Tag: M.W=100-150

Elavarasan, Samaraj; Bhaumik, Asim; Sasidharan, Manickam published the artcile< An Efficient Mesoporous Cu-Organic Nanorod for Friedlaender Synthesis of Quinoline and Click Reactions>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is hierarchical mesoporous organic polymer copper complex preparation surface area; aminobenzyl alc arylketone heterogeneous catalyst Friedlaender synthesis green chem; phenylquinoline preparation; benzylamine heterogeneous catalyst aerobic oxidative dehydrogenation green chem; arylalkyne azide benzylhalide heterogeneous catalyst regioselective click green chem.

A triazine functional hierarchical mesoporous organic polymer (HMOP) with nanorod morphol. together with large BET surface area ∼1218 m2g-1, huge pore volume&γτ”” ;6 mLg-1 and dual micro/mesopore architectures. Subsequent Cu-coordination with nitrogen atoms of the HMOP provided a robust catalyst (Cu-HMOP) to accomplish multi-step cascade reactions for preparation of N-heterocycles by different routes. For instance, the Cu-HMOP efficiently catalyzed one-pot sequential multi-step oxidative dehydrogenative coupling of 2-aminobenzyl alc. with diverse aromatic ketones to afford corresponding quinolines in excellent isolated yields (up to 97%). Secondly, the present catalyst exhibited good aerobic oxidative dehydrogenation activity of amines to imines. Thirdly, for “”click”” reaction involving azides-alkynes, the Cu-HMOP produced quant. yield for 1,4-disubstituted 1,2,3-triazole derivatives at room temperature using water as solvent. Verification of active metal leaching by a hot filtration test as well as reusability of the retrieved Cu-HMOP catalysts showed a consistent activity in the multi-component quinoline synthesis as model reaction.

ChemCatChem published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Mathoor Illam, Praseetha; Rit, Arnab published the artcile< Ruthenium(II) Complexes of Heteroditopic N-Heterocyclic Carbene Ligands: Efficient Catalysts for C-N Bond Formation via a Hydrogen-Borrowing Strategy under Solvent-Free Conditions>, Electric Literature of 5344-90-1, the main research area is ruthenium imidazolylidene triazolylidene complex preparation crystal structure benzylation catalyst; crystal structure ruthenium imidazolylidene triazolylidene complex; mol structure ruthenium imidazolylidene triazolylidene complex; benzyl alc coupling reaction benzylation aniline derivative carbeneruthenium catalyst; quinoline derivative preparation.

Both imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) have evolved to be elite groups of N-heterocyclic carbene (NHC) ligands for homogeneous catalysis. To develop efficient Ru(II)-based catalysts incorporating these ligands for C-N bond-forming reactions via H-borrowing methodol., the authors used chelating ligands integrated with ImNHC and mesoionic tzNHC donors connected via a CH2 spacer with a diverse triazole backbone. The synthesized Ru(II) complexes 3 are highly efficient for C-N bond formation across a wide range of primary amine and alc. substrates under solvent-free conditions, and among all of the complexes studied here, catalyst 3a with a mesityl substituent displayed maximum activity. Catalyst 3a is also effective for the selective mono-N-methylation of various anilines using MeOH as a coupling partner, known to be relatively more difficult than other alcs. Also, complex 3a also delivers various substituted quinolines successfully via the reaction of 2-aminobenzyl alc. with several secondary alcs. Importantly, catalyst 3a exhibited the highest activity among the reported Ru(II) complexes for both the N-benzylation of aniline [achieving a turnover number (TON) of 50000] and the realization of quinoline 8a by reacting 2-aminobenzyl alc. with 2-phenylethanol (attaining a TON of 30000). The significance of electronic tuning in the Ru(II) complexes of chelating ligands featuring a combination of ImNHC and tzNHC donors with various triazole backbones is demonstrated by applying them in diverse C-N bond-forming reactions via a H-borrowing strategy. Notably, the Ru(II) complex 3a having an N-mesityl substituent displayed the highest activity among known Ru(II) complexes for both the N-benzylation of aniline [a turnover number (TON) of 50000] and the synthesis of quinoline via the reaction of 2-aminobenzyl alc. with 2-phenylethanol (a TON of 30000).

Inorganic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger published the artcile< Resolution of trans-3-aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is Resolution separation enzymic amino cyclohexanol preparation; crystal structure hydroxycyclohexylimino thiadiazolyl benzamide preparation; mol structure hydroxycyclohexylimino thiadiazolyl benzamide preparation.

(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess. The reaction of 5-(4-cyanophenyl)-3-methyl-2-(methylthio)-1,3,4-thiadiazolium perchlorate with (-)-(1R,3R)-3-aminocyclohexanol thus prepared gave 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzonitrile (I). The crystal and mol. structures of 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzamide were reported.

Tetrahedron: Asymmetry published new progress about Crystal structure. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Budweg, Svenja; Wei, Zhihong; Jiao, Haijun; Junge, Kathrin; Beller, Matthias published the artcile< Iron-PNP-Pincer-Catalyzed Transfer Dehydrogenation of Secondary Alcohols>, Category: alcohols-buliding-blocks, the main research area is iron PNP pincer catalyst transfer dehydrogenation secondary alc; ketone preparation mol modeling; homogeneous catalysis; iron; oxidation; pincer ligands; transfer dehydrogenation.

The well-defined iron PNP pincer complex catalyst [Fe(H)(BH4)(CO)(HN{CH2CH2P(iPr)2}2)] was used for the catalytic dehydrogenation of secondary alcs. to give the corresponding ketones. Using acetone as inexpensive hydrogen acceptor enables the oxidation with good to excellent yields. DFT computations indicate an outer-sphere mechanism and support the importance of an acceptor to achieve this transformation under milder conditions.

ChemSusChem published new progress about Dehydrogenation catalysts. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Yingying; Gong, Yuxin; Song, Yanhong; Tong, Weiqi; Gong, Hegui published the artcile< Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is diaryl methane preparation; benzyl chloroformate aryl iodide deoxygenative cross electrophile coupling reaction.

This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives R1CH(R2)OC(O)Cl (R1 = C6H5, 4-FC6H4, 3-CH3C6H4, etc.; R2 = H, Me, butyl) with aryl iodides ArI (Ar = biphenyl-4-yl, naphthalen-1-yl, 3-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.) that generates a wide range of diaryl methane products R1CH(R2)Ar. The mild reaction conditions merit the C-O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Rui; Wei, Zeyuan; Zhang, Wei; Liu, Shun; Liu, Qiang published the artcile< A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes>, Synthetic Route of 403-41-8, the main research area is cobalt complex catalyst preparation; secondary alc primary preparation diastereoselective; ketone hydrogenation cobalt catalyst; aldehyde hydrogenation cobalt catalyst.

Herein, a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2 and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610) to afford alcs. was reported. This was the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Addnl., a bis(NHCs)-Co complex was successfully isolated and fully characterized and it exhibited excellent catalytic activity that equals that of the in-situ-formed catalytic system.

Chem published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Timelthaler, Daniel; Topf, Christoph published the artcile< Chromium-catalyzed transfer hydrogenation of aromatic aldehydes facilitated by a simple metal carbonyl complex>, SDS of cas: 10602-04-7, the main research area is aryl aldehyde transfer hydrogenation chromium metal carbonyl complex; alc preparation.

Authors communicate a simple method for the transfer hydrogenation of aromatic aldehydes in i-PrOH effected by the cost-effective and easy-to-handle [Cr(CO)6]. The reactions are readily carried in Ar-flushed tubes without further need of special equipment. Functional groups are widely tolerated and, if desired, the catalytic transformations can be further promoted through the addition of trimethylamine N-oxide (TMAO). This paves the way for processing thermo-labile substrates under mild reaction conditions. In addition, the introduced method is suitable for the deuteration of benzyl alc. derivatives

Journal of Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, SDS of cas: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jia; Chen, Xiaoyan; Hu, Youhong; Cheng, Gang; Zhong, Dafang published the artcile< Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics>, Formula: C6H13NO, the main research area is bromhexine metabolite blood analysis liquid chromatog mass spectrometry pharmacokinetics.

(E)-4-hydroxydemethylbromhexine (E-4-HDMB) and (E)-3-hydroxydemethylbromhexine (E-3-HDMB) were found as major metabolites, while (Z)-4-hydroxydemethylbromhexine and (Z)-3-hydroxydemethylbromhexine as minor metabolites of bromhexine in human plasma. These compounds were identified in comparison with synthetic authentic samples. A sensitive and selective rapid resolution liquid chromatog. tandem mass spectrometry (RRLC-MS/MS) method was developed to quantify the concentration of bromhexine and its two major metabolites (E-4-HDMB and E-3-HDMB) in human plasma. Following solid phase extraction, the analytes were separated on a Zorbax 1.8 μm particle size reversed-phase C18 column, using a gradient elution program with solvents consisting of 0.1% formic acid in acetonitrile and 0.1% formic acid in 5 mM ammonium acetate at a flow rate of 0.7 mL/min. Detection was carried out with an Agilent 6460 triple-quadrupole mass spectrometer operated with an electrospray ionization source mode operated in the pos. ion mode. The recovery of bromhexine, E-4-HDMB, E-3-HDMB, and internal standard (IS) was 63.1-70.9%, 60.5-68.4%, 57.0-63.5%, and 87.8%, resp. The matrix factors of bromhexine, E-4-HDMB, E-3-HDMB, and IS were 89.9-96.7%, 89.6-94.8%, 90.4-91.4%, and 103%, resp. After an oral administration of 8.0 mg bromhexine to five healthy male subjects, AUC0-24 h values of bromhexine, E-4-HDMB, and E-3-HDMB were found to be 93.5 ± 31.9, 34.0 ± 14.5, and 15.8 ± 6.89 ng h/mL, resp.; while C max values were 24.6 ± 5.16, 3.11 ± 1.13, and 5.36 ± 2.55 ng/mL, resp. Plasma concentration of bromhexine, E-4-HDMB, and E-3-HDMB declined with t 1/2 which gave 3.6 ± 0.5, 8.4 ± 2.7, and 6.4 ± 2.5 h, resp.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Blood analysis. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Formula: C6H13NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mattocks, A. R.; Driver, H. Elizabeth published the artcile< A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats>, Computed Properties of 52160-51-7, the main research area is pyrrole ester toxicity lung; heart pyrrole ester toxicity; liver pyrrole ester toxicity.

Toxic effects of 14 esters with chem. properties similar to those of pyrrolic pyrrolizidine alkaloid metabolites, were investigated in rats. The compounds were either mono- or bifunctional alkylating agents. When single doses were injected into a tail vein, the lungs were the main organ affected. All but 1 of the compounds tested caused pulmonary edema and congestion, accompanied by pleural effusion, and animals often died between 1 and 2 days after the injection. Smaller amounts of some of the esters caused a characteristic chronic lung lesion, with proliferation of alveolar tissue, resembling that produced by the pyrrolizidine alkaloids fulvine and monocrotaline. All the compounds which caused death associated with chronic lung damage were bifunctional alkylating agents. Very large doses, especially when injected rapidly, sometimes caused death within a few minutes. Thus, the ability to damage the lungs, and sometimes the heart, is a property of certain esters capable of alkylating tissues with which they come into contact, and is dependent on the chem. reactivity rather than the mol. structure of the compound Nevertheless the latter may play a part, as shown by the exceptionally high pneumotoxicity of an indole ester having a lipophilic structure with high affinity for tissue. Necrosis of the liver in some rats might be due to metabolites formed in the liver from the injected compounds or their decomposition products, rather than the active esters themselves.

Toxicology published new progress about Animal organ. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Computed Properties of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adhikary, Subhasis D.; Mandal, Debaprasad published the artcile< Polyoxometalate catalyzed imine synthesis: Investigation of mechanistic pathways>, Application In Synthesis of 5344-90-1, the main research area is preparation crystal structure zinc tungsten polyoxometalate complex; thermal decomposition zinc tungsten polyoxometalate complex; zinc tungsten polyoxometalate complex catalyst imine synthesis; imine preparation.

The syntheses of imines by oxidative coupling of primary alcs. and amines were achieved by using 2 mol% polyoxometalate (POM) Na12[WZn3(H2O)2(ZnW9O34)2] (Zn-WZn3) catalyst in the presence of t-BuOK and di-oxygen with excellent conversion (up to 100%) and selectivity (up to 100%). Non-noble metal-based POM catalyst in the presence of base represents a new reaction protocol for the selective synthesis of imine from both aromatic and aliphatic primary amines with functional group tolerance. Control experiment shows the formation of di-oxygen bind Zn-WZn3 activated species. The electron-d. of POM is mostly situated on the surface oxygen atoms of W-O-W bonds which can engage the alc. OH group and helps for the imine selectivity in the second step of imine synthesis.

Tetrahedron published new progress about Crystal structure. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application In Synthesis of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts