Tag: 100-200

In 2022,Hong, Xianfang; Guo, Jingcheng; Liu, Jinhua; Cao, Wei; Wei, Chenlong; Zhang, Ye; Zhang, Xiaoxiang; Fu, Zhenqian published an article in Science China: Chemistry. The title of the article was 《Organocatalytic dynamic kinetic resolution of N-arylindole lactams: Atroposelective construction of axially chiral amino acids bearing a C-N chiral axis》.HPLC of Formula: 100-55-0 The author mentioned the following in the article:

Organocatalytic dynamic kinetic resolution of configurationally labile cyclic mols. represents one of the most efficient methods for the atroposelective construction of axially chiral mols. bearing a tetra-ortho-substituted chiral axis. Notably, this privileged strategy is limited to constructing a C-C chiral axis. Herin, organocatalytic dynamic kinetic resolution of configurationally labile N-arylindole lactams has been successfully achieved for the first time, allowing for access to a structurally diverse set of axially chiral N-arylindole amino esters with a tetra-ortho-substituted C-N chiral axis in excellent yields and atroposelectivities. In addition to the N-arylindole skeleton, N-aryl thieno[3,2-b]pyrrole, furo[3,2-b]pyrrole, and pyrrolo[2,3-b]pyridine skeletons are also compatible with this transformation. This transition-metal-free facile strategy features a broad substrate scope, mild reaction conditions, easy scale-up and excellent atom economy. Several potentially valuable mols., such as axially chiral peptides, were efficiently generated from the resulting configurationally stable axially-chiral N-arylindole amino esters, demonstrating the power of this strategy. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-55-0

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Alcohol – Wikipedia,
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Hu, Yongke; Xia, Jiawei; Li, Jin; Li, Huaju; Li, Yanxing; Li, Shaozhong; Duanmu, Chuansong; Li, Bindong; Wang, Xin published an article in 2021. The article was titled 《Direct oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions》, and you may find the article in Journal of Materials Science.Related Products of 100-55-0 The information in the text is summarized as follows:

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Related Products of 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Zijun; Tan, Yuqi; Shen, Xiang; Ivlev, Sergei; Meggers, Eric published an article in 2021. The article was titled 《Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion》, and you may find the article in Science China: Chemistry.Electric Literature of C9H11NO The information in the text is summarized as follows:

Herein, a general intramol. C(sp3)-H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral β-amino alcs was reported. Specifically, the ring-closing C(sp3)-H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee. The method was applicable to benzylic, allylic, and propargylic C-H bonds and can even be applied to completely non-activated C (sp3)-H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates was subsequently be hydrolyzed to obtain chiral β-amino alcs. The method was very practical as the catalyst was easily synthesized on a gram scale and was recycled after the reaction for further use. The synthetic value of the new method was demonstrated with the asym. synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral β-amino alcs. that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C9H11NO

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Alcohol – Wikipedia,
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He, Junhua; Wu, Xuehui; Zhou, Yue; Chen, Jiahui published their research in Journal of Food Biochemistry in 2021. The article was titled 《Effects of different preheat treatments on volatile compounds of camellia (Camellia oleifera Abel.) seed oil and formation mechanism of key aroma compounds》.Computed Properties of C6H7NO The article contains the following contents:

In this study, volatile compounds of camellia seed oil (CSO) prepared by different preheat treatments (microwave, frying, roasting, and steaming) were identified by headspace solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS). A total of 107 volatile compounds were identified in CSO samples, including aldehydes (16), alcs. (6), ketones (3), heterocyclic compounds (26), esters (23), hydrocarbons (15), and others (17). Among them, untreated CSO is mainly hydrocarbons, roasting and steaming CSO are mainly aldehydes and alcs., while microwave and roasting CSO are dominated by aldehydes and heterocyclic compounds Fourteen volatile compounds with high relative odor activity value (ROAV ≥ 1) were selected as key aroma compounds (KACs). Principal Component Anal. (PCA) and Cluster Anal. (CA) were performed on 14 KACs, which determined that there were 3, 3, 3, 7, and 6 characteristic aroma compounds (CACs) in untreated, microwaved, frying, roasting, and steaming CSO. Addnl., the potential formation pathways and mechanism of KACs were discussed. Flavor is an important factor for consumers to choose edible oils, and it is also one of the indicators of oil quality. Different flavors of CSO can cater to the needs of different consumers. CSO manufactories can choose different preheat treatments to produce CSO with various flavors to meet different customer’s need. CSO with new flavor can extend its market share and increase its value.3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C6H7NO

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Alcohol – Wikipedia,
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Gulati, Anmol; Yeung, Charles S.; Lapointe, Blair; Kattar, Solomon D.; Gunaydin, Hakan; Scott, Jack D.; Childers, Kaleen K.; Methot, Joey L.; Simov, Vladimir; Kurukulasuriya, Ravi; Pio, Barbara; Morriello, Greg J.; Liu, Ping; Tang, Haiqun; Neelamkavil, Santhosh; Wood, Harold B.; Rada, Vanessa L.; Ardolino, Michael J.; Yan, Xin Cindy; Palte, Rachel; Otte, Karin; Faltus, Robert; Woodhouse, Janice; Hegde, Laxminarayan G.; Ciaccio, Paul; Minnihan, Ellen C.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.; Ellis, J. Michael published their research in RSC Medicinal Chemistry in 2021. The article was titled 《Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors》.Computed Properties of C3H8ClNO The article contains the following contents:

The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for Parkinson′s disease (PD). Herein, we describe the discovery and evolution of a picolinamide-derived lead series. Our initial optimization efforts aimed at improving the potency and CLK2 off-target selectivity of compound 1 by modifying the heteroaryl C-H hinge and linker regions. This resulted in compound 12 which advanced deep into our research operating plan (ROP) before heteroaryl aniline metabolite 14 was characterized as Ames mutagenic, halting its progression. Strategic modifications to our ROP were made to enable early de-risking of putative aniline metabolites or hydrolysis products for mutagenicity in Ames. This led to the discovery of 3,5-diaminopyridine 15 and 4,6-diaminopyrimidine 16 as low risk for mutagenicity (defined by a 3-strain Ames neg. result). Anal. of key matched mol. pairs 17 and 18 led to the prioritization of the 3,5-diaminopyridine sub-series for further optimization due to enhanced rodent brain penetration. These efforts culminated in the discovery of Et trifluoromethyl pyrazole 23 with excellent LRRK2 potency and expanded selectivity vs. off-target CLK2. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Alcohol – Wikipedia,
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Cadena-Cruz, Jose Eduardo; Guaman-Ortiz, Luis M.; Romero-Benavides, Juan Carlos; Bailon-Moscoso, Natalia; Murillo-Sotomayor, Kevin E.; Ortiz-Guaman, Nadia V.; Heredia-Moya, Jorge published their research in BMC Chemistry in 2021. The article was titled 《Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities》.SDS of cas: 100-83-4 The article contains the following contents:

The 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I (R = Ph, 3,4-dihydroxyphenyl, 2-nitrophenyl, etc.) were synthesized by a three-component reaction of 3-methyl-1-phenyl-5-pyrazolone with various benzaldehydes RCHO catalyzed by sodium acetate at room temperature The structures of all synthesized compounds were characterized by physicochem. properties and spectral means (IR and NMR) and evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I were synthesized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound I (R = 3,4-dihydroxyphenyl) proved to be a very potent scavenger with an IC50 of 6.2 ± 0.6μM and exhibited an IC50 of 9.9 ± 1.1μM against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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Alcohol – Wikipedia,
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《Deorphanization of an odorant receptor revealed new bioactive components for green mirid bug Apolygus lucorum (Hemiptera: Miridae)》 was written by Khashaveh, Adel; An, Xingkui; Shan, Shuang; Xiao, Yong; Wang, Qi; Wang, Shanning; Li, Zibo; Geng, Ting; Gu, Shaohua; Zhang, Yongjun. Application In Synthesis of 5-Hexen-1-ol And the article was included in Pest Management Science in 2020. The article conveys some information:

BACKGROUND : The Apolygus lucorum is one of the most destructive insect pests in China with a wide range of host plants. Interaction of A. lucorum with surrounding environment heavily relies on chem. communication. Deorphanization of receptors involved in odors detection elevates our understanding of the olfactory system of this pest and may help to develop a chem. ecol.-based control strategy. RESULTS : AlucOR80, an odorant receptor (OR) in A. lucorum was newly cloned. Gene expression anal. showed that this receptor was mainly expressed in the antennae and head of both sexes but with a male bias. The Xenopus oocytes heterologous expression system coupled with the two-electrode voltage-clamp (TEVC) recording revealed that AlucOR80 was tuned to 21 selected compounds Furthermore, electroantennogram (EAG) tests confirmed that all 21 ligands of AlucOR80 were electrophysiol. active in antennae of both sexes. Behavioral trials in a three-cage olfactometer indicated that 16 compounds were behaviorally active, amongst which, 12 components were attractants and four components were repellents for adults of both sexes. Bu butyrate and Di-Me disulfide (DMDS) were the strongest attractive and repellent compounds, resp. Importantly, we found the repellency of 1, 8-Cineole, S-(-)-cis-Verbenol and (1S)-(1)-beta-Pinene against adults of A. lucorum. CONCLUSION : Although AlucOR80 is a general OR, may play important role in the olfactory perception of A. lucorum. Screening of AlucOR80 ligands by behavioral assay provided valuable insights by which olfactory-based management approaches could be developed by utilizing the behaviorally active components as attractants or repellents. © 2019 Society of Chem. Industry The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application In Synthesis of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Fiber optic particle plasmon resonance immunosensor for rapid and sensitive detection of methamphetamine based on competitive inhibition》 was written by Chang, Ting-Chou; Chiang, Chang-Yue; Lin, Min-Hsiu; Chen, I-Kuang; Chau, Lai-Kwan; Hsu, Day-Shin; Shieh, Szu-Shan; Kuo, Chin-Jung; Wang, Shau-Chun; Chen, Yung-fou. Electric Literature of C6H15NO And the article was included in Microchemical Journal in 2020. The article conveys some information:

We report the study of methamphetamine (MA) sensing in urine samples using fiber optic particle plasmon resonance (FOPPR) biosensor. This approach is intended for on-site anal. of low-mol.-weight compounds High sensitivity detection of MA at ultra-low concentration is realized by using a competitive inhibition immunoreaction scheme based on the competition of free MA in solution for anti-MA mols. that bind to the bovine serum albumin (BSA)-MA conjugate on the gold nanoparticle surface. With the BSA-MA functionalized sensor fiber, in the presence of a fixed concentration of anti-MA and various concentrations of MA in sample, the change of transmitted light intensity through the sensor fiber relative to that in a buffer solution decreases when the MA concentration increases because of the inhibition effect of MA. Based on this sensing method, the MA-functionalized FOPPR biosensor is capable for determining the concentration of MA with high sensitivity and wide linear dynamic range of 1-1000 ng/mL. The limit of detection for MA is 0.16 ng/mL. In addition, the MA functionalized FOPPR biosensor can detect MA in diluted human urine samples without nonspecific adsorption interference.6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

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Alcohol – Wikipedia,
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《Diphenyl cyclopropenone-centered polymers for site-specific CO-releasing and chain dissociation》 was published in Chinese Chemical Letters in 2020. These research results belong to Shao, Chenchen; Duan, Hanyi; Min, Yuqin; Zhang, Xinghong. Reference of 3-Bromopropan-1-ol The article mentions the following:

The synthesis and stimuli-responsiveness of a di-Ph cyclopropenone (DPCP)-centered poly(Me acrylate) (PMA) are presented. DPCP-centered PMA could release carbon monoxide (CO) upon UV light in a switched on-and-off manner. The CO-releasing process can be reported by the variations in photoluminescence spectra. In addition, DPCP moiety covalently embedded in the crosslinked polyurethane could also release CO under UV light. Of special, DPCP-centered PMA in solution was selectively dissociated at the phenol ester bond under the ultrasound, and a force-induced hydrolyzation reaction was revealed by D2O exchanging 1H NMR spectra. The kinetic study reveals that small quantity of water could enhance the chain scission rate. This work provides a DPCP-centered polymer for site-specific CO-releasing and chain dissociation In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

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Alcohol – Wikipedia,
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《A PANI-Fe3O4@ZnO nanocomposite: a magnetically separable and applicable catalyst for the synthesis of chromeno-pyrido[d]pyrimidine derivatives》 was published in RSC Advances in 2020. These research results belong to Chaghari-Farahani, Fatemeh; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza. Name: 3-Hydroxybenzaldehyde The article mentions the following:

Herein green, practical, PANI-Fe3O4@ZnO-nanocomposite-catalyzed cyclocondensation reactions involving 4-aminocoumarin, 1,3-dimethylbarbituric acid, and aromatic aldehydes in an aqueous medium at room temperature to synthesize 9,11-dimethyl-7-aryl-6H-chromeno[3′,4′:5,6]pyrido[2,3-d]pyrimidine-6,8,10(9H,11H)triones I (Ar = C6H5, 3-HOC6H4, 4-BrC6H4, etc.) is reported. This research aims to provide an applicable and high-yield protocol that follows the principles of green chem., with the use of water as an environmentally benign medium and the PANI-Fe3O4@ZnO nanocomposite as a magnetically recoverable catalyst. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts