Tag: 100-200

Formula: C6H12OIn 2019 ,《Iron-catalyzed regioselective hydrogenation of terminal epoxides to alcohols under mild conditionsã€?appeared in Nature Catalysis. The author of the article were Liu, Weiping; Li, Wu; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias. The article conveys some information:

Here, a general methodol. was presented for the synthesis of primary alcs. CH(R1)(R2)CH2OH [R1 = n-Bu, Ph, 2-naphthyl, etc.; R2 = H, Me, Ph; R1R2 = (CH2)5, (CH2)7] in high yields, selectively under mild conditions via hydrogenation of terminal epoxides using Fe(BF4)2.6H2O/tetraphos catalyst system. The present protocol showed broad substrate scope and good functional group tolerance. The generality of this is showcased by transformation of various natural products, including steroids, terpenoids, sesquiterpenoids and drug derivatives, which gave the desired alcs. in moderate to excellent yields. Mechanistic studies confirmed the distinct feature of the catalyst system, which is active for Meinwald rearrangement of epoxides as well as for carbonyl hydrogenations. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Formula: C6H12O

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Safety of 3-Bromopropan-1-olIn 2021 ,《A fluorescent probe for the discrimination of oxidation states of palladiumã€?appeared in Chemical Science. The author of the article were Jiang, Lijun; Mak, Ho-Nam; Walter, Edward R. H.; Wong, Wing-Tak; Wong, Ka-Leung; Long, Nicholas J.. The article conveys some information:

Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture It is important to sep. quantify the different oxidation states of palladium (Pd0 and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd0 showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd0 and Pd2+ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0 and Pd2+ resp. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Safety of 3-Bromopropan-1-ol

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In 2022,Richter, Adrian; Narula, Gagandeep; Rudolph, Ines; Seidel, Ruediger W.; Wagner, Christoph; Av-Gay, Yossef; Imming, Peter published an article in ChemMedChem. The title of the article was 《Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosisã€?Recommanded Product: Azetidin-3-ol hydrochloride The author mentioned the following in the article:

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Recommanded Product: Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Recommanded Product: Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

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Milovanovic, Jelena; Gunduz, Miyase Gozde; Zerva, Anastasia; Petkovic, Milos; Beskoski, Vladimir; Thomaidis, Nikolaos S.; Topakas, Evangelos; Nikodinovic-Runic, Jasmina published their research in Catalysts in 2021. The article was titled 《Synthesis and laccase-mediated oxidation of new condensed 1,4-dihydropyridine derivativesã€?SDS of cas: 100-83-4 The article contains the following contents:

Herein the synthesis and laccase mediated oxidation of six novel 1,4-dihydropyridine-based hexahydroquinolines I [R1 = OH, R2 = H; R1 = R2 = OH; R1 = NO2, R2 = OH] and decahydroacridines II was described. Different laccase enzymes was employed with varying redox potential to convert I and II to the corresponding pyridine-containing tetrahydroquinoline and octahydroacridine derivatives, resp. Intensively colored products were detected in all biocatalytic reactions using laccase from Trametes versicolor (TvLacc), possibly due to the presence of conjugated chromophores formed in products after oxidation The NMR assessment confirmed that the oxidation product of I [R1 = OH, R2 = H] was its corresponding pyridine-bearing tetrahydroquinoline derivative Laccase from Bacillus subtillis was the most efficient enzyme for this group of substrates using HPLC assessment. Overall, it could be concluded that I [R1 = R2 = OH] and II [R1 = R2 = OH], bearing catecholic structures, were easily oxidized by all tested laccases, while I [R1 = NO2, R2 = OH] and II [R1 = NO2, R2 = OH] containing electron-withdrawing nitro-groups are not readily oxidized by laccases. Compound I [R1 = OH, R2 = H] with decahydroacridine moiety consisting of three condensed six-membered rings that contribute not only to the volume but also to the higher redox potential of the substrate rendered this compound not to be biotransformed with any of the mentioned enzymes. Overall, we showed that multiple anal. approaches were needed in order to assess biocatalytical reactions. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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Ali, Salman; Jameel, Mohammed A.; Gupta, Akhil; Langford, Steven J.; Shafiei, Mahnaz published their research in Synthetic Metals in 2021. The article was titled 《Capacitive humidity sensing performance of naphthalene diimide derivatives at ambient temperatureã€?Quality Control of 6-Aminohexan-1-ol The article contains the following contents:

We report for the first-time the development of capacitive type humidity sensors employing naphthalene diimide derivatives (NDI) as sensing layer. Three different naphthalene diimide derivatives bearing imide side chains of different hydrophilicity were designed, synthesized and characterized. X-ray diffraction and thermogravimetric analyses gave useful information about structural and thermal behavior of the newly developed materials, indicating their crystallinity and stability. Atomic force microscopy anal. revealed a variety of morphologies in thin films as a result of the structural properties of the NDIs. Devices bearing NDI layers were fabricated on ceramic substrates with gold interdigitated electrodes spaced 200μm apart. Humidity sensing performance, as a change in capacitance, was studied upon exposure to a wide range of relative humidity levels (0-95%) at ambient temperature Importantly, an increase in the capacitance of the sensors was recorded with an increase in relative humidity. The developed sensors exhibited high sensitivity, good long-term stability, excellent reproducibility, and low hysteresis. The sensor performance was also tested against different operating frequencies (250 Hz-2 kHz) to improve linearity, illustrating directions for optimized performance. These results confirm that sensors based on NDIs possess better sensing performance to other types of reported capacitive humidity sensors. After reading the article, we found that the author used 6-Aminohexan-1-ol(cas: 4048-33-3Quality Control of 6-Aminohexan-1-ol)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Quality Control of 6-Aminohexan-1-ol

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Lesperance, Maxime; Roy, Jenny; Djiemeny Ngueta, Adrien; Maltais, Rene; Poirier, Donald published their research in Steroids in 2021. The article was titled 《Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseasesã€?Application of 26153-38-8 The article contains the following contents:

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) and steroid sulfatase (STS) are involved in the synthesis of the most potent estrogen in the human body, estradiol (E2). These enzymes are known to play a pivotal role in the progression of estrogen-dependent diseases, such as breast cancer and endometriosis. Therefore, the inhibition of 17β-HSD1 and/or STS represents a promising avenue to modulate the growth of estrogen-dependent tumors or lesions. We recently established the key role of a bromoethyl side chain added at the C3-position of a 16β-carbamoyl-benzyl-E2 nucleus to covalently inhibit 17β-HSD1. To extend the structure-activity relationship study to the C16β-position of this new selective irreversible inhibitor (PBRM), we synthesized a series of analog compounds by changing the nature of the C16β-side chain but keeping the 2-bromoethyl group at position C3. We determined their 17β-HSD1 inhibitions in T-47D cells (transformation of E1 into E2), but we did not obtain a stronger 17β-HSD1 inhibitor than PBRM. Two compounds were found to be more likely to bind to the catalytic site and showed a promising but moderate inhibitory activity with estimated IC50 values of 0.5 and 0.7μM, resp. (about 10 times higher than PBRM). Interestingly, adding one or two sulfamate groups in the D-ring’s surroundings did not significantly decrease compounds’ potential to inhibit 17β-HSD1, but clearly improved their potential to inhibit STS. These results open the door to the development of a new family of steroid derivatives with dual (17β-HSD1 and STS) inhibiting actions. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8

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《Solvent-Free N-Alkylation and Dehydrogenative Coupling Catalyzed by a Highly Active Pincer-Nickel Complexã€?was written by Arora, Vinay; Dutta, Moumita; Das, Kanu; Das, Babulal; Srivastava, Hemant Kumar; Kumar, Akshai. Application of 1195-59-1 And the article was included in Organometallics in 2020. The article conveys some information:

The synthesis and characterization of a pincer-Ni complex (iPr2NNN)NiCl2(MeCN) is reported here. The authors demonstrated the utility of this pincer-Ni complex (0.02 mol % and 0.002 mol %) for the catalytic N-alkylation of amines using various alcs. Under solvent-free conditions, while the highest yield (âˆ?0%) was obtained for alkylation of 2-amino pyridine with naphthyl-1-methanol, excellent turnovers (34000 TONs) was observed for alkylation of 2-amino pyridine with 4-methoxy benzyl alc. To demonstrate the synthetic utility of these systems, high yield reactions (up to 98%) were probed for representative substrates with a higher loading of the pincer-Ni catalyst (4 mol %). DFT studies indicate that while β-hydride elimination is the RDS for alc. dehydrogenation, the N-alkylated product can be formed either via hydrogenation with a rate-determining σ-bond metathesis or by alcoholysis that has imine insertion as RDS. All the corresponding resting states were observed by HRMS(ESI) anal. The labeling experiments are also complementary to DFT studies and show evidence for the involvement of benzylic C-H bond in RDS with a kCHH/kCHD of âˆ?.5. This method was applied to accomplish efficient (2000 TONS) dehydrogenative coupling leading to various benzimidazoles. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application of 1195-59-1

