Tag: 100-200

In 2018,ACS Catalysis included an article by Ociepa, Michal; Turkowska, Joanna; Gryko, Dorota. Recommanded Product: 27489-62-9. The article was titled 《Redox-Activated Amines in C(sp3)-C(sp) and C(sp3)-C(sp2) Bond Formation Enabled by Metal-Free Photoredox Catalysisã€? The information in the text is summarized as follows:

The amino group represents one of the most prevalent structural motifs in organic chem. Therefore, application of amines as alkylating agents in synthesis is highly compelling. Herein, we present a metal-free photoredox strategy for the formation of C(sp3)-C(sp) and C(sp3)-C(sp2) bonds from redox-activated primary amine derivatives The developed reaction of 2,4,6-triphenylpyridinium salts with alkynyl p-tolylsulfones, leading to functionalized alkynes, is easily scalable and offers broad substrate scope, high chemoselectivity, and mild conditions. Its potential is also highlighted by diversification of complex mol. scaffolds. Addnl., the approach is also suitable for synthesis of (E)-alkenes from vinyl Ph sulfones. Mechanistic studies contribute to the elucidation of unexpected differences in reactivity of primary and secondary alkyl substituted pyridinium salts.trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 27489-62-9

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In 2018,Meng, Fei-Fan; Xie, Jia-Hao; Xu, Yun-He; Loh, Teck-Peng published 《Catalytically asymmetric synthesis of 1,3-bis(silyl)propenes via copper-catalyzed double proto-silylations of polar enynesã€?ACS Catalysis published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

A copper-catalyzed (CuCl2/bpy) double proto-silylations of electron-deficient conjugated enynes RCH:CHCCX (X = CO2Me, CN, COCH2CH2Ph) with silylboronate PhMe2SiBpin to synthesize functional bis(silyl)propenes (E)-RCH(SiMe2Ph)CH:C(SiMe2Ph)CH2X (3; R = aryl, alkyl, thienyl) was developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with the enynes via cascade proto-silylations and yields the corresponding Z-specific bis(silyl)propene products in up to 98% yield and 95% ee. In addition, the use instead of bipyridines chiral enantiopure substituted and annelated 2-pyridyloxazoles resulted in enantioselective synthesis of the compounds (3) was also achieved. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHRâ€? to form imines (R2C=NRâ€?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2018,Cai, Pan; Fan, Hongxian; Cao, Shuo; Qi, Jian; Zhang, Songmei; Li, Gang published 《Electrochemical conversion of corn stover lignin to biomass-based chemicals between Cu/Ni-Mo-Co cathode and Pb/PbO2 anode in alkali solutionã€?Electrochimica Acta published the findings.COA of Formula: C7H6O3 The information in the text is summarized as follows:

In this study, we put forward an effective method of producing renewable chems. from corn stover lignin with electrochem. redox between the Cu/Ni-Mo-Co cathode and Pb/PbO2 anode in sodium hydroxide solution Cyclic voltammetry tests and polarization curves were conducted to research the electrochem. oxidation performance of Pb/PbO2 anode and electrocatalytic hydrogenation of Cu/Ni-Mo-Co in lignin alkali solution Fourier transform IR spectroscopy (FTIR) and high performance liquid chromatog. (HPLC) were used to characterize the functional groups and mol. weight distribution of the lignin residue. By GC-MS anal., it confirmed that there were 24 kinds of compounds in degradation products of alkali corn stover lignin. In addition to this, some com. value chems. including trans-ferulic acid, vanillin, 3-hydroxy-4-methoxyphenyl-ethanone, syringaldehyde, acetosyringone and 4-methoxy-3-methyl-phenol were also observed The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8COA of Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.COA of Formula: C7H6O3

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Abdel-Wahhab, Mosaad A.; El-Nekeety, Aziza A.; Hathout, Amal S.; Salman, Asmaa S.; Abdel-Aziem, Sekena H.; Sabry, Bassem A.; Hassan, Nabila S.; Abdel-Aziz, Mohamed S.; Aly, Soher E.; Jaswir, Irwandi published an article in Toxicon. The title of the article was 《Bioactive compounds from Aspergillus niger extract enhance the antioxidant activity and prevent the genotoxicity in aflatoxin B1-treated ratsã€?HPLC of Formula: 54-17-1 The author mentioned the following in the article:

This study aimed to identify the bioactive compounds of the Et acetate extract of Aspergillus niger SH2-EGY using GC-MS and to evaluate their protective role against aflatoxin B1 (AFB1)-induced oxidative stress, genotoxicity and cytotoxicity in rats. Six groups of male Sprague-Dawley rats were treated orally for 4 wk included the control group, AFB1-treated group (80μg/kg b.w); fungal extract (FE)-treated groups at low (140) or high dose (280) mg/kg b.w and the groups treated with AFB1 plus FE at the two tested doses. The in vivo results showed that AFB1 significantly increased serum ALT, AST, creatinine, uric acid, urea, cholesterol, triglycerides, LDL, carcinoembryonic antigen, alpha-fetoprotein, interleukin-6, Malondialdehyde, nitric oxide, Bax, caspase-3 and P53 mRNA expression, chromosomal aberrations and DNA fragmentation. It decreased serum TP, albumin, HDL, Bcl-2 mRNA expression, hepatic and renal TAC, SOD and GPx content and induced histol. changes in the liver and kidney. FE prevented these disturbances in a dosage-dependent manner. It could be concluded that A. niger SH2-EGY extract is safe a promising agent for pharmaceutical and food industries. In the experimental materials used by the author, we found rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1HPLC of Formula: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.HPLC of Formula: 54-17-1

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Category: alcohols-buliding-blocksOn November 20, 2020 ,《Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanismsã€?appeared in ACS Catalysis. The author of the article were Rammal, Fatima; Gao, Di; Boujnah, Sondes; Hussein, Aqeel A.; Lalevee, Jacques; Gaumont, Annie-Claude; Morlet-Savary, Fabrice; Lakhdar, Sami. The article conveys some information:

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions. In the experiment, the researchers used many compounds, for example, (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Category: alcohols-buliding-blocks)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Category: alcohols-buliding-blocks Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolOn March 31, 2022, Wan, Jiang; Jiang, Chun-Xiao; Tang, Yu; Ma, Guang-Lei; Tong, Ying-Peng; Jin, Ze-Xin; Zang, Yi; E. A. Osman, Ezzat; Li, Jia; Xiong, Juan; Hu, Jin-Feng published an article in Bioorganic Chemistry. The article was 《Structurally diverse glycosides of secoiridoid, bisiridoid, and triterpene-bisiridoid conjugates from the flower buds of two Caprifoliaceae plants and their ATP-citrate lyase inhibitory activitiesã€? The article mentions the following:

The ethanolic extracts of the dried flower buds of two Caprifoliaceae plants, Lonicera japonica and Abelia x grandiflora, showed considerable inhibitory activities against ATP (ATP)-citrate lyase (ACL), a new promising drug target for the treatment of metabolic disorders. Bioassay-guided purification in conjunction with HPLC-PDA profiling led to the isolation and characterization of thirty-five (1-35) and fourteen (1-14) structurally diverse compounds from the above two plant extracts, resp. Compounds 1-9 and 1-6 are previously undescribed glycosides. Their structures were elucidated on the basis of spectroscopic data, electronic CD (ECD), and single crystal X-ray diffraction analyses. In particular, lonicejaposide A (1) has an unprecedented skeleton generated through the coupling of C-7 in secologanin with C-2 in phenylacetaldehyde via an aldol condensation. Abeliflorosides A (1) and B (2) are hitherto unknown glycosides of triterpene and bisiridoid conjugates constructed through the formation of a 1,3-dioxane moiety. All the isolates were evaluated for their inhibitory activities against ACL. Compounds 9, 25-28, 31, 1, 2, and 14 displayed significant inhibitory effects, with IC50 values ranging from 0.1 to 14.2 μM. The interactions of selected compounds possessing different structure features (e.g., 9, 25, 31, and 2) with ACL were thereafter performed by employing mol. docking studies. In addition, compound 2, the most complex triterpene-bisiridoid conjugate glycoside reported herein, also inhibited acetyl-CoA carboxylase 1 (ACC1), with an IC50 value of 7.9 μM. The dried material of the flower buds of L. japonica (honeysuckle) is a well-known traditional oriental medicine (i.e., Flos Lonicerae Japonicae, FLJ) and has long been used in large quantities. The above findings not only provide new insights for the development of multipurpose utilization of FLJ in healthcare community, but also provide profitable clues indicating that the flower buds of A. x grandiflora might be a potential alternative to FLJ in the traditional Chinese medicine market.rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolOn June 4, 2020, Xie, Huijun; Chen, Xiaoyu; Li, Miaomiao; Aisa, Haji Akber; Yuan, Tao published an article in Tetrahedron Letters. The article was 《Angustifolinoid B, a flavonoid glycoside dimer with cyclobutane from Elaeagnus angustifolia flowersã€? The article mentions the following:

