Tag: 200-300

Reference of (3-Chlorophenyl)(phenyl)methanolOn March 9, 2000, Ohkuma, Takeshi; Koizumi, Masatoshi; Ikehira, Hideyuki; Yokozawa, Tohru; Noyori, Ryoji published an article in Organic Letters. The article was 《Selective Hydrogenation of Benzophenones to Benzhydrols. Asymmetric Synthesis of Unsymmetrical Diarylmethanols》. The article mentions the following:

Trans-RuCl2[P(C6H4-4-CH3)3]2(NH2CH2CH2NH2) acts as a highly effective precatalyst for the hydrogenation of a variety of benzophenone derivatives to benzhydrols that proceeds smoothly at 8 atm and 23-35 °C in 2-propanol containing t-C4H9OK with a substrate/catalyst ratio of 2000-20000. Use of a BINAP/chiral diamine Ru complex effects asym. hydrogenation of various ortho-substituted benzophenones and benzoylferrocene to chiral diarylmethanols with consistently high ee. In the experiment, the researchers used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Reference of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Reference of (3-Chlorophenyl)(phenyl)methanol Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn June 8, 2020, Yildirim, Ayhan; Goeker, Mustafa published an article in ChemistrySelect. The article was 《D-Fructose-Derived Acetonide as a Green Neutral Organocatalyst for Proficient One-Pot and Three-Component Preparation of 1,3-Benzoxazine Monomers》. The article mentions the following:

A series of 1,3-benzoxazine monomers were successfully synthesized by simple one-pot and three-component condensation of phenol, paraformaldehyde and varying types of primary aliphatic and aromatic amines in a molar ratio of 1 : 2 : 1 and in the presence of non-acidic 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose as an effective green carbohydrate based organocatalyst obtained from renewable feedstock. This multicomponent method provided a convenient fast approach for the construction of valuable 1,3-benzoxazine monomers (8 examples) with moderate to excellent yields. The chem. structures of the synthesized benzoxazines were confirmed by FTIR, 1H NMR, 13C NMR spectra and elemental anal. The experimental part of the paper was very detailed, including the reaction process of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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《Manganese complex-catalyzed oxidation and oxidative kinetic resolution of secondary alcohols by hydrogen peroxide》 was published in Chemical Science in 2017. These research results belong to Miao, Chengxia; Li, Xiao-Xi; Lee, Yong-Min; Xia, Chungu; Wang, Yong; Nam, Wonwoo; Sun, Wei. Recommanded Product: (3-Chlorophenyl)(phenyl)methanol The article mentions the following:

The highly efficient catalytic oxidation and oxidative kinetic resolution (OKR) of secondary alcs. has been achieved using a synthetic manganese catalyst with low loading and hydrogen peroxide as an environmentally benign oxidant in the presence of a small amount of sulfuric acid as an additive. The product yields were high (up to 93%) for alc. oxidation and the enantioselectivity was excellent (>90% ee) for the OKR of secondary alcs. Mechanistic studies revealed that alc. oxidation occurs via hydrogen atom (H-atom) abstraction from an α-CH bond of the alc. substrate and a two-electron process by an electrophilic Mn-oxo species. D. functional theory calculations revealed the difference in reaction energy barriers for H-atom abstraction from the α-CH bonds of R- and S-enantiomers by a chiral high-valent manganese-oxo complex, supporting the exptl. result from the OKR of secondary alcs. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Recommanded Product: (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Recommanded Product: (3-Chlorophenyl)(phenyl)methanol

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Synthetic Route of C12H17BO2In 2021 ,《Mechanistic insights into the dearomative diborylation of pyrazines: a radical or non-radical process?》 appeared in Dalton Transactions. The author of the article were Gao, Liuzhou; Zhang, Hanyin; Liu, Xueting; Wang, Guoqiang; Li, Shuhua. The article conveys some information:

The mechanisms of the dearomative diborylation of pyrazines were studied via a combination of d. functional theory (DFT) calculations and exptl. studies. DFT calculations revealed that a non-radical mechanism involving two successive [3,3]-σ-rearrangement-type processes is responsible for the diborylation of pyrazine with bis(pinacolato)diboron (B2pin2). However, this non-radical process is highly unfavorable for the diborylation reaction of sterically hindered pyrazine (2,3-dimethylpyrazine). For the diboration reaction of 2,3-dimethylpyrazine with B2pin2 in the presence of 2,6-dichloro-4,4′-bipyridine as the catalyst, 4,4′-bipyridine-mediated radical pathway proceeding through a B-B homolytic cleavage/boryl radical addition is preferred. Control experiments combined with kinetic studies provided supportive evidence for the proposed mechanism. In the experimental materials used by the author, we found 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Synthetic Route of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Synthetic Route of C12H17BO2

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In 2022,Zhang, Wanzheng; Guillen-Soler, Melanie; Moreno-Da Silva, Sara; Lopez-Moreno, Alejandro; Gonzalez, Luisa R.; Gimenez-Lopez, Maria del Carmen; Perez, Emilio M. published an article in Chemical Science. The title of the article was 《Mechanical interlocking of SWNTs with N-rich macrocycles for efficient ORR electrocatalysis》.Electric Literature of C12H17BO2 The author mentioned the following in the article:

Substitutional N-doping of single-walled carbon nanotubes is a common strategy to enhance their electrocatalytic properties in the oxygen-reduction reaction (ORR). Here, we explore the encapsulation of SWNTs within N-rich macrocycles as an alternative strategy to display electroactive sites on the surface of SWNTs. We design and synthesize four types of mech. interlocked derivatives of SWNTs (MINTs) by combining two types of macrocycles and two types of SWNT samples. Comprehensive electrochem. characterization of these MINTs and their reference SWNTs allows us to establish structure-activity relationships. First, we show that all MINT samples are superior electrocatalysts compared to pristine SWNTs, which serves as general validation of our strategy. Secondly, we show that macrocycles displaying both N atoms and carbonyl groups perform better than those with N atoms only. Finally, we demonstrate that a tighter fit between macrocycles and SWNTs results in enhanced catalytic activity and stability, most likely due to a more effective charge-transfer between the SWNTs and the macrocycles. These results, focusing on the ORR as a testbed, show the possibility of understanding electrocatalytic performance of SWNTs at the mol. level and thus enable the design of more active and more stable catalysts in the future. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Electric Literature of C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Electric Literature of C12H17BO2

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Zhou, Ting; Wang, Lei; Huang, Xingye; Unruangsri, Junjuda; Zhang, Hualei; Wang, Rong; Song, Qingliang; Yang, Qingyuan; Li, Weihua; Wang, Changchun; Takahashi, Kaito; Xu, Hangxun; Guo, Jia published an article in 2021. The article was titled 《PEG-stabilized coaxial stacking of two-dimensional covalent organic frameworks for enhanced photocatalytic hydrogen evolution》, and you may find the article in Nature Communications.Quality Control of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The information in the text is summarized as follows:

Two-dimensional covalent organic frameworks (2D COFs) featuring periodic frameworks, extended π-conjugation and layered stacking structures, have emerged as a promising class of materials for photocatalytic hydrogen evolution. Nevertheless, the layer-by-layer assembly in 2D COFs is not stable during the photocatalytic cycling in water, causing disordered stacking and declined activity. Here, we report an innovative strategy to stabilize the ordered arrangement of layered structures in 2D COFs for hydrogen evolution. Polyethylene glycol is filled up in the mesopore channels of a β-ketoenamine-linked COF containing benzothiadiazole moiety. This unique feature suppresses the dislocation of neighboring layers and retains the columnar π-orbital arrays to facilitate free charge transport. The hydrogen evolution rate is therefore remarkably promoted under visible irradiation compared with that of the pristine COF. This study provides a general post-functionalization strategy for 2D COFs to enhance photocatalytic performances. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Quality Control of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Quality Control of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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Tamaki, Shota; Kitada, Nobuo; Kiyama, Masahiro; Fujii, Rika; Hirano, Takashi; Kim, Sung Bae; Maki, Shojiro published their research in Scientific Reports in 2021. The article was titled 《Color-tunable bioluminescence imaging portfolio for cell imaging》.SDS of cas: 78782-17-9 The article contains the following contents:

The present study describes a color-tunable imaging portfolio together with twelve novel coelenterazine (CTZ) analogs. The three groups of CTZ analogs create diverse hues of bioluminescence (BL) ranging from blue to far red with marine luciferases. We found that the hue completes the whole color palette in the visible region and shows red-shifted BL with a marine luciferase: for example, Renilla luciferase 8 (RLuc8) and Artificial Luciferase 16 (ALuc16) show 187 nm- and 105 nm-red shifted spectra, resp., by simply replacing the substrate CTZ with 1d. The optical properties of the new CTZ analogs were investigated such as the kinetic parameters, dose dependency, and luciferase specificity. The 2-series CTZ analogs interestingly have specificity to ALucs and are completely dark with RLuc derivatives, and 3d is highly specific to only NanoLuc. We further determined the theor. background of the red-shifted BL maximum wavelengths (λBL) values according to the extended π conjugation of the CTZ backbone using D. Functional Theory (DFT) calculations This color-tunable BL imaging system provides a useful multicolor imaging portfolio that efficiently images mol. events in mammalian cells. In the experiment, the researchers used many compounds, for example, Bis[(pinacolato)boryl]methane(cas: 78782-17-9SDS of cas: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.SDS of cas: 78782-17-9

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Ludwig, Jacob R.; Simmons, Eric M.; Wisniewski, Steven R.; Chirik, Paul J. published their research in Organic Letters in 2021. The article was titled 《Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling》.Application of 24388-23-6 The article contains the following contents:

A cobalt-catalyzed method for the C(sp2)-C(sp3) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N’-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Application of 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Application of 24388-23-6

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The author of 《Low-Coordinate NHC-Zinc Hydride Complexes Catalyze Alkyne C-H Borylation and Hydroboration Using Pinacolborane》 were Procter, Richard J.; Uzelac, Marina; Cid, Jessica; Rushworth, Philip J.; Ingleson, Michael J.. And the article was published in ACS Catalysis in 2019. Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The author mentioned the following in the article:

Organozinc compounds containing sp, sp2, and sp3 C-Zn moieties undergo transmetalation with pinacolborane (HBPin) to produce Zn-H species and organoboronate esters (RBPin). This Zn-C/H-B metathesis step is key to enabling Zn-catalyzed borylation reactions, and it was used in this work to develop both terminal alkyne C-H borylation and internal alkyne hydroboration. These two conversions can be combined in one pot to achieve the Zn-catalyzed conversion of terminal alkynes to 1,1-diborylated alkenes without isolation of the sensitive (to protodeboronation) alkynyl boronate ester intermediates. Mechanistic studies involving the isolation of intermediates, stoichiometric experiments, and DFT calculations all support mechanisms involving organozinc species that undergo metathesis with HBPin. Also, Zn-catalyzed hydroboration can proceed via a hydrozincation step, which does not require any exogenous catalyst in contrast to all previously reported alkyne hydrozincations. Bulky N-heterocyclic carbenes (NHCs) are key for effective catalysis as the NHC steric bulk enhances the stability of the NHC-Zn species present during catalysis and provides access to low-coordinate (NHC)Zn-H cations that are electrophilic yet Bronsted basic. This work provides an alternative approach to access synthetically desirable pinacol-organoboronate esters using earth-abundant metal-based borylation catalysts.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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The author of 《Eu3+-Functionalized Covalent Organic Framework Hybrid Material as a Sensitive Turn-On Fluorescent Switch for Levofloxacin Monitoring in Serum and Urine》 were Wang, Jin-Min; Lian, Xiao; Yan, Bing. And the article was published in Inorganic Chemistry in 2019. HPLC of Formula: 34374-88-4 The author mentioned the following in the article:

The research on luminescent lanthanide-functionalized covalent organic framework (COF)-based hybrid materials has not been reported so far. When a straightforward functionalized modification strategy is employed, a chem. stable Eu3+-modified COF hybrid material, Eu@TpPa-1, is first developed. The functional process does not affect the size and shape of TpPa-1, but after the introduction of Eu3+, Eu@TpPa-1 as a fluorescence sensor exhibits a turn-on response toward levofloxacin. Eu3+ plays a bridge role in the whole detection system, and TpPa-1 serves as a host matrix to provide protection for the introduced Eu3+. This reusable sensor shows strong pink-white and yellow emissions toward the high and low concentration ranges of levofloxacin, resp. It displays excellent sensitivity and fast response to levofloxacin within 1 min, while refraining from the interference of other coexisting species in serum and urine. The good selectivity and high antidisturbance lead Eu@TpPa-1 to be successfully applied in serum and urine systems for sensing levofloxacin. In the experiment, the researchers used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4HPLC of Formula: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.HPLC of Formula: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

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