Tag: 100-200

《A Novel Bisoxazoline-Imidazolium Salt in Ytterbium-Catalyzed Asymmetric Reduction of Ketone》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Zhai, Yujie; Xu, Wenhao; Wang, Dong; Zheng, Purui; Zhao, Xiaoming; Xu, Tao. Product Details of 126456-43-7 The article mentions the following:

Chiral N-heterocyclic carbene (NHC), a privileged ligand for transition metals, has had a profound impact on organometallic chem. The monodentate and bidentate chiral carbenes have been developed significantly, while the tridentate ones have been less exploited. Herein, we designed and synthesized a new bisoxazoline-imidazolium salt as a carbene precursor, which owns three chelating sites and two kinds of chiral information centers. A preliminary investigation on the asym. ketone reduction was also studied. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 126456-43-7

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《Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions》 was published in Research on Chemical Intermediates in 2020. These research results belong to Ghorbani, Fatemeh; Kiyani, Hamzeh; Pourmousavi, Seied Ali. Related Products of 100-83-4 The article mentions the following:

It was found that nano-SiO2-H2SO4 was catalyzed the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride and β-ketoesters toward the synthesis of α,β-unsaturated isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allowed the synthesis of several α,β-unsaturated isoxazol-5(4H)-ones using this method. Some new derivatives of isoxazolones were also synthesized and characterized. It was efficient, clean, simple, safe and ecol. friendly. This straightforward method was cost-effective and required no preparation of reactants. The three-component annulation was performed without using energy sources, for example heat, ultrasound wave, and microwave irradiation The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4

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《An Artemisinin-Derivative-(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zhang, Chen; Fortin, Pierre-Yves; Barnoin, Guillaume; Qin, Xue; Wang, Xing; Fernandez Alvarez, Alvaro; Bijani, Christian; Maddelein, Marie-Lise; Hemmert, Catherine; Cuvillier, Olivier; Gornitzka, Heinz. Reference of 3-Bromopropan-1-ol The article mentions the following:

A family of hybrid complexes combining two biol. active motifs, an artemisinin derivative and a cationic bis(NHC)-gold(I) unit, has been synthesized. One of these complexes, 2 a, has been analyzed by single-crystal X-ray diffraction. 2 a shows strong anticancer activities on a large panel of human cancer cell models (prostate, breast, lung, liver, bladder, bone, acute and chronic myeloid leukemias) with GI50 values in the nm range, together with a high selectivity. An original and distinctive mechanism of action, i.e., through inhibition of the redox antioxidant NRF2 transcription factor (strongly associated with aggressiveness and resistance to cancer therapies) has been evidenced. 2 a could remarkably sensitize to sorafenib in HepG2 liver cells, in which dysregulated NRF2 signaling is linked to primary and acquired drug resistance. 2 a also inhibited NF-κB and HIF transcriptional activities, which are also associated with progression and resistance in cancer. Our findings provide evidence that hybrid (NHC)gold(I) compounds represent a new class of organometallic hybrid mols. that may yield new therapeutic agents. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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In 2018,Gardelli, Cristina; Wada, Hiroki; Ray, Asim; Caffrey, Moya; Llinas, Antonio; Shamovsky, Igor; Tholander, Joakim; Larsson, Joakim; Sivars, Ulf; Hultin, Leif; Andersson, Ulf; Sanganee, Hitesh J.; Stenvall, Kristina; Leidvik, Brith; Gedda, Karin; Jinton, Lisa; Ryden Landergren, Marie; Karabelas, Kostas published 《Identification and pharmacological profile of an indane-based series of Ghrelin receptor full agonists》.Journal of Medicinal Chemistry published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease, and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to increase of IGF-1 plasma levels. The activation of the GH/IGF-1 axis leads to an increase of muscle mass and functional capacity. Ghrelin further acts on inflammation, appetite, and adipogenesis and for this reason was considered an important target to address catabolic conditions. We report the synthesis and properties of an indane based series of ghrelin receptor full agonists; they have been shown to generate a sustained increase of IGF-1 levels in dog and have been thoroughly investigated with respect to their functional activity. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Highly selective anti-Prelog synthesis of optically active aryl alcohols by recombinant Escherichia coli expressing stereospecific alcohol dehydrogenase》 was published in Preparative Biochemistry & Biotechnology in 2016. These research results belong to Li, Ming; Nie, Yao; Mu, Xiao Qing; Zhang, Rongzhen; Xu, Yan. Product Details of 133082-13-0 The article mentions the following:

A recombinant Escherichia coli system expressing anti-Prelog stereospecific alc. dehydrogenase from Candida parapsilosis was established as a whole-cell system for catalyzing asym. reduction of aryl ketones to anti-Prelog configured alcs. Using 2-hydroxyacetophenone as the substrate, reaction factors including pH, cell status, and substrate concentration had obvious impacts on the outcome of whole-cell biocatalysis, and xylose was found to be an available auxiliary substrate for intracellular cofactor regeneration, by which (S)-1-phenyl-1,2-ethanediol was achieved with an optical purity of 97%e.e. and yield of 89% under the substrate concentration of 5 g/L. Addnl., the feasibility of the recombinant cells toward different aryl ketones was investigated, and most of the corresponding chiral alc. products were obtained with an optical purity over 95%e.e. Therefore, the whole-cell system involving recombinant stereospecific alc. dehydrogenase was constructed as an efficient biocatalyst for highly enantioselective anti-Prelog synthesis of optically active aryl alcs. and would be promising in the pharmaceutical industry. In the experiment, the researchers used (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Product Details of 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Product Details of 133082-13-0 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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《Highly enantioselective oxidation of racemic phenyl-1,2-ethanediol to optically pure (R)-(-)-mandelic acid by a newly isolated Brevibacterium lutescens CCZU12-1》 was written by He, Yu-Cai; Ma, Cui-Luan; Zhang, Xian; Li, Liang; Xu, Jian-He; Wu, Miao-Xin. HPLC of Formula: 133082-13-0 And the article was included in Applied Microbiology and Biotechnology on August 31 ,2013. The article conveys some information:

Enantioselective oxidation of racemic phenyl-1,2-ethanediol into (R)-(-)-mandelic acid by a newly isolated Brevibacterium lutescens CCZU12-1 was demonstrated. It was found that optically active (R)-(-)-mandelic acid (e.e.p > 99.9 %) is produced leaving the other enantiomer (S)-(+)-phenyl-1,2-ethanediol intact. Using fed-batch method, a total of 172.9 mM (R)-(-)-mandelic acid accumulated in the reaction mixture after the seventh feed. Moreover, oxidation of phenyl-1,2-ethanediol using calcium alginate-entrapped resting cells was carried out in the aqueous system, and efficient biocatalyst recycling was achieved as a result of cell immobilization in calcium alginate, with a product-to-biocatalyst ratio of 27.94 g (R)-(-)-mandelic acid g-1 dry cell weight cell after 16 cycles of repeated use. The experimental process involved the reaction of (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0HPLC of Formula: 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.HPLC of Formula: 133082-13-0

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《Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides》 was written by Rueeger, Heinrich; Lueoend, Rainer; Rogel, Olivier; Rondeau, Jean-Michel; Mobitz, Henrik; Machauer, Rainer; Jacobson, Laura; Staufenbiel, Matthias; Desrayaud, Sandrine; Neumann, Ulf. Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol And the article was included in Journal of Medicinal Chemistry on April 12 ,2012. The article conveys some information:

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC50 values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels. In addition to this study using (3,5-Difluoro-4-nitrophenyl)methanol, there are many other studies that have used (3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol) was used in this study.

(3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3) belongs to nitro compounds.Application In Synthesis of (3,5-Difluoro-4-nitrophenyl)methanol Nitro compounds have very different half-wave potentials. They depend on the type, number and position of the substituents and rise.

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Name: 3-Bromopropan-1-olIn 2019 ,《Surface Modification Based on Diselenide Dynamic Chemistry: Towards Liquid Motion and Surface Bioconjugation》 was published in Angewandte Chemie, International Edition. The article was written by Xia, Jiahao; Zhao, Peng; Zheng, Ke; Lu, Chenjie; Yin, Shouchun; Xu, Huaping. The article contains the following contents:

Surface modification is an important technique in fields, such as, self-cleaning, surface patterning, sensing, and detection. The diselenide bond is a dynamic covalent bond that can undergo a diselenide metathesis reaction simply under visible light irradiation Herein the authors develop this diselenide dynamic chem. into a versatile surface modification method with a fast response and reversibility. The diselenide bond could be modified onto various substrates, such as, PDMS, quartz, and ITO conductive film glass. Different functional diselenide mols. could then be immobilized onto the surface via diselenide metathesis reaction. By using this modification method the authors could achieve liquid motion in a capillary tube under light illumination. Also this approach has the potential to serve as an efficient modification method for surface bioconjugation, which has practical applications in clin. usage.3-Bromopropan-1-ol(cas: 627-18-9Name: 3-Bromopropan-1-ol) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Name: 3-Bromopropan-1-ol

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COA of Formula: C3H8ClNOIn 2015 ,《Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study》 appeared in Journal of Medicinal Chemistry. The author of the article were Mackman, Richard L.; Sangi, Michael; Sperandio, David; Parrish, Jay P.; Eisenberg, Eugene; Perron, Michel; Hui, Hon; Zhang, Lijun; Siegel, Dustin; Yang, Hai; Saunders, Oliver; Boojamra, Constantine; Lee, Gary; Samuel, Dharmaraj; Babaoglu, Kerim; Carey, Anne; Gilbert, Brian E.; Piedra, Pedro A.; Strickley, Robert; Iwata, Quynh; Hayes, Jaclyn; Stray, Kirsten; Kinkade, April; Theodore, Dorothy; Jordan, Robert; Desai, Manoj; Cihlar, Tomas. The article conveys some information:

GS-5806 I is a novel, orally bioavailable RSV fusion inhibitor discovered following a lead optimization campaign on a screening hit. The oral absorption properties were optimized by converting to the pyrazolo[1,5-a]-pyrimidine heterocycle, while potency, metabolic, and physicochem. properties were optimized by introducing the para-chloro and aminopyrrolidine groups. A mean EC50 = 0.43 nM was found toward a panel of 75 RSV A and B clin. isolates and dose-dependent antiviral efficacy in the cotton rat model of RSV infection. Oral bioavailability in preclin. species ranged from 46 to 100%, with evidence of efficient penetration into lung tissue. In healthy human volunteers exptl. infected with RSV, a potent antiviral effect was observed with a mean 4.2 log10 reduction in peak viral load and a significant reduction in disease severity compared to placebo. In conclusion, a potent, once daily, oral RSV fusion inhibitor with the potential to treat RSV infection in infants and adults is reported. After reading the article, we found that the author used Azetidin-3-ol hydrochloride(cas: 18621-18-6COA of Formula: C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.COA of Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2020 ,《Ninhydrin Revisited: Quantitative Chirality Recognition of Amines and Amino Alcohols Based on Nondestructive Dynamic Covalent Chemistry》 appeared in Journal of Organic Chemistry. The author of the article were Pilicer, Samantha L.; Wolf, Christian. The article conveys some information:

A novel approach to chiral recognition of small mols. using the classical ninhydrin agent is introduced. Well-defined dynamic covalent chem. with amines and amino alcs. was developed and applied to quant. ee sensing with good accuracy using a straightforward mixing protocol and subsequent CD measurements. This chiroptical assay is fast, broadly useful, practical and repurposes an inexpensive reagent known for more than 100 years in a new application. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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