Tag: 100-200

In 2019,Organometallics included an article by Eberhardt, Nathan A.; Wellala, Nadeesha P. N.; Li, Yingze; Krause, Jeanette A.; Guan, Hairong. Safety of (4-Bromophenyl)methanol. The article was titled 《Dehydrogenative Coupling of Aldehydes with Alcohols Catalyzed by a Nickel Hydride Complex》. The information in the text is summarized as follows:

A nickel hydride complex, {2,6-(iPr2PO)2C6H3}NiH, has been shown to catalyze the coupling of RCHO and R’OH to yield RCO2R’ and RCH2OH, where the aldehyde also acts as a hydrogen acceptor and the alc. also serves as the solvent. Functional groups tolerated by this catalytic system include CF3, NO2, Cl, Br, NHCOMe, and NMe2, whereas phenol-containing compounds are not viable substrates or solvents. The dehydrogenative coupling reaction can alternatively be catalyzed by an air-stable nickel chloride complex, {2,6-(iPr2PO)2C6H3}NiCl, in conjunction with NaOMe. Acids in unpurified aldehydes react with the hydride to form nickel carboxylate complexes, which are catalytically inactive. Water, if present in a significant quantity, decreases the catalytic efficiency by forming {2,6-(iPr2PO)2C6H3}NiOH, which causes catalyst degradation On the other hand, in the presence of a drying agent, {2,6-(iPr2PO)2C6H3}NiOH generated in situ from {2,6-(iPr2PO)2C6H3}NiCl and NaOH can be converted to an alkoxide species, becoming catalytically competent. The proposed catalytic mechanism features aldehyde insertion into the nickel hydride as well as into a nickel alkoxide intermediate, both of which have been exptl. observed Several mechanistically relevant nickel species including {2,6-(iPr2PO)2C6H3}NiOC(O)Ph, {2,6-(iPr2PO)2C6H3}NiOPh, and {2,6-(iPr2PO)2C6H3}NiOPh·HOPh have been independently synthesized, crystallog. characterized, and tested for the catalytic reaction. While phenol-containing mols. cannot be used as substrates or solvents, both {2,6-(iPr2PO)2C6H3}NiOPh and {2,6-(iPr2PO)2C6H3}NiOPh·HOPh are efficient in catalyzing the dehydrogenative coupling of PhCHO with EtOH. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Safety of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Safety of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Alcohol – Wikipedia,
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In 2019,Dalton Transactions included an article by Wang, Hui-Sheng; Long, Qiao-Qiao; Hu, Zhao-Bo; Yue, Lin; Yang, Feng-Jun; Yin, Cheng-Ling; Pan, Zhi-Quan; Zhang, Yi-Quan; Song, You. Category: alcohols-buliding-blocks. The article was titled 《Synthesis, crystal structures and magnetic properties of a series of chair-like heterometallic [Fe4Ln2] (Ln = GdIII, DyIII, HoIII, and ErIII) complexes with mixed organic ligands》. The information in the text is summarized as follows:

Four chair-like hexanuclear Fe-Ln complexes containing mixed organic ligands, namely, [Fe4Ln2{(py)2CO2}4(pdm)2(NO3)2(H2O)2Cl4]·xCH3CN·yH2O (Ln = GdIII (1, x = 1, y = 0), DyIII (2, x = 1, y = 1), HoIII (3, x = 0, y = 2), and ErIII (4, x = 1, y = 3); (py)2CO2H2 = the gem-diol form of di-2-pyridyl ketone and pdmH2 = 2,6-pyridinedimethanol) were obtained by employing di-2-pyridyl ketone and 2,6-pyridinedimethanol reacting with FeCl3 and Ln(NO3)3 in MeCN. The structures of 1-4 are similar to each other except for the number of lattice solvent mols. Four FeIII and two LnIII in these complexes comprise a chair-like core with the body constructed by four FeIII ions and the end constructed by two LnIII ions. Among the four compounds, 2 shows field-induced single mol. magnet behavior as revealed by a.c. magnetic susceptibility studies, with the effective energy barrier and the pre-exponential factor of 22.07 K and 8.44 × 10-7 s, resp. Ab initio calculations indicated that, among 2_Dy, 3_Ho and 4_Er fragments, the energy gap between the lowest two spin-orbit states for 2_Dy is the largest, while the tunneling gap for 2 is the smallest. These might be the reasons for complex 2 exhibiting SMM behavior. Addnl., the orientations of the magnetic anisotropy of DyIII in 2 were obtained by electrostatic calculations and ab initio calculations, both indicating that the directions of the main magnetic axis of Dy1 ions are almost aligned along Dy1-O5 (O5 from the pdm2- ligand). In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: alcohols-buliding-blocks

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In 2019,Chemistry of Materials included an article by Das, Gobinda; Nagaraja, Sharadhi; Sridurai, Vimala; Shinde, Digambar B.; Addicoat, Matthew; Prakasam, Thirumurugan; Gandara, Felipe; Ravaux, Florent; Sharma, Sudhir Kumar; Nair, Geetha G.; Lai, Zhiping; Jagannathan, Ramesh; Olson, Mark A.; Trabolsi, Ali. Application In Synthesis of 2,6-Pyridinedimethanol. The article was titled 《Redox-Triggered Buoyancy and Size Modulation of a Dynamic Covalent Gel》. The information in the text is summarized as follows:

The development of stimuli-responsive materials capable of transducing external stimuli into mech. and phys. changes has always been an intriguing challenge and an inspiration for scientists. Several stimuli-responsive gels have been developed and applied to biomimetic actuators or artificial muscles. Redox-active actuators in which the mech. motion is driven chem. or electrochem. have attracted much interest, and their actuation mechanism is based on the change in electrostatic repulsion and the loss or gain of counterions to balance newly formed charges. Actuation can also be promoted by changing the hydration state of the material, leading to the release/adsorption of water mols. from the network, inducing a direct shrinking/swelling of the material, resp. A cationic crystalline dynamic covalent gel was obtained via the formation of imine bonds between 2,6-diformyl pyridine and triamino guanidinium chloride. The gel exhibits a reversible contraction/expansion behavior in response to base (oxidation, -H+, -e-) and acid (reduction +H+, +e-), resp. The oxidation induces a color change and contraction of the gel with a concomitant increase in its strength. As synthesized, the cationic gel is denser than water and sinks when placed in water. Upon oxidation, the radical cationic gel expels water mols., rendering it less dense than water and the gel is propelled to the surface without any loss of its structural integrity. These results demonstrate that a careful choice of amine and aldehyde linkers can give rise to imine-linked materials capable of tolerating and resisting extreme acidic and basic conditions while performing work. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 2,6-Pyridinedimethanol

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Alcohol – Wikipedia,
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In 2019,Bioorganic Chemistry included an article by Choi, Wonbeen; Villegas, Valente; Istre, Hannah; Heppler, Ben; Gonzalez, Niki; Brusman, Nicole; Snider, Lindsey; Hogle, Emily; Tucker, Janelle; Onate, Alma; Onate, Sandra; Ma, Lili; Paula, Stefan. HPLC of Formula: 26153-38-8. The article was titled 《Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties》. The information in the text is summarized as follows:

Inhibitors of the enzyme xanthine oxidase (XO) with radical scavenging properties hold promise as novel agents against reperfusion injuries after ischemic events. By suppressing the formation of damaging reactive oxygen species (ROS) by XO or scavenging ROS from other sources, these compounds may prevent a buildup of ROS in the aftermath of a heart attack or stroke. To combine these two properties in a single mol., we synthesized and characterized the non-purine XO inhibitor caffeic acid phenethylester (CAPE) and 19 derivatives using a convenient microwave-assisted Knoevenagel condensation protocol. Varying systematically the number and positions of the hydroxyl groups at the two Ph rings, we derived structure-activity relationships based on exptl. determined XO inhibition data. Mol. docking suggested that critical enzyme/inhibitor interactions involved π-π interactions between the phenolic inhibitor ring and Tyr914, hydrogen bonds between inhibitor hydroxyl groups and Glu802, and hydrophobic interactions between the CAPE Ph ring and non-polar residues located at the entrance of the binding site. To effectively scavenge the stable radical DPPH, two hydroxyl groups in 1,2- or 1,4-position at the Ph ring were required. Among all compounds tested, E-Ph 3-(3,4-dihydroxyphenyl)acrylate, a CAPE analog without the Et tether, showed the most promising properties. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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Alcohol – Wikipedia,
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Related Products of 100-83-4In 2019 ,《[AcMIM]FeCl4: A Magnetically Separable Organocatalyst for the Clean Synthesis of Tetrahydrobenzo[b]pyran Derivatives》 was published in Current Organocatalysis. The article was written by Saha, Arijit; Payra, Soumen; Asatkar, Archana; Patel, Ashok Raj; Banerjee, Subhash. The article contains the following contents:

A facile and convenient methodol. has been developed for the synthesis of bio-active tetrahydrobenzo[b]pyran derivatives I (R = H, 3-Cl, 4-NO2, 3,4-(OCH3)2, etc.) using [AcMIm]FeCl4 ionic liquid as an sufficient and reusable magnetically separable oganocatalyst under environment-benign conditions. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Related Products of 100-83-4

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Alcohol – Wikipedia,
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Product Details of 1195-59-1In 2021 ,《Azine-N-oxides as effective controlling groups for Rh-catalyzed intermolecular alkyne hydroacylation》 was published in Chemical Science. The article was written by Moseley, Daniel F.; Kalepu, Jagadeesh; Willis, Michael C.. The article contains the following contents:

Azine N-oxide substituted aldehydes are used as highly effective substrates with good reactivity for intermol. hydroacylation of alkynes. Employing a Rh(I)-catalyst, a mild and scalable aldehyde C-H activation, that permits the coupling with unactivated terminal alkynes was achieved in good yields and with high regioselectivities (up to >20 : 1 l:b). Both substrates can tolerate a broad variety of functional groups. The reaction can also be applied to diazine aldehydes that contain a free N-lone pair. Conversion of the hydroacylation products to the corresponding azine, through a one-pot hydroacylation/deoxygenation sequence was also demonstrated. A one-pot hydroacylation/cyclization, using N-Boc propargylamine, addnl. leads to the synthesis of a bidentate pyrrolyl ligand. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Product Details of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1195-59-1

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Alcohol – Wikipedia,
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Application In Synthesis of 2-Hydroxyphenylboronic acidIn 2020 ,《Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems》 was published in Organic Letters. The article was written by DeRatt, Lindsey G.; Lawson, Edward C.; Kumar, Kiran; Hwang, Soyon S.; DesJarlais, Renee L.; Kuduk, Scott D.. The article contains the following contents:

A tandem one-pot reaction featuring a cross-coupling followed by an intramol. oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construction providing diverse multicyclic ring systems with a pendant hydroxymethyl handle for further elaboration. This approach constitutes a convergent method for rapid access to various scaffolds. Furthermore, a comparison of computed low-energy conformers is presented to rationalize instances in which cyclization was not observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringApplication In Synthesis of 2-Hydroxyphenylboronic acid

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Alcohol – Wikipedia,
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Category: alcohols-buliding-blocksIn 2022 ,《δ-C-H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor》 was published in Organic Letters. The article was written by Herron, Alastair N.; Hsu, Ching-Pei; Yu, Jin-Quan. The article contains the following contents:

Herein, new hydrazonyl carboxylic acids RN(S(O)2R1)N=C(Me)C(O)OH (R = octyl, 2-(adamantan-1-yl)ethyl, 4-methylpentyl, etc.; R1 = 4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl, 4-(trifluoromethyl)phenyl) precursor to nitrogen-centered radicals and its application toward remote C-H fluorination and chlorination reactions of sulfonyl-protected alkyl amines R1S(O)2NHR2 (R2 = 4-fluorooctyl, 2-(2-fluorocyclobutyl)ethyl, 4-fluoro-4-methylpentyl, etc.) via 1,5-HAT were disclosed.6-Aminohexan-1-ol(cas: 4048-33-3Category: alcohols-buliding-blocks) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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Electric Literature of C7H6O2In 2020 ,《Preparation of a trihydrazinotriazine-functionalized core-shell nanocatalyst as an extremely efficient catalyst for the synthesis of benzoxanthenes》 was published in Materials Today Chemistry. The article was written by Rahimi, J.; Maleki, A.. The article contains the following contents:

Herein, trihydrazinotriazine (THDT)-coated Fe3O4@SiO2 as a novel amino-functionalized magnetic nanocompostie was introduced. The nanocatalyst was fully characterized and proved the morphol. and magnetic property of the nanoparticles by using essential analyses. The basic attributed of the amino-rich porous surface of the nanocomposite provided a desirable environment for enhancing various reaction conditions. Several benzoxanthenes were synthesized using Fe3O4@SiO2-THDT nanocatalysts, to examine the applicability of the nanocatalyst in organic reactions. The nanocomposite successfully improved the reaction conditions and provided the benzoxanthenes in an environmentally friendly procedure, which afforded product in excellent yields (80-96%) and reduced time. The nanomagnetic catalyst was easily recovered after each trial by using an external magnet. After six successive runs, the loss of catalytic activity of the nanocomposite was negligible. Finally, a plausible mechanism for the preparation of the benzoxanthenes derivatives using the THDT-functionalized core-shell magnetic nanocatalyst was propounded . In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Electric Literature of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Electric Literature of C7H6O2

Referemce:
Alcohol – Wikipedia,
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Synthetic Route of C6H7BO3In 2020 ,《A Bi-functional Second Coordination Sphere for Electrocatalytic CO2 Reduction: The Concerted Improvement by a Local Proton Source and Local Coulombic Interactions》 appeared in Chemistry Letters. The author of the article were Matsubara, Yasuo; Shimojima, Miho; Takagi, Shohei. The article conveys some information:

A homogeneous rhenium(I) electrocatalyst possessing hydroxy and ammonio groups in the second coordination sphere is reported for the reduction of carbon dioxide (CO2) to carbon monoxide, wherein the former and latter groups induce a high local concentration of protons and local coulombic interactions with a metallocarboxylate reaction intermediate, resp. In a comparison with precedent catalysts possessing single functional groups in the spheres, we found that the catalyst exhibits a concerted improvement over these single functional groups in the efficiencies of catalysis, based on exptl. standard electrode potentials for the reduction in aqueous N,N-dimethylformamide or acetonitrile solutions and the equilibrium potentials depending on the catalytic systems.2-Hydroxyphenylboronic acid(cas: 89466-08-0Synthetic Route of C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Synthetic Route of C6H7BO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts