Tag: 100-200

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Bete, Sarah C.; Wuertele, Christian; Otte, Matthias. Synthetic Route of C7H6O3. The article was titled 《A bio-inspired imidazole-functionalized copper cage complex》. The information in the text is summarized as follows:

An imidazole-functionalized cage (I) was synthesized that can coordinate to Cu(I). X-ray anal. reveals a T-shaped coordination of Cu by the imidazole ligands reminiscent of the coordination geometry found in enzymic active sites. This cage complex can catalyze the oxidation of benzylic alcs. to benzaldehydes using O as the terminal oxidant. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3,5-DihydroxybenzaldehydeIn 2019 ,《Small molecule inhibitors of the BfrB-Bfd interaction decrease Pseudomonas aeruginosa fitness and potentiate fluoroquinolone activity》 appeared in Journal of the American Chemical Society. The author of the article were Punchi Hewage, Achala N. D.; Yao, Huili; Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Lovell, Scott; Bunce, Richard A.; Eshelman, Kate; Phaniraj, Sahishna M.; Lee, Molly M.; Peterson, Blake R.; Battaile, Kevin P.; Reitz, Allen B.; Rivera, Mario. The article conveys some information:

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small mol. inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperprodn. phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of com. fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small mol. probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 100-55-0In 2021 ,《KF/clinoptilolite NPs: An efficient and heterogeneous catalyst for chemoselective silylation of alcohols and phenols》 appeared in Phosphorus, Sulfur and Silicon and the Related Elements. The author of the article were Oladee, Razieh; Zareyee, Daryoush; Khalilzadeh, Mohammad A.. The article conveys some information:

Potassium fluoride incorporated on clinoptilolite nanoparticles (KF/CP NPs) by ion exchanging is found to be an effective and inexpensive heterogeneous nanocatalyst for chemoselective silylation of alcs. and phenols with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) at room temperature Nano-powder of clinoptilolite (CP) was prepared using a planetary ball mill mech. method and characterized by dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscope (SEM) analyses. Almost all of products were obtained in high yields as well as short reaction times and the catalyst was also reused eight times without loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Esmaeili, Sajjad; Ghobadi, Nazanin; Nazari, Donya; Pourhossein, Alireza; Rasouli, Hassan; Adibi, Hadi; Khodarahmi, Reza published their research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021. The article was titled 《Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes》.Category: alcohols-buliding-blocks The article contains the following contents:

Curcumin, as the substantial constituent of the turmeric plant (Curcuma longa), plays a significant role in the prevention of various diseases, including diabetes. It possesses ideal structure features as an enzyme inhibitor, including a flexible backbone, hydrophobic nature, and several available hydrogen bond (H-bond) donors and acceptors. The present study aimed at synthesizing several novel curcumin derivatives and further evaluation of these compounds for possible antioxidant and anti-diabetic properties along with inhibitory effect against two carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase, as these enzymes are therapeutic targets for attenuation of postprandial hyperglycemia. Therefore, curcumin-based pyrido[2,3-d]pyrimidine derivatives were synthesized and identified using an instrumental technique like NMR spectroscopy and then screened for antioxidant and enzyme inhibitory potential. Total antioxidant activity, reducing power assay and 1,1-diphenyl-2- picrylhydrazyl (DPPH•) radical scavenging activity were done to appraise the antioxidant potential of these compounds in vitro. Compounds L6-L9 showed higher antioxidant activity while L4, L9, L12 and especially L8 exhibited the best selectivity index (lowest α-amylase/α-glucosidase inhibition ratio). These antioxidant inhibitors may be potential anti-diabetic drugs, not only to reduce glycemic index but also to limit the activity of the major reactive oxygen species (ROS) producing pathways.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Perylenebisimide-fullerene dyads as heavy atom free triplet photosensitizers with unique singlet oxygen generation efficiencies》 were Ozturk, Ezel; Eserci, Hande; Okutan, Elif. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2019. Electric Literature of C6H15NO The author mentioned the following in the article:

We report the synthesis, characterization, photophys. and photochem. properties of two novel perylenebisimide-fullerene dyads (7 and 8) bearing one or two perylenebisimide (PBI) units as light harvester and a fullerene as spin converter. The mol. structures of all synthesized compounds were elucidated by elemental analyses, mass spectrometry, FT-IR, 1H and 13C NMR techniques. Their optical properties were investigated by UV-vis absorption and 2D/3D fluorescence emission spectroscopies. The photochem. studies via direct and indirect method endorsed PBI-fullerene dyads (7 and 8) as efficient heavy atom free tripletphotosensitizers whereas perylene derivatives did not exhibit any singlet oxygen production The PBI-fullerene dyads exhibit excellent singlet oxygen quantum yields of 0.93 and 0.95. The PBI-fullerene dyads (7 and 8) are also able to use in the photooxidation of 1,5-dihydroxynaphtalene (DHN) to produce juglone and are recognized as stronger than MB as conventional triplet photosensitizers. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Electric Literature of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Harinath, Adimulam; Bhattacharjee, Jayeeta; Panda, Tarun K.. Formula: C7H7BrO. The article was titled 《Facile reduction of carboxylic acids to primary alcohols under catalyst-free and solvent-free conditions》. The information in the text is summarized as follows:

A facile protocol for the deoxygenative hydroboration of aliphatic and aryl carboxylic acids afforded corresponding primary alcs. under solvent-free and catalyst-free conditions was reported. The reaction proceeded under ambient temperature exhibited good tolerance towards various functional groups and generates quant. yields. The plausible mechanism involved the formation of Lewis acid-base adducts as well as the liberation of hydrogen gas. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Miller, Miles A.; Kim, Eunha; Cuccarese, Michael F.; Plotkin, Alec L.; Prytyskach, Mark; Kohler, Rainer H.; Pittet, Mikael J.; Weissleder, Ralph. SDS of cas: 27489-62-9. The article was titled 《Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease》. The information in the text is summarized as follows:

The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells and immune cells alike; however, no small mol. probes currently exist to selectively image Mer. In this work, we design and synthesize a selective near-IR fluorescent mol. probe of Mer (MERi-SiR). Confocal microscopy of metastases in mice reveals predominant probe accumulation in Mer-expressing tumor-associated macrophages. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.SDS of cas: 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dhiman, Priya; Bhatia, Meenakshi published their research in Journal of Inclusion Phenomena and Macrocyclic Chemistry on December 31 ,2020. The article was titled 《Pharmaceutical applications of cyclodextrins and their derivatives》.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The article contains the following contents:

A review. Cyclodextrins (CDs) are abundantly explored in the field of medicines for the design of various types of drug delivery systems. They are cyclic oligosaccharides carrying α (1,4) glucopyranose units and able to build aqueous soluble inclusion complexes with various small and large drug mols. These mols. have a unique structural feature and categorized into hydrophobic, hydrophilic and ionic derivatives Villiers and Schardinger in 1891, first described the chem. nature and types of cyclodextrin. Cramer and co-workers in 1955 illustrated their latent to make water soluble inclusion complexes with various active components. These CDs mols. are used in pharmaceutical field practically and economically to improve the stability, solubility as well as bioavailability of drug mols. In this review article phys. characteristic, chem. nature and applications of different cyclodextrin and their derivatives in different drug delivery systems and toxicol. effects are engrossed. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and biological activity of some new- 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione derivatives》 was written by Tabassum, Zeaba; Nizami, Syed Azhar; Gurumurthy, M.. SDS of cas: 100-83-4 And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020. The article conveys some information:

Imidazole on reaction with 1-(4-chlorophenyl) ethanone in the presence of absolute ethanol gave 1-(4-(-imidazol-1-yl) phenyl) ethanone, condensation of this with various benzaldehydes offered 1-(4-(Imidazol-1-yl)phenyl) -3-phenylprop-2-en-1-ones I [R = Ph, 3-hdroxyphenyl, 4-methoxyphenyl, 2-hydroxy-3-methoxy Ph, 3-nitrophenyl], which on cyclization with thiourea yielded 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione II. The structures of newly synthesized compounds II were confirmed by FTIR, 1HNMR and mass spectral data. Compounds II were screened for in-vitro anti-inflammatory activity by inhibition of albumin denaturation technique and antiproteinase action. All the synthesized substituted thiopyrimidine compounds II showed moderate to good anti-inflammatory activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2012,Davis, Tyler A.; Danneman, Michael W.; Johnston, Jeffrey N. published 《Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor》.Chemical Communications (Cambridge, United Kingdom) published the findings.Application In Synthesis of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

The first enantioselective synthesis of a potent GlyT1 inhibitor is described. A 3-nitroazetidine donor is used in an enantioselective aza-Henry reaction catalyzed by a bis(amidine)-triflic acid salt organocatalyst, delivering the key intermediate with 92% ee. This adduct is reductively denitrated and converted to the target through a short sequence, thereby allowing assignment of the absolute configuration of the more potent enantiomer. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts