Tag: 200-300

In ,Organic Letters included an article by Pan, Ting; Shi, Pan; Chen, Bo; Zhou, Da-Gang; Zeng, Ya-Li; Chu, Wen-Dao; He, Long; Liu, Quan-Zhong; Fan, Chun-An. COA of Formula: C13H11ClO. The article was titled 《CuH-Catalyzed Asymmetric 1,6-Conjugate Reduction of p-Quinone Methides: Enantioselective Synthesis of Triarylmethanes and 1,1,2-Triarylethanes》. The information in the text is summarized as follows:

The first copper hydride (CuH)-catalyzed asym. 1,6-conjugate reduction of p-quinone methides is reported. This protocol provides a new method to access a variety of triarylmethanes and 1,1,2-triarylethanes in good yields with excellent enantioselectivities and broad functional group tolerance. The results came from multiple reactions, including the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.COA of Formula: C13H11ClO

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《Construction of covalent organic framework with unique double-ring pore for size-matching adsorption of uranium》 was written by Zhang, Jie; Zhou, Lihong; Jia, Zhimin; Li, Xiaofeng; Qi, Yue; Yang, Chuting; Guo, Xinghua; Chen, Shanyong; Long, Honghan; Ma, Lijian. Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused ontriformylphloroglucinol benzene diamine derivative covalent organic framework adsorbent uranium. The article conveys some information:

The separation and recovery of key nuclides such as uranium and plutonium from effluents related to nuclear industry is of great significance for alleviating the shortage of nuclear energy resources and protecting the environment and human health. However, the high temperature, strong acidity and radioactivity of the nuclear effluents pose a severe challenge to the separation materials used in such conditions. The diversity of structure, flexibility of design, and excellent physicochem. stability of covalent organic framework materials (COFs) provide the possibility for the directional design and preparation of adsorbents for use under harsh conditions. Herein, three COFs with similar structure, different pore sizes and connecting modules were synthesized. The ingenious structure predesign enables Dp-COF to have three carboxyl groups oriented toward the pore center and laid out in appropriate spatial positions, which builds hydrogen-bonding bridges between carboxycarbonyl and hydroxyl groups, and thus constructs for the first time a unique COF material with a double-ring pore. The inner pore size of the “”double-ring”” is slightly larger than the diameter of uranyl hydrate, which leads to a size-matching adsorption of uranium by Dp-COF, thus greatly reducing the effect of protonation. Even in the simulated spent fuel reprocessing liquid with pH = 1.0, the adsorption capacity of Dp-COF for uranium can reach 66.3 mg g-1, and the adsorption capacity reaches 317.3 mg g-1 at pH = 4.5, which is very rare among the reported COFs. More excitingly, the removal rate for uranium reaches up to an unprecedented 99.8% due to the size-matching effect, more than any analogous adsorbents. This study not only proposes new ideas for the design and regulation of the microscopic configuration of COF materials, but also provides an alternative approach for the preparation of efficient uranium adsorbents. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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In 2013,Liu, Jianfei; Uprety, Bibek; Gyawali, Shailendra; Woolley, Adam T.; Myung, Nosang V.; Harb, John N. published 《Fabrication of DNA-Templated Te and Bi2Te3 Nanowires by Galvanic Displacement》.Langmuir published the findings.Application of 6381-59-5 The information in the text is summarized as follows:

This paper demonstrates the use of galvanic displacement to form continuous Te-based nanowires on DNA templates, enabling the conversion of metals, which can be deposited site-specifically, into other materials needed for device fabrication. Specifically, galvanic displacement reaction of Cu and Ni nanowires was used to fabricate Te and Bi telluride nanowires on λ-DNA templates. The method is simple, rapid, highly selective, and applicable to a number of different materials. Continuous Ni and Cu nanowires are formed on DNA templates by seeding with Ag followed by electroless plating of the desired metal. These wires are then displaced by a galvanic displacement reaction where either Te or Bi2Te3 is deposited from an acidic solution containing HTeO2+ ions or a combination of HTeO2+ and Bi3+ ions, and the metal wire is simultaneously dissolved due to oxidation Both Te and Bi telluride wires can be formed from Ni templates. In contrast, Cu templates only form Te nanowires under the conditions considered. Therefore, the composition of the metal being displaced can be used to influence the chem. of the resulting nanowire. Galvanic displacement of metals deposited on DNA templates has the potential to enable site-specific fabrication of a variety of materials and, thereby, make an important contribution to the advancement of useful devices via self-assembled nanotemplates. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acidOn October 31, 2012 ,《A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents》 appeared in PLoS One. The author of the article were Luo, Jian; Swaminath, Gayathri; Brown, Sean P.; Zhang, Jane; Guo, Qi; Chen, Michael; Nguyen, Kathy; Tran, Thanhvien; Miao, Lynn; Dransfield, Paul J.; Vimolratana, Marc; Houze, Jonathan B.; Wong, Simon; Toteva, Maria; Shan, Bei; Li, Frank; Zhuang, Run; Lin, Daniel C.-H.. The article conveys some information:

Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroendocrine cells of the small intestine. Several GPR40 agonists, including AMG 837 and TAK-875, have been disclosed, but no GPR40 synthetic agonists have been reported that engage both the insulinogenic and incretinogenic axes. In this report we provide a mol. explanation and describe the discovery of a unique and potent class of GPR40 full agonists that engages the enteroinsular axis to promote dramatic improvement in glucose control in rodents. GPR40 full agonists AM-1638 and AM-6226 stimulate GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic islets, leading to enhanced glucose control in the high fat fed, streptozotocin treated and NONcNZO10/LtJ mouse models of type 2 diabetes. The improvement in hyperglycemia by AM-1638 was reduced in the presence of the GLP-1 receptor antagonist Ex(9-39)NH2. After reading the article, we found that the author used (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid)

(S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8) belongs to alkynes. The addition of nonpolar E−H bonds across C≡C is general for silanes, boranes, and related hydrides. The hydroboration of alkynes gives vinylic boranes which oxidize to the corresponding aldehyde or ketone. In the thiol-yne reaction the substrate is a thiol.Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid

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The author of 《A facilely synthesized glutathione-functionalized silver nanoparticle-grafted covalent organic framework for rapid and highly efficient enrichment of N-linked glycopeptides》 were Ma, Yu-Fang; Wang, Li-Juan; Zhou, Ying-Lin; Zhang, Xin-Xiang. And the article was published in Nanoscale in 2019. SDS of cas: 34374-88-4 The author mentioned the following in the article:

The development of facilely synthetic materials for highly efficient enrichment of N-linked glycopeptides is essential in glycoproteome anal. In this work, by utilizing the self-assembling of glutathione (GSH) on silver nanoparticles (Ag NPs), and the formation and dispersion of Ag NPs on a robust TpPa-1 substrate, a newly functionalized covalent organic framework (COF) called TpPa-1@Ag@GSH was synthesized via a simple two step post-synthetic modification. TpPa-1@Ag@GSH and intermediate products were confirmed and evaluated by NMR spectroscopy, Fourier transform IR spectroscopy, X-ray diffraction, transmission electron microscopy, SEM-energy dispersive spectroscopy, Brunauer-Emmett-Teller and thermogravimetric analyses. Benefiting from the judicious selection of the substrate, the abundance of binding sites, relatively high affinity between GSH and N-linked glycopeptides, and the multivalent interactions between N-linked glycopeptides and unoccupied surfaces of Ag NPs, this porous material showed great performance in N-linked glycopeptide enrichment. By enriching N-linked glycopeptides in tryptic digests of human serum IgG (human IgG) followed by mass spectrometry anal., our method was proved to have good sensitivity (1 fmol), high selectivity (1 : 1500, human IgG to bovine serum albumin), high binding capacity (160 mg g-1, IgG/TpPa-1@Ag@GSH), ultra-fast capture ability (only 1 min incubation time), and good reusability (at least 5 times). It was also successfully applied to the enrichment of N-linked glycopeptides from complex biol. samples. Our work improved the enrichment selectivity of COFs, reached the most rapid capture ability among off-column enrichment materials, and provided a very facile and easily popularized post-synthetic modification route for COFs in glycoproteome anal. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4SDS of cas: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.SDS of cas: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

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In 2019,Synthesis included an article by Blank, Lena; Fagnoni, Maurizio; Protti, Stefano; Rueping, Magnus. SDS of cas: 24388-23-6. The article was titled 《Visible Light-Promoted Formation of C-B and C-S Bonds under Metal- and Photocatalyst-Free Conditions》. The information in the text is summarized as follows:

A green, efficient, photoinduced synthesis of arylboronic esters and aryl sulfides has been developed. Bench stable arylazo sulfones were used as radical precursors for a photocatalyst- and additive-free carbon-heteroatom bond formation under visible light. The protocols are applicable to a wide range of substrates, providing products in good yields. In addition to this study using 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane, there are many other studies that have used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6SDS of cas: 24388-23-6) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).SDS of cas: 24388-23-6

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Shen, Haigen; Xiao, Hawen; Zhu, Lin; Li, Chaozhong published an article on January 31 ,2020. The article was titled 《Copper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes》, and you may find the article in Synlett.Product Details of 20880-92-6 The information in the text is summarized as follows:

The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R1CCC(=CH2)R2 (R1 = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R2 = H, Me) is described. With Cu(CH3CN)4BF4as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF3)2 at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF3)=CHCF3 in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R1C(CF3)=C=C(CH2CF3)R2 exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

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《Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C》 was written by Dalal, Juned; Rana, Rakesh; Harale, Kishore; Hanif, Sarmad; Kumar, Nitin; Singh, Deepti; Chhikara, Manoj Kumar. Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate And the article was included in Vaccine on August 23 ,2019. The article conveys some information:

Significant improvement has been made in the development of vaccines against Neisseria meningitidis infections since the introduction of polysaccharide-protein conjugate vaccines. Conventional bacterial capsular polysaccharide (PS) based conjugate vaccines require unique and expensive manufacturing facilities, complex production processes and extensive quality testing. Synthetic oligosaccharide (OS) based approach is one of the novel technologies that is being developed to simplify production of conjugate vaccines. OSs can be chem. synthesized to a desired length long enough to represent the antigenic epitopes which often present as a homogenous mixture We prepared OSs corresponding to tetramer and octamer of N. meningitidis serogroup C (MenC) PS by organic synthesis. The MenC tetramer and octamer were further conjugated with tetanus toxoid to produce resp. monovalent conjugates having the desired physico-chem. characteristics. The conjugates were evaluated in a mouse model for immunogenicity and compared with a licensed PS conjugate vaccine. Synthetic conjugates could induce anti-MenC PS IgG as well as serum bactericidal titers at levels comparable to those elicited by the licensed vaccine. The increase in length of synthetic oligomers from tetramer to octamer did not appear to increase immunogenicity. The results establish the pre-clin. proof of concept for a synthetic MenC oligosaccharide conjugate vaccine candidate. In the experimental materials used by the author, we found 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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In 2013,Gao, Yang; Zhang, Guo-fu; Wang, Wen-guang published 《Research on predispersion process for preparing Cu-CNTs composite powders by electroless copper plating》.Biaomian Jishu published the findings.Computed Properties of C4H12KNaO10 The information in the text is summarized as follows:

CNTs were pre-dispersed by ionic surfactants(SDBS) and Non-ionic surfactants(TX10). Without activation and sensitization processing, copper was deposited directly on the surfaces of CNTs by electroless plating. Compared the effect of two dispersants, studied the affect of pH, temperature and time on coating effect. The results of the study show that the dispersing effect of SDBS is better and in the condition of 30°C water bath, pH of 11 to 12, electroless copper plating for 30 min, CNTs are coated completely by Cu. The experimental process involved the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Computed Properties of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Computed Properties of C4H12KNaO10 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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In 1994,Vox sanguinis included an article by Morfini, M; Mannucci, P M; Ciavarella, N; Schiavoni, M; Gringeri, A; Rafanelli, D; Di Bona, E; Chistolini, A; Tagliaferri, A; Rodorigo, G. Name: Octadecan-9-ol. The article was titled 《Prevalence of infection with the hepatitis C virus among Italian hemophiliacs before and after the introduction of virally inactivated clotting factor concentrates: a retrospective evaluation.》. The information in the text is summarized as follows:

In July 1985, all coagulation factor concentrates were withdrawn from the market in Italy and replaced with virally inactivated concentrates. A retrospective survey comparing the prevalence of the antibody to the hepatitis C virus (anti-HCV) in hemophiliacs multitransfused with nonvirally inactivated concentrates until 1985 with that in previously untreated hemophiliacs transfused exclusively with virally inactivated concentrates since 1985 has been conducted in 9 Italian hemophilia centers. The centers, which follow about one-fourth of all the Italian hemophiliacs, provided information about 708 patients infused for the first time before 1985 (group A) and 80 patients infused for the first time between 1985 and 1991 (group B). The prevalence of anti-HCV was 83% (591/708) in group A and 6% (5/80) in group B. For the 5 anti-HCV-seropositive patients from group B, dry heating, hydrophobic interaction chromatography plus dry heating (2 patients), hot vapor and pasteurization were the virucidal methods used for the concentrates implicated in HCV transmission. In the case associated with pasteurization, there is the possibility of intrafamilial transmission of HCV. It appears from this retrospective analysis that there has been a substantial reduction in the risk of HCV transmission since the adoption of virucidal methods. However, these methods do not eliminate completely the risk, which might be further reduced by the recent adoption of anti-HCV screening for plasma donations used to manufacture concentrates. In the part of experimental materials, we found many familiar compounds, such as Octadecan-9-ol(cas: 591-70-8Name: Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: Octadecan-9-ol

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