Tag: 100-200

《Palladium-catalyzed coupling reaction of halo heteroaromatic compounds in waterã€?was written by Inoue, Naoki; Sugimoto, Osamu; Tanji, Ken-ichi. Category: alcohols-buliding-blocks And the article was included in Heterocycles on April 13 ,2007. The article conveys some information:

Palladium-catalyzed coupling reaction of π-deficient heteroaromatic halides with terminal alkynes in water was accomplished with excellent to good yields without any side reactions such as hydrolysis. The experimental process involved the reaction of 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Category: alcohols-buliding-blocks)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A facile synthesis of ZrOx-MnCO3/graphene oxide (GRO) nanocomposites for the oxidation of alcohols using molecular oxygen under base free conditionsã€?was written by Adil, Syed Farooq; Assal, Mohamed E.; Shaik, Mohammed Rafi; Kuniyil, Mufsir; AlOtaibi, Nawaf M.; Khan, Mujeeb; Sharif, Muhammad; Alam, M. Mujah; Al-Warthan, Abdulrahman; Mohammed, Jabair Ali; Sdiqui, Mohammed Rafiq H.; Tahir, Muhammad Nawaz. Recommanded Product: 821-41-0This research focused onzirconium manganese carbonate graphene oxide nanocomposite alc oxidation. The article conveys some information:

Graphene and its nanocomposites are showing excellent potential in improving the catalytic performances of different materials. However, the synthetic protocol and its form, such as graphene oxide (GRO) or highly reduced graphene oxide (HRG), influence the catalytic efficiencies. Here, we present, a facile synthesis of graphene oxide (GRO) and ZrOx-MnCO3-based nanocomposites [(1%)ZrOx-MnCO3/(x%)GRO] and their outcome as an oxidation catalyst for alc. oxidation under mild conditions using O2 as a clean oxidant. The ZrOx-MnCO3/GRO catalyst prepared by incorporating GRO to pre-calcined ZrOx-MnCO3 using ball milling showed remarkable enhancement in the catalytic activities as compared to pristine ZrOx-MnCO3, ZrOx-MnCO3 supported on HRG or ZrOx-MnCO3/GRO prepared by in-situ growth of ZrOx-MnCO3 onto GRO followed by calcination. The catalyst with composition (1%)ZrOx-MnCO3/(1%)GRO exhibited superior specific activity (57.1 mmol/g·h) with complete conversion and >99% selectivity of the product within a short period of time (7 min) and at a relatively lower temperature (100°C). The catalyst could be recycled at least five times with a negligible decrease in efficiency and selectivity. The catalytic study was extended to different aromatic as well as aliphatic alcs. under optimized conditions, which confirmed the efficiency and selectivity of the catalyst. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 821-41-0

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Alcohol – Wikipedia,
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Recommanded Product: 26153-38-8In 2022 ,《Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Proteinã€?was published in Molecules. The article was written by Ruggiero, Dafne; Terracciano, Stefania; Lauro, Gianluigi; Pecoraro, Michela; Franceschelli, Silvia; Bifulco, Giuseppe; Bruno, Ines. The article contains the following contents:

The multidomain BAG3 protein is a member of the BAG (Bcl-2-associated athanogene) family of co-chaperones, involved in a wide range of protein-protein interactions crucial for many key cellular pathways, including autophagy, cytoskeletal dynamics, and apoptosis. Basal expression of BAG3 is elevated in several tumor cell lines, where it promotes cell survival signaling and apoptosis resistance through the interaction with many protein partners. In addition, its role as a key player of several hallmarks of cancer, such as metastasis, angiogenesis, autophagy activation, and apoptosis inhibition, has been established. Due to its involvement in malignant transformation, BAG3 has emerged as a potential and effective biol. target to control multiple cancer-related signaling pathways. Recently, by using a multidisciplinary approach we reported the first synthetic BAG3 modulator interfering with its BAG domain (BD), based on a 2,4-thiazolidinedione scaffold and endowed with significant anti-proliferative activity. Here, a further in silico-driven selection of a 2,4-thiazolidinedione-based compound was performed. Thanks to a straightforward synthesis, relevant binding affinity for the BAG3BD domain, and attractive biol. activities, this novel generation of compounds is of great interest for the development of further BAG3 binders, as well as for the elucidation of the biol. roles of this protein in tumors. Specifically, we found compound 6 as a new BAG3 modulator with a relevant antiproliferative effect on two different cancer cell lines (IC50: A375 = 19.36 μM; HeLa = 18.67 μM).3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8

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Alcohol – Wikipedia,
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Computed Properties of C7H6O2In 2019 ,《Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetateã€?was published in ACS Omega. The article was written by Jadhav, Chetan K.; Nipate, Amol S.; Chate, Asha V.; Songire, Vishal D.; Patil, Anil P.; Gill, Charansingh. H.. The article contains the following contents:

The diisopropyl Et ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford pharmacol. promising 1,2,3,4-tetrahydropyrimidines in high yields at room temperature The key benefits of the present scheme are the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclability of the catalyst, and solvent-free conditions, thus providing economic and environmental advantages. In addition, a series of 4-oxo-6-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles analogs were synthesized and selected for their in vitro antifungal and antibacterial activities. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Computed Properties of C7H6O2

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Alcohol – Wikipedia,
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Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《Rhodium(III)-Catalyzed Intramolecular Olefin Hydroarylation of Aromatic Aldehydes Using a Transient Directing Groupã€?was published in Organic Letters. The article was written by Guan, Zhe; Chen, Siwei; Huang, Yue; Yao, Hequan. The article contains the following contents:

A Rh(III)-catalyzed intramol. olefin hydroarylation of aromatic aldehydes with a transient directing group has been described. The bidentate directing groups in situ generated from aromatic aldehydes and β-alanine could enable the subsequent C-H activation and hydroarylation with excellent site selectivities and high functional group compatibility. The further conversion of the aldehyde group showcased the broad application prospects of this methodol. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

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Alcohol – Wikipedia,
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Computed Properties of C6H7NOIn 2022 ,《Heterogeneous Catalysis for Oxidation of Alcohol via 1-Methyl-2-azaadamanane N-oxyl Immobilized on Magnetic Polystyrene Nanosphereã€?appeared in ChemistrySelect. The author of the article were Guo, Xiaqun; Li, Meichao; Wang, Jianli; Li, Chunmei; Hu, Xinquan; Jin, Liqun; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu. The article conveys some information:

A highly promising heterogeneous strategy was describedn in which a catalytic amount of 1-methyl-2-azaadamanane N-oxyl immobilized on magnetic polystyrene nanosphere (1-Me-AZADO/MPNs) was used and a series of carbonyl compounds were obtained from various alcs. in 73-99% isolated yields and high selectivity (>99%) under Anelli conditions, thus offering a greener and more convenient methods in the synthesis of carbonyl compounds The attractive features of convenient magnetic separation (within seconds), good recyclability (up to 20 runs) and fast reaction rates (5-20 min) were very efficient to improve the utility of azaadamantane-type-nitroxyl radicals in the oxygenation. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C6H7NO

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《Visible light-mediated ring-opening polymerization of lactones based on the excited state acidity of ESPT moleculesã€?was written by Zhang, Xun; Hu, Siping; Ma, Qiang; Liao, Saihu. Safety of 5-Hexen-1-ol And the article was included in Polymer Chemistry in 2020. The article conveys some information:

The excited state acidity of ESPT mols. is first demonstrated as a suitable means of catalysis for the light-regulated ring-opening polymerization of lactones, in combination with a photosensitizer as the energy-transfer cocatalyst to harness light. Under blue light irradiation, this method could afford metal-free polyesters with well-controlled mol. weights and narrow dispersities. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Safety of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Safety of 5-Hexen-1-ol

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Alcohol – Wikipedia,
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《Butadiyne-Bridged (Porphinato)Zinc(II) Chromophores Assemble into Free-Standing Nanosheetsã€?was published in Organometallics in 2020. These research results belong to Liu, Chuan; Liu, Kaixuan; Mukhopadhyay, Arindam; Paulino, Victor; Bernard, Brianna; Olivier, Jean-Hubert. Product Details of 26153-38-8 The article mentions the following:

The mol. engineering of chromophores that enable the controlled and reliable formation of hierarchical solid-state architectures is at the forefront of developing hybrid semiconducting materials. While the rules and principles to assemble monomeric porphyrin-derived building blocks are well established, the aggregation of larger π-conjugated cores that feature electronically coupled porphyrin arrays was vastly underexplored. In the present contribution, the authors report the synthesis, spectroscopy, assembly, and solid-state properties of a class of butadiyne-bridged (porphinato)zinc(II) dimer chromophores. Spectroscopic study unravels the formation of aggregates in an aqueous medium, giving 2-dimensional objects that expand across microscale dimensions. Anal. of the height profile exploiting at. force microscopy indicates that one porphyrin dimer comprises the thickness of the solid-state hierarchical superstructure and underscores the promise of this approach to engineer solid-state platforms for (opto) electronic devices. Also, initiation of noncovalent interactions between building blocks by a chem. stimulus (pH) reveals that a nucleation-growth process governs the aggregation of the π-conjugated chromophores in an aqueous medium. This work provides tools to modulate the structure-function relations of supramol. architectures equipped with enticing optical properties. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Product Details of 26153-38-8

Referemce:
Alcohol – Wikipedia,
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《Discovery of novel artemisinin-sulfonamide hybrids as potential carbonic anhydrase IX inhibitors with improved antiproliferative activitiesã€?was published in Bioorganic Chemistry in 2020. These research results belong to An, Ran; Lin, Bin; Zhao, Shuang; Cao, Chun; Wang, Yuanxin; Cheng, Xue; Liu, Yichuang; Guo, Mengbi; Xu, Hang; Wang, Yitong; Hou, Zhuang; Guo, Chun. Category: alcohols-buliding-blocks The article mentions the following:

A series of artemisinin-sulfonamide hybrids (1-16) have been designed and synthesized by using mol. hybridization approach and investigated for the inhibitory activity of four human (h) carbonic anhydrases (CAs, EC 4.2.1.1), hCA I, II, IX and XII. The results indicated most of the target compounds showed better CA IX and CA XII inhibitory activity than the starting segment sulfanilamide. Among all the compounds, compound 3 (IC50: 5 nM) showed the best CA IX inhibitory efficacy. The p-aminobenzenesulfonamide derivatives showed significant antiproliferative activities against MDA-MB-231 breast cancer cell line and HT-29 colon cancer cell line under hypoxic conditions where CA IX and CA XII are overexpressed and most of them showed no apparent cytotoxic effects toward MCF-10A normal mammary epithelial cell. Among these derivatives, compound 3 displayed the most potent antiproliferative activities (IC50: 0.65 μM) against HT-29 cell line under hypoxia and low cytotoxicity (IC50: 78.0 μM) toward normal cell line. Meanwhile, compound 3 was found to efficiently decrease the hypoxia-induced extracellular acidification in both cancer cells. Mol. docking studies of compounds 3, 4, 5 and 9 revealed the proper interactions between the hybrid mols. and the active site of CA IX. All the results proved the effectiveness of the hybridization approach to develop novel artemisinin-sulfonamide compounds targeting CA IX for cancer treatment.3-Bromopropan-1-ol(cas: 627-18-9Category: alcohols-buliding-blocks) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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《Visible Light-Induced α-C(sp3)-H Acetalization of Saturated Heterocycles Catalyzed by a Dimeric Gold Complexã€?was published in Organic Letters in 2020. These research results belong to Si, Xiaojia; Zhang, Lumin; Wu, Zuozuo; Rudolph, Matthias; Asiri, Abdullah M.; Hashmi, A. Stephen K.. Formula: C7H9NO2 The article mentions the following:

Saturated heterocyclic acetals are useful fragments in organic synthesis and other fields. Herein, C(sp3)-H dehydrogenative cross-couplings of ethers, tetrahydrothiophene, and N-Boc-pyrrolidine were achieved under visible light irradiation by using 4-iodoanisole and an in situ-formed gold complex. The broad functional group compatibility and substrate scope indicate that our strategy is a promising way to synthesize acetal analogs. The method was successfully applied in late-stage modifications of bioactive mols. Gram scale syntheses and mechanistic studies are also presented. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts