Tag: 100-200

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Cheng; Xia, Jiahao; Ji, Shaobo; Fan, Zhiyuan; Xu, Huaping. Quality Control of 3-Bromopropan-1-ol. The article was titled 《Visible-light-induced metathesis reaction between diselenide and ditelluride》. The information in the text is summarized as follows:

The Se-Te bond was prepared by a metathesis reaction between diselenides and ditellurides, which could be manipulated with the presence or absence of visible light. Addnl., the apparent activation energy of the exchange process was measured to be only 28.01 kJ mol-1, explaining the high reactivity and sensitivity to light. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

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In 2018,European Journal of Inorganic Chemistry included an article by Hastings, Samantha D.; Cagle, Ethan C.; Totsch, Timothy R.; Tyus, Shakyra D.; Gray, Gary M.. Recommanded Product: 1195-59-1. The article was titled 《Comparative Study of Novel Phosphordiamidite and Phosphite Ligands Used in Alkene Hydroformylation; Synthesis, Characterization, Metalation, and Catalytic Evaluation》. The information in the text is summarized as follows:

Three novel ligands have been prepared by the reactions of 1,1′-(chlorophosphinediyl)bis(1H-pyrrole) with either 2-pyridinemethanol or 2,6-pyridinedimethanol or the reaction of 1,1′-biphenyl-2,2′-diyl phosphorochloridite with 2-pyridinemethanol. Measurement of |1JP-Se| values demonstrate that the phosphite donor is less basic than the phosphoramidite donors. Coordination preferences of the ligands in octahedral cis-tetracarbonylmolybdenum(0) and square planar cis-dichloropalladium(II) complexes have been evaluated using multinuclear NMR and x-ray crystallog. Rhodium(I) complexes of the bidentate ligands have been evaluated as catalysts for styrene hydroformylation, and their activities are nearly double those of catalysts containing traditional phosphites. The regioselectivities of the RhI complexes of the bidentate ligands are not significantly different at 80° and 20 atm and are not affected by the addition of a lithium salt. In contrast, changing reaction conditions causes the % n-aldehyde to vary from 15 to 50%. The regioselectivity of the catalyst containing the bidentate phosphoramidite/pyridine ligand was more sensitive to pressure than temperature with both effects being significant. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 1195-59-1

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In 2012,Roughley, Stephen D.; Browne, Helen; Macias, Alba T.; Benwell, Karen; Brooks, Teresa; D’Alessandro, Jalanie; Daniels, Zoe; Dugdale, Sarah; Francis, Geraint; Gibbons, Ben; Hart, Terance; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Matassova, Natalia; Mansell, Howard; Merrett, Angela; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Simmonite, Heather; Tan, Kiri; Walls, Steven B.; Wong, Melanie published 《Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity》.Bioorganic & Medicinal Chemistry Letters published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:

Attempts to optimize the human fatty acid amide hydrolase (FAAH) inhibition and physicochem. properties of previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084, are reported. The SAR of a series of analogs and in vivo dose-dependent FAAH inhibition in an anandamide-loading study in rats were determined The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Siddiqui, Bina S.; Adil, Qayyum; Begum, Sabira; Siddiqui, Salimuzzaman published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Synthesis of alkyl catechols and evaluation of their antibacterial and cytotoxic activity》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:

A series of potential biol. active mono-, di- and tetra- alkyl catechols were prepared through Friedel- Crafts alkylation of catechol, and evaluated for their antibacterial and cytotoxic activity. The mono-substituted alkyl derivatives showed maximum antibacterial activity in vitro which increased with the increasing length of the alkyl chains. Primary screening results indicated that all the monoalkyl derivatives except 4- (2-octyl) catechol inhibited the growth of Bordetella bronchoseptica and maximum zones of inhibition were observed in case of monohexyl catechols (both n- and 2-hexyl) and monobenzyl derivative In case of Gram-neg. organisms growth of Klebsiella pneumoniae and Acinetobacter calcoaceticus was inhibited by several derivatives Mono-3-octyl-, monononyl- and monobenzyl catechols markedly inhibited the growth of Kl. pneumoniae. Mono-2-heptyl catechol inhibited the growth of six Gram-neg. bacteria. Min. inhibitory concentration of six most active compounds of the series was determined against Gram-pos. and Gram-neg. organisms; it ranged from > 100 μg/mL to 10μg/mL. The antibacterial activity of catechol was not significant. Cytotoxicity test done by brine shrimp assays showed that the order of cytotoxicity decreases in going from mono- to tetra- alkyl catechols, and among the mono- alkyl products, a decrease in order of cytotoxicity was noted in going from mono-Me catechol (LD50 = 59) to monopentyl catechol (LD50 = 173) after which the order of cytotoxicity gradually increased up to the largest alkyl substituent tested i.e. monononyl catechol (LD50 = 114). Me and Et catechol, which were almost inactive in respect of their antibacterial activity possessed pronounced cytotoxicity as compared to higher homologs. Catechol itself did not show significant cytotoxicity (LD50 = 393.27). The results came from multiple reactions, including the reaction of 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Safety of 4-Butylbenzene-1,2-diol

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Kadri, Safwen; El Ayed, Mohamed; Mabrouk, Maha; Limam, Ferid; Elkahoui, Salem; Aouani, Ezzedine; Mokni, Meherzia published an article on February 5 ,2019. The article was titled 《Characterization, anti-oxidative effect of grape seed powder and in silico affinity profiling of polyphenolic and extra-phenolic compounds for calpain inhibition》, and you may find the article in Journal of Pharmaceutical and Biomedical Analysis.Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The information in the text is summarized as follows:

Vitis vinifera grape is a highly cultivated crop and solid wastes generated by the wine industry are largely under exploited. Plentiful studies have intended analyzing the polyphenolic content of grape seeds but characterization of non phenolic compounds is rather scarce. The present study aimed at the selective extraction of lipid, phenolic and aqueous phases from grape seed powder (GSP) in order to establish their intimate composition, as well as their antioxidant and chelating properties underlying partly their biol. effects. Major non phenolic compounds identified in the lipid phase were glyceryl-monostearate and 2-monostearin whereas fructofuranose and sucrose were the most abundant in the aqueous phase. Among the most abundant compounds detected in the various phases, the polyphenol quercetin exhibited the best affinity and free binding energy towards the active site of the calcium-dependent protease calpain. Polyphenols likely constitute the bioactive part of GSP that should be exploited as safe modulators of intracellular signaling which is likely at the basis of their health beneficial effects. Nevertheless other compounds as lipids or sugars should be valorized along with polyphenols to improve their bioavailability into highly protected organs as brain or eye. The experimental process involved the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Safety of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolOn June 1, 2022, Tang, Luying; Sun, Yanhui; Ge, Peipei; Chen, Lei; Cheung, Peter C. K.; Ding, Zhongyang; Fang, Jinshan published an article in International Journal of Biological Macromolecules. The article was 《Biogenetic nanocarriers with enhanced pH stability formed by zein and selectively depolymerized mushroom hyperbranched β-glucans》. The article mentions the following:

Hyperbranched polysaccharide from Pleurotus tuber-regium (PTR-HBPS) is a βamp;beta;-glucan with high degree of branching (DB, 0.69) and a mol. weight (Mw) of 31.2 x 105 g/mol with mixed βamp;beta;-1, 4/ββ-1, 4, 6β/β-1, 6 glucosidic linkages. PTR-HBPS was depolymerized by cellulase and βamp;beta;-glucosidase under optimized conditions to form PC (PTR-HBPS depolymerized by cellulase) and PG (PTR-HBPS depolymerized by βamp;beta;-glucosidase) fractions with a min. Mw of 2.74 x 105 and 3.98 x 105 g/mol, resp. PC fractions had no significant changes for its primary structure in terms of glycosidic linkages, DB, and triple helical structure, while the DB of PG fractions was reduced to 0.63 with the loss of triple helical structure. Nanoparticles fabricated by PC fractions with zein showed better stability under different pH conditions. Enzymic depolymerized low Mw β-glucan derived from PTR-HBPS with similar structural characteristics as the native one has potential as nanocarriers for food bioactive substances. The experimental process involved the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Reference of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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《Introduction of a novel dicationic Bronsted acidic ionic liquid based on pyrazine and its application in the synthesis of xanthenediones and 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions》 was written by Sadati Sorkhi, Seyyed Erfan; Hashemi, Mohammad M.; Ezabadi, Ali. Category: alcohols-buliding-blocksThis research focused onxanthenedione preparation green chem; dimethyl cyclohexanedione aryl aldehyde cyclocondensation ionic liquid catalyst; pyrimidinone preparation green chem; aryl aldehyde ethyl acetoacetate urea cyclocondensation ionic liquid catalyst; pyrazine acidic ionic liquid preparation. The article conveys some information:

A novel dicationic Bronsted acidic ionic liquid based on pyrazine I has been prepared and characterized by FTIR, 1H NMR, 13C NMR, MS, thermal gravimetric and differential thermal gravimetric anal. and also Hammett acidity function. The prepared dicationic ionic liquid I is found to be an efficient and reusable catalyst for the synthesis of xanthenediones II (Ar = Ph, 2-bromophenyl, thiophen-2-yl, etc.) and 3,4-dihydropyrimidin-2(1H)-ones III (Ar1 = 3-chlorophenyl, thiophen-2-yl, 4-fluorophenyl, etc.) under solvent-free conditions. The merits of the developed procedure include novelty in terms of the ionic liquid, easy preparation of the ionic liquid, I easy workup, reusability of the catalyst, high yield, short reaction time and absence of toxic organic solvent.3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

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Related Products of 4048-33-3In 2020 ,《Templated Supramolecular Structures of Multichromic, Multiresponsive Perylene Diimide-Polydiacetylene Films》 was published in Macromolecules (Washington, DC, United States). The article was written by Martin, Ian J.; Shih, Kuo-Chih; Nieh, Mu-Ping; Kasi, Rajeswari M.. The article contains the following contents:

We report a detailed synthesis and characterization of novel polymeric supramol. structures composed of semiconducting perylene diimide (PDI)-imidazole templates of varying methylene spacer length (n = 3, 4, and 6) hydrogen-bonded to a conjugated polymer backbone of acid-functionalized polydiacetylene (PDA), 10,12 pentacosadiynoic acid. First, a combination of mol. and morphol. characterization tools confirmed that the templated supramol. structures are a result of the synergistic effect of intermol. PDI π-π stacking coupled with noncovalent imidazole-acid interactions. Second, a simple and scalable solid-state polymerization of the drop-cast films by UV radiation delivers multichromic, multiresponsive films capable of unique phase/morphol.-switching properties with a high degree of local ordering. Thermal studies by differential scanning calorimetry and morphol. studies by wide- and small-angle X-ray scattering (WAXS/SAXS, resp.) show dramatic morphol. effects and trends in crystallinity with methylene spacer group extension. Furthermore, UV-vis studies displayed an unusual PDA “”purple phase”” transition, which was addnl. verified by SAXS as a coexistence of previously known red- and blue-phase PDA. Finally, the polymerized drop-cast films displayed reversible thermo- and solvatochromic responses after a second treatment of UV radiation and addnl. UV-thermal cycling revealed the extent of reversibility. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Related Products of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Related Products of 4048-33-3

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In 2022,Boukherrouba, Emeline; Larosa, Camille; Nguyen, Kim-Anh; Caburet, Jeremy; Lunven, Laurent; Bonnet, Hugues; Fortune, Antoine; Boumendjel, Ahcene; Boucherle, Benjamin; Chierici, Sabine; Peuchmaur, Marine published an article in European Journal of Medicinal Chemistry. The title of the article was 《Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers》.Application of 26153-38-8 The author mentioned the following in the article:

Tauopathies, such as Alzheimer′s disease, have been the subject of several hypotheses regarding the way to treat them. Hyperphosphorylation of tau protein leading to its aggregation is widely recognized as a key step in the development of these diseases resulting in neuronal dysfunction. The AcPHF6 model of tau that includes the shorter critical fragment involved in the protein aggregation was used in vitro to identify new potential inhibitors. Following a previous study on aurone derivatives, we herein compare this polyphenol family to a very close one, the benzylidene-2,3-dihydro-1H-inden-1-one (also named indanone). The structure activity relationship studies bring to light the importance of the hydroxylation pattern in both series: the more hydroxylated, the more active. In addition, the three-dimensional shape of the mols. is involved in their interaction mode with their target, thus defining their role either as inhibitors of fiber elongation or as fiber-binding mols. Indanone 13a was identified as a promising inhibitor: its activity was confirmed by CD and at. force microscopy studies. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8

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Jana, Akash; Kumar, Amol; Maji, Biplab published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Manganese catalyzed C-alkylation of methyl N-heteroarenes with primary alcohols》.Reference of 3-Pyridinemethanol The article contains the following contents:

C-Alkylations of nine different classes of methyl-substituted N-heteroarenes including quinolines, quinoxalines, benzimidazoles, benzoxazoles, pyrazines, pyrimidines, pyridazines, pyridines, and triazines were disclosed. A bench stable earth-abundant Mn(I)-complex catalyzed the chemoselective hydrogen-transfer reaction utilizing a diverse range of primary alcs. as the non-fossil fuel-derived carbon source. The diversified N-heteroarenes were isolated in high yields and selectivities. Water was produced as the sole byproduct, making the protocol environmentally benign. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Reference of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 3-Pyridinemethanol

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