Synthanecine D and E [I; R = (CH2)2OH, Me] were each prepared in 5 steps from EtO2CCH:CHCH2CO2Et and MeNHCHMeCH2CO2Et, resp. Esters of I [R = (CH2)2OH, Me] behave as analogs of pyrrolizidine alkaloids which can be metabolically dehydrogenated in animals to pyrrole derivatives II [R = (CH2)2OH, Me, R1 = CH2OH, R2 = H] which are monofunctional alkylating agents. The successful esterification of (hydroxymethyl)pyrroles requires rigorous exclusion of moisture and the presence of a tertiary base to prevent polymerization The electrophilic reactivities of 19 (hydroxymethyl)pyrrole and -indole derivatives, including II [R = (CH2)2OH, Me, R1 = CH2OH, R1 = H], towards 4-p-nitrobenzylpyridine are compared. KOH-catalyzed cyclization of EtO2CCH2NMeCH(CH2CO2Et)2, an intermediate in the preparation of I [R = (CH2)2OH], gave 45% II (R = H, R1 = CO2Et, R2 = OH).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alkylation kinetics. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gomez, M.; Murcia, M. D.; Serrano-Arnaldos, M.; Gomez, E.; Gomez, J. L.; Hidalgo, A. M.; Maximo, M. F. published the artcile< Developing the rate equations for two enzymatic Ping-Pong reactions in series: Application to the bio-synthesis of Bis(2-ethylhexyl) azelate>, COA of Formula: C8H18O, the main research area is Bis 2 ethylhexyl azelate lipase ping pong reaction.

In this work, the rate equations of two simultaneous bisubstrate Ping-Pong in series reactions have been developed for the first time. To obtain these equations, the approximation to the stationary state has been applied and, for the total balance of enzyme, all the intermediate complexes of the two reactions, which are present simultaneously in the reaction medium, have been taken into account. To check the kinetic equations obtained, the synthesis of bis(2-ethylhexyl) azelate by transesterification from di-Et azelate and 2-ethylhexanol, in the presence of the immobilized lipase Novozym 435, has been used as reaction model. The reaction has been carried out in solvent-free conditions in a batch reactor. A design model of the reactor has also been developed and solved by applying a numerical method. The model equations have been implemented in users software in Visual Basic for Applications. In that software a routine, based on a very well-known procedure to minimize the sum of the square errors, has also been implemented. By using this software, the model parameters have been determined by fitting the exptl. data to the model. A high determination coefficient was obtained, which validated both the kinetic equations and the reactors design model.

Biochemical Engineering Journal published new progress about 104-76-7. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Da Hun; Jaladi, Ashok Kumar; Lee, Ji Hye; Kim, Tae Sung; Shin, Won Kyu; Hwang, Hyonseok; An, Duk Keun published the artcile< Catalytic Hydroboration of Aldehydes, Ketones, and Alkenes Using Potassium Carbonate: A Small Key to Big Transformation>, Electric Literature of 403-41-8, the main research area is aldehyde ketone alkene hydroboration potassium carbonate catalyst.

An efficient transition-metal-free protocol for the hydroboration of aldehydes and ketones (reduction) was developed. The hydroboration of a wide range of aldehydes and ketones with pinacolborane (HBpin) under the K2CO3 catalyst was studied. The reaction system is practical and reliable and proceeds under extremely mild and operationally simple conditions. No prior preparation of the complex metal catalyst was required, and hydroboration occurred stoichiometrically. Further, the chemoselective reduction of aldehydes over ketones was carried out. Moreover, the authors demonstrated the use of K2CO3 as an efficient catalyst for the hydroboration of alkenes. The operational simplicity, inexpensive and transition-metal-free catalyst, and the applicability to gram-scale synthesis strengthen its potential applications for hydroboration (reduction) at an industrial scale.

ACS Omega published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paradiz Dominguez, Maximilian; Demirkurt, Beguem; Grzelka, Marion; Bonn, Daniel; Galmiche, Laurent; Audebert, Pierre; Brouwer, Albert M. published the artcile< Fluorescent Liquid Tetrazines>, Application In Synthesis of 104-76-7, the main research area is branched alkoxy tetrazine photophys property rheol viscosity; excited states; fluorescence; inter system crossing; rheology; viscosity.

Tetrazines with branched alkoxy substituents are liquids at ambient temperature that despite the high chromophore d. retain the bright orange fluorescence that is characteristic of this exceptional fluorophore. Here, we study the photophys. properties of a series of alkoxy-tetrazines in solution and as neat liquids We also correlate the size of the alkoxy substituents with the viscosity of the liquids We show using time-resolved spectroscopy that intersystem crossing is an important decay pathway competing with fluorescence, and that its rate is higher for 3,6-dialkoxy derivatives than for 3-chloro-6-alkoxytetrazines, explaining the higher fluorescence quantum yields for the latter. Quantum chem. calculations suggest that the difference in rate is due to the activation energy required to distort the tetrazine core such that the nπ*S1 and the higher-lying ππ*T2 states cross, at which point the spin-orbit coupling exceeding 10 cm-1 allows for efficient intersystem crossing to occur. Femtosecond time-resolved anisotropy studies in solution allow us to measure a pos. relationship between the alkoxy chain lengths and their rotational correlation times, and studies in the neat liquids show a fast decay of the anisotropy consistent with fast exciton migration in the neat liquid films.

Molecules published new progress about Anisotropy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Emayavaramban, Balakumar; Chakraborty, Priyanka; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< Cp*Co(III)-catalyzed N-alkylation of amines with secondary alcohols>, Reference of 403-41-8, the main research area is amine alkylation sec alc cobalt catalyst; tetrahydroquinoline preparation; aminoalc intramol amination cobalt catalyst.

Herein Cp*Co(III)-catalyzed direct N-alkylation of amines starting from secondary alcs. was reported for the first time. The reaction tolerates a wide variety of functional groups, including various aryl amines and amides. Various 1,5-aminoalcs. efficiently underwent intramol. amination with excellent isolated yields of the expected 2-aryltetrahydroquinolines. The preliminary mechanistic investigations and DFT calculations suggest that [Cp*CoI2] is an active species, that PCy3 stabilizes the high-valent hydride intermediate, and that the reaction indeed proceeds through hydrogen auto-transfer processes.

Organic Chemistry Frontiers published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei published the artcile< Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is copper triazolylnaphthyridinylpyridine complex preparation catalyst.

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment

Green Chemistry published new progress about Catalysts. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fan, Xiaojing; Jiao, Xin; Liu, Jinguang; Jia, Meng; Blanchard, Chris; Zhou, Zhongkai published the artcile< Characterizing the volatile compounds of different sorghum cultivars by both GC-MS and HS-GC-IMS>, Formula: C8H18O, the main research area is sorghum volatile compound GC MS IMS; GC-IMS; GC-MS; Odor-active value; Sorghum; Volatile compound.

The current study applied both GC-MS and GC-IMS for characterizing volatile compounds of six Australian sorghum cultivars. For raw sorghum, the result of GC-MS showed that ester compounds were abundant in six raw samples. Among these esters, the content of hexadecanoic acid Et ester was highest in all of the raw samples. Compound 3-octanone only existed in Apollo, Bazley and Liberty, and 2-undecanone was found to be in MR43. Result of GC-IMS showed that signals of benzaldehyde, 2,3-butanedione were generally noted in six raw samples. In general, The Apollo and Buster had more volatile compounds, followed by Bazley and Liberty. In contrast, MR43 and G44 had least volatile compounds For cooked sorghums, more fatty aldehydes are formed compared to its corresponding raw sample, in which current data indicated that 40 volatile compounds were identified by GC-MS, and 11 of them were identified as the key aroma compounds More important, variation in the compounds of hexanal, heptanal, octanal, 2-heptenal, nonanal, trans- 2-octenal, benzeneaceldehyde, (E)-2-nonenal, 1-octen-3-ol, 1-pentanol, 2-methoxy-4-vinylphenol and 2-pentylfuran might be applied for explaining the aroma characteristics among six sorghum cultivars. Result of GC-IMS showed that 26 volatile compounds but not in results from GC-MS detection, indicating advantage of methodol. combination for a better understanding impact of cultivars and cooking on volatile characteristics of sorghums.

Food Research International published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tressl, Roland; Kersten, Evelyn; Wondrak, Georg; Rewicki, Dieter; Kruger, Ralph-Peter published the artcile< Fragmentation of sugar skeletons and formation of Maillard polymers>, Formula: C6H9NO, the main research area is fragmentation pathway sugar skeleton; Maillard polymer formation.

Labeling experiments involving the reaction of 13C-labeled hexoses, pentoses, and D-lactose with 4-aminobutyric acid (GABA) (isoleucine) are described. The distribution of the label was investigated by MS and gave an insight into the formation pathways leading to complementary labeled compounds from hexoses and pentoses with intact carbon skeletons and indicated distinct fragmentations of the sugar skeletons into C5- and C4-compounds (furans, N-alkylpyrrolemethanols, N-alkyl-2-formylpyrroles and N-alkylpyrroles). These compounds undergo polycondensations to melanoidin-like macromols. under mild reaction conditions. In a series of model experiments, different types of polymers were investigated, and individual oligomers (e.g. I) were characterized by 1H/13C-NMR spectroscopy and FAB-/MALDI-TOF-MS. The authors postulate that these polycondensation reactions represent the most important driving force in the Maillard reaction.

Special Publication – Royal Society of Chemistry published new progress about Fragmentation reaction. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Formula: C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Cheng; Wang, Minyan; Lu, Hongjian; Zhao, Binlin; Shi, Zhuangzhi published the artcile< Enabling the Use of Alkyl Thianthrenium Salts in Cross-Coupling Reactions by Copper Catalysis>, Recommanded Product: (4-Ethynylphenyl)methanol, the main research area is internal alkyne chemoselective photochem preparation; terminal alkyne thianthrenium salt Sonogashira copper catalyst; alkane chemoselective preparation; alkyl thianthrenium trifluoromethanesulfonate Grignard reagent Kumada copper catalyst; alkynylation; copper; photoredox reactions; radical; sulfonium salts.

Here, a series of thianthrenium salts was synthesized that act as reliable alkylation reagents and readily engage in copper-catalyzed Sonogashira reactions to build C(sp3)-C(sp) bonds under mild photochem. conditions. Diverse alkyl thianthrenium salts, including Me and disubstituted thianthrenium salts, were employed with great functional breadth, since sensitive Cl, Br, and I atoms, which were poorly tolerated in conventional approaches, were compatible. The generality of developed alkyl reagents had also been demonstrated in copper-catalyzed Kumada reactions.

Angewandte Chemie, International Edition published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Recommanded Product: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts