Tag: 100-200

The author of 《Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity》 were Zhang, Zheng; Banerjee, Monimoy; Davis, Rachel E.; Blagg, Brian S. J.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Application In Synthesis of 3-Bromopropan-1-ol The author mentioned the following in the article:

The development of C-terminal heat shock protein 90 kDa (Hsp90) inhibitors has emerged as a potential treatment for cancer. Similarly, small mols. that target the mitochondria have proven to be efficacious towards cancer, as the reprogramming of mitochondrial function is often associated with oncogenic transformation. Herein, we report the development of triphenylphosphonium (TPP)-conjugated Hsp90 C-terminal inhibitors, their anti-proliferative activity, and accumulation in the mitochondria. In general, TPP-conjugated Hsp90 C-terminal inhibitors were found to manifest increased activity against various cancer cell lines when compared to the parent compounds In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Application In Synthesis of 3-Bromopropan-1-ol

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The author of 《New polymeric adsorbent materials used for removal of phenolic derivatives from wastewaters》 were Davidescu, Corneliu-Mircea; Ardelean, Radu; Popa, Adriana. And the article was published in Pure and Applied Chemistry in 2019. Name: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

For the treatment of waste waters containing phenols or phenolic compounds several unconventional methods are applied, such as: inverse osmosis, coagulation, solvent extraction, flotation-coagulation combined processes, adsorption, and anaerobic processes. From all used remediation processes adsorption has a higher applicability degree due to its main advantages: simplicity, ease of use and operation and high efficiency. It is important to develop and use new adsorbents with higher regeneration degree and longer life time. Chem. modification of polymeric matrixes with pendant functional groups is a valuable method used to improve the surface and interface chem. of polymeric adsorbents, to achieve better adsorption performance and to design tailor-made adsorbents with respect to specific pollutants. In present study new adsorbent materials were obtained starting from chloromethylated styrene-divinylbenzene copolymers with different degrees of crosslinking (6.7%, 12% and resp. 15% DVB), functionalized by reaction with 3-hydroxibenzaldehyde. The polymeric intermediates were further modified by polymer-analogous reaction with iso-propylamine and diethylphosphite with the aim to improve their adsorptive properties. The obtained polymeric adsorbents were tested for remediation of waters containing phenol (P), 2,3-dimethylphenol (2,3-DMP) and 2,4,6-trimethyl-phenol (2,4,6-TMP). Based on obtained exptl. data the adsorption mechanism, process kinetics and thermodn. were studied.3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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The author of 《Molecular capture using the precipitate of creaming-down by (-)-epigallocatechin-3-O-gallate》 were Tsutsumi, Hiroyuki; Sato, Ayano; Fujino, Satoru; Fujioka, Yusuke; Ishizu, Takashi. And the article was published in Chemical & Pharmaceutical Bulletin in 2019. Recommanded Product: 3-Pyridinemethanol The author mentioned the following in the article:

An aqueous solution of equimol. amounts of 2-chloropyrimidine and (-)-epigallocatechin 3-O-gallate (EGCg) afforded a colorless block crystal, which was determined to be a 2 : 2 complex of 2-chloropyrimidine and EGCg by X-ray crystallog. anal. The 2 : 2 complex was formed by the cooperative effect of three intermol. interactions, π-π and CH-π interactions, and intermol. hydrogen bonds. Upon formation of the 2 : 2 complex, a 2-chloropyrimidine mol. was captured by a hydrophobic space formed by the three aromatic rings of A, B, and B’ rings of two EGCg mols. The mol. capture abilities of various heterocyclic compounds using EGCg were evaluated by ratio of the heterocyclic compounds included in the precipitates of complex of EGCg to the heterocyclic compounds used. The amount of the heterocyclic compounds was measured by an integrated value of corresponding proton signals in the quant. 1H-NMR spectrum. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3-Pyridinemethanol

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Quality Control of (4-Bromophenyl)methanolIn 2020 ,《Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity》 was published in Angewandte Chemie, International Edition. The article was written by Ng, Teng Wei; Liao, Gang; Lau, Kai Kiat; Pan, Hui-Jie; Zhao, Yu. The article contains the following contents:

The authors report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary Me carbinols with primary alcs. has significant advantage of delivering higher-order secondary alcs. in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction also was achieved using a com. available chiral ruthenium complex to deliver secondary alcs. with moderate yield and up to 92% ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Quality Control of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Quality Control of (4-Bromophenyl)methanol It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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Category: alcohols-buliding-blocksIn 2020 ,《Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420》 appeared in Journal of Organic Chemistry. The author of the article were Patel, Nitinchandra D.; Wei, Xudong; Byrne, Denis; Narayanan, Bikshandarkoil A.; Pennino, Scott; Sarvestani, Max; Saha, Anjan; Haddad, Nizar; Kapadia, Suresh; Lorenz, Jon C.; DeCroos, Philomen; Ye, Andrew; Lee, Heewon; Grinberg, Nelu; Hossain, Azad; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H.. The article conveys some information:

4-Sulfonylquinolines and a 4-sulfonylpyridine underwent chemoselective nucleophilic aromatic substitution reactions with alcs. using either potassium tert-butoxide or potassium hexamethyldisilazide (when tertiary alcs. were used) in DMF to yield quinolinyl or pyridinyl ethers. Using this method, quinolinyl ether-containing HCV NS3/4a protease inhibitors BI 201420MU, BILN2061, and a related macrocyclic HCV protease inhibitor were prepared convergently. After reading the article, we found that the author used trans-4-Aminocyclohexanol(cas: 27489-62-9Category: alcohols-buliding-blocks)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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COA of Formula: C6H7NOIn 2020 ,《Quantitative perspective on online flow reaction profiling using a miniature mass spectrometer》 appeared in Organic Process Research & Development. The author of the article were Sheng, Huaming; Corcoran, Emily B.; Dance, Zachary E. X.; Smith, Joseph P.; Lin, Zhihao; Ordsmith, Victoria; Hamilton, Simon; Zhuang, Ping. The article conveys some information:

Online mass spectrometry has proven to be a useful tool for characterizing many aspects of chem. reactions. However, to the best of the authors’ knowledge, no reference standard (RS) quantitation approach has been applied in online MS profiling work to date. In this study, we present a RS approach for online quantitation of an aerobic oxidation reaction in flow using a miniature mass spectrometer, with both internal RS and external RS quantitation approaches being evaluated. Quinoline, a structurally similar and chem. inert compound under these reaction conditions, was chosen as the RS to quantify the pyridine aldehyde product. To investigate the optimal RS concentration and instrument attenuation, calibration curves were established by plotting the product/RS peak intensity ratio against the theor. product yield at different attenuation (dilution factor) values. The MS quantitation results for the actual flow reactions were validated with conventional offline 1H NMR anal. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C6H7NO

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Alcohol – Wikipedia,
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Safety of 3-PyridinemethanolIn 2020 ,《Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols》 appeared in Asian Journal of Organic Chemistry. The author of the article were Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D.. The article conveys some information:

Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
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Safety of 6-Aminohexan-1-olIn 2022 ,《Study of [2]- and [3]Rotaxanes Obtained by Post-Synthetic Aminolysis of a Kinetically Stable Carbonate-Containing Pseudorotaxane》 appeared in European Journal of Organic Chemistry. The author of the article were Waeles, Philip; Gauthier, Maxime; Coutrot, Frederic. The article conveys some information:

Here the synthesis and study of dibenzo-24-crown-8 (DB24C8)-based [2]- and [3]rotaxanes that contain an ammonium as the best mol. station and carbamate moieties as secondary mol. stations was reported. The common post-interlocking synthesis relies on the aminolysis of the N-succinimidyl carbonate extremity of an activated though insulated pseudorotaxane. The N-succinimidyl carbonate-based thread’s extremity proved to be small enough to allow the slow slippage of the DB24C8 around the thread and large enough to allow insulation of the kinetically stable pseudorotaxane. Due to its sensitivity towards amine compounds, the activated carbonate end of the encircled thread allowed post-interlocking aminolysis-based conversion into mech. interlocked rotaxanes by providing the same way the carbamate secondary station for the DB24C8 in the thread backbone. Translation of the DB24C8 along the threaded axle between the two mol. stations was investigated. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Safety of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Safety of 6-Aminohexan-1-ol

Referemce:
Alcohol – Wikipedia,
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COA of Formula: C6H7BO3In 2022 ,《GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1》 appeared in Journal of Medicinal Chemistry. The author of the article were Taylor, Alexander M.; Bailey, Chris; Belmont, Lisa D.; Campbell, Robert; Cantone, Nico; Cote, Alexandre; Crawford, Terry D.; Cummings, Richard; DeMent, Kevin; Duplessis, Martin; Flynn, Megan; Good, Andrew C.; Huang, Hon-Ren; Joshi, Shivangi; Leblanc, Yves; Murray, Jeremy; Nasveschuk, Christopher G.; Neiss, Adrianne; Poy, Florence; Romero, F. Anthony; Sandy, Peter; Tang, Yong; Tsui, Vickie; Zawadzke, Laura; Sims, Robert J. III; Audia, James E.; Bellon, Steven F.; Magnuson, Steven R.; Albrecht, Brian K.; Cochran, Andrea G.. The article conveys some information:

Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small mols. that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery efforts. Highly potent and selective ligands with good cellular permeability have been proposed as chem. probes for use in exploring the functions of many of the bromodomain proteins. We report here the discovery of a class of such inhibitors targeting the family VIII bromodomains of SMARCA2 (BRM) and SMARCA4 (BRG1), and PBRM1 (polybromo-1) bromodomain 5. We propose one example from this series, GNE-064, as a chem. probe for the bromodomains SMARCA2, SMARCA4, and PBRM1(5) with the potential for in vivo use. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
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Badhani, Gaurav; Joshi, Abhisek; Adimurthy, Subbarayappa published an article in 2021. The article was titled 《Ionic-Liquid-Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C-N, C-S, and C-C Bond Formation》, and you may find the article in European Journal of Organic Chemistry.Name: 3-Pyridinemethanol The information in the text is summarized as follows:

The tetra-Me ammonium hydroxide catalyzed oxidative coupling of amines RNH2 (R = Ph, cyclohexyl, pentyl, etc.) and alcs. R1CH2OH (R1 = Ph, 4-pyridyl, 2-naphthyl, etc.) for the synthesis of imines RN=CHR1 under metal-free conditions by utilizing oxygen from air as the terminal oxidant has been described. Under the same conditions, with ortho-phenylene diamines 1,2-(NH2)2C6H3R2 (R2 = 3-Me, 4,5-(Me)2, 4-F, etc.) and 2-aminobenzenethiols like 2-aminobenzenethiol and 2-amino-4-chlorobenzenethiol the corresponding benzimidazoles I (R3 = 6-Me, 5,6-Me2, 5-Cl, etc.; X = NH) and benzothiazoles I (R3 = H, 5-Cl; X = S) were obtained. Quinoxalines II (R4 = H, 6-Me, 6,7-Me2, 6-Cl, 6-F; Y = N) were obtained from ortho-phenylene diamines and 1-phenylethane-1,2-diol, and the conditions were then extended to the synthesis of quinoline building blocks II (R4 = 4-ClC6H4, 4-BrC6H4, 4-MeOC6H4, 2-naphthyl; Y = CH) by reaction of 2-amino benzyl alcs. like 2-aminobenzenemethanol either with 1-phenylethan-1-ol or acetophenone derivatives R4COMe. The formation of C-N, C-S and C-C bonds was achieved under metal-free conditions. A broad range of amines (aromatic, aliphatic, cyclic and heteroaromatic) as well as benzylic alcs. including heteroaryl alcs. reacted smoothly and provided the desired products. The mild reaction conditions, com. available catalyst, metal-free, good functional-group tolerance, broad range of products (imines, benzimidazoles, benzothiazoles, quinoxalines and quinolines) and applicability at gram scale reactions are the advantages of the present strategy. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 3-Pyridinemethanol

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