Tag: M.W=0-100

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H8O2

A mixture of Int-172-22 (7 g, 26.17 mmol), 23 (14.09 mL, 157 mmol), K2CO3 (4.34 g, 31.4 mmol), DPPP (521 mg, 1.3 mmol) and Pd(OAc)2 (59 mg, 0.26 mmol) in 60 mL H2O/toluene (9:1) was heated at 90oC for 24h. After the mixture was cooled to room temperature, concentrated HCl (15 mL) was slowly added and the mixture was stirred at room temperature for 1h. The product was extracted with EtOAc (3X). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The product was purified by column chromatography using hexanes/EtOAc (0 to 20% EtOAc in hexanes) and obtained as a pale yellow solid (1.3 g) in 27% yield. LCMS: (M+1) m/z = 184.

With the rapid development of chemical substances, we look forward to future research findings about 764-48-7.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; BLACKTHORN THERAPEUTICS, INC.; ROBERTS, Edward; GUERRERO, Miguel A.; URBANO, Mariangela; ROSEN, Hugh; JONES, Rob; LAXAMANA, Candace Mae; ZHAO, Xianrui; TURTLE, Eric Douglas; (331 pag.)WO2018/170492; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., name: Cyclopropanol

To a solution of 4-bromo-2-fluoropyridine (3000 mg, 17.05 mmol) and cyclopropanol (1287 mg, 22.16 mmol) in NMP (22.6 mL) was added sodium tert-butoxide (22.7 mL, 22.67 mmol) . After 50 min, the reaction mixture was partitioned between ethyl acetate and water (100 mL) . The organic layer was separated, washed with water, brine, dried over Na2SO4,filtered and concentrated. The resulting residue was purified by a flash column chromatography on silica gel (ISCO 40g SiO2column, eluting with 0-25% EtOAc/hexanes) to afford the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DEBENHAM, John S.; COX, Jason M.; LAN, Ping; SUN, Zhongxiang; FENG, Zhe; SUN, Chunrui; SEGANISH, W. Michael; LAI, Zhong; ZHU, Chen; BARA, Thomas; RAJAGOPANALAN, Murali; DANG, Qun; KIM, Hyunjin M.; HU, Bin; HAO, Jinglai; (112 pag.)WO2018/107415; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-(Aziridin-1-yl)ethanol

Example 45(4-chlorophenyl)[4-chloro-3-phenyl-2-(2,2,2-trifluoroethoxy)quinolin-6-yl](1-methyl-1H-imidazol-5-yl)methanol TFA(100 mg, 0.202 rnniol, Example 65), 2,2,2 -trifluoroethanol (14,5 L, 0.202 mmol), toluene (2 ml), and sodium hydride (60% dispersion in mineral oil, 20 mg, 0.51 mmol) were combined in a round bottom flask under an N2atmosphere. The reaction solution was heated to reflux and reflux ed overnight. The reaction solution was cooled to room temperature then transferred to a separatory tunnel with EtOAc dilution, and extracted with saturated, aqueous NH4CI then saturated, aqueous NaHCOi solutions. The organic phase was separated then dried over MgS04, filtered and concentrated under reduced pressure. The crude product was purified by flash column chromatography (silica gel, 0-10% DCM / MeOH) then via reverse phase chromatography using acetonitrile with 0.05%) trifluoroacetic acid in water as eluent. The fractions from the purification containing the desired product were transferred to a separatory funnel with EtOAc and extracted with a saturated, aqueous NaHC03solution. The aqueous layer was separated, extracted with EtOAc, then the combined organic phases were dried over Mg804, filtered and concentrated under reduced pressure to provide the title compound. MS (ESS): mass caicd. for C28H20CI2F3N3O2, 557.1 ; m/z found, 558.3 [M+Hf; NMR (600 MHz, CDCI3) delta ppm 8.38 (s, 1 H), 8.17 (d, J = 2.0 Hz, 1H), 7.87 (d, J —— 8.8 Hz, 1H), 7.60 (dd, J —— 8.8, 2.1 Hz,1 1 1). 7.52 – 7.43 (m, 3H), 7.38 – 7.31 (m, 6H), 6.56 (s, 1 H), 4.92 (q, J —– 8.4 Hz, 21 1). 3.62 (s.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARBAY, Kent; EDWARDS, James, P.; KREUTTER, Kevin, D.; KUMMER, David, A.; MAHAROOF, Umar; NISHIMURA, Rachel; URBANSKI, Maud; VENKATESAN, Hariharan; WANG, Aihua; WOLIN, Ronald, L.; WOODS, Craig, R.; FOURIE, Anne; XUE, Xiaohua; CUMMINGS, Maxwell, D.; LEONARD, Kristi, A.; WO2015/57203; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 504-63-2, 1,3-Propanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 504-63-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 504-63-2

Propane-1,3-diol (5.0 g, 65.78 mmol) was taken in 50 mL of dry THF. Next, NaH (60% dispersion in mineral oil, 2.49 g, 65.78 mmol) was added in portions at 0 C. The reaction mixture was stirred at 0 C for 30 min. Tetrabutylammonium iodide (TBAI) (1.6 g, 0.66 mmol) was added to it followed by the addition of 4-methoxybenzylbromide (13.2 g, 65.78 mmol) in THF (50 mL). The reaction mixture was stirred for a further 2 h at room temperature. Ice water (15 mL) was added carefully to the reaction mixture to quench any excess of NaH. The reaction mixture was extracted with EtOAc (50 mL). The organic layer was washed with water (15 mL) and brine (20 mL). Evaporation and purification by means of silica gel chromatography (EtOAc/hexane = 20:80) afforded compound 8 (11.6 g, 90%) as a colorless liquid. IR: nu 3393, 1613, 1513, 1462, 1248 cm-1; 1H NMR (200 MHz, CDCl3): 7.22 (2H, d, J = 8.0 Hz), 6.83 (2H, d, J = 8.0 Hz), 4.41 (2H, s), 3.79 (3H, s), 3.70 (2H, d, J = 7.0 Hz), 3.56 (2H, d, J = 7.0 Hz), 2.52 (1H, br s), 1.86-1.74 (2H, m); 13C NMR (50 MHz): delta; ESIMS: m/z 197 [M+H]+, Anal. Calcd for C11H16O3: C, 67.35; H, 8.16. Found: C, 67.46; H, 8.11.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.

Reference:
Article; Das, Biswanath; Nagendra, Siddavatam; Reddy, Cheruku Ravindra; Tetrahedron Asymmetry; vol. 22; 11; (2011); p. 1249 – 1254;,
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Application of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

Free, i.e., monomeric HMPA was reacted with MEA hydrochloride in the presence of a molecular sieve additive. Conditions of the reaction, conversions and selectivities are shown in Table 12.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2002-24-6, 2-Aminoethanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Monsanto Technology LLC; US2005/54871; (2005); A1;,
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Reference of 627-30-5 ,Some common heterocyclic compound, 627-30-5, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 500 mL three-necked flask was charged with a magnetic stirrer and a thermometer, and 5.2 g of p-toluenesulfonic acid (0.03 mol) was added thereto.94.5 g of 3-chloropropanol (1.0 mol), 200 mL of dichloromethane, and 16.2 g of 3,4-dihydropyran (1.5 mol) were stirred at room temperature 20-25 C for 1 h.After the reaction liquid was subjected to gas chromatography to detect 3-chloropropanol, 100 mL of water was added to the system.After stirring for 5 min, the phases were separated, and the organic phase was washed with 100 mL of brine, dried over anhydrousDistillation under reduced pressure, collecting 110-115 C fraction (vacuum degree 30 mbar),A colorless transparent liquid of 164.6 g, which is 2-(3-chloropropoxy)tetrahydro-2H-pyran, has a GC content of 98.2% and a yield of 91.13%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,627-30-5, its application will become more common.

Reference:
Patent; Hunan Youse Chenzhoufu Chemical Co., Ltd.; Wang Gang; Peng Zhimin; Liu Bin; Li Jun; Li Zhipeng; Su Wanli; Zhang Zhenhua; (11 pag.)CN109336740; (2019); A;,
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Reference of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step A Synthesis of Compound Int-19a TBDPSC1 (9.0 mL, 35.0 mmol) was added dropwise to a stirred hazy solution of 2- methylenepropane-l,3-diol (3 g, 34.1 mmol) and imidazole (4.70 g, 69.0 mmol) in DCM (340 mL). The reaction mixture was stirred at room temperature overnight. The following morning, the reaction mixture was concentrated under reduced pressure (~80 mL) before being filtered through a pad of celite, rinsing over with additional DCM / MeOH. The filtrate was evaporated under reduced pressure. The resulting oil was purified by silica gel column (220 g) (0452) chromatography eluting with 0-20% EtOAc / hexanes to afford compound Int-19a. NMR (500 MHz, CDCb): d 7.69 (d, J = 7.4 Hz, 4H); 7.49 – 7.37 (m, 6H); 5.16 (app. s, 1H); 5.13 (app. s, 1H); 4.27 (s, 2H); 4.19 (d, J = 6.2 Hz, 2H); 1.80 (t, J = 6.1 Hz, 1H); 1.08 (s, 9H).

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Tao; APGAR, James, M.; WHITEHEAD, Alan; ZHANG, Yonglian; HU, Zhiyong; SHURTLEFF, Valerie, W.; MCCAULEY, John, A.; RAHEEM, Izzat, T.; (97 pag.)WO2019/209667; (2019); A1;,
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Reference of 627-30-5 ,Some common heterocyclic compound, 627-30-5, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 500 mL three-necked flask was charged with a magnetic stirrer and a thermometer, and 5.2 g of p-toluenesulfonic acid (0.03 mol) was added thereto.94.5 g of 3-chloropropanol (1.0 mol), 200 mL of dichloromethane, and 16.2 g of 3,4-dihydropyran (1.5 mol) were stirred at room temperature 20-25 C for 1 h.After the reaction liquid was subjected to gas chromatography to detect 3-chloropropanol, 100 mL of water was added to the system.After stirring for 5 min, the phases were separated, and the organic phase was washed with 100 mL of brine, dried over anhydrousDistillation under reduced pressure, collecting 110-115 C fraction (vacuum degree 30 mbar),A colorless transparent liquid of 164.6 g, which is 2-(3-chloropropoxy)tetrahydro-2H-pyran, has a GC content of 98.2% and a yield of 91.13%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,627-30-5, its application will become more common.

Reference:
Patent; Hunan Youse Chenzhoufu Chemical Co., Ltd.; Wang Gang; Peng Zhimin; Liu Bin; Li Jun; Li Zhipeng; Su Wanli; Zhang Zhenhua; (11 pag.)CN109336740; (2019); A;,
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Reference of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step A Synthesis of Compound Int-19a TBDPSC1 (9.0 mL, 35.0 mmol) was added dropwise to a stirred hazy solution of 2- methylenepropane-l,3-diol (3 g, 34.1 mmol) and imidazole (4.70 g, 69.0 mmol) in DCM (340 mL). The reaction mixture was stirred at room temperature overnight. The following morning, the reaction mixture was concentrated under reduced pressure (~80 mL) before being filtered through a pad of celite, rinsing over with additional DCM / MeOH. The filtrate was evaporated under reduced pressure. The resulting oil was purified by silica gel column (220 g) (0452) chromatography eluting with 0-20% EtOAc / hexanes to afford compound Int-19a. NMR (500 MHz, CDCb): d 7.69 (d, J = 7.4 Hz, 4H); 7.49 – 7.37 (m, 6H); 5.16 (app. s, 1H); 5.13 (app. s, 1H); 4.27 (s, 2H); 4.19 (d, J = 6.2 Hz, 2H); 1.80 (t, J = 6.1 Hz, 1H); 1.08 (s, 9H).

According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Tao; APGAR, James, M.; WHITEHEAD, Alan; ZHANG, Yonglian; HU, Zhiyong; SHURTLEFF, Valerie, W.; MCCAULEY, John, A.; RAHEEM, Izzat, T.; (97 pag.)WO2019/209667; (2019); A1;,
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Reference of 14320-38-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Referential Example 79] (1RS,2RS)-4-Methoxy-1,2-cyclopentanediol (mixture of 4-position stereoisomers): 60% sodium hydride (800 mg) was added portionwise to a solution of 3-cyclopentene-1-ol (1.68 g) and methyl iodide (1.25 ml) dissolved in tetrahydrofuran (20 ml) under ice cooling, and the mixture was stirred overnight at room temperature.. Water and diethyl ether was added to the reaction mixture to separate an organic layer, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure with ice cooling to obtain crude 4-methoxy-1-cyclopentene.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14320-38-8, Cyclopent-3-enol.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1405852; (2004); A1;,
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