Tag: 200-300

Category: alcohols-buliding-blocksOn October 31, 2009 ,《Iridium complexes of N-heterocyclic carbenes in C-H borylation using energy efficient microwave technology: influence of structure, ligand donor strength and counter ion on catalytic activity》 appeared in Green Chemistry. The author of the article were Rentzsch, Christoph F.; Tosh, Evangeline; Herrmann, Wolfgang A.; Kuehn, Fritz E.. The article conveys some information:

Bridged and unbridged N-heterocyclic carbene (NHC) ligands were metalated with [Ir(COD)Cl]2 to give Ir(I) mono- and biscarbene substituted catalysts [Ir(COD)NHC(Cl)] and [Ir(COD)(NHC)2][X] (X: I, PF6, BF4, CF3COO, OTf). The prepared NHC-complexes were tested in the C-H borylation reaction of aromatic carbons with bis(pinacolato)diboron (B2pin2) and pinacolborane (HBpin). The use of microwave technol. in this study not only facilitates a time efficient screening of a wide range of influences such as ligand σ-donor strength and structural motif as well as the effects of the complex counterion, but also provides an energy efficient heating source. Catalyst (η4-1,5-cyclooctadiene)(1,1′-methyl-3,3′-propylene-diimidazol-2,2′-diylidene)iridium(I) trifluoroacetate (6TFA), which features a chelating NHC ligand, proved to be the most effective catalyst and further studies with this complex in the borylation of mono- and disubstituted benzene derivatives exploring chemo- and regioselectivity were undertaken. In the experimental materials used by the author, we found 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Category: alcohols-buliding-blocks)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Category: alcohols-buliding-blocks

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Application of 1082066-29-2On October 31, 2019 ,《Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer》 appeared in Bioorganic Chemistry. The author of the article were Skarbek, Charles; Serra, Silvia; Maslah, Hichem; Rascol, Estelle; Labruere, Raphael. The article conveys some information:

This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of doxorubicin and their biol. evaluation as anticancer agents. The determination of the most sensitive cancer type toward arylboronate prodrugs is crucial for further consideration of these mols. in clin. phase. To address this goal, an arylboronate-based profluorescent probe was used to compare the capacity of various cancer cell lines to efficiently convert the precursor into the free fluorophore. On the selected MiaPaCa-2 pancreatic cancer cells, a benzeneboronate prodrug exhibited 67% of the cytotoxicity obtained with the free doxorubicin. The prodrug was also able to induce tumor regression on MiaPaCa-2 pancreatic tumor model in ovo. Using this model, the amount of free doxorubicin liberated from this prodrug into the tumor was equivalent to the quantity measured after direct intratumoral injection of the same concentration of doxorubicin. After reading the article, we found that the author used (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Application of 1082066-29-2)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application of 1082066-29-2

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Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateIn 2014 ,《Investigation of radiation sensitivity of some tartrate compounds》 appeared in Radiation Protection Dosimetry. The author of the article were Bal, M. O.; Tuner, H.. The article conveys some information:

Potential ESR (ESR) dosimetric application of different compounds of sodium tartrate, such as sodium tartrate dihydrate, sodium bitartrate monohydrate and potassium sodium tartrate tetrahydrate, was investigated in the range of 0.74-25 Gy. While the radiation-induced intermediates produced in these compounds are similar, their radiation yields are different. It is found that the radiation yield of sodium tartrate dihydrate is higher than other compounds of sodium tartrates. Comparison of the radiation yields were also made between well-known samples of ammonium tartrate, alanine and lithium formate. It is found that the radiation yields of sodium tartrate dihydrate, sodium bitartrate monohydrate and potassium sodium tartrate tetrahydrate have the values of 1.22, 0.18 and 0.13, resp.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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In 2022,Asai, Kento; Miura, Masahiro; Hirano, Koji published an article in Journal of Organic Chemistry. The title of the article was 《Palladium-Catalyzed Cross-Coupling Reaction of Diarylmethanol Derivatives with Diborylmethane》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

A palladium-catalyzed cross-coupling reaction of diarylmethanol derivatives RC(R1)OR2 (R = Ph, naphthalen-2-yl, phenanthren-9-yl, 4-phenylbenzen-1-yl; R1 = H, Ph, 4-chlorophenyl, 2H-1,3-benzodioxol-5-yl; R2 = Boc, Ph, OMe, etc.) with diborylmethane has been developed. The reaction proceeds chemoselectively to deliver the corresponding homobenzylic boronates RC(R1)CH2Bpin in good yields. In the experimental materials used by the author, we found Bis[(pinacolato)boryl]methane(cas: 78782-17-9Category: alcohols-buliding-blocks)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Category: alcohols-buliding-blocks Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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Wang, Yaxin; Zhao, Jianyou; Qiao, Tianjiao; Zhang, Jian; Chen, Gong published their research in Chinese Journal of Chemistry on December 31 ,2021. The article was titled 《Tunable System for Electrochemical Reduction of Ketones and Phthalimides》.COA of Formula: C13H11ClO The article contains the following contents:

An efficient, tunable system for electrochem. reduction of ketones R1C(O)R2 (R1 = Ph, pyridin-2-yl, 4-chlorophenyl, etc.; R2 = H, t-Bu, thiophen-2-yl, 3-bromophenyl, etc.) and phthalimides I (R3 = prop-2-en-1-yl, phenoxymethyl, Bn, etc.) at room temperature without the need for stoichiometric external reductants was reported. By utilizing NaN3 as the electrolyte and graphite felt as both the cathode and the anode, it was able to selectively reduce the carbonyl groups of the substrates to alcs. R1C(OH)R2, pinacols (R1C(OH)R2)2, or methylene groups e.g., 13-chloro-4-azatricyclo[9.4.0.0 (3,8)]pentadeca-1(11),3,5,7,12,14-hexaene by judiciously choosing the solvent and an acidic additive. The reaction conditions were compatible with a diverse array of functional groups, and phthalimides I could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds e.g., 10-azatetracyclo[8.7.0.0(2,7).0(12,17)]heptadeca-2,4,6,12(17),13,15-hexaen-11-one. Mechanistic studies showed that the reactions involved electron, proton, and hydrogen atom transfers. Importantly, an N3/HN3 cycle operated as a hydrogen atom shuttle, which was critical for reduction of the carbonyl groups to methylene groups e.g., 13-chloro-4-azatricyclo[9.4.0.0 (3,8)]pentadeca-1(11),3,5,7,12,14-hexaene. In addition to this study using (3-Chlorophenyl)(phenyl)methanol, there are many other studies that have used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.COA of Formula: C13H11ClO

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Tu, Jia-Lin; Tang, Wan; Xu, Wei; Liu, Feng published an article on February 5 ,2021. The article was titled 《Iminyl-Radical-Promoted C-C Bond Cleavage/Heck-Like Coupling via Dual Cobaloxime and Photoredox Catalysis》, and you may find the article in Journal of Organic Chemistry.Related Products of 20880-92-6 The information in the text is summarized as follows:

Herein an unprecedented protocol for radical-olefin coupling of α-imino-oxy acids and alkenes for the synthesis of alkene-containing nitriles via synergistic photoredox and cobaloxime catalysis was reported. With visible-light irradiation, the transformation provided a variety of corresponding alkene-containing nitriles under mild reaction conditions. The C-C bond cleavage/Heck-like coupling reaction generated E-selective coupling products with excellent chemo- and stereo-selectivity. This iminyl-radical-mediated reaction was external-oxidant-free, exhibited wide functional-group compatibility, and occurred with the extrusion of acetone, H2, and CO2. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Related Products of 20880-92-6

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Lu, Xiao-Yu; Xia, Ze-Jie; Gao, Ang; Liu, Qi-Le; Jiang, Run-Chuang; Liu, Chuang-Chuang published an article in Journal of Organic Chemistry. The title of the article was 《Dual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters》.Formula: C12H20O6 The author mentioned the following in the article:

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp2)-C(sp3) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chem., under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic mols. The results came from multiple reactions, including the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6

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Lenssen, T; Dankelman, J; Horeman, T published an article on January 22 ,2022. The article was titled 《SATA-LRS: A modular and novel steerable hand-held laparoscopic instrument platform for low-resource settings☆.》, and you may find the article in Medical engineering & physics.Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The information in the text is summarized as follows:

BACKGROUND: Hospitals in low resource settings (LRS) can benefit from modern laparoscopic methodologies. However, cleaning, maintenance and costs requirements play a stronger role while training and technology are less available. Steerable laparoscopic instruments have additional requirements in these settings and need extra identified adaptations in their design. METHOD: Several modular detachability and tip steerability features were applied to the SATA-LRS instrument platform designed specifically for LRS. Ten subjects participated a dis- and reassembly experiment to validate the modularity, and in a steering experiment using a custom made set-up to validate steering. RESULTS: A new steerable SATA-LRS instrument was developed with the ability to exchange end-effectors through a disassembly of the shafts. Experiments showed an average 34 and 90 s for complete dis- and reassembly, respectively. Participants were able to handle the instrument independently after a single demonstration and 4 rounds of repetitions. Precise tip-target alignment in the box set-up showed a very short learning-curve of 6 repetitions. CONCLUSION: A novel instrument platform with articulating and rotating end-effector was designed for LRS. Within a minute the SATA-LRS can be disassembled to component level for inspection, cleaning, maintenance and repair, and can be autonomously reassembled by novices after a minimal training. The modular buildup is expected to reduce purchasing and repair costs. The instrument has been shown intuitive by use without extensive training. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Application of 591-70-8On September 21, 2007 ,《1-Phenylethyl isocyanate is a powerful reagent for the chiral analysis of secondary alcohols and hydroxy fatty acids with remote stereogenic centres》 was published in Journal of Chromatography A. The article was written by Habel, Andreas; Spiteller, Dieter; Boland, Wilhelm. The article contains the following contents:

1-Phenylethyl isocyanate (1-PEIC), a chiral derivatization reagent for the resolution of secondary alcs. is a powerful tool to determine the configuration and enantiomeric excess of medium- to long-chain secondary alcs. by capillary gas chromatog. The separation of 1-phenylethylcarbamates (1-PECs) of secondary alcs. was systematically evaluated depending on the position of the stereogenic center in the mol., in alkanols (C15-18), alkenols (C15-18) and hydroxy fatty acids (C14-18). The successful separation of the diastereomeric carbamates of (±)-heptadecan-7-ol or (±)-12-hydroxyoctadecanoic acid Me ester by gas liquid chromatog. demonstrates the unique separation power for 1-PECs for analytes with remote stereogenic centers. Saturated derivatives showed consistently higher resolution factors than the corresponding unsaturated derivatives In the experimental materials used by the author, we found Octadecan-9-ol(cas: 591-70-8Application of 591-70-8)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Application of 591-70-8

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Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneOn March 16, 2015, Gonzalez, Miguel I.; Bloch, Eric D.; Mason, Jarad A.; Teat, Simon J.; Long, Jeffrey R. published an article in Inorganic Chemistry. The article was 《Single-Crystal-to-Single-Crystal Metalation of a Metal-Organic Framework: A Route toward Structurally Well-Defined Catalysts》. The article mentions the following:

Metal-organic frameworks featuring ligands with open chelating groups are versatile platforms for the preparation of a diverse set of heterogeneous catalysts through postsynthetic metalation. The crystalline nature of these materials allows them to be characterized via x-ray diffraction, which provides valuable insight into the structure of the metal sites that facilitate catalysis. A highly porous and thermally robust zirconium-based metal-organic framework, Zr6O4(OH)4(bpydc)6 (bpydc2- = 2,2′-bipyridne-5,5′-dicarboxylate), bears open bipyridine sites that readily react with a variety of solution- and gas-phase metal sources to form the corresponding metalated frameworks. Remarkably, Zr6O4(OH)4(bpydc)6 undergoes a single-crystal-to-single-crystal transformation upon metalation that involves a change in space group from Fm3-m to Pa3-. This structural transformation leads to an ordering of the metalated linkers within the framework, allowing structural characterization of the resulting metal complexes. Also, Zr6O4(OH)4(bpydc)6 yields an active heterogeneous catalyst for arene C-H borylation when metalated with [Ir(COD)2]BF4 (COD = 1,5-cyclooctadiene). These results highlight the unique potential of metal-organic frameworks as a class of heterogeneous catalysts that allow unparalleled structural characterization and control over their active sites. The results came from multiple reactions, including the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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