Tag: M.W=0-100

Application of 2854-16-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

The compound 4-geo (101.3 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (71.0 mg), and HO-Bt (61.9 mg) were added to methylene chloride (2.1 mL), and the mixed solution was stirred at room temperature under an argon atmosphere for 5 minutes. To the mixed solution was added a methylene chloride solution (1.0 mL) of hydroxyisobutylamine (59.8 g), and the resulting mixed solution was stirred for 4.5 hours. To the mixed solution was added a saturated sodium carbonate aqueous solution, and the water phase was extracted with ethyl acetate. The organic phase was washed with a saturated saline solution. After removing the organic solvent under vacuum, the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1?1/2) to obtain 118.0 mg (a yield of 97.5percent) of a yellow viscous oily desired product. Data of the obtained compound are as follows: 1H-NMR (CDCl3, 400 MHz) delta: 1.19-1.34 (1H, m), 1.24 (6H, m), 1.76 (1H, t, J=9.0 Hz), 2.13 (2H, dd, J=6.8, 13.8 Hz), 2.25 (2H, dd, J=6.8, 13.8 Hz), 3.33 (2H, d, J=6.1 Hz), 4.99 (1H, dd, J=4.9, 8.8 Hz), 5.11 (1H, dd, J=4.9, 8.8 Hz), 5.44 (1H, dd, J=9.8, 15.3 Hz), 5.64 (1H, td, J=6.8, 14.9 Hz), 5.81 (1H, d, J=15.3 Hz), 5.83 (1H, s), 6.82 (1H, td, J=6.8, 15.3 Hz); 13C-NMR (CDCl3, 100 MHz), delta: 19.21, 27.35, 31.16, 31.62, 50.45, 56.98, 61.52, 71.10, 81.09, 84.94, 123.77, 130.28, 132.55, 144.20, 166.89; ESI-MS m/z: +ESI 426 [M+Na]+, 404 [M+H]+, -ESI 402 [M-H]-. HRESI-MS m/z: 426.0972 (Calcd for C19H25NO5FeNa: 426.0980). IR (film): cm-1: 3302, 2918, 2035, 1961, 1669, 1627, 622, 610, 571.

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TSUMURA & CO.; Aoki, Katsuyuki; US2013/245303; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 927-74-2, 3-Butyn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 927-74-2, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 3-Butyn-1-ol

To a stirred solution of the product of Preparation 19 (4.5 g, 16.3 mmol) in diethylamine (100 mL) was added but-3-yn-1-ol (1.9 mL, 32.6 mmol), Pd(PPh3)2Cl2 (500 mg, 1.63 mmol) and CuI (154 mg, 0.815 mmol) and resulting mixture was stirred for 17 h at room temperature. The solvent was then removed under reduced pressure and the residue was dissolved in diethyl ether (200 mL) and this solution was filtered to remove salts. The solvent was then removed under reduced pressure and the crude product was purified by silica gel chromatography (60% EtOAc/Hexane) to afford the title intermediate (3.03 g, 91% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,927-74-2, its application will become more common.

Reference:
Patent; Mammen, Mathai; Mischki, Trevor; Hughes, Adam; Ji, Yu-Hua; US2006/35933; (2006); A1;,
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Reference of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of carbon disulfide (452 pL, 7.5 mmol, 1.5 eq.) in 10 mL anhydrous THF under intert atomsphere of argon, is added dropwise at 0 C 2-(methylamino)ethanol (400pL, 5.0 mmol, 1.0 eq.). After stirring atO Cfor5 minutes, sodium hydride (60% dispersion inmineral oil, 200 mg, 5.0 mmol, 1 .0 eq.) is added in portions. After 30 minutes of stirring at 0 0C the mixture is concentrated under reduced pressure and washed with cyclohexane toremove mineral oil and dried overnight under reduced pressure to yield a pale yellow powder (842 mg, 4.9 mmol, 97 % yield).1H NMR (400 MHz, MeOD) 6 (ppm): 3,57 (s, 3H, CH3), 3,87 (t, J = 6 Hz, 2H, CH2N),4,27 (t, J = 6 Hz, 2H, CH2O)130 NMR (100 MHz, MeOD) 6 (ppm): 44,7 (CH3N), 59,1 (CH2N), 61,2 (CH2O), 214,0 (CS2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-83-1, 2-(Methylamino)ethanol.

Reference:
Patent; UNIVERSITE PARIS EST CRETEIL VAL DE MARNE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); MOTTERLINI, Roberto; FORESTI, Roberta; MARTENS, Thierry; RIVARD, Michael; WO2015/140337; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 534-03-2, name is 2-Aminopropane-1,3-diol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Aminopropane-1,3-diol

0.91 g of 2-amino-l , 3-propandiol and 1.13 g of triethylamine are solubilised in 15 ml of tetrahydrofuran at 0C. The solution is stirred and placed under nitrogen atmosphere. A solution of 2.74 g of palmitoyl chloride is added dropwise slowly within 30 min. After another 30 min of stirring at ambient temperature, the mixture is dry evaporated. The residue is solubilised using 15 ml of ethyl acetate and extracted using 10 ml of water which is disposed. The organic phase is anhydrified using Na2S04 and dry evaporated under vacuum. The raw amide thus obtained is used without further purification. The residue is suspended at 0C and under nitrogen gas atmosphere in 20 ml of S0C12. The mixture is stirred at 0C for 30 minutes, then at ambient temperature for 6 hours. The solution thus obtained is dry evaporated at a low pressure. The residue is purified by crystallization from 15 ml of tert-butyl methyl ether, isolated and dried under vacuum. The crystallized product is suspended in 20 ml of anhydrous toluene and 1.3 g of potassium tert- butoxide are added. The mixture is heated at 40C for 2 hours, then it is cooled at 4C. The solution is extracted 3 times using 6 ml of water and the extracts are disposed. The organic phase is dry evaporated at’ a low pressure and the residue purified through flash chromatography in a column of silica gel using – as eluent – a mixture of hexane and ethyl acetate 1:3. The fractions containing the pure product are recombined and dry evaporated under vacuum. (About 90% yield) The 2-pentadecyl-4-hydroxymethyl-2-oxazoline product has the following characteristics: Molecular formula C19H37N02; C=73.26%, H=11.97%, N=4.50%, 0=10.27%; Solubility: poorly soluble in water, >10 mg/ml in ethanol; Mr 311.5; ESI-MS: 312 (MH+) .

The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EPITECH GROUP S.r.L.; DELLA VALLE, Francesco; DELLA VALLE maria Federica; DI MARZO, Vincenzo; CUZZOCREA, Salvatore; WO2013/121449; (2013); A1;,
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Application of 109-83-1 ,Some common heterocyclic compound, 109-83-1, molecular formula is C3H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10 g (calculated on the basis of the dry substance) of a Cu/Ni-based Raney catalyst (Degussa AG, BOO 111) was placed first as a suspension in water in a 600 ml autoclave with stirrer, pressure control valve and jacket heating and 75 g N-methyl-ethanolamine as well as 204 g of a 20% by weight sodium hydroxide solution were added. The autoclave was closed and the contents were heated to a temperature of 160 C. with the aid of the jacket heating. An increasing pressure of hydrogen was generated in this process which was kept at 10 bar (absolute) by the controlled opening of the pressure control valve. The release of gas was completely finished after 4 hours and the reactor was cooled to 90 C. After the stirrer was switched off, the catalyst sedimented within one hour and a portion of the supernatant clear solution of Na sarcosinate was moved from the autoclave through a plunge pipe. The catalyst remained in the reactor and could be used again in further batches.For each further cycle the suspension of catalyst remaining in the reactor was admixed with the said amounts of N-methylethanolamine and sodium hydroxide solution and the reaction was started by heating.With the exception of the initial batch, 270 g of a colourless solution of Na sarcosinate containing 40.0% by weight (corresponds to a yield of 97.2% of theory) was obtained per cycle.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; Thalhammer, Franz; Gastner, Thomas; US2009/163739; (2009); A1;,
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Electric Literature of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add hexadecane bromide (1.52 g, 5 mmol) to the reaction flask.And 1,3-propanediol (1.14 g, 15 mmol),Add 5 ml of dimethyl sulfoxide and 5 ml of tetrahydrofuran to dissolve.Add sodium hydroxide (800mg, 20mmol)The reaction was carried out for 24 hours at room temperature.Dilute with 10 ml of water,Adjust the pH to neutral with 2M dilute hydrochloric acid,Extracted with ethyl acetate 3 times,Combine the organic phase,Washed with saturated brine and concentrated.Purified by silica gel column chromatography to give compound 1.0g, Yield: 66.7%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 504-63-2, 1,3-Propanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (46 pag.)CN109485676; (2019); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, molecular weight is 89.14, as common compound, the synthetic route is as follows.Application In Synthesis of 3-Aminobutan-1-ol

in a microwave-tube, ethyl 2-[benzyloxycarbonyl(2-oxoethyi)amino]acetate (330 mg, 1 .18 mmol) was diluted in DCM (8 ml), then (+/-)-3-aminobutan-1-ol (1 16 mg, 1.24 mmol) and acetic acid (39 muIota, 673 prnol) were added to give a colorless solution. The reaction mixture was submitted to microwave heating for 1.5 h at 140 C. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0% to 50% EtOAc in heptane) to give the title compound (183 mg, 51 %) as a colorless oil. The relative stereochemistry of the product was unambiguously assigned by NOESY NMR experiments. (1085) MS (ESI, m/z): 305.2 [(M+H)+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2867-59-6, 3-Aminobutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; LERNER, Christian; KREIS, Lukas; HILPERT, Hans; (268 pag.)WO2017/158151; (2017); A1;,
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Electric Literature of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.

2-Methylene-propane-1,3-diol (2.2 g; 24.96 mmol) and dibutyltin oxide (6.85 g; 27.96 mmol) were refluxed in chloroform/methanol (100 ml 10: 1) for 24 h to obtain a clear solution. The solvent was removed under reduced pressure to give the stannoxane derivative as a white solid. Cesium fluoride (7.25 g; 47.7 mmol) was added and the mixture was dried under high vacuum. To this reaction mixture, DMF (20 ml) and benzyl bromide (3.27 ml ; 27.5 mmol) were added and the reaction mixture was stirred for 24 h at 25 °C. After that, the reaction mixture was heated at 50 °C for 1 h. The mixture is cooled to 25 °C and diluted with ethyl acetate (100 ml) and water (2 ml). The reaction mixture is stirred vigorously for 30 min and then filtered through a pad of celite to remove dibutyltin oxide. The filtrate was washed with water and then with brine, dried over Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography eluting with 20 percent ethyl acetate/hexane to yield 2.6 g (60percent) compound 71a) as oil. 1H-NMR (CDCl3) : delta 7.36-7.28 (m, 5H), 5.20 (s, 1H), 5.15 (s, 1H), 4.51 (s, 2H), 4.19 (s, 2H), 4.10 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92881; (2005); A1;,
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Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of compound 3a or 3b (1 mmol),benzene (50 ml), Et3N (1 ml) and morpholine (1 ml) was stirred for 5 h at80C. The solvents were evaporated in vacuo and the residues werechromatographed on a column with Al2O3 (hexane-diethyl ether, 3 :1) toafford products 8a or 8b, respectively

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
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Application of 124-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Fe(OTf)3 (1 mol%) was added to a magnetically stirred mixture of anamine (1 mmol) and Boc2O (1 mmol) at room temperature. The mixturewas stirred until completion of the reaction (TLC), then diluted withEtOAc and washed with water. The organic layer was dried overanhydrous MgSO4, then the solvent was distillated off under vacuum toyield the highly pure N-Boc derivatives

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Feng, Chengliang; Chu, Ningning; Zhang, Shuguang; Cai, Jin; Chen, Junqing; Hu, Huayou; Ji, Min; Journal of Chemical Research; vol. 37; 12; (2013); p. 757 – 760;,
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