Tag: 100-200

Reddy, Sravanthi S.; Pal, Sunit; Ghosh, Sudip; Prabhakaran, Erode N. published their research in ChemBioChem in 2021. The article was titled 《Hydrogen Bond Surrogate-Constrained Dynamic Antiparallel β-Sheetsã€?Synthetic Route of C3H7BrO The article contains the following contents:

Antiparallel β-sheets are important secondary structures within proteins that equilibrate with random-coil states; however, little is known about the exact dynamics of this process. Here, the first dynamic β-sheet models that mimic this equilibrium have been designed by using an H-bond surrogate that introduces constraint and torque into a tertiary amide bond. 2D NMR data sufficiently reveal the structure, kinetics, and thermodn. of the folding process, thereby leading the way to similar anal. in isolated biol. relevant β-sheets. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Synthetic Route of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Synthetic Route of C3H7BrO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Morack, Tobias; Onneken, Carina; Nakakohara, Hiroshi; Mueck-Lichtenfeld, Christian; Gilmour, Ryan published their research in ACS Catalysis in 2021. The article was titled 《Enantiodivergent Prenylation via Deconjugative Isomerizationã€?Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The article contains the following contents:

A light-enabled deconjugative isomerization of activated alkenes containing an aryl ketone antenna, e.g., (E)-2,4-dimethyl-1-phenylpent-2-en-1-one is disclosed through sequential geometric isomerization/hydrogen atom transfer (HAT)/protonation. Detailed mechanistic analyses have guided the development of an enantioselective variant of this atom economical process (up to 99% and 95:5 e.r.). Importantly, the chiral pool quasi-enantiomers quinine and quinidine serve as effective catalysts, thereby rendering this addition to the chiral drug discovery module portfolio enantiodivergent. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sohar, Pal; Lazar, Janos; Bernath, Gabor published an article on February 28 ,1985. The article was titled 《Saturated heterocycles. 67. Isolation and structure elucidation of the by-product formed in the aminomethylation of α-methylstyreneã€? and you may find the article in Chemische Berichte.Product Details of 55218-73-0 The information in the text is summarized as follows:

Aminomethylation of α-methylstyrene gave pyridine derivative I (R = H) along with a significant amount of its hydroxymethyl derivative (I; R = CH2OH) (II). The structure of II was determined spectrally by conversion to its aromatic, acyl, and N-Me derivative In the part of experimental materials, we found many familiar compounds, such as (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Product Details of 55218-73-0)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Product Details of 55218-73-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Qiu; Liao, Zhehui; Liu, Zhili; Wen, Jiajia; Li, Chenguang; He, Jiamin; Deng, Jiazhen; Cen, Shan; Cao, Tongxiang; Zhou, Jinming; Zhu, Shifa published their research in Nature Communications on December 31 ,2022. The article was titled 《Divergent synthesis of benzazepines and bridged polycycloalkanones via dearomative rearrangementã€?Quality Control of 4,4-Diethoxybutan-1-amine The article contains the following contents:

Here, a catalyst-free dearomative rearrangement of o-nitrophenyl alkynes I (R = Ts, Ms; R1 = H, Me, Cl, methoxycarbonyl, etc.; R2 = H, Et, Ph; R3 = H, Cl, F, OMe, methoxycarbonyl; R1R3 = -O-CH2-O-; R4 = H, F; X = C, N; n = 2,3) and II (R = Ts, Ms, Boc; R5 = H, Me; R1 R5 = -CH=CH-CH=CH-) is successfully established by leveraging the remote oxygen transposition and a weak N-O bond acceleration. This reaction features high atom-, step- and redox-economy, which provides a divergent entry to a series of biol. important benzazepines III and bridged polycycloalkanones IV. The reaction is proposed to proceed through a tandem oxygen transfer cyclization/(3 + 2) cycloaddition/(homo-)hetero-Claisen rearrangement reaction. The resulting polycyclic system is richly decorated with transformable functionalities, such as carbonyl, imine and diene, which enables diversity-oriented synthesis of alkaloid-like polycyclic frameworks e.g., V. The experimental part of the paper was very detailed, including the reaction process of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Quality Control of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHRâ€? to form imines (R2C=NRâ€?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Quality Control of 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2020,RSC Advances included an article by Sharma, Vishal R.; Mehmood, Arshad; Janesko, Benjamin G.; Simanek, Eric E.. Name: 4,4-Diethoxybutan-1-amine. The article was titled 《Efficient syntheses of macrocycles ranging from 22-28 atoms through spontaneous dimerization to yield bis-hydrazonesã€? The information in the text is summarized as follows:

Acid treatment of a triazine displaying both a tethered acetal and BOC-protected hydrazine group leads to spontaneous condensation to yield macrocyclic dimers I (n = 1, 2; m = 1, 2, 3) in excellent yields and purity. By varying the length of the tether-the condensation product of an amino acid and amino acetal-rings comprising 22-28 atoms can be accessed. Glycine and β-alanine were used for the amino acid. The amino acetal comprised 2, 3 or 4 carbon atoms in the backbone. High-performance liquid chromatog. (HPLC) was employed to assess purity as well as to fingerprint the six homodimeric products. By combining the protected monomers and subjecting them to acid, mixtures of homodimers and heterodimers are obtained. When all six protected monomers are combined, at least 14 of the 21 theor. dimeric products are observed by HPLC. Single crystal X-ray diffraction and solution NMR studies reveal the diversity of shapes available to these mols. In the experimental materials used by the author, we found 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Name: 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis of novel 2-(het)arylpyrrolidine derivatives and evaluation of their anticancer and anti-biofilm activityã€?was published in Molecules in 2019. These research results belong to Smolobochkin, Andrey; Gazizov, Almir; Sazykina, Marina; Akylbekov, Nurgali; Chugunova, Elena; Sazykin, Ivan; Gildebrant, Anastasiya; Voronina, Julia; Burilov, Alexander; Karchava, Shorena; Klimova, Maria; Voloshina, Alexandra; Sapunova, Anastasia; Klimanova, Elena; Sashenkova, Tatyana; Allayarova, Ugulzhan; Balakina, Anastasiya; Mishchenko, Denis. SDS of cas: 6346-09-4 The article mentions the following:

A library of novel 2-(het)arylpyrrolidine-1-carboxamides I [R = H, n-hexyl, 4-MeOC6H4, etc.; Ar = 4-hydroxy-6-methyl-pyran-2-one-3-yl, 4-hydroxycoumarin-3-yl, 1,3-benzodioxol-5-ol-6-yl, 6-chloro-4-((4-yl-3-hydroxyphenyl)amino)-5-nitrobenzo[c][1,2,5]oxadiazole 1-oxide] was obtained via a modular approach based on the intramol. cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds toward M-Hela tumor cell lines was twice that of reference drug tamoxifen, whereas cytotoxicity toward normal Chang liver cell did not exceed tamoxifen toxicity. In vivo studies showed that the number of surviving animals on day 60 of observation was up to 83% and increased life span (ILS) was up to 447%. Addnl., some pyrrolidine-1-carboxamides possessing a benzofuroxan moiety obtained were found to effectively suppress bacterial biofilm growth. Thus, these compounds were promising candidates for further development both as anti-cancer and anti-bacterial agents. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4SDS of cas: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).SDS of cas: 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptidesã€?was written by Duan, Jicheng; Du, Yun-Fei; Pang, Xiaobo; Shu, Xing-Zhong. Computed Properties of C6H15NOThis research focused onvinyl triflate alkyl sulfonate Nickel catalyst reductive cross coupling; peptide alkyl tosylate Nickel catalyst cross coupling. The article conveys some information:

The coupling reactions between vinyl/aryl and alkyl C-O electrophiles that can be derived from chem. feedstocks and naturally occurring functional groups was reported. This method provided an efficient approach to the synthesis of a wide range of functionalized, and/or secondary alkyl substituted cycloalkenes that are difficult to synthesize by conventional methods. The reaction proceeded with broad substrate scope, and tolerated various functional groups such as alc., aldehyde, ketone, ester, amide, alkene, alkyne, heterocycles, organotin and organosilicon compounds The synthetic utility of this method was demonstrated by providing facile access to important building blocks. The possibility to apply this method for late-stage modification of peptides was also demonstrated. A broad range of functionalized alkyl groups was selectively introduced into tyrosine in peptides via C-C bond formation, which was a challenge to the existing procedures. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Computed Properties of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cu/N-Oxyl-catalyzed aerobic oxidative esterification to oxalic acid diesters from ethylene glycol via highly selective intermolecular alcohol oxidationã€?was published in Green Chemistry in 2022. These research results belong to Morino, Yusuke; Yatabe, Takafumi; Suzuki, Kosuke; Yamaguchi, Kazuya. Safety of 3,3,3-Trifluoropropan-1-ol The article mentions the following:

One of the ideal green esterification reactions is aerobic oxidative esterification using only a stoichiometric amount of different alcs. via intermol. selective alc. oxidation followed by hemiacetal formation by the addition of the other alc. and hemiacetal oxidation to esters. However, oxalic acid diester synthesis via oxidative esterification has not been reported to date, possibly owing to the difficulty of selectivity control of intermol. alc. oxidation and the chelating effects of ethylene glycol-derived alcs./hemiacetals on inhibiting oxidation catalysts. Herein, using a CuCl/tetramethylethylenediamine/1,5-dimethyl-9-azanoradamantane N-oxyl catalyst, authors describe a highly efficient aerobic oxidative esterification reaction of ethylene glycol to various oxalic acid diesters via selective oxidation of ethylene glycol-derived alcs./hemiacetals even in the presence of other aliphatic primary alcs. Notably, the green reaction works well using an ideal stoichiometric ratio of ethylene glycol and primary/secondary alcs. Thorough exptl. investigation and theor. calculations revealed that highly selective oxidative esterification is enabled by the preferential bidentate coordination of ethylene glycol-derived alcs./hemiacetals to the Cu(II) species, followed by efficient two-electron/one-proton transfer. In the part of experimental materials, we found many familiar compounds, such as 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C6H12OIn 2019 ,《Hydrosulfonylation of Unactivated Alkenes by Visible Light Photoredox Catalysisã€?was published in Organic Letters. The article was written by Wang, Juan-Juan; Yu, Wei. The article contains the following contents:

The anti-Markovnikov hydrosulfonylation of unactivated alkenes with sodium sulfinates was realized via [Ir(dF(CF3)ppy)2(dtbbpy)]PF6-mediated visible light photoredox catalysis. The presence of an acid such as acetic acid is essential for the reaction to take place. A variety of unactivated alkenes can be transformed into sulfones with good yield and high regioselectivity using this reaction, which is proposed to proceed by a radical mechanism. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Computed Properties of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6-Aminohexan-1-olIn 2019 ,《Sensitization of Hypoxic Tumor to Photodynamic Therapy via Oxygen Self-Supply of Fluorinated Photosensitizersã€?was published in Biomacromolecules. The article was written by Liu, Zhiyong; Xue, Yudong; Wu, Mengsi; Yang, Guoliang; Lan, Minbo; Zhang, Weian. The article contains the following contents:

Photodynamic therapy (PDT) utilizes photosensitizers to convert innoxious oxygen to cytotoxic reactive oxygen species under an appropriate light thus induce cancer cells necrosis. However, PDT performs in an oxygen-dependent method to destroy cells while hypoxia is a feature for most solid tumors. To effectively improve the PDT effect against solid tumors, an oxygen self-supplying and pH-sensitive therapeutic nanoparticle (PTFC) has been developed by the self-assembly of a tetrakis(pentafluorophenyl) chlorin (TFPC)-conjugated block copolymer (POEGMA-b-P(DEAEMA-co-GMA)). PTFC nanoparticles can transport oxygen to tumor site with their accumulation in tumor on account of the good oxygen solubility, therefore relieving the oxygen deficiency of solid tumor and enhancing the PDT efficacy. It’s worth noting that the oxygen loading was realized by fluorinated photosensitizer itself. In addition, the phototoxicity of PTFC nanoparticles is greatly improved in an acidic aqueous environment due to the DEAEMA unit protonation, which not only enhanced the cellular uptake of nanoparticles but also weakened the aggregation of photosensitizers. Taking the hypoxia and acidic microenvironment of solid tumors, PTFC nanoparticles could be efficiently taken up and disassembled to release oxygen upon accumulated at tumor sites, thus significantly improving the PDT efficacy against solid tumors.6-Aminohexan-1-ol(cas: 4048-33-3Reference of 6-Aminohexan-1-ol) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Reference of 6-Aminohexan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts