Tag: 100-200

Application of 627-18-9In 2021 ,《Facile synthesis of Antibacterial, Biocompatible, quaternized Poly(ionic liquid)s with pendant saccharides》 appeared in European Polymer Journal. The author of the article were Zheng, Zhaoquan; Wang, Bingyu; Chen, Jing; Wang, Yan; Miao, Ziyue; Shang, Cenyao; Zhang, Qiang. The article conveys some information:

Glycopolymer has been developed in bactericidal applications, but the traditional synthesis, such as click chem., needs poly-step reactions and complicated processes. Herein, incorporating the glyco-units into the polymers by quaternization has been exploited to give a facile strategy by Copper-mediated reversible deactivation radical polymerization (Cu(0)-RDRP) to prepare quaternized poly(ionic liquid)s (PILs) with pendant saccharide. The obtained PILs have the suitable property of killing typical Gram-neg. Escherichia coli and Gram-pos. Staphylococcus aureus. Simultaneously, they perform the lower hemolytic rate of blood cells, higher selectivity index against bacteria, and higher affinity with Con A (ConA) than those quaternized by bromohydrin at the same quaternization degree. This result demonstrated that the introduced saccharide units, such as glucose and mannose, could maintain the electrostatic interaction to kill bacteria, perform lectin recognition behavior and interaction with ConA, and relatively harmlessness against red blood cells. Moreover, the sugar-containing PILs became insoluble and still antibacterial after anion exchange reaction. These new findings illuminated that such quaternized antibacterial agents with saccharide units that are easy-to-prepare, low cytotoxic could pave the way for further water disinfectant and pathogen control application. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Application of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application of 627-18-9

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Electric Literature of C7H9NO2In 2021 ,《Cobalt complexes of an OSNSO-tetrapodal pentadentate ligand: Synthesis, structures and reactivity》 appeared in Inorganica Chimica Acta. The author of the article were Thevenin, Lucas; Daran, Jean-Claude; Poli, Rinaldo; Fliedel, Christophe. The article conveys some information:

The novel pentadentate tetrapodal proligand 2,6-bis[(2-hydroxyphenyl)thiomethyl]pyridine (1·H2) and its cobalt(II) complex [Co(1)] (2) were synthesized and characterized by several anal. (EA, ESI-MS) and spectroscopic methods (NMR or EPR, FTIR), including x-ray crystallog. for 1·H2. Cyclic voltammetry studies showed that 2 undergoes a reversible metal-based oxidation (CoII/CoIII). Complex 2 was designed to be applied to organometallic mediated radical polymerization (OMRP), however it exhibited an extremely poor solubility in non-coordinating solvents and several vinyl monomers (styrene, vinyl acetate and tert-Bu acrylate), which hampers its potential as moderator. Complex 2 has a high affinity towards Lewis bases, such as pyridine, leading to the clean formation of the mono-pyridine adduct 2·py, as confirmed by x-ray crystallog. In 2·py, ligand 1 is pentacoordinated to the CoII center, with the two thioether-phenolate (S,O) moieties oriented anti to each other, and the only free coordination site of the octahedron is completed by the addnl. pyridine, trans to the central pyridine linker of 1. The equilibrium between 2 and 2·py could be studied by 1H NMR. Complex 2 could be cleanly and quant. oxidized to its diamagnetic iodo cobalt(III) analog [Co(1)I] (3), by simple reaction with iodine. The latter could then be subjected to a halide abstraction reaction, mediated by K[B(C6F5)], affording the cationic complex [Co(1)][B(C6F5)], 4. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Electric Literature of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Electric Literature of C7H9NO2

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Recommanded Product: 4048-33-3In 2020 ,《Synthesis of β-1,3-glucan mimics by β-1,3-glucan trisaccharyl monomer polymerization》 appeared in Carbohydrate Polymers. The author of the article were Miyagawa, Atsushi; Yamamura, Hatsuo. The article conveys some information:

β-1,3-Glucans are important as immunostimulating agents in living organisms. The multivalent binding of β-1,3-glucans to dectin-1, a cell surface receptor, activates immunol. defenses. To study artificial immunostimulating agents, glycopolymers carrying β-1,3-glucan trisaccharides as artificial ligands were synthesized. The β-1,3-glucan trisaccharide, defined as an active unit of β-1,3-glucan, was constructed from D-glucose by glycosylation. A norbornene group was introduced as a polymerizable group into the trisaccharide derivative at the aglycon. The prepared endo/exo norbornene stereoisomers of the monomers were separated by silica gel chromatog. and identified by NMR spectroscopy and mass spectrometry. The synthesized glycosyl monomers were polymerized and copolymerized with norbornene using 2nd generation Hoveyda-Grubbs catalyst, deprotected, and purified by gel filtration to prepare water-soluble glycopolymers of varied compositions and high mol. weights These polymers will have the potential for multivalent binding to dectin-1 to activate immune response and facilitate studies to understand the binding mechanisms of β-1,3-glucans with dectin-1. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Recommanded Product: 4048-33-3

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Reference of 6-Aminohexan-1-olIn 2020 ,《Synthesis and properties of thermoplastic polyisocyanurates:polyisocyanuratoamide, polyisocyanurato(ester-amide) and polyisocyanurato(urea-ester)》 appeared in Journal of Renewable Materials. The author of the article were Hou, Rui; Zhang, Zhihuang; Zhang, Guangzhao; Tang, Donglin. The article conveys some information:

It has been proved that introducing isocyanurate into polymer chains could improve the flame retardancy of polymers. We describe in this work the synthesis and the thermal property study of three thermoplastic polyisocyanurates, which are polyisocyanuratoamide (PICA-6), polyisocyanurato(ester amide) (PICEA-6) and polyisocyanurato(urea ester) (PICUE-6). These polymers show similar and improved thermal stability with the existence of isocyanurate rings. PICA-6 is more crystallizable than the rest two and the melting temperature is found to be around 240°C but it still crystallizes slowly. For PICEA-6 and PICUE-6, only glass transition can be observed on the DSC traces. The glass transition temperature follows the order of PICA-6 > PICEA-6 > PICUE-6 (101.9, 77.9 and 28.7°C, resp.). In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Reference of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Reference of 6-Aminohexan-1-ol

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Alcohol – Wikipedia,
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In 2022,Hall, Ryan C.; Qin, Jingcan; Laney, Victoria; Ayat, Nadia; Lu, Zheng-Rong published an article in ACS Applied Bio Materials. The title of the article was 《Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI》.Quality Control of 2,6-Pyridinedimethanol The author mentioned the following in the article:

MRI is increasingly utilized for the diagnosis of liver disease and focal liver lesions. Although liver-targeted gadolinium-based contrast agents (GBCAs) have high efficacy, there continue to be safety concerns regarding release of toxic Gd(III) ions. Herein, Mn(EOB-PC2A) is synthesized as a nongadolinium alternative for liver-specific MRI. Mn(EOB-PC2A) has an r1 relaxivity of 2.8 mM-1 s-1 in Dulbecco’s phosphate-buffered saline (DPBS) and 5.9 mM-1 s-1 in saline containing human serum albumin at 1.5 T. It has a strong uptake in hepatocytes with minimal toxicity and demonstrated robust liver-specific enhancement at a dose of 60 μmol/kg. Mn(EOB-PC2A) is a promising liver-specific contrast agent for liver MRI. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2,6-Pyridinedimethanol

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In 2022,Wekesa, Amon K.; Nyamato, George S.; Kowenje, Chrispin O.; Ojwach, Stephen O. published an article in Inorganica Chimica Acta. The title of the article was 《Coordination behavior and binding properties of 2,6-pyridinedimethanol with Cu(II), Zn(II), and Cd(II) cations》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Selective extraction of water-bound metal cations through chelating agents is investigated. Reactions of 2,6-pyridinedimethanol (L1) with Cu(NO3)2·3H2O, Zn(NO3)2·6H2O and Cd(NO3)2·4H2O produced complexes [Cu(L1)2] (1), [Zn(L1)2] (2), and [Cd2(μ-NO3)(L1)2] (3), resp. The solid-state structures of 1, 2, and 3 confirmed that L1 coordinates in a tridentate fashion. The chelating ligand 2,6-pyridinedimethanol (L1) was also used as a model chelating agent for liquid-liquid extraction of copper(II), zinc(II), cadmium(II), and lead(II) cations from water using dichloromethane as the organic solvent. The relative affinities of these chelating ligands for Cu(II), Zn(II), Cd(II), and Pb(II) by liquid-liquid extraction were found to be in the order Cu(II) > Zn(II) > Pb(II) > Cd(II). Extraction efficiencies of 85% for Cu(II), 80% for Zn(II), 58% for Pb(II), and 45% for Cd(II) were observed In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: alcohols-buliding-blocks

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Lee, Young Woong; Yeop, Jiwoo; Kim, Jin Young; Woo, Han Young published an article in 2021. The article was titled 《Fullerene-Based Photoactive A-D-A Triads for Single-Component Organic Solar Cells: Incorporation of Non-Fused Planar Conjugated Core》, and you may find the article in Macromolecular Research.Electric Literature of C6H15NO The information in the text is summarized as follows:

Two acceptor-donor-acceptor (A-D-A) single-component (SC) photovoltaic triad mols., P3T4Rh-C6-PC61BM and P3T4Rh-C10-PC61BM, were synthesized. A conformation-locked planar conjugated core, 1,4-bis(thiophenylphenylthiophene)-2,5-difluorophenylene (P3T4), with intrachain noncovalent coulombic interactions was coupled with two fullerene derivatives, [6,6]-phenyl-C61 butyric acid propargyl ester, via copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition The D-A separation was varied by modulating the spacer alkyl chain length (C6 and C10). Both SC triads exhibited maximum absorption by the P3T4 core at λabs = 507-510 nm, as well as absorption by PC61BM at ∼300 nm. Because of the broken conjugation between the P3T4 core and PC61BM termini, the HOMO (-5.58 to -5.59 eV) was determined by the P3T4 moiety, and the LUMO (-3.89 to -3.92 eV) was determined by PC61BM in the SC structures. In diluted solution, both SC triads showed significant photoluminescence quenching, indicating efficient intramol. charge transfer between the P3T4 and PC61BM moieties. However, the semicrystalline packing of the P3T4 core was severely disrupted by the incorporation of a bulky PC61BM moiety at each terminus, which degraded the carrier transport and diode characteristics of SC organic solar cells (SCOSCs) based on P3T4Rh-C6-PC61BM and P3T4Rh-C10-PC61BM, as indicated by poor power conversion efficiency (∼0.4%). No clear spacer length effect was observed To improve the performance of SCOSCs, a design strategy is needed that enhances the intermol. packing and ordering of the D and A moieties, which are important prerequisites for the development of optimal SC photoactive mols. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

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Wei, Dongyue; Yang, Peng; Yu, Chuanman; Zhao, Fengkai; Wang, Yilei; Peng, Zhihua published their research in Journal of Organic Chemistry in 2021. The article was titled 《N-Alkylation of Amines with Alcohols Catalyzed by Manganese(II) Chloride or Bromopentacarbonylmanganese(I)》.Product Details of 100-55-0 The article contains the following contents:

A manganese-catalyzed N-alkylation reaction of amines with alcs. via hydrogen autotransfer strategy was demonstrated. The developed practical catalytic system included an inexpensive, nontoxic, com. available MnCl2 or MnBr(CO)5 as the metal salt and triphenylphosphine as a ligand provided access to diverse aromatic, heteroaromatic, and aliphatic secondary amines in moderate-to-high yields. In addition, this operationally simple protocol was scalable to the gram level and suitable for synthesizing heterocycles such as indole and resveratrol-derived amines known to be active for Alzheimer’s disease. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Product Details of 100-55-0

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Alcohol – Wikipedia,
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《Curcumin mono-carbonyl analogs as potent antibacterial compounds: synthesis, biological evaluation and docking simulation study》 was written by Wijianto, B.; Ritmaleni; Purnomo, H.; Nurrochmad, A.. Category: alcohols-buliding-blocks And the article was included in Rasayan Journal of Chemistry in 2020. The article conveys some information:

The present study aims to synthesize, evaluate biol. activity, and study docking of new analog compounds I (R = H; R1 = H, Cl; R2 = H, OH, Br; R3 = H, OH; R4 = H, Br; R5 = H, F; R6 = H; RR6 = -(CH2)3-, -(CH2)2-) as antibacterial. Claisen-Schmidt method used to synthesize compds I. The new analog compounds I have antibacterial activity with IC50 values of 37.1μM, 140μM, resp.; 79μM and 117μM in the aureus; 56.6μM, 282μM, 97.6μM and 186.1μM in subtilis; 291.2μM, 1025.9μM, 679.81μM and 561.9μM in E.coli; 29.5μM, 310.5μM, 32.9μM and 130.6μM in P. aeruginosa; 66.6μM, 328.6μM, 49.3μM and 253.8μM in mutans; 97.2μM, 392.2μM, 129.6μM, and 191.6μM in faecalis; 44,811μM (A113) in C.albicans. Synthesized mono-carbonyl curcumin analog compounds I have antibacterial activity through inhibition of bacterial cell wall synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

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《Iridium-Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols: A Route to Access Branched Ketones and Alcohols》 was published in Journal of Organic Chemistry in 2020. These research results belong to Genc, Sertac; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya. Reference of (4-Bromophenyl)methanol The article mentions the following:

Under borrowing hydrogen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones RCOCH(CH2R1)CH2R2 [R = Ph, 2-naphthyl, 4-MeOC6H4, etc.; R1 = Ph, 1-naphthyl, n-heptyl, etc.; R2 = Ph, 1-naphthyl, 4-MeOC6H4, etc.] via the alkylation of secondary alcs. with primary alcs. was reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcs. as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcs. PhCH(OH)CH(CH2R3)CH2R4 [R3 = Ph, n-heptyl; R4 = Ph, 4-MeC6H4, 4-BrC6H4] was achieved by the addition of an external hydrogen source to the reaction mixture In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6Reference of (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Reference of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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