Tag: 100-200

In 2010,Palmer, Andreas M.; Chiesa, Vittoria; Schmid, Anja; Muench, Gabriela; Grobbel, Burkhard; Zimmermann, Peter J.; Brehm, Christof; Buhr, Wilm; Simon, Wolfgang-Alexander; Kromer, Wolfgang; Postius, Stefan; Volz, Jurgen; Hess, Dietmar published 《Tetrahydrochromenoimidazoles as Potassium-Competitive Acid Blockers (P-CABs): Structure – Activity Relationship of Their Antisecretory Properties and Their Affinity toward the hERG Channel》.Journal of Medicinal Chemistry published the findings.Electric Literature of C3H8ClNO The information in the text is summarized as follows:

Potassium-competitive acid blockers constitute a new therapeutic option for the treatment of acid-related diseases that are widespread and constitute a significant economical burden. Enantiomerically pure (tetrahydro)chromenoimidazoles I [R1 = 2-MeC6H4, R2 = Et, R3 = H; R1 = 2-(c-C3H5)C6H4, R2 = R3 = Me, etc.] were prepared using either the readily available candidate I (R1 = 2-MeC6H4, R2 = R3 = Me) as starting material or where the Noyori asym. reduction of ketones, e.g., II, was the key reaction. A comprehensive SAR regarding the influence of the 5-carboxamide and the 8-aryl residue on in vitro activity, acid-suppression in the Ghosh Schild rat, and affinity toward the hERG channel was established. In addition, efficacy and duration of the antisecretory action was examined for the most promising target compounds by 24 h pH-metry in the fistula dog and a significantly different SAR was observed as compared to the Ghosh Schild rat. Several (tetrahydro)chromenoimidazoles were identified that possessed a comparable profile as the candidate I (R1 = 2-MeC6H4, R2 = R3 = Me). In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Electric Literature of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Electric Literature of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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SDS of cas: 4048-33-3In 2020 ,《Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles》 appeared in Angewandte Chemie, International Edition. The author of the article were Li, Yamin; Jarvis, Rachel; Zhu, Kuixin; Glass, Zachary; Ogurlu, Roza; Gao, Peiyang; Li, Peixuan; Chen, Jinjin; Yu, Yingjie; Yang, Yongjie; Xu, Qiaobing. The article conveys some information:

Developing safe and efficient delivery systems for therapeutic biomacromols. is a long-standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In vivo studies in adult mice demonstrated the successful delivery of genome engineering protein and mRNA mols. in the skeletal muscle (via i.m. injection), lung and spleen (via i.v. injection), and brain (via lateral ventricle infusion). The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.SDS of cas: 4048-33-3

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Synthetic Route of C6H15NOIn 2021 ,《Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications》 appeared in Angewandte Chemie, International Edition. The author of the article were Sun, Jing; Xiao, Lingling; Li, Bo; Zhao, Kelu; Wang, Zili; Zhou, Yu; Ma, Chao; Li, Jingjing; Zhang, Hongjie; Herrmann, Andreas; Liu, Kai. The article conveys some information:

Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to their high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein adhesive for underwater and in vivo applications. In this soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role for the formation of ultra-strong adhesive coacervates. Remarkably, the adhesion capability is superior to com. cyanoacrylate when tested in ambient conditions. Moreover, the adhesion is stronger than other reported protein-based adhesives in underwater environment. The ex vivo and in vivo experiments demonstrate the persistent adhesive performance and outstanding behaviors for wound sealing and healing. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO

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In 2022,Logvinenko, Ivan G.; Kondratov, Ivan S.; Pridma, Stanislav O.; Tolmachova, Nataliya A.; Morev, Roman N.; Dolovanyuk, Violetta G.; Boretskyi, Andrii L.; Stepaniuk, Roman O.; Trofymchuk, Serhii A.; Muck-Lichtenfeld, Christian; Daniliuc, Constantin G.; Haufe, Gunter published an article in Journal of Fluorine Chemistry. The title of the article was 《Synthesis and physical chemical properties of CF3O-containing secondary amines-Perspective building blocks for drug discovery》.HPLC of Formula: 18621-18-6 The author mentioned the following in the article:

Conformational and electronic effects of the trifluoromethoxy group make it attractive to be introduced in biorelevant structures. A mini-library of CF3O-substituted piperidines, pyrrolidines and azetidines was synthesized in 4-5 steps from com. amino alcs. Comparison of the measured pKa- and log D7.4 values of selected regioisomeric CF3O piperidines with the corresponding CF3- and MeO analogs shows that the effect on the acid/base properties and lipophilicity is rather complex and depends of the substitution position and the conformation of the mols. For the most stable conformers of β-OCF3 compounds 2-(trifluoromethoxymethyl)piperidine and 3-trifloromethoxypiperidine, DFT calculations and X-ray data for 2-(trifluoromethoxymethyl)piperidine show a favored gauche-arrangement with regard to the amino group. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
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In 2022,Haure, Maxime; Nguyen, Thi Kim Chi; Cendres, Aurelie; Perino, Sandrine; Licandro, Helene; Wache, Yves published an article in European Food Research and Technology. The title of the article was 《Glycosidically bound volatile profiles of green and roasted coffee beans and aromatic potential of spent coffee ground》.Name: 3-Pyridinemethanol The author mentioned the following in the article:

Coffee volatile compounds formation has been studied for years and the main flavor precursors have been identified. Coffee glycosidically bound volatiles (GBVs) are still underexplored and, yet, can act as aroma precursors during the post-harvesting processing and roasting. Free volatile compounds and GBVs of green coffee beans (CB), roasted CB and spent coffee ground (SCG) were analyzed. Roasting led to the formation of a new GBVs pool from green to roasted CB and SCG. Most of the GBVs of green CB were hydrolyzed during roasting. On the other hand, pyrroles, cycloketones, pyridines and pyrans were identified for the first time as bound volatiles and occurred only after the roasting process. This study supports the importance of GBVs on coffee aroma formation during the post-harvest processing. The release of the GBVs of roasted CB during brewing could enhance the varietal aromas of industrial ready-to-drink coffees. Furthermore, the SCG GBVs could be used as a new source of natural flavours for perfume industries. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: 3-Pyridinemethanol

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Olyaei, Abolfazl; Adl, Alireza; Vessally, Esmail published an article in 2021. The article was titled 《An efficient one-pot synthesis of novel 6-hydroxy-14-aryl-8H-dibenzo[a,i]xanthene-8,13(14H)-diones derived from lawsone》, and you may find the article in Research on Chemical Intermediates.Related Products of 100-83-4 The information in the text is summarized as follows:

An efficient and convenient procedure for the synthesis of novel 6-hydroxy-14-aryl-8H-dibenzo[a,i]xanthene-8,13(14H)-dione derivatives was developed by one-pot, three-component condensation reaction between 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and 2,3-naphthalenediol in glacial acetic acid under reflux conditions. This domino reaction implies Knoevenagel condensation, Michael addition, intramol. cyclization and dehydration. This reaction avoided tedious workup procedure due to the direct precipitation of products from the reaction medium. The notable features of this domino transformation were operational simplicity, clean reaction, easy handling, easy purification process and high yields of the products. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4

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Chen, Ling; Bisoyi, Hari Krishna; Huang, Yinliang; Huang, Shuai; Wang, Meng; Yang, Hong; Li, Quan published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Healable and Rearrangeable Networks of Liquid Crystal Elastomers Enabled by Diselenide Bonds》.Computed Properties of C3H7BrO The article contains the following contents:

Based on liquid crystal elastomer (LCE) materials, hierarchically structured soft actuators can meet some requirements for human-friendly working mode and execute complex tasks with intelligent adaptation to environmental changes. However, few researchers have paid much attention to the preparation methods of multicomponent/hierarchical LCE actuators. The authors demonstrate the successful integration of an exchangeable diselenide chain extender for the preparation of dynamic LCEs, which could be reprogrammed on heating or under visible light illumination. Also, the rearrangeable polydiselenide networks could be applied to develop the self-welding technol. toward fabricating hierarchically structured LCE actuators with sophisticated deformability without using any auxiliary reagent (adhesive, tape, catalysts or initiator) during the assembling process. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Computed Properties of C3H7BrO

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Li, Xiao-Qiang; Duan, Guo-Yi; Chen, Jun-Wu; Han, Li-Jun; Zhang, Suo-Jiang; Xu, Bao-Hua published their research in Applied Catalysis, B: Environmental in 2021. The article was titled 《Regulating electrochemical CO2RR selectivity at industrial current densities by structuring copper/poly(ionic liquid) interface》.Application In Synthesis of 2,6-Pyridinedimethanol The article contains the following contents:

Ionic liquid-based electrocatalytic CO2 reduction faces the challenge of achieving high selectivity toward value-added C2+ products at high reaction rate (≥ 100 mA cm-2). Herein, novel copper@poly(ionic liquid) (Cu@PIL) hybrids demonstrate multi-electron reduction (> 2e-) with current densities ≥ 300 mA cm-2. Remarkably, Cu@PIL with F- anion exhibits high C2+ faradaic efficiency of 58 % with a high partial c.d. of 174 mA cm-2. Further, a highest C2+ partial c.d. of 233 mA cm-2 was also achieved. Exptl. combined theor. investigations reveal that the “”individual”” ionic pairs in the outer PIL layer enrich local CO2 concentration, thereby promoting the CO2 supply. Besides, an interfacial elec. field is induced by the unbonded imidazolium moieties at Cu-PIL interface, which stabilize intermediates. Anions, differing in the electron-donating number to the imidazolium moieties, influence both the enrichment of CO2 and the stabilization of intermediates, thus regulating c.d. and product selectivity.2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 2,6-Pyridinedimethanol

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Akbarpour, Tahereh; Khazaei, Ardeshir; Yousefi Seyf, Jaber; Sarmasti, Negin published their research in Applied Organometallic Chemistry in 2021. The article was titled 《Synthesis of 1-aminoalkyl-2-naphthol derivatives using an engineered copper-based nanomagnetic catalyst (Fe3O4@CQD@Si(OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu)》.Application In Synthesis of 3-Hydroxybenzaldehyde The article contains the following contents:

In the present study, a mol. level engineered-based method was used to synthesize a copper-based nanomagnetic catalyst (Fe3O4@CQD@Si(OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu). The as-synthesized catalyst was characterized using different techniques, including IR, X-ray powder diffraction (XRD), field emission SEM (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), EDX elemental mapping, induced coupled plasma (ICP), thermal gravimetric anal. (TGA), DTA, and a vibrating sample magnetometer (VSM). The Fe3O4 nanoparticles surface was protected using carbon quantum dots (CQDs) instead of conventional SiO2. The activity of the as-synthesized catalyst was evaluated in the synthesis of 1-aminoalkyl-2-naphthols derivatives, e.g., I. The solvent-free condition has short reaction time and high reaction yield, 87.5% after five cycles. How the reaction was triggered by the catalyst was determined by IR. Strong evidence was provided for the stability of the as-synthesized novel copper-based heterogeneous magnetic nanocatalyst. The effect of temperature and the amount of the catalyst (optimal reaction conditions) were determined using a systematic approach, namely, the design of experiment (DOE). The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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《Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease》 was written by Leonard, Kristi A.; Madge, Lisa A.; Krawczuk, Paul J.; Wang, Aihua; Kreutter, Kevin D.; Bacani, Genesis M.; Chai, Wenying; Smith, Russell C.; Tichenor, Mark S.; Harris, Michael C.; Malaviya, Ravi; Seierstad, Mark; Johnson, Marguerite E.; Venable, Jennifer D.; Kim, Suzie; Hirst, Gavin C.; Mathur, Ashok S.; Rao, Tadimeti S.; Edwards, James P.; Rizzolio, Michele C.; Koudriakova, Tatiana. Reference of trans-4-Aminocyclohexanol And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

To identify Janus kinase (JAK) inhibitors that selectively target gastrointestinal tissues with limited systemic exposures, a class of imidazopyrrolopyridines with a range of phys. properties was prepared and evaluated. We identified compounds with low intrinsic permeability and determined a correlation between permeability and physicochem. properties, clogP and tPSA, for a subset of compounds This low intrinsic permeability translated into compounds displaying high colonic exposure and low systemic exposure after oral dosing at 25 mg/kg in mouse. In a mouse PK/PD model, oral dosing of lead compound 2 demonstrated dose-dependent inhibition of pSTAT phosphorylation in colonic explants post-oral dose but low systemic exposure and no measurable systemic pharmacodynamic activity. We thus demonstrate the utility of JAK inhibitors with low intrinsic permeability as a feasible approach to develop gut-restricted, pharmacol. active mols. with a potential advantage over systemically available compounds that are limited by systemic on-target adverse events. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Reference of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Reference of trans-4-Aminocyclohexanol

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