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《Structure-induced Lewis-base Ga4B2O9 and its superior performance in Knoevenagel condensation reactionã€?was written by Yang, Yao; Wang, Duo; Jiang, Pengfei; Gao, Wenliang; Cong, Rihong; Yang, Tao. Formula: C7H6O2 And the article was included in Molecular Catalysis in 2020. The article conveys some information:

Solid Lewis-base catalysis is important in the production of fine chems. A Lewis-base Ga4B2O9 was synthesized by high temperature solid state reactions. It exhibited a high yield (90%) and a high stability in Knoevenagel condensation reactions, where several aldehydes were combined with malononitrile to form α,β-unsaturated compounds through nucleophilic addition reactions. Reaction kinetics analyses indicated Knoevenagel condensation reactions over Ga4B2O9 catalyst obeyed a second-order characteristics and the calculated activation energy was âˆ?1.6 kJ/mol, suggesting that Langmuir-Hinshelwood absorption pathway was probably employed. The structural evolution from Ga4B2O9→GaBO3→Î?Ga2O3 evidenced that the structure-induced basicity of Ga4B2O9 attributed to the special μ3-O atoms linked exclusively to 3 five-coordinated Ga3+. This investigation proves a convincing structure-property correlation in Ga-based solid base materials and helps developing an alternative avenue towards the design of new intrinsic solid base catalysts. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Formula: C7H6O2

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The author of 《A novel phosphonic acid functional polythiophene fluorescent sensor for Ca2+ and its live cell imagingã€?were Yang, Ting; Hu, Zhiru; Liu, Jilin; Zhang, Zhiquan; Feng, Guodong. And the article was published in Analytical Methods in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

Calcium ions are indispensable to various physiol. activities of the body, so the detection of calcium ions is very important. In this work, a new water-soluble polythiophene derivative poly{((thiophene-3,4-diylbis(oxy))bis(propane-3,1-diyl))bis(phosphonic acid)} (PT-PHO) was designed and synthesized via oxidative polymerization with FeCl3. The polymer containing phosphonic acid groups could be used as a “”turn off”” fluorescent sensor for Ca2+ detection. Under optimal conditions, PT-PHO exhibits high selectivity and sensitivity to detect Ca2+ among metal ions. The fluorescence intensity of PT-PHO shows a linear response toward Ca2+ in the range of 0.05-50 μmol L-1 with a limit of detection (LOD) of 44 nmol L-1. In addition, PT-PHO has low toxicity and good biocompatibility. Thus, it could be used for imaging lysosomes in cells and detecting intracellular calcium ions. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Category: alcohols-buliding-blocks

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In 2019,ACS Omega included an article by de Fatima, Angelo; Docampo-Palacios, Maite; Alvarez-Hernandez, Anislay; Pasinetti, Giulio M.; Dixon, Richard A.. Application of 26153-38-8. The article was titled 《An Efficient Synthesis of Deoxyrhapontigenin-3-O-β-D-glucuronide, a Brain-Targeted Derivative of Dietary Resveratrol, and Its Precursor 4′-O-Me-Resveratrolã€? The information in the text is summarized as follows:

Bioactive dietary polyphenols have health benefits against a variety of disorders, but some benefits of polyphenols may be not directly related to them, but rather to their metabolites. Recently, we have identified the brain-available phenol glucuronide metabolite deoxyrhapontigenin-3-O- β-D-glucuronide (I) in perfused rat brains following sub-acute treatment with the stilbene resveratrol. However, the role of such a metabolite in the neuroprotective activity of resveratrol is not understood, in part due to the non-com. availability of I for performing biol. evaluation in animal models of Alzheimer’s disease or other neurol. disorders. Here, we describe a concise chem. synthesis of deoxyrhapontigenin-3-O- β-D-glucuronide and its precursor, 4-O-Me-resveratrol, accomplished in 4 and 6 steps with 74% and 21% overall yields, resp., starting from com. available 3,5-dihydroxybenzaldehyde. Pivotal reactions employed in the synthesis include the palladium-catalyzed C-C coupling between 3,5-di-tert-butyldiphenylsilyloxystyrene and p-iodoanisole in the presence of tributylamine and the acid-catalyzed glucuronidation between the trichloroacetimidate-activated glucuronic acid and 4-O-Me-resveratrol. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8

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