Tag: 200-300

Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateIn 2021 ,《Selectivity between an Alder-ene reaction and a [2+2] cycloaddition in the intramolecular reactions of allene-tethered arynes》 was published in Organic Chemistry Frontiers. The article was written by Le, Anh; Lee, Daesung. The article contains the following contents:

Substituent-dependent reactivity and selectivity in the intramol. reactions of arynes tethered with an allene were described. With a 1,3-disubstituted allene moiety, an Alder-ene reaction of an allenic C-H bond was preferred over a [2+2] cycloaddition, whereas a [2+2] cycloaddition of the terminal π-bond of the allene was preferred with a 1,1-disubstituted allene. With a 1,1,3-trisubstituted allene-tethered aryne, an Alder-ene reaction with an allylic C-H bond was preferred over a [2+2] cycloaddition After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Nallagonda, Rajender; Karimov, Rashad R. published an article in 2021. The article was titled 《Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters》, and you may find the article in ACS Catalysis.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Category: alcohols-buliding-blocks)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Category: alcohols-buliding-blocks Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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In 2019,Nature Chemistry included an article by Fawcett, Alexander; Biberger, Tobias; Aggarwal, Varinder K.. Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane. The article was titled 《Carbopalladation of C-C σ-bonds enabled by strained boronate complexes》. The information in the text is summarized as follows:

Transition-metal-catalyzed cross-coupling reactions, particularly those mediated by Pd, are some of the most broadly used chem. transformations. The fundamental reaction steps of such cross-couplings typically include oxidative addition, transmetalation, carbopalladation of a π-bond and/or reductive elimination. Herein, the authors describe an unprecedented fundamental reaction step: a C-C σ-bond carbopalladation. Specifically, an aryl Pd(II) complex interacts with a σ-bond of a strained bicyclo[1.1.0]butyl boronate complex to enable addition of the aryl Pd(II) species and an organoboronic ester substituent across a C-C σ-bond. The overall process couples readily available aryl triflates and organoboronic esters across a cyclobutane unit with total diastereocontrol. The pharmaceutically relevant 1,1,3-trisubstituted cyclobutane products are decorated with an array of modular building blocks, including a boronic ester that can be readily derivatized. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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In 2018,Kischkewitz, Marvin; Gerleve, Carolin; Studer, Armido published 《Radical-Polar Crossover Reactions of Dienylboronate Complexes: Synthesis of Functionalized Allylboronic Esters》.Organic Letters published the findings.Computed Properties of C13H26B2O4 The information in the text is summarized as follows:

Radical-polar crossover reactions of dienylboronates CH2:CR1CHCR2Bpin with R4I and R3Li are applied to the synthesis of functionalized secondary and tertiary allylboronic esters R4CH2CR1:CHC2R3Bpin (3a-l, R1 = H, Me, Et; R2 = H, Me; R3 = Bu, s-Bu; R4 = fluoroalkyl, NCCMe2, EtO2CMe2). The transition-metal-free three-component coupling uses readily accessible dienylboronate esters as substrates in combination with various sp3/sp2 carbon nucleophiles and com. alkyl iodides as radical precursors. In the visible light-initiated radical chain process, two new C-C bonds are formed, and the E-double bond geometry in the product allylboronic esters is controlled with good to excellent selectivity.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Computed Properties of C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Computed Properties of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Xing, Chun-Hui; Hu, Qiao-Sheng published an article on February 10 ,2010. The article was titled 《Ni(COD)2/4-ClC6H4COR-catalyzed addition reactions of arylboroxines with aldehydes》, and you may find the article in Tetrahedron Letters.Product Details of 63012-03-3 The information in the text is summarized as follows:

Secondary aralkyl alcs. RCH(OH)R1 (R = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, 4-ClC6H4, 3-ClC6H4, 2-MeOC6H4, PhCH2CH2, Ph2CHCH2, Me2CHCH2, cyclohexyl; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeC6H4) are prepared in 81-96% yields by the addition of triarylboroxines (R1BO)3 to aldehydes RCHO in the presence of bis(η4-1,2,5,6-cyclooctadiene)nickel(0) and 4-chlorophenyl carbonyl compounds 4-ClC6H4COR2 (R2 = H, Me, Ph), particularly 4-chlorobenzophenone. In the experiment, the researchers used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Product Details of 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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The author of 《Design, synthesis and anticancer activity of dihydropyrimidinone-semicarbazone hybrids as potential human DNA ligase 1 inhibitors》 were Sashidhara, Koneni V.; Singh, L. Ravithej; Shameem, Mohammad; Shakya, Sarika; Kumar, Anoop; Laxman, Tulsankar Sachin; Krishna, Shagun; Siddiqi, Mohammad Imran; Bhatta, Rabi S.; Banerjee, Dibyendu. And the article was published in MedChemComm in 2016. Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

A series of new dihydropyrimidinone-semicarbazone hybrids were successfully synthesized by integrating regioselective multicomponent reaction with the pharmacophore hybridization approach. All the synthesized compounds were evaluated for their hLig1 inhibition potency and most of them were found to be good to moderately active. Out of the tested derivatives, compound 6f showed selective anti-proliferative activity against HepG2 cells in a dose-dependent manner with an IC50 value of 10.07 ± 1.2. It also reduced cell survival at ≤20 μM concentration Further, anal. of treated HepG2 cell lysates by western blot assay showed increased γ-H2AX levels and upregulation of p53, leading to apoptosis. In silico docking results explain the binding modes of compound 6f to the DNA-binding domain of hLig1 enzyme thereby preventing its nick sealing activity. In addition, the favorable pharmacokinetic properties suggest that this new class of hLig1 inhibitors could be promising leads for further drug development. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Name: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

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In 2016,MedChemComm included an article by Sashidhara, Koneni V.; Rao, K. Bhaskara; Sonkar, Ravi; Modukuri, Ram K.; Chhonker, Yashpal S.; Kushwaha, Pragati; Chandasana, Hardik; Khanna, A. K.; Bhatta, Rabi S.; Bhatia, Gitika; Suthar, Manish Kumar; Saxena, Jitendra Kumar; Kumar, Vikash; Siddiqi, Mohammad Imran. Recommanded Product: 153759-59-2. The article was titled 《Hybrids of coumarin-indole: design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models》. The information in the text is summarized as follows:

In this study, a series of coumarin-indole hybrids have been synthesized and evaluated for their lipid lowering activity. Preliminary biol. screening of the synthesized compounds was undertaken in an in vitro model of the HMG-CoA reductase enzyme, and the activity was confirmed in Triton WR-1339 induced hyperlipidemic rats. Among the hybrids, compound 26 was found to be the best as it significantly reduced the serum and hepatic lipid profiles in an HFD-fed hyperlipidemic rat model. The mechanism of action seems to be associated with the regulation of HMG-CoA reductase activity in the liver, which is in good agreement with binding mode studies. Compound 26 exhibited favorable pharmacokinetic behavior for its oral administration, which underscores the potential of this template as a new class of hypolipidemic agents. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Recommanded Product: 153759-59-2

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Recommanded Product: Octadecan-9-olOn November 30, 2014 ,《A general method for the synthesis of enantiopure aliphatic chain alcohols with established absolute configurations. Part 2, via catalytic reduction of acetylene alcohol MαNP esters》 appeared in Tetrahedron: Asymmetry. The author of the article were Akagi, Megumi; Sekiguchi, Satoshi; Taji, Hiromi; Kasai, Yusuke; Kuwahara, Shunsuke; Watanabe, Masataka; Harada, Nobuyuki. The article conveys some information:

A general method for synthesizing enantiopure (100% ee) aliphatic alcs. with established absolute configurations has been developed and applied to alcs. CH3(CH2)n-CH(OH)-(CH2)mCH3, the enantiomeric discrimination of which is the most difficult, if m = n + 1 and n is large. Racemic saturated alcs. with short chains could be directly enantioresolved as (S)-(+)-2-methoxy-2-(1-naphthyl)propionic acid [MαNP acid (I)] esters by HPLC on silica gel, and their absolute configurations were simultaneously determined by 1H NMR diamagnetic anisotropy. However, the application of this powerful MαNP ester method to alcs. with long chains was difficult, because of smaller values of the separation factor α. In such cases, the use of the corresponding acetylene alc. MαNP esters was crucial. Acetylene alc. MαNP esters were largely separated by HPLC on silica gel, and their absolute configurations were unambiguously determined by 1H NMR as reported in the Part 1 paper. The MαNP esters obtained with established absolute configurations were catalytically hydrogenated to yield saturated alc. MαNP esters. It was evidenced that no racemization occurred at the stereogenic center of the alc. moiety during catalytic hydrogenation, by the co-injection of MαNP esters in HPLC. From the MαNP esters obtained, enantiopure (100% ee) aliphatic chain alcs. with established absolute configurations were recovered. Although the [α]D values of these alcs. were too small for the identification of the enantiomers, it was clarified that the anal. HPLC of MαNP esters is useful for identification in most cases. In the experimental materials used by the author, we found Octadecan-9-ol(cas: 591-70-8Recommanded Product: Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Recommanded Product: Octadecan-9-ol

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《A new preparative method for optically active diarylcarbinols》 was published in Tetrahedron: Asymmetry in 1991. These research results belong to Toda, Fumio; Tanaka, Koichis; Koshiro, Kenzo. Related Products of 63012-03-3 The article mentions the following:

Diarylcarbinols RC6H4CHPhOH (I; R = 3-Me, 4-Me, 3-Cl, 4-Cl, 3-Br, 4-Br, 3-MeO, 3-NO2, 4-NO2) were resolved by complexation with brucine. Me3CCHPhOH and Cl3CCHPhOH were resolved similarly, but ortho isomers of I were not resolved, although they also formed complexes with brucine. The experimental part of the paper was very detailed, including the reaction process of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Related Products of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Related Products of 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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《Fabrication of 2D-2D heterojunction catalyst with covalent organic framework (COF) and MoS2 for highly efficient photocatalytic degradation of organic pollutants》 was written by Khaing, Kyu Kyu; Yin, Dongguang; Ouyang, Yinggen; Xiao, Songtao; Liu, Bingqi; Deng, Linlin; Li, Luqiu; Guo, Xiandi; Wang, Jun; Liu, Jinliang; Zhang, Yong. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

In this work, for the first time, we fabricated a novel covalent organic framework (COF)-based 2D-2D heterojunction composite MoS2/COF by a facile hydrothermal method. The results of photocatalytic degradation of TC and RhB under simulated solar light irradiation showed that the as-prepared composite exhibited outstanding catalytic efficiency compared with pristine COFs and MoS2. The significantly enhanced catalytic efficiency can be ascribed to the formation of 2D-2D heterojunction with a well-matched band position between COF and MoS2, which can effectively restrain the recombination of charge carriers and increase the light absorption as well as the sp. surface area. Moreover, the fabricated 2D-2D layered structure can effectively increase the contact area with an intimate interface contact, which greatly facilitates the charge mobility and transfer in the interfaces. This study reveals that artful integration of organic (COFs) and inorganic materials into a single hybrid with a 2D-2D interface is an effective strategy to fabricate highly efficient photocatalysts. A novel COF-based 2D-2D heterojunction composite MoS2/COF was prepared by a facile hydrothermal method. The as-prepared composite exhibited outstanding catalytic efficiency compared with pristine COFs and MoS2. The significantly enhanced catalytic efficiency is assigned to the formation of a band position of a well-matched heterojunction and the 2D-2D layered structure. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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