Tag: 100-200

《Nano-WO3-SO3H as a New Photocatalyst Insight Through Covalently Grafted Bronsted Acid: Highly Efficient Selective Oxidation of Benzyl Alcohols to Aldehydes》 was written by Hosseini, Saber; Amoozadeh, Ali; Akbarzadeh, Yasaman. Electric Literature of C7H7BrOThis research focused ontungsten oxide benzyl alc aldehyde Bronsted acid oxidation. The article conveys some information:

Modification of nano-WO3 with -SO3H groups as a covalently grafted solid acid reduced its band-gap energy from 2.8 to 2.4 eV and made it an ideal nominee for photocatalytic reaction under visible light irradiation This nano-photocatalyst has been successfully used for the selective oxidation of different benzyl alcs. to corresponding aldehydes under blue LED irradiation The reaction became approx. two times faster with excellent yields. It has shown that the nitrobenzene as an available industrial oxidant is applicable for photocatalytic oxidation of benzyl alc.; remarkably high yield and selectivity have been observed The experimental process involved the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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《Mechanistic insight into the azo radical-promoted dehydrogenation of heteroarene towards N-heterocycles》 was written by Bains, Amreen K.; Adhikari, Debashis. Electric Literature of C7H7BrOThis research focused ontriazine pyrimidine preparation mechanism kinetics; alc amidine hydrochloride dehydrogenation nickel catalyst. The article conveys some information:

Herein, a molecularly defined nickel catalyst, which can perform two annulation reactions under mild conditions (80°, 8 h), towards the sustainable synthesis of triazine I (R = H, 4-Me, 4-F, etc.) and pyrimidine II (R = H, 4-Me, 2-F, etc.; R1 = Me, C6H5, 4-MeC6H4, 4-FC6H4) has been reported. Mechanistically, the important role of the catalyst in promoting the dehydrogenation of heteroarenes is clearly described. The binding of the saturated heterocycle to the metal catalyst underwent a pre-equilibrium step (K = 238 at 80°), which is followed by a crucial hydrogen atom transfer. A series of kinetics experiments including Van’t Hoff, Eyring anal. and interception of pyrimidinyl radical disclosed the details of the dehydrogenation process. This ligand-driven, base metal catalytic approach is significantly different from the considerably evaluated metal-ligand cooperative bond activation strategies, which may offer an alternative dehydrogenation pathway that demands less energy.(4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

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《Effects of substituents on bridging ligands on the single-molecule magnet properties of Zn2Dy2 cluster complexes》 was written by Liu, Cai-Ming; Hao, Xiang; Zhang, De-Qing. Name: 2,6-PyridinedimethanolThis research focused onzinc dysprosium salen Schiff base pyridinedimethanol cluster complex preparation; magnetic property zinc dysprosium salen Schiff base pyridinedimethanol; crystal structure zinc dysprosium salen Schiff base pyridinedimethanol. The article conveys some information:

Two new Zn2Dy2 complexes were constructed from Zn (II) salen-type Schiff base complex fragment and 2,6-pyridinedimethanol (H2pdm) or its Br-substituted analog (4-bromopyridine-2,6-diyl)dimethanol (H2Brpdm); their mol. formulas are [Zn2Dy2(L)2(pdm)2(MeOH)2](ClO4)2 [1, H2L = N, N’- bis(3-methoxysalicylidene)-1,3-diaminopropane] and [Zn2Dy2(L)2(Brpdm)2(MeOH)2](ClO4)2 [2], the Dy (III) ions of which have a NO7 triangular dodecahedral coordination sphere. The two complexes show not only ferromagnetic interaction but also field-induced single-mol. magnet (SMM) behavior, which are rare Dy (III)-containing cluster complexes with the NO7 triangular dodecahedral coordination sphere that can show good magnetic relaxation. The energy barrier value of complex 2 is higher than those of complex 1 and the Dy (III) complexes with the DyNO7 triangular dodecahedral coordination configuration reported in the literature.2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 2,6-Pyridinedimethanol

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Formula: C6H12OIn 2019 ,《Systematically Controlled Decomposition Mechanism in Phosphorus Flame Retardants by Precise Molecular Architecture: P-O vs P-N》 was published in ACS Applied Polymer Materials. The article was written by Markwart, Jens C.; Battig, Alexander; Zimmermann, Lisa; Wagner, Martin; Fischer, Jochen; Schartel, Bernhard; Wurm, Frederik R.. The article contains the following contents:

Flame retardants (FR) are inevitable additives to many plastics. Halogenated organics are effective FRs but are controversially discussed due to the release of toxic gases during a fire or their persistence if landfilled. Phosphorus-containing compounds are effective alternatives to halogenated FRs and have potential lower toxicity and degradability. In addition, nitrogen-containing additives were reported to induce synergistic effects with phosphorus-based FRs. However, no systematic study of the gradual variation on a single phosphorus FR containing both P-O and P-N moieties and their comparison to the resp. blends of phosphates and phosphoramides was reported. This study developed general design principles for P-O- and P-N-based FRs and will help to design effective FRs for various polymers. We synthesized a library of phosphorus FRs that only differ in their P-binding pattern from each other and studied their decomposition mechanism in epoxy resins. Systematic control over the decomposition pathways of phosphate (P=O(OR)3), phosphoramidate (P=O(OR)2(NHR)), phosphorodiamidate (P=O(OR)(NHR)2), phosphoramide (P=O(NHR)3), and their blends was identified, for example, by reducing cis-elimination and the formation of P-N-rich char with increasing nitrogen content in the P-binding sphere. Our FR epoxy resins can compete with com. FRs in most cases, but we proved that the blending of esters and amides outperformed the single-mol. amidates/diamidates due to distinctively different decomposition mechanisms acting synergistically when blended. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Formula: C6H12O

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Recommanded Product: 3-HydroxybenzaldehydeIn 2020 ,《A highly efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by strontium pyroarsenate nano-plates》 was published in Journal of Molecular Structure. The article was written by Esmaeili, Rozhin; Kafi-Ahmadi, Leila; Khademinia, Shahin. The article contains the following contents:

The present work described the one-pot multicomponent synthesis of heterocyclic 3,4-dihydropyrimidin-2-(1H)-ones I [R1 = H, 2-Cl, 4-OH, etc.; R2 = OMe, OEt; X = O] and thiones II [X = S] (DHPMs) under via Biginelli reaction of benzaldehydes, alkyl acetates, urea/thiourea under solvent-free conditions by Sr2As2O7 nanocatalyst. Sr2As2O7 nanocatalyst was synthesized by solvothermal reactions at stoichiometric molar ratio. The characterizations of the as-prepared nanomaterials were performed by X-ray powder diffraction (XRPD) and fourier-transform IR (FTIR) techniques. According to Rietveld anal. data, it was found that reaction time had a considerable effect on crystal phase change from monoclinic to tetragonal crystal system. Field emission scanning electron microscope (FESEM) images showed that the morphol. of the obtained materials was changed by increasing the reaction time, from 24 to 120 h, from long-length rods to multigonal plates. Langmuir-Hinshelwood kinetic model revealed that the reactions followed a pseudo-first order kinetic model.3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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Recommanded Product: 3,5-DihydroxybenzaldehydeIn 2018 ,《Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells》 appeared in Toxicology In Vitro. The author of the article were Silva, Matheus de Freitas; Coelho, Leticia Ferreira; Guirelli, Isadora Mitestainer; Pereira, Rodrigo Machado; Ferreira-Silva, Guilherme Alvaro; Graravelli, Graciana Y.; Horvath, Renato de Oliveira; Caixeta, Ester Siqueira; Ionta, Marisa; Viegas, Claudio. The article conveys some information:

Curcumin (1) and resveratrol (2) are bioactive natural compounds that display wide pharmacol. properties, including antitumor activity. However, their clin. application has been limited due to their low solubility and bioavailability. Nevertheless, independent studies have considered these compounds as interesting prototypes for developing new chem. structures useful for anticancer therapy. Herein, we report the synthesis of novel curcumin-like hydrazide analogs (3a and 3b), and a series of curcumin-resveratrol hybrid compounds (4a-f), and the evaluation of their cytotoxic potential on three tumor cell lines MCF-7 (breast), A549 (lung), and HepG2 (liver). Cell viability was significantly reduced in all tested cell lines when compounds 4c-4e were used. The IC50 values for these compounds on MCF-7 cells were lower than those for curcumin, resveratrol, or curcumin combined with resveratrol. We evidenced that 4c promoted a drastic increase of G2/M population. The accumulation of cells in mitosis onset in treated cultures was due to, at least in part, the ability of 4c to modulate nuclear kinase proteins, which orchestrate important events in mitosis progression. We have also observed significant reduction of the relative RNAm abundance of CCNB1, PLK1, AURKA, AURKB in samples treated with 4c, with concomitant increase of CDKN1A (p21). Thus, compound 4c is a promising multi-target antitumor agent that should be considered for further in vivo studies. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 3,5-Dihydroxybenzaldehyde

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2020 ,《Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst》 appeared in Journal of Organic Chemistry. The author of the article were Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.. The article conveys some information:

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chem. to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approx. 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Gauthier, Maxime; Coutrot, Frederic published their research in Chemistry – A European Journal in 2021. The article was titled 《Weinreb Amide, Ketone and Amine as Potential and Competitive Secondary Molecular Stations for Dibenzo-[24]Crown-8 in [2]Rotaxane Molecular Shuttles》.Electric Literature of C6H15NO The article contains the following contents:

This paper reported the synthesis and study of new pH-sensitive DB24C8-based [2]rotaxane mol. shuttles that contain within their axle four potential sites of interaction for the DB24C8: ammonium, amine, Weinreb amide and ketone. In the protonated state, the DB24C8 lay around the best ammonium site. After either deprotonation or deprotonation-then-carbamoylation of the ammonium, different localizations of the DB24C8 were seen, depending on both the number and nature of the secondary stations and steric restriction. Unexpectedly, the results indicated that the Weinreb amide was not a proper secondary mol. station for the DB24C8. Nevertheless, through its methoxy side chain, it slowed down the shuttling of the macrocycle along the threaded axle, thereby partitioning the [2]rotaxane into two translational isomers on the NMR timescale. The ketone was successfully used as a secondary mol. station, and its weak affinity for the DB24C8 was similar to that of a secondary amine. After reading the article, we found that the author used 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

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Yaseen, Anaheed A.; Al-Tikrity, Emaad T. B.; Yousif, Emad; Ahmed, Dina S.; Kariuki, Benson M.; El-Hiti, Gamal A. published their research in Polymers (Basel, Switzerland) in 2021. The article was titled 《Effect of Ultraviolet Irradiation on Polystyrene Containing Cephalexin Schiff Bases》.Reference of 3-Hydroxybenzaldehyde The article contains the following contents:

Synthesis and application of new UV photostabilizers for polystyrene and this research was focused on four cephalexin Schiff bases I [Ar = 3-OHC6H4, 4-BrC6H4, 4-OMeC6H4, 4-NMe2C6H4]. The reaction of cephalexin and 3-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-methoxybenzaldehyde, and 4-bromobanzaldehyde under acidic condition afforded the corresponding Schiff bases I in high yields. The Schiff bases were characterized and their surfaces were examined The Schiff bases were mixed with polystyrene to form homogenous blends and their effectiveness as photostabilizers was explored using different methods. The methods included monitoring the changes in the IR spectra, weight loss, depression in mol. weight, and surface morphol. on irradiation In the presence of the Schiff bases, the formation of carbonyl group fragments, weight loss, and decrease in mol. weight of polystyrene were lower when compared with pure polystyrene. In addition, undesirable changes in the surface such as the appearance of dark spots, cracks, and roughness were minimal for irradiated polystyrene containing cephalexin Schiff bases. Mechanisms by which cephalexin Schiff bases stabilize polystyrene against photodegradation was also suggested. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Reference of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Reference of 3-Hydroxybenzaldehyde

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Zalesak, Frantisek; Kovac, Ondrej; Lachetova, Eliska; Stastna, Nikola; Pospisil, Jiri published their research in Journal of Organic Chemistry in 2021. The article was titled 《Unified Approach to Benzo[d]thiazol-2-yl-Sulfonamides》.Application of 4048-33-3 The article contains the following contents:

In this paper, a unified approach to N-substituted and N,N-disubstituted benzothiazole (BT) sulfonamides I [R = n-Bu, cyclohexyl, Bn, furan-2-ylmethyl, etc.; R1 = H, Me; RR1 = -(CH2)5-, -(CH2)2CH(OH)(CH2)2], II, III (R2 = propan-2-yl, Bn, oxiran-2-ylmethyl, etc.; RR2 = -(CH2)6-) and IV (Ar = Ph, 3-fluorophenyl, 4-chlorophenyl, etc.) was reported. The approach to BT-sulfonamides I and II starts from simple com. available building blocks (benzo[d]thiazole-2-thiol and primary and secondary amines such as allylamine, benzylamine, piperidine, etc.) that are connected via (a) a S oxidation/S-N coupling approach, (b) a S-N coupling/S-oxidation sequence, or via (c) a S-oxidation/S-F bond formation/SuFEx approach. The labile N-H bond in N-monoalkylated BT-sulfonamides III (pKa (BTSO2N(H)Bn) = 3.34 ± 0.05) further allowed to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonamides IV were accessed with the help of the Chan-Lam coupling reaction. Developed methods were further used in stereo and chemoselective transformations of podophyllotoxin and several amino alcs. such as 3-aminopropan-1-ol and 6-aminohexan-1-ol. In the experiment, the researchers used many compounds, for example, 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application of 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts