Tag: 200-300

Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Pragati; Modukuri, Ram K.; Singh, Pratiksha; Soni, Isha; Shukla, P. K.; Chopra, Sidharth; Pasupuleti, Mukesh published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus》.Electric Literature of C12H14O3 The author mentioned the following in the article:

A series of novel hybrids I [R = t-Bu, iso-Pr, n-propyl; R1 = 4-Me-C6H4, 4-MeO-C6H4, furan-2-yl, thiophene-2-yl; R2 = CO2Et, 4-MeO-C6H4, 3,4-dimethoxyphenyl.] possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus septicemia model demonstrated that compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Electric Literature of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Liu, Jiandong; Gong, Hegui; Zhu, Shaolin published an article on February 22 ,2021. The article was titled 《Nickel-catalyzed, regio- and enantioselective benzylic alkenylation of olefins with alkenyl bromide》, and you may find the article in Angewandte Chemie, International Edition.Computed Properties of C12H20O6 The information in the text is summarized as follows:

A NiH-catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Computed Properties of C12H20O6) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Computed Properties of C12H20O6

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Application of 401797-00-0On March 12, 2014, Waki, Minoru; Maegawa, Yoshifumi; Hara, Kenji; Goto, Yasutomo; Shirai, Soichi; Yamada, Yuri; Mizoshita, Norihiro; Tani, Takao; Chun, Wang-Jae; Muratsugu, Satoshi; Tada, Mizuki; Fukuoka, Atsushi; Inagaki, Shinji published an article in Journal of the American Chemical Society. The article was 《A Solid Chelating Ligand: Periodic Mesoporous Organosilica Containing 2,2′-Bipyridine within the Pore Walls》. The article mentions the following:

Synthesis of a solid chelating ligand for the formation of efficient heterogeneous catalysts is highly desired in the fields of organic transformation and solar energy conversion. Here, we report the surfactant-directed self-assembly of a novel periodic mesoporous organosilica (PMO) containing 2,2′-Bipyridine (bpy) ligands within the framework (BPy-PMO) from a newly synthesized organosilane precursor [(i-PrO)3Si-C10H6N2-Si(Oi-Pr)3] without addition of any other silane precursors. BPy-PMO had a unique pore-wall structure in which bipyridine groups were densely and regularly packed and exposed on the surface. The high coordination ability to metals was also preserved. Various bipyridine-based metal complexes were prepared using BPy-PMO as a solid chelating ligand such as Ru(bpy)2(BPy-PMO), Ir(ppy)2(BPy-PMO) (ppy = 2-phenylpyridine), Ir(cod)(OMe)(BPy-PMO) (cod = 1,5-cyclooctadiene), Re(CO)3Cl(BPy-PMO), and Pd(OAc)2(BPy-PMO). BPy-PMO showed excellent ligand properties for heterogeneous Ir-catalyzed direct C-H borylation of arenes, resulting in superior activity, durability, and recyclability to the homogeneous analogous Ir catalyst. An efficient photocatalytic hydrogen evolution system was also constructed by integration of a Ru-complex as a photosensitizer and platinum as a catalyst on the pore surface of BPy-PMO without any electron relay mols. These results demonstrate the great potential of BPy-PMO as a solid chelating ligand and a useful integration platform for construction of efficient mol.-based heterogeneous catalysis systems. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Application of 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Application of 401797-00-0 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Category: alcohols-buliding-blocksOn June 1, 2018, Gupta, Sampa; Adhikary, Sulekha; Modukuri, Ram K.; Choudhary, Dharmendra; Trivedi, Ritu; Sashidhara, Koneni V. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Benzofuran-pyran hybrids: A new class of potential bone anabolic agents》. The article mentions the following:

Benzofuran moiety is an important pharmacophore showing pos. effects on bone health. In the present study, sixteen benzofuran-pyran hybrids were synthesized and were evaluated for their osteogenic effects on primary osteoblast cells isolated from calvaria. Compounds 22 and 24 were found potent in stimulating osteoblast differentiation as assessed by the alk. phosphatase activity. These compounds were also found to be nontoxic to osteoblast cells as compared to the control cells in MTT assay. Further, Alizarin Red-S staining for visualization of calcium nodules demonstrated compounds 22 and 34 as active in enhancing mineralization in osteoblast cells. Addnl., transcriptional anal. of these compounds on osteoblast cells revealed that compound 22 up-regulated the expression of osteogenic genes RUNX2, BMP-2, COL-1, thus substantiating that compound 22 having two geminal Me groups in its R3 position is a potent osteogenic agent. Addnl., compound 22 enhanced the ability of bone marrow stromal cells to differentiate towards osteoblast lineage and therefore can be further studied in vivo in bone loss model. In the experiment, the researchers used many compounds, for example, 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Category: alcohols-buliding-blocks)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Category: alcohols-buliding-blocksDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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《Sol-gel derived LaFeO3/SiO2 nanocomposite: synthesis, characterization and its application as a new, green and recoverable heterogeneous catalyst for the efficient acetylation of amines, alcohols and phenols》 was written by Farhadi, Saeed; Jahanara, Kosar; Sepahdar, Asma. Application of 63012-03-3 And the article was included in Journal of the Iranian Chemical Society on August 31 ,2014. The article conveys some information:

LaFeO3/SiO2 nanocomposite was synthesized by the sol-gel process from metal nitrates and tetra-Et orthosilicate (TEOS) as the SiO2 source. The nanocomposite product was characterized by XRD, FT-IR, SEM, and surface area measurements and was used as a heterogeneous catalyst for the efficient acetylation of amines, alcs., and phenols to the corresponding acetates using acetic anhydride under solvent-free conditions. Among the various substrates, acetylation of amines was preceded rapidly, so that an amine group could be selectively acetylated in the presence of alc. or phenolic hydroxyl groups by the appropriate choice of reaction time. The catalyst can also be reused several times without the loss of activity. In addition, the catalytic activity of the LaFeO3/SiO2 nanocomposite was higher than that of the pure LaFeO3 nanoparticles. The method is high yielding, clean, cost effective, compatible with the substrates having other functional groups and very suitable for the practical organic synthesis.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Application of 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Application of 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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《Promoter free allylation of trichloroacetimidates with allyltributylstannanes under thermal conditions to access the common 1,1′-diarylbutyl pharmacophore》 was published in Organic & Biomolecular Chemistry in 2018. These research results belong to Mahajani, Nivedita S.; Chisholm, John D.. COA of Formula: C13H11ClO The article mentions the following:

4,4-Diaryl-1-butenes such as Ph2CHCH2CH:CH2 and selected 4-aryl-1-butenes were prepared by allylation of diarylmethyl and electron-rich benzylic trichloroacetimidates such as Ph2CHOC(:NH)CCl3 with allyltributylstannane and allylic stannanes in MeNO2 without the addition of other promoters or catalysts. In the experimental materials used by the author, we found (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.COA of Formula: C13H11ClO

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Synthetic Route of C9H6O6In 2020 ,《Solid-Vapor Interface Engineered Covalent Organic Framework Membranes for Molecular Separation》 was published in Journal of the American Chemical Society. The article was written by Khan, Niaz Ali; Zhang, Runnan; Wu, Hong; Shen, Jianliang; Yuan, Jinqiu; Fan, Chunyang; Cao, Li; Olson, Mark A.; Jiang, Zhongyi. The article contains the following contents:

Covalent organic frameworks (COFs) with intrinsic, tunable, and uniform pores are potent building blocks for separation membranes, yet poor processing ability and long processing time remain grand challenges. Herein, we report an engineered solid-vapor interface to fabricate a highly crystalline two-dimensional COF membrane with a thickness of 120 nm in 9 h, which is 8 times faster than the reported literature. Due to the ultra-thin nature and ordered pores, the membrane exhibited an ultra-high permeance (water ∼ 411 L m-2 h-1 bar-1 and acetonitrile ∼ 583 L m-2 h-1 bar-1) and excellent rejection of dye mols. larger than 1.4 nm (> 98%). The membrane exhibited long-term operation which confirmed its outstanding stability. Our solid-vapor interfacial polymerization method may evolve into a generic platform to fabricate COFs and other organic frameworks membranes. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Synthetic Route of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Synthetic Route of C9H6O6

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Recommanded Product: 6381-59-5In 2017 ,《Theoretical and experimental features of nano-crystals Rochelle salt: piezoelectric resonance and phase transition》 was published in Journal of Nanoscience and Nanotechnology. The article was written by Pereira, D. P.; Del Nero, J.; Moreira, M. Dionizio; de Oliveira, P. C.; Alcantara, P.; Remedios, C. M. R.; Moreira, S. G. C.. The article contains the following contents:

A new methodol. based on Three-Electrode System (TES) technique was used to measure both, elastic (C44) and piezoelec. (d14) constants of Rochelle salt (RS) crystal. This technique was also used to observe the phase transitions at -18 °C and 24 °C, manifested as an increase of the output signal at these temperatures Mech. wave attenuation coefficient (α) into the crystal was found. Also, first principle methodol. in the framework of the d. functional theory was utilized to confirm the electronic structure of Rochelle Salt. The results present high accuracy theor./exptl. as well as a complete agreement with those known in the literature done by different methodologies. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Reference of Bis[(pinacolato)boryl]methaneIn 2021 ,《Reactivity Trends with Borylalkyl Copper(I) Species》 appeared in European Journal of Inorganic Chemistry. The author of the article were Corro, Macarena; Salvado, Oriol; Gonzalez, Sara; Dominguez-Molano, Paula; Fernandez, Elena. The article conveys some information:

A review. The renaissance on the application of gem-diborylalkanes from 2010, has allowed the conquest of new synthetic application towards C-C and C-N bond formation. The activation of gem-diborylalkanes by Cu(I) catalysts, generates active borylalkyl copper(I) species that are able to trap several electrophilic reagents, in an efficient way. In addition, the modification of Cu(I) complexes with chiral ligands, induces asym. platforms towards the synthesis of enantioenriched organoboron compounds The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Reference of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Reference of Bis[(pinacolato)boryl]methane

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《Boron-enabled geometric isomerization of alkenes via selective energy-transfer catalysis》 was published in Science (Washington, DC, United States) in 2020. These research results belong to Molloy, John J.; Schaefer, Michael; Wienhold, Max; Morack, Tobias; Daniliuc, Constantin G.; Gilmour, Ryan. Quality Control of Bis[(pinacolato)boryl]methane The article mentions the following:

Isomerization-based strategies to enable the stereodivergent construction of complex polyenes from geometrically defined alkene linchpins remain conspicuously underdeveloped. Mitigating the thermodn. constraints inherent to isomerization is further frustrated by the considerations of atom efficiency in idealized low-mol. weight precursors. In this work, it is reported a general ambiphilic C3 scaffold that can be isomerized and bidirectionally extended. Predicated on highly efficient triplet energy transfer, the selective isomerization of β-borylacrylates is contingent on the participation of the boron p orbital in the substrate chromophore. Rotation of the C(sp2)-B bond by 90° in the product renders re-excitation inefficient and endows directionality. This subtle stereoelectronic gating mechanism enables the stereocontrolled syntheses of well-defined retinoic acid derivatives In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Quality Control of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Quality Control of Bis[(pinacolato)boryl]methane

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