A novel flavonoid glycoside dimer with an unprecedented cyclobutane moiety, named angustifolinoid B (1), was isolated from Elaeagnus angustifolia flowers. Its structure was determined by extensive spectroscopic anal. (HRMS, NMR) and chem. hydrolysis. The new dimer was formed via a [2 + 2] cycloaddition between two sym. tiliroside. Bioassay revealed that compound 1 showed significant α-glucosidase inhibitory activity with IC50 value at 4.40 μM. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Quality Control of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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《Metal-Free Visible Light Hydroperfluoroalkylation of Unactivated Alkenes Using Perfluoroalkyl Bromidesã€?was written by Yajima, Tomoko; Shigenaga, Satsuki. Electric Literature of C6H12OThis research focused onunactivated alkene perfluoroalkyl bromide hydroperfluoroalkylation visible light organocatalyst; perfluoroalkyl alkane preparation; visible light hydroperfluoroalkylation promoter; organic dye hydroperfluoroalkylation organocatalyst. The article conveys some information:

Organic dye-catalyzed visible light induced hydroperfluoroalkylation of unactivated alkenes is described. Hydroperfluoroalkylation proceeds selectively and is applicable for various perfluoroalkyl bromide and alkenes including internal alkenes. The reaction mechanism is discussed, and it is shown that the hydrogen source varies with reaction conditions. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Electric Literature of C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Electric Literature of C6H12O

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Application In Synthesis of 6-Aminohexan-1-olIn 2019 ,《Imine and metal-ligand dynamic bonds in soft polymers for autonomous self-healing capacitive-based pressure sensorsã€?was published in Soft Matter. The article was written by Pignanelli, Julia; Billet, Blandine; Straeten, Matthew; Prado, Michaela; Schlingman, Kory; Ahamed, Mohammed Jalal; Rondeau-Gagne, Simon. The article contains the following contents:

In this work, a facile and simple yet effective method to generate intrinsic autonomous self-healing polymers was developed, leading to new materials that can be easily fine-tuned both mech. and chem. The new materials were designed to incorporate two dynamic and reversible types of chem. bonds, namely dynamic imine and metal-coordinating bonds, to enable autonomous self-healing, controlled degradability and ultra-high tunable stretchability (up to 800% strain) based on the ratio of metal to ligand incorporated. Through an easy condensation reaction, imine bonds are generated at the end-termini of a short siloxane chain. The new dynamic system was characterized by a variety of techniques, including tensile-pull strain testing, at. force microscopy and UV-Vis spectroscopy, which showed that the highly dynamic imine bonds, combined with coordination with Fe2+ ions, allow for the material to regenerate 88% of its mech. strength after phys. damage. The materials were also controlled to be degraded in mild acidic conditions. Lastly, application in self-healable electronics was demonstrated through the fabrication of a capacitive-based pressure sensor, which shows good sensitivity and dynamic response (~0.33 kPa-1) before and after healing. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Application In Synthesis of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Application In Synthesis of 6-Aminohexan-1-ol

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Quality Control of 3,5-DihydroxybenzaldehydeIn 2018 ,《Transforming a C3-Symmetrical Liquid Crystal to a π-Gelator by Alkoxy Chain Variationã€?was published in ACS Omega. The article was written by Sandeep, Anjamkudy; Praveen, Vakayil K.; Shankar Rao, D. S.; Krishna Prasad, S.; Ajayaghosh, Ayyappanpillai. The article contains the following contents:

Rational understanding of the structural features involving different noncovalent interactions is necessary to design a liquid crystal (LC) or an organogelator. Herein, we report the effect of the number and positions of alkoxy chains on the self-assembly induced phys. properties of a few π-conjugated mols. For this purpose, we designed and synthesized three C3-sym. mols. based on oligo(p-phenylenevinylene), C3OPV1-3. The self-assembly properties of these mols. are studied in the solid and solution states. All of the three mols. follow the isodesmic self-assembly pathway. Upon cooling from isotropic melt, C3OPV1 having nine alkoxy chains (-OC12H25) formed a columnar phase with two-dimensional rectangular lattice and retained the LC phase even at room temperature Interestingly, when one of the -OC12H25 groups from each of the end benzene rings is knocked out, the resultant mol., C3OPV2 lost the LC property, however, transformed as a gelator in toluene and n-decane. Surprisingly, when the -OC12H25 group from the middle position is removed, the resultant mol. C3OPV3 failed to form either the LC or the gel phases. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

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