Tag: 100-200

Recommanded Product: 6346-09-4On May 3, 2019 ,《Synthesis of Multisubstituted Pyrroles from Enolizable Aldehydes and Primary Amines Promoted by Iodine》 appeared in Journal of Organic Chemistry. The author of the article were Huang, Wenbo; Chen, Shaomin; Chen, Zhiyan; Yue, Meie; Li, Minghao; Gu, Yanlong. The article conveys some information:

1,2,4-Trisubstituted pyrroles were synthesized from enolizable aliphatic aldehydes and primary aliphatic amines by using iodine as the dual Lewis acid/mild oxidant. In the presence of 3.0 equiv of TBHP, enolizable α,β-unsaturated aldehyde, for example, cocal reacted with aromatic primary amines to form C2-iodized N-arylpyrroles. An acetal-containing pyrrole was successfully prepared from 4-aminobutyraldehyde di-Et acetal, which can be converted easily to 5,6,7,8-tetrahydroindolizine derivatives In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 54-17-1On March 31, 2019, Gabr, S. K.; Bakr, R. O.; Mostafa, E. S.; El-Fishawy, A. M.; El-Alfy, T. S. published an article in South African Journal of Botany. The article was 《Antioxidant activity and molecular docking study of Erythrina neillii polyphenolics》. The article mentions the following:

Species of genus Erythrina have a great contribution in folk medicine; various species are utilized as a tranquilizer, to treat insomnia, inflammation and colic. Besides, Erythrina species have reported antioxidant, hepatoprotective and anxiolytic activities. Erythrina × neillii is a hybrid obtained through a cross between E. herbacea L. and E. humeana Spreng. It has not been well-studied for its chem. or biol. profile; therefore it represents an interesting field of study. In this study, seven phenolic compounds; two hydrolysable tannins (1,3), one phenolic acid (2) and four known flavonoids (4-7) were isolated and characterized for the first time in E × neillii and Erythrina genus except for vitexin (7). Isolated compounds were assessed for their antioxidant activities using ORAC assay. 2″”-O-galloyl orientin (6) exhibited the highest activity followed by 2″”-O-galloyl vitexin (5). Flexible mol. docking on heme oxygenase, an important stress protein that is involved in cellular protection, antioxidant and anti-inflammatory activities, justified the antioxidant activity of the isolated compounds The best scoring was observed with 2″”-O-galloyl orientin forming four binding interactions with residues, Arg 136 (two interactions), Met34 and Gly139. Erythrina × neillii offered powerful and available antioxidant beside significantly active phytoconstituents. After reading the article, we found that the author used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Related Products of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Related Products of 54-17-1

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Inhibition of the autoxidation of fats and oils. IX. Antioxidant activity of some 4-alkylcatechols》 was published in Nippon Nogei Kagaku Kaishi in 1954. These research results belong to Tamura, Saburo; Okubo, Hide; Kaneta, Hiroshi. Computed Properties of C10H14O2 The article mentions the following:

cf. C.A. 50, 6403b. 4-Alkylcatechols, 1,2,4-(HO)2C6H3R (I), were synthesized and studied for the relationship between the antioxidant property and chem. structure. Veratrole (20 g.) and 13 g. Ac2O in PhNO2 with 26 g. AlCl3 below 0° gave 19 g. 4-acetylveratrole, b15 170-5°, 13 g. of which was hydrogenated with 40 g. Zn amalgam to 6 g. 4-ethylveratrole, b55 150°, which was demethylated with HI to 60% I (R = Et) (II), b9 130-2°. Similar processes gave: I (R = Bu) (III), b5 143-8°, m. 42-3°, from 4-butylveratrole, b8 128-35° (prepared from 4-butyroylveratrole, b9 175°, m. 52-3°); I (R = hexyl) (IV), b5 164-70°, from 4-hexylveratrole, b11 155-60° (prepared from 4-hexanoylveratrole, b17 176-8°); I (R = decyl) (V), m. 73-4°, from 4-decylveratrole, m. 25-6° (prepared from 4-decanoylveratrole, m. 60-1°); and I (R = dodecyl) (VI), m. 75-6°, from 4-dodecylveratrole, m. 39-40° (prepared from 4-dodecanoylveratrole, m. 57°). Guaiacol propionate, b8 115-18°, prepared from guaiacol and propionic acid in the presence of SOCl2, was treated with AlCl3 and CS2 to obtain 4-propionylguaiacol, b15 182-7°, which was converted to 4-propylguaiacol, b15 130-6°, and then to I (R = Pr) (VII), b12 155-7°. Other I were prepared from catechol esters: 4-valeroylcatechol, b10 245-55°, gave I (R = pentyl) (VIII), b7 155-60°; and 4-octanoylcatechol, b4 210-20°, gave I (R = octyl) (IX), b5 175-80°. The relative antioxidant activity was expressed as in Part V (C.A. 50, 6402b). At 0.01% on a molar basis, the results by the active O method (hrs.) and the inhibitor ratio, resp., were: lard (no antioxidant), 4.5, -; dihydronorguaiaretic acid (IXa), 28.0, 0.53; catechol, 26.0, 0.48; II, 61.0, 1.25 (the most active); VII, 52.0, 1.07; III, 51.0, 1.05; VIII, 48.0, 0.98; IV, 47.0, 0.96; IX, 40.5, 0.81; V, 50.0, 1.00; VI, 42.0, 0.84; propionylcatechol, 8.0, 0.05; and dodecanoylcatechol, 8.0, 0.08. However, most of these alkylcatechols were apt to produce eczema on human skin and discolored the product. In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5Computed Properties of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Computed Properties of C10H14O2

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Alcohol – Wikipedia,
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《Asymmetric hydrogenation of α-hydroxy ketones with an iridium/f-amphox catalyst: efficient access to chiral 1,2-diols》 was published in Organic Chemistry Frontiers in 2017. These research results belong to Wu, Weilong; Xie, Yun; Li, Pan; Li, Xiuxiu; Liu, Yuanhua; Dong, Xiu-Qin; Zhang, Xumu. Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol The article mentions the following:

The tridentate f-amphox ligands has been successfully applied to the iridium-catalytic asym. hydrogenation of various α-hydroxy ketones RC(O)CH2OH (R = CH3CH2, 3-BrC6H4, furan-2-yl, naphthalen-2-yl, etc.) to afford the corresponding chiral 1,2-diols (S)/(R)-RCH(OH)CH2OH with excellent results (almost all products up to 99% yield and >99%ee). This catalytic system displayed extremely high activity, achieving up to 1000000 turnover number (TON). The great performance of this asym. hydrogenation procedure makes the preparation of various chiral 1,2-diols highly practical with great potential. In the part of experimental materials, we found many familiar compounds, such as (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Reference of (1S)-1-(2-chlorophenyl)ethane-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 821-41-0In 2019 ,《Surface Modification and Functionalization of Boron Nitride Nanotubes via Condensation with Saturated and Unsaturated Alcohols for High Performance Polymer Composites》 was published in ACS Applied Nano Materials. The article was written by Smith, Kamia K.; Redeker, Neil D.; Rios, Juan C.; Mecklenburg, Matthew H.; Marcischak, Jacob C.; Guenthner, Andrew J.; Ghiassi, Kamran B.. The article contains the following contents:

Over the past decade, boron nitride nanotubes (BNNTs) have been researched extensively due to their desirable phys., thermal, and mech. properties. However, a major challenge for BNNT utilization in applications is their poor processability and difficulty associated with their incorporation into materials and composites. The desire to incorporate BNNTs into relevant materials, specifically within the aerospace industry, calls for improving their processability. The successful grafting of reactive functionalities allows for improvements to the compatibility of BNNTs in polymer systems, allowing for the manufacturing of high performance BNNT-polymer composites. The research presented here addresses this concern, introducing a facile method for covalent surface functionalization of BNNTs with a diverse set of functional moieties allowing for homogeneous dispersibility in solvent. The grafted functionalities in this work are based on alkyl-, vinyl-, and propargyl-terminated alcs. covalently bound to BNNTs that were subjected to an oxidizing perchloric acid treatment. NMR spectroscopy, though not typically used for BNNT characterization, was successfully employed as a primary means to determine functionalization. Addnl. characterization methods including FTIR, SEM, TEM, and TGA also provide evidence of functionalization. Surface-functionalized materials were produced exhibiting up to 6 wt % functionality. Furthermore, visual anal. showed improved and stable dispersions lasting over 24 h, leading to potential benefits in processing for applications. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0Application of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application of 821-41-0

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Alcohol – Wikipedia,
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《A facile and highly efficient transfer hydrogenation of ketones and aldehydes catalyzed by palladium nanoparticles supported on mesoporous graphitic carbon nitride》 was published in Journal of Chemical Research in 2020. These research results belong to Nisanci, Bilal; Dagalan, Ziya. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

A novel transfer hydrogenation methodol. for the reduction of ketones (14 examples) and benzaldehyde derivatives (12 examples) to the corresponding alcs. using Pd nanoparticles supported on mesoporous graphitic carbon nitride (mpg-C3N4/Pd) as a reusable catalyst and ammonia borane as a safe hydrogen source in an aqueous solution MeOH/H2O (volume/volume = 1/1) was described. The catalytic hydrogenation reactions were conducted in a com. available high-pressure glass tube at room temperature and the corresponding alcs. were obtained in high yields in 2-5 min. Moreover, the presented transfer hydrogenation protocol showed partial halogen selectivity with bromo-, fluoro- and chloro-substituted carbonyl analogs. In addition, the present catalyst can be reused up to five times without losing its efficiency and scaling-up the reaction enabled α-methylbenzyl alc. to be produced in 90% isolated yield. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 3-Pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Amphiphilic Fluorescence Resonance Energy-Transfer Dyes: Synthesis, Fluorescence, and Aggregation Behavior in Water》 was published in Chemistry – A European Journal in 2020. These research results belong to Dou, Shilei; Wang, Ying; Zhang, Xin. COA of Formula: C6H15NO The article mentions the following:

Amphiphilic pyrene/perylene bis-chromophore dyes were synthesized from unsym. substituted perylene bisimide dyes, which were obtained through three synthetic methods. The optical and aggregation behaviors of these functional dyes were studied by means of UV/Vis absorption and fluorescence spectroscopy, dynamic light scattering, and TEM. These dyes are highly fluorescent and cover the whole visible-light region. A donor/acceptor dye displays intramol. fluorescence resonance energy transfer (FRET), with a high efficiency of up to 96.4% from pyrene to perylene bisimide chromophores, which leads to a high fluorescence color sensitivity to environmental polarity. Under a λ=365 nm UV lamp, the light-emitting colors of the donor/acceptor dye change from green to yellow with increasing solvent polarity, which demonstrates application potential as a new class of FERT probes. The donor/acceptor dye in water was assembled into hollow vesicles with a narrow size distribution. The bilayer structure of the vesicular wall was directly observed by means of TEM. These vesicular aggregates in water are fluorescent at λ=650-850 nm within the near-IR region. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.COA of Formula: C6H15NO

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Metal-, Photocatalyst-, and Light-Free Minisci C-H Alkylation of N-Heteroarenes with Oxalates》 were Dong, Jianyang; Wang, Zhen; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. And the article was published in Journal of Organic Chemistry in 2019. Quality Control of 5-Hexen-1-ol The author mentioned the following in the article:

Herein, the authors report a mild protocol for metal-, photocatalyst-, and light-free Minisci C-H alkylation reactions of N-heteroarenes with alkyl oxalates derived from primary, secondary, and tertiary alcs. The protocol uses environmentally benign persulfate as a stoichiometric oxidant and does not require high temperatures or large excesses of either of the substrates, making the procedure suitable for late-stage C-H alkylation of complex mols. Notably, several pharmaceuticals and natural products could be functionalized or prepared with this protocol, thus demonstrating its utility.5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Quality Control of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “”Tail Switching”” Strategy on a Piperazinyl Azetidine Skeleton》 were Chen, Zhen; Mori, Wakana; Deng, Xiaoyun; Cheng, Ran; Ogasawara, Daisuke; Zhang, Genwei; Schafroth, Michael A.; Dahl, Kenneth; Fu, Hualong; Hatori, Akiko; Shao, Tuo; Zhang, Yiding; Yamasaki, Tomoteru; Zhang, Xiaofei; Rong, Jian; Yu, Qingzhen; Hu, Kuan; Fujinaga, Masayuki; Xie, Lin; Kumata, Katsushi; Gou, Yuancheng; Chen, Jingjin; Gu, Shuyin; Bao, Liang; Wang, Lu; Collier, Thomas Lee; Vasdev, Neil; Shao, Yihan; Ma, Jun-An; Cravatt, Benjamin F.; Fowler, Christopher; Josephson, Lee; Zhang, Ming-Rong; Liang, Steven H.. And the article was published in Journal of Medicinal Chemistry in 2019. Related Products of 18621-18-6 The author mentioned the following in the article:

Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathol. conditions, including chronic pain, inflammation, cancer, and neurodegeneration. Herein, we disclose a novel array of reversible and irreversible MAGL inhibitors by means of “”tail switching”” on a piperazinyl azetidine scaffold. We developed a lead irreversible-binding MAGL inhibitor 8 and reversible-binding compounds 17 and 37, which are amenable for radiolabeling with 11C or 18F. [11C]8 ([11C]MAGL-2-11) exhibited high brain uptake and excellent binding specificity in the brain toward MAGL. Reversible radioligands [11C]17 ([11C]PAD) and [18F]37 ([18F]MAGL-4-11) also demonstrated excellent in vivo binding specificity toward MAGL in peripheral organs. This work may pave the way for the development of MAGL-targeted positron emission tomog. tracers with tunability in reversible and irreversible binding mechanisms. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones》 were Taha, Muhammad; Alkadi, Khaled A. A.; Ismail, Nor Hadiani; Imran, Syahrul; Adam, Aishah; Kashif, Syed Muhammad; Shah, Syed Adnan Ali; Jamil, Waqas; Sidiqqui, Salman; Khan, Khalid Mohammed. And the article was published in Arabian Journal of Chemistry in 2019. SDS of cas: 100-83-4 The author mentioned the following in the article:

A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones I [R1 = C5H4N, 4-FC6H4, 2,4-(HO)2C6H3, etc.] was synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involved a 3-step reaction in which a pyridine diamine was converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target mols. after treating them with the appropriate benzohydrazone derivatives The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound I [R1 = 2,4,6-(HO)3C6H2] (140.16 ± 0.36μM) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts