Tag: 100-200

《Phosphonium-based porous ionic polymer with hydroxyl groups: a bifunctional and robust catalyst for cycloaddition of CO2 into cyclic carbonates》 was published in Polymers (Basel, Switzerland) in 2020. These research results belong to Lei, Yizhu; Wan, Yali; Zhong, Wei; Liu, Dingfu; Yang, Zhou. Computed Properties of C3H7BrO The article mentions the following:

The integration of synergic hydrogen bond donors and nucleophilic anions that facilitates the ring-opening of epoxide is an effective way to develop an active catalyst for the cycloaddition of CO2 with epoxides. In this work, a new heterogeneous catalyst for the cycloaddition of epoxides and CO2 into cyclic carbonates based on dual hydroxyls-functionalized polymeric phosphonium bromide (PQPBr-2OH) was presented. Physicochem. characterizations suggested that PQPBr- 2OH possessed large surface area, hierarchical pore structure, functional hydroxyl groups, and high d. of active sites. Consequently, it behaved as an efficient, recyclable, and metal-free catalyst for the additive and solventfree cycloaddition of epoxides with CO2. Comparing the activity of PQPBr-2OH with that of the reference catalysts based on mono and non-hydroxyl functionalized polymeric phosphonium bromides suggested that hydroxyl functionalities in PQPBr-2OH showed a critical promotion effect on its catalytic activity for CO2 conversion. Moreover, PQPBr-2OH proved to be quite robust and recyclable. It could be reused at least ten times with only a slight decrease of its initial activity. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Computed Properties of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Computed Properties of C3H7BrO

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The author of 《Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives》 were Gokmen, Zeliha; Onan, Mehmet Erdi; Deniz, Nahide Gulsah; Karakas, Didem; Ulukaya, Engin. And the article was published in Synthetic Communications in 2019. Electric Literature of C6H15NO The author mentioned the following in the article:

New N- and S,S-substituted-1,4-naphthoquinone (1,4 NQ) derivatives such as I [R = 2-furoyl, 4-FC6H4CH2, 2-pyridinyl, etc.] and II resp. were synthesized in excellent yields and were completely characterized by spectroscopic anal. IR, NMR (1H and 13C), MS and microanal. The cytotoxic activities of 1,4-NQ derivatives I and II were examined against A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, I [R = 2-furoyl] and II were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116)). The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Electric Literature of C6H15NO

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The author of 《Preparation of golf ball-shaped microspheres with fluorinated polycaprolactone via single-solvent electrospraying for superhydrophobic coatings》 were Li, Wulong; Wang, Haipeng; Li, Zhanxiong. And the article was published in Progress in Organic Coatings in 2019. Recommanded Product: 6-Aminohexan-1-ol The author mentioned the following in the article:

1H,1H,2H,2H-Perfluorooctyl polyacrylate (PTFOA) with a controllable mol. weight was successfully synthesized via atom-transfer radical polymerization (ATRP) followed by condensation with polycaprolactone (PCL) to obtain a new fluorinated block copolymer. Then, the copolymer PCL-b-PTFOA was processed via single-solvent electrospraying in chloroform to fabricate hierarchically porous microspheres. The microsphere size could be controlled from 5.13 ± 0.51 μm to 8.61 ± 0.90 μm, and the pore size on the microsphere surface could be controlled from 282.5 ± 42.0 nm to 603.3 ± 99.6 nm. Solvent evaporation-induced phase separation and fluorinated segment migration are the major reasons for the formation of the golf ball-shaped microspheres. In this study, the influence of electro-spraying parameters on the size and morphol. of the porous microspheres was systemically studied. The golf ball-shaped microspheres significantly improved the surface roughness and the CA of their coatings reached 167.3 ± 1.7°. Furthermore, a superhydrophobic fabric was produced by pretreating cotton fabric with adhesive followed by coating with PCL-b-PTFOA via electrospraying. The robust superhydrophobicity can be obtained by the stable binding of PCL-b-PTFOA microspheres onto the fibers, with the CA reaching 155.3 ± 1.1°. Electrospraying of the fluoropolymer microsphere coating was proven to be a very promising technique to produce superhydrophobic coatings on textiles through a simple procedure. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Recommanded Product: 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Recommanded Product: 6-Aminohexan-1-ol

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In 2019,Arabian Journal of Chemistry included an article by Maddila, S.; Abafe, O. A.; Bandaru, H. N.; Maddila, S. N.; Lavanya, P.; Seshadri, Nuthangi; Jonnalagadda, S. B.. Name: 3-Hydroxybenzaldehyde. The article was titled 《V-CaHAp as a recyclable catalyst for the green multicomponent synthesis of benzochromenes》. The information in the text is summarized as follows:

A simple and efficient one-pot method has been developed for the synthesis of benzochromenes I [R = 2-Cl, 4-CH3CH2, 2,5-(OCH3)2, etc.], using V-CaHAp as a heterogeneous catalyst by the condensation of aldehydes RC6H4CHO, β-naphthol and malononitrile in ethanol as solvent at room temperature for 20 min. The reaction, with this catalyst is carried out under mild reaction conditions with very good to excellent yields (89-98%). The material can be recycled very easily and reused for at least 6 runs without substantial loss in activity, which makes this methodol. environmentally benign. A feasible and cost-effective synthesis by using non-toxic materials and minimal catalyst, which is easy to handle has been achieved. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

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In 2019,Journal of Organic Chemistry included an article by Ma, Xiantao; Yu, Jing; Yan, Ran; Yan, Mengli; Xu, Qing. Recommanded Product: 3-Pyridinemethanol. The article was titled 《Promoting Effect of Crystal Water Leading to Catalyst-Free Synthesis of Heteroaryl Thioether from Heteroaryl Chloride, Sodium Thiosulfate Pentahydrate, and Alcohol》. The information in the text is summarized as follows:

It is observed the crystal water in sodium thiosulfate pentahydrate (Na2S2O3·5H2O) can promote its multicomponent reaction with heteroaryl chlorides and alcs., providing a facile, green, and specific synthesis of unsym. heteroaryl thioethers via one-step formation of two C-S bonds under catalyst-, additive-, and solvent-free conditions. Mechanistic studies suggest that the crystal water in Na2S2O3·5H2O is crucial in generating the key thiol intermediates and byproduct NaHSO4, which then catalyzes the dehydrative substitution of alcs. with thiols to afford thioethers. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 3-Pyridinemethanol

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Recommanded Product: 89466-08-0In 2021 ,《Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach》 was published in Chemistry Letters. The article was written by Nishiyama, Yoshitake; Akiyama, Kei; Sakata, Yuki; Hosoya, Takamitsu; Yoshida, Suguru. The article contains the following contents:

A facile synthetic method for unsym. tetraarylpyrazines I (R = 4-CH3C6H4, 2-naphthyl; R1 = 4-CF3C6H4, 4-(OTBS)C6H4, 4-NCC6H4; R2 = C6H5, 4-CH3OC6H4; R3 = 4-FC6H4, 4-N(CH3)2C6H4, 2-OHC6H4, 4-F3CC6H4, 4-N(C6H5)2C6H4) by sequential cross-couplings is disclosed. This 5-step synthesis was achieved from 2-amino-3,5-dibromo-6-chloropyrazine through four-fold cross-coupling and diazotization. Dibenzo-fused quinoxaline like 2-(4-methoxyphenyl)-7-methyl-3-(4-(trifluoromethyl)phenyl)dibenzo[f,h]quinoxaline synthesis was also accomplished by further intramol. coupling.2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringRecommanded Product: 89466-08-0

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COA of Formula: C3H8ClNOIn 2012 ,《Synthesis of the side chain of tebipenem pivoxil》 was published in Zhongguo Xinyao Zazhi. The article was written by Huang, Xiaoguang; Huang, Binge; Zhu, Shaoxuan. The article contains the following contents:

The side chain 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride of tebipenem pivoxil was synthesized. 1-(4,5-Dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride was prepared from 2-(methylthio)-4,5-dihydrothiazole by a 4-step process, i.e. successively reacted with 3-hydroxyazetidine hydrochloride, methanesulfonyl chloride, potassium ethanethioate and hydrolysis. The total yield of 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride was 42%. This method increases the yield of 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride, simplifies the process and decreases the cost. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6COA of Formula: C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.COA of Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Synthetic Route of C7H6O2In 2021 ,《Design, synthesis and in silico screening of benzoxazole-thiazolidinone hybrids as potential inhibitors of SARS-CoV-2 proteases》 was published in RSC Advances. The article was written by Krishna Cheerala, Vijay Sai; Ghanta, Prasanth; Neelakantan, Sundaresan Chittor. The article contains the following contents:

Hybrid mols. in the recent years have gained significant importance in drug research as promising therapeutic agents. We report a novel combination of two such bioactive scaffolds (benzoxazole and 4-thiazolidinone B-T hybrids) as inhibitors of SARS-CoV-2. The study uses an in silico approach to identify the potential of B-T hybrids as possible inhibitors of the SARS-CoV-2 proteases. Mol. docking was employed to identify the interactions of B-T hybrids with the two proteases – 3CLp (the 3-chymotrypsin-like protease) and PLp (the papain-like protease). Docking results of the screened 81 hybrids indicated that BT10 and BT14 interacted with the catalytic dyad residue of 3CLp (Cys145) with the best binding energy. MD simulations revealed that BT10 formed stable interactions via 4 hydrogen bonds with the catalytic site residues of 3CLp. In the case of PLp, BT27 and MBT9 interacted with the catalytic triad residue of PLp (His272) with high binding energy. MD simulations demonstrated that the reference drug Tipranavir relocated to the thumb region of the protease whereas BT27 remained in the active site of PLp stabilized by 2 hydrogen bonds, while MBT9 relocated to the BL2 loop of the palm region. The MM-PBSA and interaction entropy (IE) anal. indicated that BT14 exhibited the best ΔG (of -6.83 kcal mol-1) with 3CLp, while BT27 exhibited the best ΔG (of -7.76 kcal mol-1) with PLp. A four-step synthetic procedure was employed to synthesize the B-T hybrids starting from ammonium thiocyanate. The short-listed compounds in the case of 3CLp were synthesized and characterized using IR, NMR, and HRMS spectroscopic techniques. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Synthetic Route of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Synthetic Route of C7H6O2

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Synthetic Route of C6H15NOIn 2022 ,《A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications》 appeared in RSC Chemical Biology. The author of the article were Swanson, W. Benton; Durdan, Margaret; Eberle, Miranda; Woodbury, Seth; Mauser, Ava; Gregory, Jason; Zhang, Boya; Niemann, David; Herremans, Jacob; Ma, Peter X.; Lahann, Joerg; Weivoda, Megan; Mishina, Yuji; Greineder, Colin F.. The article conveys some information:

Acidic pH is critical to the function of the gastrointestinal system, bone-resorbing osteoclasts, and the endolysosomal compartment of nearly every cell in the body. Non-invasive, real-time fluorescence imaging of acidic microenvironments represents a powerful tool for understanding normal cellular biol., defining mechanisms of disease, and monitoring for therapeutic response. While com. available pH-sensitive fluorescent probes exist, several limitations hinder their widespread use and potential for biol. application. To address this need, we developed a novel library of pH-sensitive probes based on the highly photostable and water-soluble fluorescent mol., Rhodamine 6G. We demonstrate versatility in terms of both pH sensitivity (i.e., pKa) and chem. functionality, allowing conjugation to small mols., proteins, nanoparticles, and regenerative biomaterial scaffold matrixes. Furthermore, we show preserved pH-sensitive fluorescence following a variety of forms of covalent functionalization and demonstrate three potential applications, both in vitro and in vivo, for intracellular and extracellular pH sensing. Finally, we develop a computation approach for predicting the pH sensitivity of R6G derivatives, which could be used to expand our library and generate probes with novel properties. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO

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HPLC of Formula: 100-83-4In 2020 ,《New Copper Complex on Fe3O4 Nanoparticles as a Highly Efficient Reusable Nanocatalyst for Synthesis of Polyhydroquinolines in Water》 appeared in Catalysis Letters. The author of the article were Ashraf, Muhammad Aqeel; Liu, Zhenling; Peng, Wan-Xi; Gao, Caixia. The article conveys some information:

A simple, environmentally friendly and economical route for the preparation of a novel copper-Schiff-base organometallic complex on Fe3O4 nanoparticles (Fe3O4@Schiff-base-Cu) using an inexpensive and simple method and available materials is presented. This magnetic nanocatalyst was comprehensively characterized using Fourier transform IR spectroscopy (FT-IR), X-Ray Diffractometer (XRD), inductively coupled plasma at. emission spectroscopy (ICP), energy-dispersive X-ray spectroscopy (EDS), SEM (SEM), X-ray mapping, thermogravimetric anal. (TGA) and vibrating sample magnetometer (VSM) anal. In the second stage, the catalytic activity of this catalyst was studied in the synthesis of polyhydroquinoline derivatives I [R = Ph, 4-ClC6H4, 3,4-(HO)2C6H3, etc.] via Hantzsch reaction of aryl aldehydes RCHO, dimedone, Et acetoacetate and ammonium acetate in water as a green solvent. A simple preparation of the catalyst from the com. available materials, high catalytic activity, simple operation, short reaction times, high yields and use of green solvent can be regarded as advantages of this protocol. In addition, this nanocatalyst was easily recovered using external magnet and reused for several times without significant loss of its catalytic efficiency. Finally, the leaching, heterogeneity and stability of Fe3O4@Schiff-base-Cu were studied by hot filtration test and ICP technique. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4HPLC of Formula: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.HPLC of Formula: 100-83-4

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