Tag: 100-200

Product Details of 89466-08-0In 2019 ,《Palladium-Catalyzed Directed meta-Selective C-H Allylation of Arenes: Unactivated Internal Olefins as Allyl Surrogates》 appeared in Angewandte Chemie, International Edition. The author of the article were Achar, Tapas Kumar; Zhang, Xinglong; Mondal, Rahul; Shanavas, M. S.; Maiti, Siddhartha; Maity, Sabyasachi; Pal, Nityananda; Paton, Robert S.; Maiti, Debabrata. The article conveys some information:

Palladium(II)-catalyzed meta-selective C-H allylation of arenes RC6H4(CH2)nXR1 [R = H, 3-Me, 3-Br, 4-F, etc.; R1 = 2-(pyrimidin-5-yl)phenoxy, 2-(pyridin-3-yl)phenoxy, 2-(8-nitroquinolin-3-yl)phenoxy, etc.; X = SO2, C(O), Si(i-Pr)2, CH2; n = 1-4] including 2-(pyrimidin-5-yl)phenyl (2S)-2-(6-methoxynaphthalen-2-yl)propanoate has been developed utilizing synthetically inert unactivated acyclic internal olefins R2CH2CH=CHCH2R3 [R2 = Me, Et, n-Pr, pentyl, etc.; R3 = Me, COOMe, [[(1S,2R,5S)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy]carbonyl, etc.] as allylic surrogates. The strong σ-donating and π-accepting ability of pyrimidine-based directing group facilitates the olefin insertion by overcoming inertness of the typical unactivated internal olefins. Exclusive allyl over styrenyl products, e.g., (E)-I selectivity as well as E stereoselectivity were achieved with broad substrate scope, wide functional-group tolerance, and good to excellent yields. Late-stage functionalizations of pharmaceuticals were demonstrated. Exptl. and computational studies shed light on the mechanism and point to key steric control in the palladacycle, thus determining product selectivities. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Product Details of 89466-08-0

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Alcohol – Wikipedia,
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In 2022,Kwon, Na Yeon; Kim, Youngseo; Kataria, Meenal; Park, Su Hong; Cho, Seunguk; Harit, Amit Kumar; Woo, Han Young; Cho, Min Ju; Park, Sungnam; Choi, Dong Hoon published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Donor-σ-Acceptor Dyad-Based Polymers for Portable Sensors: Controlling Photoinduced Electron Transfer via Tuning the Frontier Molecular Orbital Energies of Acceptors》.Product Details of 4048-33-3 The author mentioned the following in the article:

In this study, we synthesized three novel aromatic imide-based conjugated donor(D)-σ-acceptor (A) dyad-based polymers showing different photophys. properties. These D-σ-A dyad-based polymers (e.g., BDTBT-NI, BDTBT-NDI, and BDTBT-PDI) consist of the same conjugated donor main chains (benzodithiophene-bithiophene (BDTBT)) and side chains bearing different imide acceptors (naphthalimide (NI), naphthalene diimide (NDI), or perylenediimide (PDI)). The photophys. and electrochem. characteristics of the three polymers were studied using various methods, including UV-visible absorption, steady-state fluorescence, and time-resolved fluorescence experiments as well as cyclic voltammetry. As the acceptor strength of the side chain was increased, photoinduced electron transfer from the donor backbone to the acceptor side-chain moiety was found to occur more effectively. Among the three polymers, BDTBT-PDI was found to be used as an efficient extractor and portable naked-eye sensing probe for Fe2+ ions; notably, it exhibited a “”turn-on”” fluorescence response with a detection limit at a picomolar concentration The BDTBT-PDI:Fe2+ complex was also used for ultrasensitive detection of spermine (with a Stern-Volmer constant of 6.7 × 106 M-1) in urine samples and was established as an efficient portable test kit for the real-time detection of spermine in the vapor released from fermented food samples. Finally, the “”on-off”” fluorescence behavior of BDTBT-PDI in the presence of Fe2+ and spermine enabled us to develop mol. logic gates using this polymer. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Product Details of 4048-33-3

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Application of 627-18-9In 2020 ,《Controlled synthesis of sugar-containing poly(ionic liquid)s》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Chen, Jing; Li, Die; Bao, Chunyang; Zhang, Qiang. The article contains the following contents:

A facile synthetic route is reported toward sugar-containing pyridinium-based poly(ionic liquid)s (PILs). Reversible deactivation radical polymerization of 4-vinyl pyridine could generate a well-defined poly(4-vinyl pyridine) in a self-generating biphasic system. Subsequent quaternization and anion exchange reaction could yield a library of functional PILs with pendent sugar units and varied anions. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Application of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application of 627-18-9

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Safety of 3-Bromopropan-1-olIn 2020 ,《Self-Assembly of Poly(3-hexylthiophene) Bottlebrush Polymers into End-On-End Linear Fiber Morphologies》 was published in Macromolecules (Washington, DC, United States). The article was written by Obhi, Nimrat K.; Jarrett-Wilkins, Charles N.; Hicks, Garion E. J.; Seferos, Dwight S.. The article contains the following contents:

Bottlebrush polymers are a special class of nonlinear polymers with a high d. of polymeric side chains. Bottlebrush homopolymers typically do not interact and instead self-segregate as single macromols., where low chain entanglement results from the high steric repulsion between side chains. We report here the synthesis of poly(3-hexylthiophene) (P3HT) bottlebrush polymers and the unusual observation that these interesting mols. self-assemble by end-on-end linear assembly into long fibers. As-cast bottlebrush polymers are disordered and disperse freely as expected; however, thermal annealing promotes the evolution of long fibers. The use of P3HT allows for noncovalent interactions that are absent in other bottlebrush polymers, including π-π interaction and n-hexyl interdigitation. Optical spectroscopy provides evidence of these interactions that appear to drive end-on-end linear assembly. Interestingly, only end-on-end linear assembly is observed by TEM width anal., since it is more favorable than side-to-side assembly due to steric constraints. This is further confirmed in solution when using a poor solvent to self-assemble bottlebrush polymers. To the best of our knowledge, this end-on-end linearly assembled morphol. has not been previously observed for bottlebrush polymers and is a direct result of incorporating π-conjugated materials.3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Safety of 3-Bromopropan-1-ol

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Application In Synthesis of trans-4-AminocyclohexanolIn 2021 ,《New quinolinone O-GlcNAc transferase inhibitors based on fragment growth》 appeared in Frontiers in Chemistry (Lausanne, Switzerland). The author of the article were Weiss, Matjaz; Loi, Elena M.; Sterle, Masa; Balsollier, Cyril; Tomasic, Tihomir; Pieters, Roland J.; Gobec, Martina; Anderluh, Marko. The article conveys some information:

Herein, the extension of 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives with several new fragments was reported. Compound I [R = CO2Et; n = 0] was identified as the most potent fragment with an IC50 value of 116.0μM. If compared with the most potent inhibitor of the first series, compound I [R = CO2H; n = 1] (IC50 = 117.6μM), it was concluded that the new fragments did not improve OGT inhibition remarkably. Therefore, compound I [R = CO2H; n = 1] was used as the basis for the design of a series of compounds with the elongation toward the O-GlcNAc binding pocket as the free carboxylate allowed easy conjugation. 2-Oxo-N-(4-(pyridin-4-ylcarbamoyl)benzyl)-1,2-dihydroquinoline-4-carboxamide with an IC50 value of 144.5μM showed the most potent OGT inhibition among the elongated compounds, but it lost inhibition potency when compared to the UDP mimetic compound I [R = CO2H; n = 1]. Therefore it was assumed that the binding of the compounds in the O-GlcNAc binding pocket was likely not crucial for OGT inhibition. Furthermore, evaluation of the compounds with two different assays revealed that some inhibitors most likely interfere with the com. available UDP-Glo glycosyltransferase assay, leading to false pos. results. This observation called for caution, when evaluating UDP mimetic as OGT inhibitors with the UDP-Glo glycosyltransferase assay, as misinterpretations can occur. The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Application In Synthesis of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application In Synthesis of trans-4-Aminocyclohexanol

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Alcohol – Wikipedia,
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HPLC of Formula: 4048-33-3In 2020 ,《Crucial Role of the Spacer in Tuning the Length of Self-Assembled Nanorods》 appeared in Macromolecules (Washington, DC, United States). The author of the article were Han, Shuaiyuan; Mellot, Gaelle; Pensec, Sandrine; Rieger, Jutta; Stoffelbach, Francois; Nicol, Erwan; Colombani, Olivier; Jestin, Jacques; Bouteiller, Laurent. The article conveys some information:

Polymeric supramol. nanorods were prepared in toluene by self-assembly of tris(urea) stickers connected on both sides through alkyl spacers of different lengths to short polystyrene (PS) arms. Several tris(urea) initiators or chain transfer agents were synthesized straightforwardly and used to grow well-defined PS arms via atom transfer radical polymerization (ATRP) or reversible addition fragmentation chain transfer (RAFT) polymerization Self-assembly was investigated by means of Fourier-transform IR (FTIR) spectroscopy and light/neutron scattering. A dramatic impact of the spacer separating the tris(urea) sticker from the PS arms on the extent of self-assembly was observed in toluene as long as the d.p. of the PS arms (x) was kept short (x ~10). Indeed, supramol. nanorods several hundreds of nanometers in length for a few nanometers in radius were obtained with a spacer consisting of nine atoms, whereas five times shorter nanorods were obtained for a spacer of only five atoms, and spherical particles were found in the absence of any spacer, all other parameters remaining unchanged. These results reveal the possibility to tune the length of polymer-decorated supramol. nanorods with minimal modification of the assembling sticker and without affecting the functionality of the rods. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3HPLC of Formula: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.HPLC of Formula: 4048-33-3

Referemce:
Alcohol – Wikipedia,
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Amouzadeh Tabrizi, Mahmoud; Nazari, Leila; Acedo, Pablo published their research in Sensors and Actuators, B: Chemical in 2021. The article was titled 《A photo-electrochemical aptasensor for the determination of severe acute respiratory syndrome coronavirus 2 receptor-binding domain by using graphitic carbon nitride-cadmium sulfide quantum dots nanocomposite》.Application In Synthesis of 6-Aminohexan-1-ol The article contains the following contents:

Herein, a photoelectrochem. aptasensor for the quant. measurement of the severe acute respiratory syndrome coronavirus-2 receptor-binding domain (Sars-Cov-2 RBD) has been reported for the first time. For this purpose, first, graphitic carbon nitride and (gC3N4) and cadmium sulfide (CdS) quantum dots were fabricated and characterized. After that, gC3N4 and CdS were mixed well. The fabricated nanomaterials were characterized by scanning transmission electron microscopy. Then, the CdS QDs-gC3N4 nanocomposite was added to the solution containing chitosan as an amine-rich polymer to generate a Chitosan/CdS-gC3N4 nanocomposite. Subsequently, the surface of the ITO electrode was modified with Chitosan/CdS-gC3N4. After that, the amine-terminal aptamer probes were immobilized on the surface of the Chitosan/CdS QDs-gC3N4/ITO electrode by using glutaraldehyde as an amine-amine crosslinker. The electrochem. performances of the electrodes were studied using cyclic voltammetry (CV), electrochem. Impedance Spectroscopy (EIS), and photo-electrochem. (PEC). The surface coverage of the immobilized aptamer probe was founded to be 26.2 pmol.cm-2. The obtained results demonstrated that the proposed photo-electrochem. aptasensor can be used for the measurement of Sars-Cov-2 RBD within 0.5-32.0 nM. The limit of detection (LOD) was obtained to be 0.12 nM (at 3σ/slope). The affinity of the Aptamer/Chitosan/CdS QDs-gC3N4/ITO was also founded to be 3.4 nM by using Langmuir-typical adsorption systems. The proposed photo-electrochem. aptasensor was applied for the measurement of the spiked Sars-Cov-2 RBD in human saliva samples at two concentrations The effect of the interfering biomaterials such as human IgG human IgA, human IgM, and human serum albumin was also studied. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Application In Synthesis of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application In Synthesis of 6-Aminohexan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Efficient production of red Monascus pigments with single non-natural amine residue by in situ chemical modification》 were Huang, Yaolin; Liu, Lujie; Zheng, Gaowei; Zhang, Xuehong; Wang, Zhilong. And the article was published in World Journal of Microbiology & Biotechnology in 2019. Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Filamentous fungi Monascus sp. has been utilized for fermentative production of food colorant (Red Yeast Rice) for more than 1000 years in China. The main colorant components of Red Yeast Rice are mixture of red Monascus pigments (RMPs) with various primary amine residues. In the present work, the non-natural primary amine p-aminobenzamide, exhibiting as non-involved in nitrogen microbial metabolism, nontoxicity to microbial cells, and chem. reactivity with orange Monascus pigments (OMPs), was screened. Based on the screened result, RMPs with the single p-aminobenzamide residue were produced by cell suspension culture in a nonionic surfactant micelle aqueous solution via in situ chem. modification of OMPs. Furthermore, in situ chem. modification of OMPs also provided a strategy for maintaining a relatively low OMP concentration and then efficient accumulation of high concentration of RMPs (3.3 g/l). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Alcohol – Wikipedia,
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The author of 《Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance》 were Li, Wei; Wang, Guotong; Lai, Jixing; Li, Shengkun. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application of 126456-43-7 The author mentioned the following in the article:

Multifunctional isoquinoline-oxazolines (MIQOXs) were conceived and synthesized from com. available chiral amino acids. The multifunctional role of MIQOXs was demonstrated by Pd-catalyzed highly enantioselective addition of arylboronic acids to nitrostyrenes, and by the discovery of novel antifungal candidates. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 126456-43-7

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Alcohol – Wikipedia,
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The author of 《Facile and efficient protocols for C-C and C-N bond formation reactions using a superparamagnetic palladium complex as reusable catalyst》 were Karimi Zarchi, Mohammad Ali; Darbandizadeh Mohammad Abadi, Seyed Shahab Addin. And the article was published in Research on Chemical Intermediates in 2019. Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Facile and efficient protocols for some multicomponent coupling reactions such as the Suzuki reaction and synthesis of polyhydroquinoline and 2,3-dihydroquinazoline-4-(1H)-one derivatives using a superparamagnetic palladium complex as catalyst was developed. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
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