Tag: 100-200

In 2019,Transition Metal Chemistry (Dordrecht, Netherlands) included an article by Qin, Yutian; Wang, Bowei; Li, Jiayi; Wu, Xingchun; Chen, Ligong. Quality Control of 2,6-Pyridinedimethanol. The article was titled 《Cobalt imine-pyridine-carbonyl complex functionalized metal-organic frameworks as catalysts for alkene epoxidation》. The information in the text is summarized as follows:

Aerobic epoxidation of alkene is a green and economical route to produce epoxides. For such reaction, transition metal complexes exhibit favorable catalytic activity. In this work, NH2-MIL-101, a stable metal-organic framework (MOF) material with large surface area and high pore volume, was functionalized with pyridine-2,6-dicarbaldehyde and Co(NO3)2, to realize the immobilization of Co(II) via imine-pyridine-carbonyl (N,N,O) tridentate ligands bonding to MOF skeleton. The modified materials were applied as heterogeneous catalysts for the aerobic epoxidation of cyclohexene at ambient temperature, and multiple factors were studied to explore their influences on catalytic effects. Under the optimal reaction conditions, satisfactory substrate conversion and epoxide selectivity were reached. In addition, this catalytic system is suitable for a variety of alkene substrates. Furthermore, recycle experiments and IR spectroscopy characterization illustrated that the coordination surroundings of Co are altering smoothly during the reaction process, thus having an impact on the performance of catalyst. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 2,6-Pyridinedimethanol

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In 2018,Sao, Soumik; Naskar, Sumit; Mukhopadhyay, Narottam; Das, Mousumi; Chaudhuri, Debangshu published 《Assisted π-stacking: a strong synergy between weak interactions》.Chemical Communications (Cambridge, United Kingdom) published the findings.Related Products of 1195-59-1 The information in the text is summarized as follows:

Synergy between a pair of weak non-covalent interactions can predispose a mol. self-assembly towards a specific pathway. We report assisted π-stacking, a synergy between aromatic π-stacking and n → π* interactions that exhibits an unprecedented strength and thermal stability. Natural bond orbital anal. reveals the non-additive nature of the interaction.2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 1195-59-1

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In 2017,Pilicer, Samantha L.; Bakhshi, Pegah R.; Bentley, Keith W.; Wolf, Christian published 《Biomimetic Chirality Sensing with Pyridoxal-5′-phosphate》.Journal of the American Chemical Society published the findings.Product Details of 126456-43-7 The information in the text is summarized as follows:

Pyridoxal-5′-phosphate (PLP) is introduced to a biomimetic indicator displacement assay for simultaneous determination of the absolute configuration, enantiomeric composition and concentration of unprotected amino acids, amino alcs. and amines. The chiroptical assay is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for CD and fluorescence sensing anal. The substrate binding yields characteristic Cotton effects that provide information about the target compound ee and the synchronous release of the indicator results in a nonenantioselective off-on fluorescence response that is independent of the enantiomeric sample composition and readily correlated to the total analyte concentration The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 126456-43-7

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Suvarna, Vasanti; Gujar, Parul; Murahari, Manikanta; Sharma, Dhvani; Chamariya, Rinkal published an article on January 31 ,2022. The article was titled 《Supramolecular ternary inclusion complexes of Irbesartan with hydroxypropyl-beta-cyclodextrin》, and you may find the article in Journal of Drug Delivery Science and Technology.Computed Properties of C6H12O6 The information in the text is summarized as follows:

Current study investigated the formation of binary and ternary inclusion complexes of Irbesartan (IRB) with Hydroxypropyl-β-Cyclodextrin (HP-βCD) as host and L-Arginine (L-Arg) as ternary agent. Inclusion complexes were characterized using solubility, invitro release, DSC and XRD studies. Host-guest interactions were explored by FTIR, 1H NMR and mol. docking studies. Significant enhancement in stability constant and complexation efficiency of HP-βCD was observed in ternary complexes due to the presence of L-Arg. Ternary complexes exhibited greater solubility and dissolution of IRB than binary complexes. Thus, ternary complexation of IRB could offer an innovative strategy for improvement of solubility and dissolution of IRB. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Computed Properties of C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Computed Properties of C6H12O6

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Shaghafi, Michael B.; Barrett, David G.; Willard, Francis S.; Overman, Larry E. published an article on February 15 ,2014. The article was titled 《The insulin secretory action of novel polycyclic guanidines: Discovery through open innovation phenotypic screening, and exploration of structure-activity relationships》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.SDS of cas: 93524-95-9 The information in the text is summarized as follows:

We report the discovery of the glucose-dependent insulin secretogogue activity of a novel class of polycyclic guanidines through phenotypic screening as part of the Lilly Open Innovation Drug Discovery platform. Three compounds from the University of California, Irvine, I.HCl, II.HCl and III.HCl, having the 3-arylhexahydropyrrolo[1,2-c]pyrimidin-1-amine scaffold acted as insulin secretagogues under high, but not low, glucose conditions. Exploration of the structure-activity relationship around the scaffold demonstrated the key role of the guanidine moiety, as well as the importance of two lipophilic regions, and led to the identification of IV.HCl, which stimulated insulin secretion in isolated rat pancreatic islets in a glucose-dependent manner. In the experimental materials used by the author, we found 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9SDS of cas: 93524-95-9)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 93524-95-9

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Recommanded Product: 4,4-Diethoxybutan-1-amineOn September 27, 2021 ,《Direct Amidation of Esters by Ball Milling》 was published in Angewandte Chemie, International Edition. The article was written by Nicholson, William I.; Barreteau, Fabien; Leitch, Jamie A.; Payne, Riley; Priestley, Ian; Godineau, Edouard; Battilocchio, Claudio; Browne, Duncan L.. The article contains the following contents:

The direct mechanochem. amidation of esters RC(O)OR1 (R = Cy, Ph, pyridin-2-yl, etc.; R1 = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R2NHR3 (R2 = H, Me, Et; R3 = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R2R3 = -(CH2)2O(CH2)2-, -(CH2)5-, -(CH2)6-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R2)R3 and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent. In the experimental materials used by the author, we found 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 4,4-Diethoxybutan-1-amine

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《New Aqueous Solutions with Lower Viscosities than Water》 was published in Bulletin of the Chemical Society of Japan in 2021. These research results belong to Haraguchi, Kazutoshi; Kimura, Yuji. Computed Properties of C3H5F3O The article mentions the following:

Liquid water exhibits many anomalous phys. properties because of its unique structure and hydrogen bonding networks, which were mostly uncovered at the beginning of the 20th century. Because of its interesting properties and microstructures under various conditions and in aqueous solutions, understanding the behavior of water is important, but remains scientifically challenging. Regarding the viscosity of aqueous solutions, despite the discovery 147 years ago that very small amounts of certain salts decrease the viscosity of water slightly, there has been no significant progress to date. Herein, we report new aqueous solutions, with low additive fractions and much lower viscosities than pure water, which exhibit unique viscosity-composition curves. The findings should spark renewed interest in scientific research on water, which may greatly impact numerous industries. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Computed Properties of C3H5F3O)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Computed Properties of C3H5F3O

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《Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors》 was written by Jorgensen, William T.; Gulliver, Damien W.; Katte, Timothy A.; Werry, Eryn L.; Reekie, Tristan A.; Connor, Mark; Kassiou, Michael. Safety of 3,5-DihydroxybenzaldehydeThis research focused onWAY 267464 conformationally rigid derivative preparation oxytocin vasopressin receptor; Arginine vasopressin 1(a) receptor; Diazepine; Oxytocin receptor; WAY-267,464. The article conveys some information:

WAY-267,464 (I) and twelve conformationally rigid analogs were synthesized, characterized and evaluated in cellular assays with the aim of systematically exploring interactions with the oxytocin receptor (OTR). Each analog was evaluated in radioligand binding displacement assays at both human OTR and arginine vasopressin 1a receptors (V1aR). Physiol. characterization was determined by whole cell IP1 accumulation assays on stably transfected human embryonic kidney (HEK) cells. Incorporation of the rigid, optionally substituted benzene ring abolished OTR activity and diminished V1aR pharmacol. when compared to I. A general trend was observed in V1aR affinity for the Pr analogs which identified the ortho-substituted analog II as the best in series (Ki = 251 nM) followed by a decrease in affinity through the meta and para-derivatives ( Ki = 874 nM, 1756 nM resp.). This study confirms the importance of the central pharmacophoric motifs of WAY-267,464 and illuminates the differences in the binding pocket of the highly conserved OTR and V1aR. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

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Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《Fungal endophyte Phomopsis liquidambari biodegrades soil resveratrol: a potential allelochemical in peanut monocropping systems》 was published in Journal of the Science of Food and Agriculture. The article was written by Wang, Hong-Wei; Sun, Kai; Guan, Yong-Xiang; Qiu, Mei-Hua; Zhang, Li; Dai, Chuan-Chao. The article contains the following contents:

Most allelochems. are secondary products released from root excretions or plant residues that accumulate in continuous cropping systems and cause severe decline in peanut yield. Resveratrol is a plant-derived stilbene that is released from peanut residues and accumulates in the soil; however, its allelopathic effects on peanut production are overlooked. Effective management solutions need to be developed to relieve allelopathy caused by soil resveratrol. Here, the biodegradation of resveratrol by the fungal endophyte Phomopsis liquidambari was investigated in a mineral salt medium and a soil trial. Resveratrol and its metabolites (produced by degradation by P. liquidambari) were detected by high-performance liquid chromatog.-mass spectrometry (HPLC-MS). Resveratrol released from peanut residues reached a maximum concentration of 0.18μg g-1 soil in litterbag experiments Exogenous resveratrol inhibited peanut growth, nodule formation, and soil dehydrogenase activity, and reduced the soil microbial biomass carbon content and bacterial abundance, indicating an allelopathic role in peanut growth. More than 97% of the resveratrol was degraded within 72 and 168 h by P. liquidambari in pure culture and soil conditions, resp. Resveratrol was first cleaved to 3,5-dihydroxybenzaldehyde and 4-hydroxybenzaldehyde, which were subsequently oxidized into 3,5-dihydroxybenzoic acid and 4-hydroxybenzoic acid, resp. Fungal resveratrol cleavage oxygenase and the related gene expression were enhanced when P. liquidambari was induced by the resveratrol during the incubation. Our results indicate that the practical application of the fungal endophyte P. liquidambari has strong potential for biodegrading soil resveratrol, which can cause allelopathy in peanut continuous cropping systems, c 2019 Society of Chem. Industry. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

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Quality Control of 3-PyridinemethanolIn 2019 ,《Room temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Ming; Li, Yukui; Li, Yinwu; Liu, Jiahao; Shu, Siwei; Liu, Yan; Ke, Zhuofeng. The article contains the following contents:

The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcs. by a bis-NHC manganese complex is presented. This system was applied to a large range of alcs. and anilines, including biol. relevant motifs and challenging methanol. Exptl. and computational studies suggest an outer-sphere mechanism for this NHC-Mn system. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Quality Control of 3-Pyridinemethanol

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