Tag: 100-200

Synthetic Route of C7H6O2In 2020 ,《SBA-15/PrN(CH2PO3H2)2 as a novel and efficient mesoporous solid acid catalyst with phosphorous acid tags and its application on the synthesis of new pyrimido[4,5-b]quinolones and pyrido[2,3-d]pyrimidines via anomeric based oxidation》 appeared in Microporous and Mesoporous Materials. The author of the article were Jalili, Fatemeh; Zarei, Mahmoud; Zolfigol, Mohammad Ali; Rostamnia, Sadegh; Moosavi-Zare, Ahmad Reza. The article conveys some information:

In this work, SBA-15/PrN(CH2PO3H)2 as a novel and heterogeneous catalyst containing of phosphorous acid groups was fully characterized by using various anal. techniques. A good range of novel pyrido[2,3-d]pyrimidines and pyrimido[4,5-b]quinolines were synthesized in the presence of SBA-15/PrN(CH2PO3H)2 under solvent-free condition. The major advantages of the described method are high yields, short reaction times and reusability of the catalyst. The obtained results from this research will be supported by the idea of rational designs, syntheses and applications of task-specific catalysts and mols. for the development of biomimetic anomeric based oxidation and/or aromatization mechanism. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Synthetic Route of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Synthetic Route of C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3-PyridinemethanolIn 2019 ,《Synthesis and antitumor activity of novel pyridinium fullerene derivatives》 appeared in International Journal of Nanomedicine. The author of the article were Yasuno, Takumi; Ohe, Tomoyuki; Ikeda, Hitomi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko. The article conveys some information:

Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in-vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. The derivatives inhibited the proliferation of cancer cell lines, including cisplatin resistant cells and doxorubicin-resistant cells. It was also shown that compounds I (10μM), II (10μM) and III (10μM) induced the intracellular oxidative stress. In addition, compound III (20 mg/kg) and cis-14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. These fullerene derivatives served as the lead compounds for a novel type of antitumor agents . The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2019 ,《Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis》 appeared in Journal of the American Chemical Society. The author of the article were Li, Jiaming; Ahmed, Tonia S.; Xu, Chen; Stoltz, Brian M.; Grubbs, Robert H.. The article conveys some information:

The Δ12-Prostaglandin J family was recently discovered and has potent anticancer activity. Concise syntheses of four Δ12-prostaglandin J natural products (7-8 steps in the longest linear sequences), I, II, III, and IV, are reported, enabled by convergent stereoretentive cross-metathesis. Exceptional control of alkene geometry was achieved through stereoretention. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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Application In Synthesis of 2,6-PyridinedimethanolIn 2020 ,《Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists》 appeared in European Journal of Medicinal Chemistry. The author of the article were Fang, Xiong; Meng, Qian; Zhang, Huijun; Liang, Boqiang; Zhu, Siyu; Wang, Juan; Zhang, Chaozai; Huang, Lina S.; Zhang, Xingquan; Schooley, Robert T.; An, Jing; Xu, Yan; Huang, Ziwei. The article conveys some information:

CXCR4, a well-studied coreceptor of human immunodeficiency virus type 1 (HIV-1) entry, recognizes its cognate ligand SDF-1α (also named CXCL12) which plays many important roles, including regulating immune cells, controlling hematopoietic stem cells, and directing cancer cells migration. These pleiotropic roles make CXCR4 an attractive target to mitigate human disorders. Here a new class of sym. polyamines was designed and synthesized as potential small mol. CXCR4 antagonists. Among them, a representative compound 21 (namely HF50731) showed strong CXCR4 binding affinity (mean IC50 = 19.8 nM) in the CXCR4 competitive binding assay. Furthermore, compound 21 significantly inhibited SDF-1α-induced calcium mobilization and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function. The structure-activity relationship anal., site-directed mutagenesis, and mol. docking were conducted to further elucidate the binding mode of compound 21, suggesting that compound 21 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288. Our studies provide not only new insights for the fragment-based design of small mol. CXCR4 antagonists for clin. applications, but also a new and effective mol. probe for CXCR4-targeting biol. studies. The results came from multiple reactions, including the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Jud, Wolfgang; Salazar, Chase A.; Imbrogno, Joseph; Verghese, Jenson; Guinness, Steven M.; Desrosiers, Jean-Nicolas; Kappe, C. Oliver; Cantillo, David published an article in Organic Process Research & Development. The title of the article was 《Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow》.Recommanded Product: 3-Pyridinemethanol The author mentioned the following in the article:

An electrochem. method was developed for a mediated oxidation of primary alcs. to carboxylic acids. The method is compatible with a variety of alcs. bearing N-containing heterocycles in undivided batch and flow modes. The use of a heterogeneous NiOOH electron-proton transfer mediator avoids the need for homogeneous catalysts that contribute to more unit operations during downstream purging and increased process mass intensity. To demonstrate the applicability of this method for continuous processing, a single-pass flow electrochem. oxidation of nicotinyl alc. to nicotinic acid is demonstrated with a 77% isolated yield. The NiOOH-coated anodes show no reduction in catalysis efficiency over 12 h, and minimal Ni metal leaching (22.3μg per L) is observed The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Keegan, Bradley M.; Catalfano, Kevin C.; Banerjee, Monimoy; Blagg, Brian S. J. published an article in 2022. The article was titled 《Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation》, and you may find the article in ACS Medicinal Chemistry Letters.Reference of 2-Hydroxyphenylboronic acid The information in the text is summarized as follows:

KU-177 was recently shown to disrupt interactions between Hsp90 and Aha1 in vitro. Subsequent studies in recombinant thioflavin T (ThT) assays demonstrated that KU-177 ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation, which was confirmed by TEM. Using KU-177 as a lead compound, derivatives of KU-177 were synthesized and evaluated for their ability to disrupt Aha1/Hsp90 interactions and inhibit P301L tau aggregation. Preliminary structure-activity relationships were revealed, which led to the identification of a new lead compound that contains a cis-like amide bond. The new lead compounds retain the ability to disrupt Aha1/Hsp90 interactions in SH-SY5Y and SK-BR-3 cells without direct inhibition of Hsp90, providing a new scaffold for subsequent drug discovery efforts. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

El-Massaoudi, Mohamed; Radi, Smaail; Lamsayah, Morad; Tighadouini, Said; Seraphin, Konan Kouakou; Kouassi, Lazare Kouakou; Garcia, Yann published an article in 2021. The article was titled 《Ultra-fast and highly efficient hybrid material removes Cu(II) from wastewater: Kinetic study and mechanism》, and you may find the article in Journal of Cleaner Production.Computed Properties of C7H9NO2 The information in the text is summarized as follows:

Water pollution by toxic elements represents a significant risk to the environment and human ecosystem, and a number of efforts are developed to find a suitable solution In this work, a new adsorbent based on silica gel as an inert material modified on surface by a pincer ligand was prepared The hybrid material has been synthesized via a simple Schiff base reaction and characterized by several relevant phys. methods. The adsorbent shows an extremely rapid efficiency in removal of copper (less than 8 min) with maximum sorption capacity of 1.90 mmol g-1 and a rapid efficiency for zinc, cadmium and lead (less than 20 min) with adsorption capacities 0.52, 0.49 and 0.43 mmol g-1, resp. A kinetic study shows that the sorption can be described by a pseudo second-order model, and that the process is thermodynamically spontaneous and endothermic. The adsorbent shows a high selectivity to Cu(II) and a great reusability after five adsorption-desorption cycles. Theor., energy dispersive X-ray fluorescence (EDX) and Fourier transform-IR spectroscopy studies demonstrate that the uptake occurs by a coordination reaction between metal ions and the pincer ligand on the surface of the adsorbent. The efficiency of this new hybrid material was confirmed in removal of Cu(II) from real water samples originating from Abidjan Atlantic sea bay, one of the most polluted region in West Africa, as well as from rivers located near Oujda, Morocco. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Computed Properties of C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gautam, Rajendra P.; Barile, Christopher J. published their research in Journal of Physical Chemistry C in 2021. The article was titled 《Preparation and Electron-Transfer Properties of Self-Assembled Monolayers of Ferrocene on Carbon Electrodes》.Formula: C6H15NO The article contains the following contents:

In this article, ferrocene is used as a redox-active species to study the electron-transfer properties of self-assembled monolayers (SAMs) on carbon. Glassy carbon electrodes were modified using different compositions of alkyl amine SAMs having various chain lengths and diluent chemistries. An amide coupling reaction was carried out to attach ferrocenecarboxylic acid to the amine-terminated SAMs. We investigated the role defect sites in the SAMs play in effecting electron transfer to the appended ferrocene mols. by modifying the SAMs with ZnO electrodeposits. There is a significant change in the electron-transfer rates as a function of SAM linker length only when the SAM defect sites are blocked with ZnO electrodeposits. These findings imply that defect-driven direct electron transfer occurs on ferrocene-modified SAMs on heterogeneous carbon electrodes in contrast to the alkyl linker tunneling mechanism that is known for well-ordered SAMs on Au electrodes. Finally, we demonstrate that the surface modification protocols used here are amenable to a wide range of carbon electrodes. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – An Asian Journal included an article by Chulakova, Dilyara R.; Pradipta, Ambara R.; Lodochnikova, Olga A.; Kuznetsov, Danil R.; Bulygina, Kseniya S.; Smirnov, Ivan S.; Usachev, Konstantin S.; Latypova, Liliya Z.; Kurbangalieva, Almira R.; Tanaka, Katsunori. Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《Facile Access to Optically Active 2,6-Dialkyl-1,5-Diazacyclooctanes》. The information in the text is summarized as follows:

Herein, the 1,5-diazacyclooctane (1,5-DACO) bearing a chiral auxiliary obtained from the formal [4+4] cycloaddition of N-alkyl-α,β-unsaturated imines was reported. 1,5-DACO could be further derivatized by nucleophilic alkylation to give various chiral substituted 1,5-DACO derivatives I [R = Me, vinyl, Ph, etc.]. The removal of the chiral auxiliary was effectively carried out using hydrogenation over Pearlman’s catalyst. This methodol. allows the production of a broad range of unprecedented optically active 2,6-dialkyl-1,5-DACO II, which could not be accessed by other methods. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of the Indian Chemical Society included an article by Ahmed, Atiur. Related Products of 89466-08-0. The article was titled 《One-pot synthesis of chromenes by Suzuki-Miyaura cross-coupling reactions with benzyl bromides》. The information in the text is summarized as follows:

An efficient one-pot synthesis of chromenes e.g., 6H-benzo[c]chromene has been developed from 2-bromocarbaldehydes RCHO (R = 2-bromophenyl, 2-bromo-4-methylphenyl, 2-bromonaphthalen-1-yl, etc.) through tandem benzyl bromide formation followed by Pd(O)-catalyzed Suzuki-Miyaura cross-coupling and substitution reaction. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Related Products of 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Related Products of 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts