Tag: M.W=100-150

Mandler, Michael D.; Degnan, Andrew P.; Zhang, Shasha; Aulakh, Darpandeep; Georges, Ketleine; Sandhu, Bhupinder; Sarjeant, Amy; Zhu, Yeheng; Traeger, Sarah C.; Cheng, Peter T.; Ellsworth, Bruce A.; Regueiro-Ren, Alicia published the artcile< Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry>, COA of Formula: C9H8O, the main research area is halogenated azidopyridine preparation structure thermal property click reaction; safety shock sensitivity energetic material.

Owing to their participation in Click reactions, bifunctional azides are valuable intermediates in the preparation of medicines and biochem. tool compounds Despite the privileged nature of pyridines among pharmaceutical scaffolds, reports of the synthesis and characterization of azidopyridines bearing a halogen substituent for further elaboration are almost completely unknown in the literature. As azidopyridines carry nearly equal numbers of nitrogen and carbon atoms, we hypothesized that safety concerns limited the application of these useful bifunctional building blocks in medicinal and biol. chem. To address this concern, we prepared and characterized nine azidopyridines bearing a single fluorine, chlorine, or bromine atom. All were examined by differential scanning calorimetry (DSC), in which they demonstrated exotherms of 228-326 kJ/mol and onset temperatures between 119 and 135°C. Selected azidopyridines were advanced to mech. stress testing, in which impact sensitivity was noted for one regioisomer of C5H3FN4. The utility of these versatile intermediates was demonstrated through their use in a variety of Click reactions and the diversification of the halogen handles.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tironi, Matteo; Hopkinson, Matthew N. published the artcile< Silver-Catalyzed Nucleophilic Deoxydifluoromethylthiolation of Activated Aliphatic Alcohols with BT-SCF2H>, Related Products of 10602-04-7, the main research area is difluoromethylthioether preparation; aliphatic alc difluoromethyl thio methylbenzothiazolium triflate nucleophilic deoxydifluoromethylthiolation silver.

Deoxygenative conversion of alcs. into difluoromethylthioethers is reported using 2-((difluoromethyl)thio)-3-methylbenzo[d]thiazol-3-ium triflate (BT-SCF2H) as a source of -SCF2H anions. The presence of silver(I) triflate as a catalyst was found to be crucial for stabilizing the in situ-generated anion, while the concomitant formation of a reactive 2-(alkoxy)benzothiazolium electrophile likely ensures a fast onward substitution reaction, avoiding the build-up of -SCF2H. To the best of authors’ knowledge, this process represents the first report of a direct nucleophilic substitution reaction with -SCF2H and delivers products containing the medicinally relevant difluoromethylthio motif in a single step from widely available alcs.

European Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Related Products of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Valihura, K. V.; Larina, O. V.; Kyriienko, P. I.; Balakin, D. Yu.; Soloviev, S. O. published the artcile< Influence of Modifying Additives of Lanthanum and Cerium Oxides on Acid-Base Characteristics and Catalytic Properties of MgO-Al2O3 Systems in the Process of Gas-Phase Conversion of Ethanol to 1-Butanol>, Formula: C8H18O, the main research area is butanol ethanol lanthanum cerium magnesium aluminum oxide catalytic property.

The process of ethanol condensation to 1-butanol in the presence of MgO-Al2O3 systems modified with lanthanum and cerium oxide additives was studied. It is shown that MgO-Al2O3 doping with lanthanum and cerium oxides leads to an increase in the total concentration of acid and basic sites on the surface of the catalysts. It was found that increasing the concentration of basic sites for La- and Ce-containing samples promotes an increase in the yield of acetaldehyde but does not lead to an increase in the yield of 1-butanol due to a decrease in the number of aldol condensation sites. Increasing the concentration ratio of basic and acid sites of the surface helps to increase the productivity of the catalyst for 1-butanol.

Theoretical and Experimental Chemistry published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Rakesh; Sinha, Suman; Das, Siuli; Chakraborty, Gargi; Paul, Nanda D. published the artcile< Iron Catalyzed Synthesis of Pyrimidines Under Air>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is pyrimidine preparation; alc amidine multicomponent dehydrogenative coupling iron catalyst.

A well-defined Fe(II)-complex featuring redox non-innocent 2-phenylazo-(1,10-phenanthroline) ligand, as a catalyst, a wide array of 2,4,6-trisubstituted pyrimidines I (R = NH2, Me, Ph, 4-chlorophenyl, cyclopropy; R1 = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R2 = Ph, cyclopropyl, 4-(trifluoromethyl)phenyl, etc.) was prepared via multicomponent dehydrogenative coupling of primary R2CH2OH and secondary alcs. R1CH(CH3)OH with amidines NH2N(R)=NH under air at 100°C. A few control experiments were carried out to understand and unveil the plausible reaction mechanism.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Yueyang; Lin, Song; Yan, Houchun; Guo, Hongyue; Li, Qingsong published the artcile< Liquid-liquid equilibrium data measurement and thermodynamic modelling for ternary mixtures composed of water, diethylene glycol dimethyl ether and different solvents at 298.2 K>, Product Details of C8H18O, the main research area is water diethylene glycol dimethyl ether liquid equilibrium thermodn modeling.

Liquid-liquid equilibrium (LLE) data for water + diethylene glycol di-Me ether + {methyl iso-Bu carbinol, Me iso-Bu ketone, Me iso-Pr ketone, Me tert-Bu ether, n-octanol and 2-ethyl-1-hexanol} was measured at 298.2 K under 101.3 kPa. The effect of separating diethylene glycol di-Me ether from water is evaluated by the distribution coefficient and the separation coefficient The Othmer-Tobias and Hand equations were chosen to examine the exptl. LLE data. Meanwhile, the data was correlated by the NRTL and UNIQUAC thermodn. models with AAD% less than 0.55 and RMSD% less than 0.77. The separation performance of six solvents was compared using the σ-profile anal. via the exploration of the intermol. interaction.

Journal of Chemical Thermodynamics published new progress about Density. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Jingxiu; Chen, Qingmao; Luo, Zhigao; Tang, Xiaodong; Zhao, Jinwu published the artcile< N-Heterocyclic carbene copper catalyzed quinoline synthesis from 2-aminobenzyl alcohols and ketones using DMSO as an oxidant at room temperature>, Product Details of C7H9NO, the main research area is quinoline preparation; aminobenzyl alc Friedlander reaction ketone heterocyclic carbene catalyst.

A facile and practical process for the synthesis of quinolines through an N-heterocyclic carbene copper catalyzed indirect Friedlander reaction from 2-aminobenzyl alc. and aryl ketones using DMSO as an oxidant at room temperature is reported. The quinolines, e.g., I (R1 = 4-MeC6H4, 2-ClC6H4, 3-thienyl, etc., R2 = H; R1 = Ph, R2 = Me), were synthesized in acceptable yields.

RSC Advances published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Savych, Olena; Kuchkovska, Yuliya O.; Bogolyubsky, Andrey V.; Konovets, Anzhelika I.; Gubina, Kateryna E.; Pipko, Sergey E.; Zhemera, Anton V.; Grishchenko, Alexander V.; Khomenko, Dmytro N.; Brovarets, Volodymyr S.; Doroschuk, Roman; Moroz, Yurii S.; Grygorenko, Oleksandr O. published the artcile< One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles>, Computed Properties of 6850-39-1, the main research area is one pot parallel combinatorial synthesis dialkylaminotetrazole; aminotetrazole library preparation; 2,2,2-trifluoroethylthiocarbamate; REAL (readily accessible) compounds; heterocyclization; tetrazoles; thiourea.

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds

ACS Combinatorial Science published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Computed Properties of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Shao-Qian; Wang, Yi-Fan; Zhao, Wei-Cheng; Lin, Guo-Qiang; He, Zhi-Tao published the artcile< Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis>, COA of Formula: C9H8O, the main research area is fluoroester conjugated enyne copper palladium hydrocarbonation catalyst; allene stereoselective preparation gold cyclization; fluorinated hydrofuran stereoselective preparation.

Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process.

Journal of the American Chemical Society published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (conjugated). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zharkov, Mikhail N.; Arabadzhi, Svetlana S.; Kuchurov, Ilya V.; Zlotin, Sergei G. published the artcile< Continuous nitration of alcohols in a Freon flow>, HPLC of Formula: 104-76-7, the main research area is alc nitration continuous Freon flow.

The first ever installation for continuous nitration in a liquefied gas mobile phase was developed. The installation was used to convert 2-ethylhexan-1-ol, diethylene glycol, and glycerol into their corresponding nitro esters. The starting compounds were treated with a 10% excess of dinitrogen pentoxide in liquefied 1,1,1,2-tetrafluoroethane (TFE) medium. The flow reactions proceeded at room temperature and ≤10 bar pressure with excellent conversion and selectivity. An important feature of the developed procedure is TFE recycling which prevents its release into the atm. The proposed approach for nitro esters flow production outperforms the known batch-type analogs in terms of having a far better specific productivity (by two orders of magnitude), reduced fire and explosion risks, and less pronounced neg. impact on the environment. The enumerated advantages along with equipment availability lay the foundation for the development of a highly efficient nitration technol., which is characterized by reduced amounts of waste by employing a TFE medium.

Reaction Chemistry & Engineering published new progress about Nitration. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Rongzhou; Qi, Jipeng; Yue, Yuancheng; Lian, Zhe; Xiao, Haibin; Zhuo, Shuping; Xing, Lingbao published the artcile< Ambient-pressure hydrogenation of ketones and aldehydes by a metal-ligand bifunctional catalyst [Cp*Ir(2,2'-bpyO)(H2O)] without using base>, Quality Control of 403-41-8, the main research area is secondary alc preparation green chem; ketone hydrogenation bifunctional iridium complex catalyst; primary alc preparation green chem; aldehyde hydrogenation bifunctional iridium complex catalyst.

An efficient catalytic system for hydrogenation of ketones R1C(O)R2 [R1 = Me, 3,4-dichlorophenyl, 2-naphthyl, pyridin-2-yl, etc.; R2 = Me, Pr, hexyl; R1R2 = -(CH2)5-] and aldehydes R3CHO (R3 = nonyl, cyclohexyl, 4-cyanophenyl, pyridin-2-yl, etc.) using a Cp*Ir complex [Cp*Ir(2,2′-bpyO)(H2O)] bearing a bipyridine-based functional ligand as catalyst has been developed. A wide variety of secondary and primary alcs. (R1)(R2)CHOH and R3CH2OH resp. was synthesized by the catalyzed hydrogenation of ketones and aldehydes under facile atm.-pressure without a base. The catalyst also displays an excellent chemoselectivity towards other carbonyl functionalities and unsaturated motifs. This catalytic system exhibits high activity for hydrogenation of ketones and aldehydes with H2 gas.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Quality Control of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts