Alcohols-buliding-blocks

Vagapova, L. I. published the artcileKabachnik-Fields Reaction in the Synthesis of New Acetal-Containing Aminophosphine Oxides, Quality Control of 6346-09-4, the publication is Russian Journal of General Chemistry (2018), 88(9), 1912-1914, database is CAplus.

The Kabachnik-Fields reaction in a ternary system of 4,4-diethoxybutylamine-dialkyl(tolyl)-phosphine acid-3,5-di-tert-butyl-4-hydroxybenzaldehyde (or paraformaldehyde) afforded new aminophosphine oxides containing 3,5-di-tert-butyl-4-hydroxyphenol moiety and an acetal group.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C11H8O3, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Saeidian, Hamid published the artcileThe first general protocol for N-monoalkylation of sulfamate esters: benign synthesis of N-alkyl Topiramate (anticonvulsant drug) derivatives, COA of Formula: C12H20O6, the publication is Journal of Sulfur Chemistry (2015), 36(5), 463-470, database is CAplus.

A novel protocol for the highly selective N-monoalkylation of the sulfamate ester moiety has been developed. This reaction proceeded efficiently using alkyl halides, benzyl halides and α-halo ketones as the electrophile in the presence of KF-Al₂O₃ as a cost-effective and robust catalyst. This approach provides new access to N-monoalkylated Topiramate (anticonvulsant drug) derivatives I (R = CH₃, C₂H₅, CH₂C₆H₅, Bn, etc.) which are potentially of great importance in medicinal chem.

Journal of Sulfur Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Maoqun published the artcileDiscovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Medicinal Chemistry (2020), 63(11), 6164-6178, database is CAplus and MEDLINE.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity vs. other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC₅₀ 0.0192 μM)(I) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC₅₀ 0.0231 μM)(II), displayed >500-fold selectivity vs. P2X2 and P2X3, and 10-fold selectivity vs. P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as neg. allosteric modulators, and mol. modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H26O2, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileCombined experimental, DFT theoretical calculations and biological activity of sulfaclozine azo dye with 1-hydroxy-2-naphthoic acid and its complexes with some metal ions, Formula: C11H8O3, the publication is New Journal of Chemistry (2019), 43(44), 17466-17485, database is CAplus.

Sulfaclozine-1-hydroxy-2-naphthoic acid azo dye (Scna) and its metal complexes with Ni(II) Cu(II), Zn(II) and Pd(II) metal ions were prepared and characterized using different techniques. The nonisothermal degradation of Pd(II)-(Scna) was studied using Flynn-Wall-Ozawa and Starink methods at various heating rates (5, 10, 15 and 20° min^-1) from the TG/derivative TG (TG/DrTG) and DTA curves. The values of the activation energy (E) obtained using the two methods are in impeccable harmony. Theor. studies (d. functional theory, DFT) were also carried out to support the corresponding exptl. results. Computational calculations were achieved using a DFT/GEN level of theory. Theor. aspects, in terms of geometrical optimization and mol. charge d. plots are also mentioned using the standard basis set LANL2DZ for metal ions. A suitable distorted square planar for Pd-(Scna), distorted tetrahedral for Cu₂-(Scna), and distorted octahedral with Ni-(Scna) and Zn-(Scna)₂ structures were observed for the complexes. The electronic structure and nonlinear optical parameters (NLO) of the complexes were calculated The nature of the interaction between the metal ions and the ligand, mol. stability and bond strengths were studied using DFT calculations employing natural bond orbital (NBO) anal. The complexes are nonplanar and demonstrate the expected optical properties. The synthesized ligand (Scna) and its complexes were screened for antimicrobial activity against bacteria, Staphylococcus aureus as the Gram-pos. and Escherichia coli as the Gram-neg., using the disk diffusion method. The Zn-(Scna)₂ complex displayed the highest activity against both bacteria.

New Journal of Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Kader, Nora S. published the artcileSpectroscopic studies, density functional theory calculations, non-linear optical properties, biological activity of 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid and its chelates with Nickel(II), Copper(II), Zinc(II) and Palladium(II) metal ions, Computed Properties of 86-48-6, the publication is Journal of Molecular Structure (2021), 129203, database is CAplus.

Novel Nickel(II), Copper(II), Zinc(II) and Palladium(II) chelates with 1-hydroxy-4-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)diazenyl)-2-naphthoic acid (H₃L) have been produced and clarified using several physicochem. techniques. Quantum mech. calculations of energies, geometries were achieved by using the d. functional theory with Becke’s three parameter exchange functional, the Lee_Yang_Parr correlation functional (B3LYP/GEN) combined with 6.311 G (d,p) and LANL2DZ basis sets. The analyses of HOMO and LUMO have been used to justify the charge transfer within the ligand and its chelates. The considered small energy gap between Occupied MO (HOMO) and LUMO energies expressions that the charge transfer occurs within the ligand and its chelates. The results show that the azo dye ligand exists in two tautomeric structures, the first structure (H₃L), the sulfonamide (SO₂NH), while the second one, the sulfonamide group in enolic form (H₂L-OH). The H₂L-OH tautomer has energy of 12.93 kcal/mol higher than that of H₃L. The structure of H₃L was the most stable and used as the ligand in this study. The bond lengths of Ni(II) ion with the donating sites of the ligand in Ni-(H₂L)₂ chelate suggest a distorted octahedral geometry, Cu₂-(L) chelate, suggests a highly distorted tetrahedral geometry, Zn-(HL) chelate displays a distorted octahedral geometry, Pd-(H₂L) chelate approves a distorted square planar geometry around its own central metal ion. Geometrical parameters, mol. electrostatic potential maps and total electron densities analyses of the ligand and its chelates have been carried out. Mol. stability, hyper conjugative interactions, intramol. charge transfer and bond strength have been examined by applying of natural bond orbital (NBO) anal. Total static dipole moment, mean polarizability, anisotropy of the polarizability, mean first-order hyperpolarizability have been also achieved. From the mol. hyperpolarizability (<β>), The computed (<β>) values show that for the ligand (H₃L) and its Ni-(H₂L)₂, Cu₂-(L), Zn-(HL) and Pd-(H₂L) are ∼23, ∼70, ∼44, ∼132 and ∼38 times greater than that of Urea, indicating all the studied ligand and its chelates reveal significant polarizability and first-order hyperpolarizability and are predicted to be successful for Non-Linear Optical (NLO) materials. The analyses of the chelates indicate that the Zn(II) and Pd(II) form 1:1, Ni(II) form 1:2 while Cu(II) ion form 2:1 (M:L) and non-electrolytic behavior of chelates indicate the absence of counter ion. Ni-(H₂L)₂ complex had zero antibacterial activity against E. coli while its activity is higher than the azo dye against Staphylococcus aureus. Pd-H₂L complex had almost the same activity as the azo dye against both types of bacteria. The higher activity of Zn-HL and Cu₂-L complexes can be explained by their chelation.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdelaleem, Eglal A. published the artcileAn Innovative Method, Interference Subtraction, for Determination of Drugs in Syrups in Presence of Potential Interfering Excipients, Product Details of C13H19Br2ClN2O, the publication is Analytical Chemistry Letters (2018), 8(6), 782-793, database is CAplus.

Pharmaceutical dosage forms contain both active ingredients and inactive materials called exipients, most of which cause high interference specially in direct UV-spectrophotometry. This problem is highly obvious in syrups which may contain preservatives, coloring agents, thickening agents and sweetening agents. Thus, there is an urgent need to develop and validate a simple, accurate and selective method named interference subtraction method for determination of drugs in syrups in presence of these excipients without pre-separation by solving this interference. This newly designed method was successfully applied to; Oxybutynin hydrochloride in Detronin syrup, Ambroxol hydrochloride in Muco syrup and Ibuprofen in both Brufen syrup and Megafen N oral suspension. These chosen syrups contain different excipients causing different types of interference. This innovative method was validated according to ICH guidelines. The results obtained by interference subtraction method were statistically compared with those obtained by the official and /or reported methods of the proposed drugs.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Product Details of C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lotfy, Hayam Mahmoud published the artcileStability indicating spectrophotometric methods for determination of Nicardipine in the presence of its alkaline induced degradation products, Formula: C10H15NO, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2016), 8(3), 62-66, database is CAplus.

Objective: Derivative, ratio spectra derivative and ratio difference spectrophotometric methods were developed and validated for simultaneous determination of Nicardipine (NIC) in the presence of its alk. induced degradation products. Methods: In these methods the overlapped spectra of NIC and its alk. induced degradation products were well resolved by measuring the amplitudes of first derivative (D1) spectra and the second derivative (D2) at 382.3 and 239 nm, resp. NIC was determined by ratio spectra derivative by measuring the amplitude at 244 nm. The ratio difference spectrophotometric method was developed in which the difference between amplitudes at 237.5 nm and 260 nm of the ratio spectra were recorded. The linearity range for the applied methods was 2-18 μg/mL. Results: All the developed methods were validated according to ICH Guidelines, NIC was determined with acceptable accuracy and precision. Conclusion: These methods were suitable as stability indicating methods for the determination of NIC in the presence of its alk. induced degradation products either in bulk powder or in a pharmaceutical formulation. Statistical anal. of the results with those obtained by applying a reported method has been carried out revealing high accuracy and good precision.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azam, Syed Sikander published the artcileInvestigation of novel chemical inhibitors of human lysosomal acid lipase: virtual screening and molecular docking studies, Safety of 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Combinatorial Chemistry & High Throughput Screening (2014), 17(5), 473-482, database is CAplus and MEDLINE.

In the current study, identification of new potent small inhibitors of human lysosomal acid lipase using structure-based methods has been reported. Virtual Screening (VS), compounds from literature and mol. docking studies were employed to find the suitable inhibitors against lysosomal acid lipase (LAL). Specifically for this study a homol. model of LipA enzyme was generated based on the structure of dog gastric lipase. As a result of structure-based virtual screening 28 inhibitors were identified from ZINC database. Rest of the inhibitors were selected from literature. Among the studied 65 inhibitors, compound having zinc ID ZINC15707335 exhibiting min. binding affinity and hydrogen bond and hydrophobic interactions with specific amino acid residues was selected as lead compound

Combinatorial Chemistry & High Throughput Screening published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Safety of 4-Morpholino-1,2,5-thiadiazol-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Helal, Mustafa R. published the artcileConformational analysis of some β-halohydrins via G3 calculations, Synthetic Route of 55376-31-3, the publication is Jordan Journal of Chemistry (2013), 8(1), 19-30, database is CAplus.

The conformational anal. of fifteen β-halohydrins, XCR₁R₂CR₃R₄OH, (X = F, Cl and Br) had been studied by ab initio G3 method. The enthalpies of formation values were calculated for nine conformers of each β-halohydrin. The (g^–, g⁺) and (g⁺, g^–) conformers are the most stable due to intramol. H-bond formation. These H-bonds are weaker than intermol. H-bonds formed between alkyl halides and alcs. This trend is more obvious in fluoro-species. The rotation of C- X bond of (g^–, g⁺) conformers by 360° gives three transition states, this rotation was found to require 6-7 kcal/mol.

Jordan Journal of Chemistry published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C4H9BrO, Synthetic Route of 55376-31-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lagerspets, Emi published the artcileWater tolerant base free Copper (I) catalyst for the selective aerobic oxidation of primary alcohols, Quality Control of 111-29-5, the publication is Molecular Catalysis (2022), 112167, database is CAplus.

Authors report here a base free copper(I) catalyst for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to their corresponding lactones or lactols. In the presence of the in situ generated Cu(I)-catalyst with 2,2′-dipyridylamine (dpa) as a ligand and 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO) as a persistent radical, the oxidation reaction proceeds under true aerobic conditions, at ambient temperature, utilizing air as the oxidant and without added base. High catalytic activity without over oxidation was achieved for numerous primary alcs. (aliphatic, allylic, benzylic and diols) with different substitution patterns. The catalyst’s stability is unique among reported Cu(I)-catalysts. It is not moisture or air sensitive, and is capable of e.g. oxidizing aliphatic and benzyl alcs. in a water/acetonitrile solution in moderate or in quant. yield (> 99%) in 3 h.

Molecular Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts