Tag: 100-200

《Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol》 was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2020. These research results belong to Nizamov, Ilyas S.; Salikhov, Ramazan Z.; Timushev, Ildus D.; Nikitin, Yevgeniy N.; Nizamov, Ilnar D.; Yakimov, Vladimir Yu.; Shulaeva, Marina P.; Pozdeev, Oscar K.; Batyeva, Elvira S.; Cherkasov, Rafael A.; Ponomareva, Anna S.. Quality Control of 3-Pyridinemethanol The article mentions the following:

A new series of chiral carboxypyridinium dithiophosphates I (R = pyridin-2-yl, pyridin-3-yl, pyridin-4-yl) was synthesized by the reactions of acids RC(O)OH with dithiophosphoric acid on the basis (1S)-endo-(-)-borneol in benzene or ethanol. The compound 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium/3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane which possessed antifungal activity against Candida albicans. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 3-Pyridinemethanol

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In 2017,Maxwell, Brad D. published 《The syntheses of [13C6] and [phenyl-14C(U)]BMS-816336, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, for type 2 diabetes》.Journal of Labelled Compounds and Radiopharmaceuticals published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:

Type 2 diabetes is a significant worldwide health problem. To support the development of BMS-816336 as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 for type 2 diabetes, the synthesis of carbon-14 labeled material was required for use in metabolic profiling. [Phenyl-14C(U)]BMS-816336 (A) was synthesized in 8 steps and 22% radiochem. yield from com. available [14C(U)]bromobenzene. The radiochem. purity of A was 100% having a specific activity of 84.4 μCi/mg or 28.8 mCi/mmol for a total of 8.9 mCi. It was also necessary to synthesize [13C6]BMS-816336 (B) for use as a liquid chromatog./mass spectrometry standard B was also prepared in 8 labeled steps in 26% yield from [13C6]bromobenzene. In the experiment, the researchers used many compounds, for example, Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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The author of 《Photochemical synthesis and properties of axially chiral naphthylpyridines》 were Wessig, Pablo; Pick, Charlotte. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2011. Electric Literature of C8H7NO The author mentioned the following in the article:

Five alkynyl pyridines were prepared and cyclized to naphthylpyridines as the main products in the course of a Photo-Dehydro-Diels-Alder reaction. Four of the final products (I,II,III,IV) are axially chiral and the determination of the rotational barrier by DFT calculations, dynamic NMR and HPLC experiments is demonstrated. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Electric Literature of C8H7NO) was used in this study.

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C8H7NO

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《Drug-Encapsulated Cyclodextrin (CD) Nanosponges (NSs)》 was published in Methods in Molecular Biology (New York, NY, United States) in 2021. These research results belong to Tannous, Maria; Caldera, Fabrizio; Hoti, Gjylije; Dianzani, Umberto; Cavalli, Roberta; Trotta, Francesco. Formula: C6H12O6 The article mentions the following:

A review. To date, a number of nanocarriers, either inorganic or organic, have been developed to improve the delivery and therapeutic efficacy of various drugs. Drug delivery systems have attempted to overcome the undesirable pharmacokinetic problems encountered. Among the various nanomaterials that have been designed as potential nanocarriers, cyclodextrin-based polymers are of particular interest in this review. Cyclodextrins (CD) are a class of cyclic glucopyranose oligomers, obtained from starch by enzymic action, with a characteristic toroidal shape that forms a truncated cone-shaped lipophilic cavity. The main common native cyclodextrins are named α, β, and γ which comprise six, seven, and eight glucopyranose units, resp. Cyclodextrins have the capability to include compounds whose size and polarity are compatible with those of their cavity. Cyclodextrin-based crosslinked polymers, often referred to as ”cyclodextrin nanosponges” (CDNSs), attract great attention from researchers for solving major bioavailability problems such as inadequate solubility, poor dissolution rate, and limited stability of some agents, as well as increasing their effectiveness and decreasing unwanted side effects. Registered patents about this novel system in various fields, different pharmaceutical applications, and classes of drugs encapsulated by CDNSs are detailed. The features outlined make CDNSs a promising platform for the development of innovative and advanced delivery systems. In the experimental materials used by the author, we found rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Formula: C6H12O6

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The author of 《Synthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy》 were Singh, Sangh Priya; Tripathi, Shashank; Yadav, Anamika; Kant, Ruchir; Srivastava, Hemant Kumar; Srivastava, Ajay Kumar. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2020. Application of 6346-09-4 The author mentioned the following in the article:

A modular approach for the construction of β- and γ-lactam fused dihydropyrazinones from the readily available Ugi adducts was described. The sequential construction of rings through base-mediated cycloisomerization followed by acid-mediated cyclization yielded β-lactam fused dihydropyrazinones. However, the Ugi-derived dihydropyrazinones afforded γ-lactam fused dihydropyrazinones under base-mediated cycloisomerization. The regioselectivity in the cycloisomerization reactions was explained on the basis of ring-strain. Substrate scope, limitations and mechanistic investigations through DFT-calculations was explored. In addition to this study using 4,4-Diethoxybutan-1-amine, there are many other studies that have used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application of 6346-09-4) was used in this study.

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 6346-09-4

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《Phosphonate inhibitors of West Nile virus NS2B/NS3 protease》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Skorenski, Marcin; Milewska, Aleksandra; Pyrc, Krzysztof; Sienczyk, Marcin; Oleksyszyn, Jozef. Synthetic Route of C8H19NO2 The article mentions the following:

West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)P(OPh)2 displaying Ki and k2/Ki values of 0.4 μM and 28 265 M-1s-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease. In the part of experimental materials, we found many familiar compounds, such as 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Synthetic Route of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C8H19NO2

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《Theophylline as a Green Catalyst for the Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones》 was written by Mohamadpour, Farzaneh. Name: 3-Hydroxybenzaldehyde And the article was included in Organic Preparations and Procedures International in 2020. The article conveys some information:

A green, readily available, and inexpensive method is developed to synthesize 1H-Pyrazolo[1,2-b]phthalazine-5,10-diones. Theophylline has shown significant potential to be an alternative green catalyst for the synthesis of these valuable heterocyclic compounds In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Name: 3-Hydroxybenzaldehyde

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《RP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: Method development and validation》 was written by Nageswara Rao, Ramisetti; Ramakrishna, Kuntamukkala; Sravan, Bompelli; Santhakumar, Kondapalli. Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol And the article was included in Journal of Pharmaceutical and Biomedical Analysis on April 15 ,2013. The article conveys some information:

A stability indicating reversed phase HPLC method was developed and validated for determination of process related impurities and forced degradants of carisbamate (CRS) in bulk drugs. Carisbamate when subjected to acid/base hydrolysis, H2O2 oxidation, photolysis and thermal stress significant degradation was observed during acid/base hydrolysis and the degradants were isolated and characterized by ESI-MS, 1H and 13C NMR. MS/MS and 2D-NMR (COSY and HSQC) studies revealed the possible isomerization of CRS under stress conditions. The optimum separation was accomplished on Agilent XDB C18 column (150 mm × 4.6 mm; 5 μm) using 0.02 M KH2PO4 (pH = 3.5) and CH3CN as a mobile phase in a gradient elution mode at a flow rate of 1.0 mL/min. The eluents were monitored by PDA detector at 211 nm and quantitation limits were obtained in the range of 0.1-0.3 μg/mL for CRS, degradants and other impurities. The LC method was validated with respect to accuracy, precision, linearity, robustness and limits of detection and quantification as per ICH guidelines. In addition to this study using (1S)-1-(2-chlorophenyl)ethane-1,2-diol, there are many other studies that have used (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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《Thermal behavior of aminotrimethoxysilanphosphonate functionalized onto styrene-divinylbenzene copolymer》 was published in International Journal of Polymer Analysis and Characterization in 2020. These research results belong to Popa, Adriana; Macarie, Lavinia; Dragan, Ecaterina S.; Parvulescu, Viorica; Ilia, Gheorghe; Plesu, Nicoleta. Computed Properties of C7H6O2 The article mentions the following:

The chlorometylated styrene-divinylbenzene copolymer with different percent of divinylbenzene (code: S-6.7 DVB, S-12DVB, and S-15DVB) was functionalized with 3-hydroxybenzaldehyde for obtaining intermediated polymers. The aminotrimethoxysilanphosphonate groups were grafted by one-pot reactions in THF using three components: polymers grafted with aldehyde groups (code: CHO-6.7, CHO-12, and CHO-15), 3-aminopropyltrimethoxysilane, diethylphosphite. The aminotrimethoxysilanphosphonate groups functionalized onto styrene-(6.7, 12, and 15%) divinylbenzene copolymer (code: PAF-6.7, PAF-12, and PAF-15) and evolution of the reaction were evidenced by FT-IR spectroscopy and porous structure by N2 adsorption-desorption, SEM microscopy. The thermal behavior of aldehydes and materials: PAF-6.7, PAF-12, and PAF-15 are different than initial polymer supports. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Computed Properties of C7H6O2

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In 2022,Koike, Tatsuki; Constantinescu, Cristian C.; Ikeda, Shuhei; Nishi, Toshiya; Sunahara, Eiji; Miyamoto, Maki; Cole, Patricia; Barret, Olivier; Alagille, David; Papin, Caroline; Morley, Thomas; Fowles, Krista; Seibyl, John; Tamagnan, Gilles; Kuroita, Takanobu published an article in European Journal of Nuclear Medicine and Molecular Imaging. The title of the article was 《Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase》.Recommanded Product: 18621-18-6 The author mentioned the following in the article:

Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued as a drug for treatment of seizures in developmental and epileptic encephalopathies. Herein, we describe the successful discovery and the preclin. validation of the novel radiolabeled CH24H ligand (3-[18F]fluoroazetidin-1-yl){1-[4-(4-fluorophenyl)pyrimidin-5-yl]piperidin-4-yl}methanone ([18F]T-008) and its tritiated analog, [3H]T-008. In vitro autoradiog. (ARG) studies in the CH24H wild-type (WT) and knockout (KO) mouse brain sections were conducted using [3H]T-008. PET imaging was conducted in two adult rhesus macaques using [18F]T-008. Each macaque received two test-retest baseline scans and a series of two blocking doses of soticlestat administered prior to [18F]T-008 to determine the CH24H enzyme occupancy. PET data were analyzed with Logan graphical anal. using plasma input. A Lassen plot was applied to estimate CH24H enzyme occupancy by soticlestat. In ARG studies, binding of [3H]T-008 was specific to CH24H in the mouse brain sections, which was not observed in CH24H KO or in wild-type mice after pretreatment with soticlestat. In rhesus PET studies, the rank order of [18F]T-008 uptake was striatum > cortical regions > cerebellum, which was consistent with CH24H distribution in the brain. Pre-blocking with soticlestat reduced the maximum uptake and increased the washout in all brain regions in a dose-dependent manner. Calculated global occupancy values for soticlestat at a dose of 0.89 mg/kg were 97-98%, indicating maximum occupancy. The preclin. in vitro and in vivo evaluation of labeled T-008 demonstrates that [18F]T-008 is suitable for imaging CH24H in the brain and warrants further studies in humans. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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