Tag: 100-200

Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors was written by Aronov, Alex M.;Baker, Christopher;Bemis, Guy W.;Cao, Jingrong;Chen, Guanjing;Ford, Pamella J.;Germann, Ursula A.;Green, Jeremy;Hale, Michael R.;Jacobs, Marc;Janetka, James W.;Maltais, Francois;Martinez-Botella, Gabriel;Namchuk, Mark N.;Straub, Judy;Tang, Qing;Xie, Xiaoling. And the article was included in Journal of Medicinal Chemistry in 2007.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol The following contents are mentioned in the article:

The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p(I), a potent and selective inhibitor of ERK. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols was written by Rashid, Showkat;Bhat, Bilal A.;Mehta, Goverdhan. And the article was included in Tetrahedron Letters in 2019.Reference of 52010-89-6 The following contents are mentioned in the article:

An interesting albeit unexpected deviation during attempted Tanabe γ-lactone annulation on 4-hydroxycyclohexanones has led to a general, one-pot synthesis of benzofurans and naphtho[2,3-b]furans from readily assembled precursors. The utility of this adaptable methodol. has been demonstrated through concise syntheses of natural products, stereumene B, paeoveitol D and (±)-paeoveitol. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6Reference of 52010-89-6).

2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 52010-89-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Neopentylic rearrangement of 2,2-disubstituted-1,3-propanediols in acid was written by Mazet, Michel. And the article was included in Bulletin de la Societe Chimique de France in 1969.Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

The dehydration and substituent migration rates (Yvernault, Th. and Mazet, M., 1969), of 2,2-dihydrocarbyl-1,3-propanediols were studied in H2SO4. The reaction occurred by a synchronic ionization-migration mechanism. The substituents had a steric effect. The rates increased with the mol. weight of one of the substituents, and were higher for aryl, as compared to alkyl groups. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The influence of fluorine position on the properties of fluorobenzoxaboroles was written by Adamczyk-Wozniak, Agnieszka;Cabaj, Malgorzata K.;Dominiak, Paulina M.;Gajowiec, Patrycja;Gierczyk, Blazej;Lipok, Jacek;Popenda, Lukasz;Schroeder, Grzegorz;Tomecka, Ewelina;Urbanski, Piotr;Wieczorek, Dorota;Sporzynski, Andrzej. And the article was included in Bioorganic Chemistry in 2015.COA of Formula: C7H6BFO2 The following contents are mentioned in the article:

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pK_a and multinuclear NMR characterization. The mol. and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690. This study involved multiple reactions and reactants, such as 7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3COA of Formula: C7H6BFO2).

7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H6BFO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The influence of fluorine position on the properties of fluorobenzoxaboroles was written by Adamczyk-Wozniak, Agnieszka;Cabaj, Malgorzata K.;Dominiak, Paulina M.;Gajowiec, Patrycja;Gierczyk, Blazej;Lipok, Jacek;Popenda, Lukasz;Schroeder, Grzegorz;Tomecka, Ewelina;Urbanski, Piotr;Wieczorek, Dorota;Sporzynski, Andrzej. And the article was included in Bioorganic Chemistry in 2015.Related Products of 174671-93-3 The following contents are mentioned in the article:

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pK_a and multinuclear NMR characterization. The mol. and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690. This study involved multiple reactions and reactants, such as 7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3Related Products of 174671-93-3).

7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 174671-93-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Determination of characteristic factors of the rate of migration of a group between vicinal carbon atoms was written by Yvernault, Theophile;Mazet, Michel. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences in 1969.Synthetic Route of C9H20O2 The following contents are mentioned in the article:

The total 1st order rate constants for the rearrangement of HOCH2CR1RCH2OH to HOCH2CR(OH)CH2R1 (R and R1 are Me, Et, Pr, Bu, Bz, and Ph) were determined by azeotropic distillation The migration rate appears, as a 1st approximation, to be the product of 2 independent factors: the migratory power of the group, and an assistance factor of the adjacent group. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Synthetic Route of C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of novel isoxazole-benzoquinone hybrids via 1,3-dipolar cycloaddition reaction as key step was written by Ravi Kumar, P.;Behera, Manoranjan;Raghavulu, K.;Jaya Shree, A.;Yennam, Satyanarayana. And the article was included in Tetrahedron Letters in 2012.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

An efficient method for the preparation of novel 2-(5-arylisoxazol-3-yl)cyclohexa-2,5-diene-1,4-dione hybrids via 1,3-dipolar cycloaddition followed by an oxidation reaction using ceric ammonium nitrate (CAN) has been described. Using this method, various aryl as well as alkyl substituted isoxazole-benzoquinone hybrids were synthesized in high yields. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6Category: alcohols-buliding-blocks).

2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Improved hydrolytic stability of amine-neutralized polyester resin dispersions using 2-butyl-2-ethyl-1,3-propanediol was written by Anonymous. And the article was included in Research Disclosure in 1993.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

Use of 5-100 mol% replacement of one or more diol monomers with 2-butyl-2-ethyl-1,3-propanediol (I) resulted in an improvement of hydrolytic stability of polyester dispersion as measured by decrease in pH of the dispersions after storage for 28 days at 125F (52°). I also reduced viscosity of the dispersion. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation of carboxyl-terminated polyester resin for two-component matting superdurable weather resistant powder coatings was written by He, Tao;Gu, Yuxin;Xie, Jing;Lin, Xien;Ruan, Deliang;Liang, Baorong. And the article was included in Tuliao Gongye in 2014.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

This article has described the preparation of a carboxyl-terminated polyester resin based on isophthalic acid for two-component matting super durable powder coatings. The prepared powder coating showed a matting effect with only 21∼26 gloss. The coating was featured by its lower gloss, smooth appearance and outstanding weather durability. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Category: alcohols-buliding-blocks).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quantitative gas chromatography of insect repellent mixture M-1960 was written by Acree, Fred Jr.;Beroza, Morton. And the article was included in Journal of Economic Entomology in 1962.Application of 115-84-4 The following contents are mentioned in the article:

Repellents in the M-1960 clothing impregnant, 2-butyl-2-ethyl-1,3-propanediol, N-butylacetanilide, and benzyl benzoate, can be analyzed quant. by gas chromatography. The analyses are conducted at 225° using 200 γ of each repellent on an 8-foot column of 5% Dow-Corning Silicone 550 on Haloport-F with a thermal conductivity detector. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Application of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts