Alcohols-buliding-blocks

Basu Baul, Tushar published the artcileSynthesis, characterization and structural systematics in diorganotin complexes with O,N,O’-tris-chelating semirigid diaza-scaffolds: Mono- vs. di-nuclear compounds, Synthetic Route of 96-20-8, the publication is Journal of Organometallic Chemistry (2020), 121522, database is CAplus.

Nine novel diorganotin(IV) complexes of O,N,O’ chelating ligands were synthesized viz., [Bu₂Sn(L²)]₂·0.25 (C₆H₁₄) (1), [Me₂Sn(L¹)]₂·(C₇H₈) (2), [Bu₂Sn(L¹)]₂·(C₇H₈) (3), [Me₂Sn(L³)]₂·(C₇H₈) (4), 2 [Bu₂Sn(L³)]₂·4 (Bu₂Sn(L³)) (5), [Ph₂Sn(L³)] (6), [Ph₂Sn(L¹)] (7), [Ph₂Sn(L⁴)] (8) and [Ph₂Sn(L²)] (9) and structurally characterized. The ligand scaffolds differ with respect to the chem. link between the coordinating N and O atoms, which is either an alkyl or an aryl moiety. Diffraction results indicate that the smallest Me groups favor dimerization via Sn-O-Sn bridging and six-coordination at the cation. Among these dinuclear derivatives, more asym. O bridges and longer Sn···Sn separations are found for the less nucleophilic phenolate O. In contrast, the bulky Ph substituents prevent aggregation for both classes of ligands and always lead to five-coordinated mononuclear species. The Bu groups are sterically more demanding than Me but flexible, resulting in an intermediate behavior. When the O,N,O’ ligand with phenolate O coordinates a SnBu₂ fragment, a borderline situation occurs and both mono- and dinuclear complexes coexist in the same crystalline solid. For better comparability the authors introduce a slightly modified geometry index τ’₅, in which the basal angle α is subtended by the organic substituents, regardless of its absolute value. τ’₅ represents a sensitive indicator for the coordination geometry about Sn^IV. Sn NMR results revealed that all compounds exist as mononuclear pentacoordinated species in solution

Journal of Organometallic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mukherji, Ananya published the artcileSterically Strained Bronsted Pair Catalysis by Bulky Pyridinium Salts: Direct Stereoselective Synthesis of 2-Deoxy and 2,6-Dideoxy-β-thioglycosides from Glycals, HPLC of Formula: 20880-92-6, the publication is Journal of Organic Chemistry (2021), 86(23), 17226-17243, database is CAplus and MEDLINE.

A sterically strained ionic Bronsted pair complex obtained from a sterically bulky base 2,4,6-tri-tert-butylpyridine and hydrochloric acid unusual reactivity to the anionic chloride. The complete shielding of the cationic [N-H]⁺ by the bulky ortho-tert-Bu groups weakens the possible hydrogen-bonding interactions with the chloride anion, and the [N-H]⁺···Cl^– distance is unusually longer (3.10 Å). This results in strained/frustrated electrostatic interactions between the ion-pair, thus infusing an increased reactivity in both of the ions, which results in the activation of a third mol. like thiol via hydrogen-bonding. This intriguing weak interaction-based reactivity has been utilized to develop an organocatalytic synthesis of 2-deoxy-β-thioglycosides from glycals. While the ¹H NMR studies showcase the diamagnetic activation of thiols in the presence of the catalyst, the ESR (EPR) studies reveal the generation of a radical species that suggests a possible frustrated radical pair catalysis. Besides, IR spectroscopic studies explain the intriguing influence of size/charge d. of the anion on the solvation-insusceptible, cationic [TTBPyH]⁺ and on the observed reactivity.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sawkar, Anu R. published the artcileGaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles, Category: alcohols-buliding-blocks, the publication is Chemistry & Biology (Cambridge, MA, United States) (2005), 12(11), 1235-1244, database is CAplus and MEDLINE.

Summary: Gaucher disease is a lysosomal storage disorder caused by deficient glucocerebrosidase activity. We have previously shown that the cellular activity of the most common Gaucher disease-associated glucocerebrosidase variant, N370S, is increased when patient-derived cells are cultured with the chem. chaperone N-nonyl-deoxynojirimycin. Chem. chaperones stabilize proteins against misfolding, enabling their trafficking from the endoplasmic reticulum. Herein, the generality of this therapeutic strategy is evaluated with other glucocerebrosidase variants and with addnl. candidate chem. chaperones. Improved chem. chaperones are identified for N370S glucocerebrosidase. Moreover, we demonstrate that G202R, a glucocerebrosidase variant that is known to be retained in the endoplasmic reticulum, is also amenable to chem. chaperoning. The L444P variant is not chaperoned by any of the active site-directed mols. tested, likely because this mutation destabilizes a domain distinct from the catalytic domain.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Simoes, Ana V. C. published the artcileAmphiphilic meso(sulfonate ester fluoroaryl)porphyrins: refining the substituents of porphyrin derivatives for phototherapy and diagnostics, Quality Control of 2240-88-2, the publication is Tetrahedron (2012), 68(42), 8767-8772, database is CAplus.

A set of amphiphilic fluorinated porphyrins appended with sulfonate ester groups were synthesized and fully characterized. The reaction proceeds efficiently, with high yields, with an improved methodol. Their potential use as imaging and phototherapeutic agents was assessed measuring relevant photophys. properties. It is shown that these porphyrins have good photostability, long triplet lifetimes (between 47 μs and 102 μs), high singlet oxygen quantum yields (0.74≤FD≤1.00), low fluorescence quantum yields (<0.04) and sharp ¹⁹F NMR peaks. The data on the new meso(sulfonate ester fluoroaryl)porphyrins illustrate the potential of perfluorinated sulfonate esters to improve phys. properties relevant for cancer imaging and photodynamic therapy.

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C10H16Br3N, Quality Control of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abraham, Michael H. published the artcileDescriptors for fluorotelomere alcohols. Calculation of physicochemical properties, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Physics and Chemistry of Liquids (2021), 59(6), 932-937, database is CAplus.

Abraham model solute descriptors are calculated for several environmentally important fluorotelomer alcs. from published partition coefficient and solubility data. The various descriptors all show a gradual trend from 1:2FTOH to 8:2FTOH. The maximum deviation from self-consistent values is 0.19 log units in the calculations on vapor pressure (concentration in air) and solubility in water (concentration in water).

Physics and Chemistry of Liquids published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mazari, Shaukat Ali published the artcileThermal degradation kinetics of morpholine for carbon dioxide capture, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Environmental Chemical Engineering (2020), 8(3), 103814, database is CAplus.

Deterioration of amines under process operating conditions for sour gas treatment is a severe problem. New amines are being investigated to replace conventional amines which face operational, economic and environmental challenges. Morpholine (MOR) is an understudied amine for carbon dioxide (CO₂) capture which comes with good CO₂ capture characteristics like CO₂ absorption rate, CO₂ solubility etc. This study investigates the stability of aqueous morpholine under stripper conditions. Effect of CO₂ loading and temperature have been investigated on the degradation kinetics of MOR. CO₂ loading is varied from 0 to 0.48 mol CO₂/mol alkalinity and temperatures is varied 135-190°C. Thermal degradation experiments were conducted using 316 stainless steel cylinders, closed with Swagelok endcaps. The degraded samples were analyzed by using Gas Chromatog.-Mass Spectrometry (GC-MS), Gas Chromatog.-Flame Ionization Detector (GC-FID) and Liquid Chromatog. Quadrupole Time-of-Flight Mass Spectrometry (LC-QToF-MS) for morpholine concentration and identification of degradation products. Morpholine demonstrated higher stability up to 150°C. However, higher degradation rate is found at temperatures 175°C and above. Degradation rate increases with CO₂ loading. Identified degradation products are tabulated in the text and reaction mechanisms for formation of some of the key degradation products are also provided. A kinetic model for the rate of degradation of morpholine is proposed, which shows a decent agreement with exptl. data. Comparison shows that morpholine is thermally more stable compared to monoethanolamine (MEA), diethanolamine (DEA), methyldiethanolamine (MDEA) and piperazine (PZ).

Journal of Environmental Chemical Engineering published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolli, Martin H. published the artcileNovel S1P₁ Receptor Agonists – Part 3: From Thiophenes to Pyridines, Application In Synthesis of 57044-25-4, the publication is Journal of Medicinal Chemistry (2014), 57(1), 110-130, database is CAplus and MEDLINE.

In preceding communications the authors summarized the authors’ medicinal chem. efforts leading to the identification of thiophene derivatives acting as potent, selective, and orally active S1P₁ agonists. As a continuation of these efforts, the authors replaced the thiophene by a 2-, 3-, or 4-pyridine and obtained less lipophilic, potent, and selective S1P₁ agonists (e.g., efficiently reducing blood lymphocyte count in the rat). Structural features influencing the compounds’ receptor affinity profile and pharmacokinetics are discussed. In addition, the ability to penetrate brain tissue has been studied for several compounds As a typical example for these pyridine based S1P₁ agonists, N-((S)-3-{4-[5-(2-Diethylamino-6-methylpyridin4-yl)[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide showed EC₅₀ values of 0.6 and 352 nM for the S1P₁ and S1P₃ receptor, resp., displayed favorable PK properties, and penetrated well into brain tissue. In the rat, N-((S)-3-{4-[5-(2-Diethylamino-6-methylpyridin4-yl)[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide maximally reduced the blood lymphocyte count for at least 24 h after oral dosing of 3 mg/kg.

Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagao, Yukinori published the artcileSyntheses of leuco triphenylmethane derivatives and their UV-VIS spectra, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is Nippon Kagaku Kaishi (1987), 1839-45, database is CAplus.

Leuco triphenylmethane derivatives (I; R = H, Me, OMe, NMe₂; Z = O, S, NMe, NPh) were prepared by the condensation of aromatic ketones with substituted benzenes or by Grignard reactions of aromatic ketones with bromoaryl compounds I turned into colored cations in acidic medium. UV-visible spectra in AcOH and H₂SO₄ were measured and discussed in terms of the effects of substituent R and bridging group Z. A good correlation between λ_max of the xanthene derivatives and the Hammett σ value of the substituents was observed, and the effect of the bridging group on the longest λ_max was that the bathochromic shift increased as the electron-donating ability of the bridging group decreased except for Z = S. The effects of R and Z were very similar to those of substituents on the Y band in triphenylmethane dyes having substituents on 2 rings.

Nippon Kagaku Kaishi published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beck, R. published the artcileA Novel L₃-Phase from a Ca-Salt of an Anionic Surfactant and a Cosurfactant, COA of Formula: C11H24O3, the publication is Journal of Physical Chemistry B (2002), 106(13), 3335-3338, database is CAplus.

An L₃-phase is observed for the first time in a ternary phase diagram of a Ca-salt of an α-sulfonated alkyl fatty acid Me ester, the cosurfactant (2-ethylhexyl)monoglyceride and water. As for other ternary surfactant/cosurfactant systems, the L₃-phase occurs with increasing cosurfactant/surfactant ratios after the L_α-phase. Some properties of the newly observed L₃-phases are the same as for other known L₃-phases. It is a low viscosity, optically isotropic fluid with a low flow birefringence. The time constants τ of the elec. birefringence results scale with τ ∼ O^-3. Its conductivity is very much higher than that of the neighboring L_α-phase, but there are some marked differences from known L₃-phases. This novel L₃-phase is thermodynamically stable despite ionic structure of the surfactant. We found no two phase region between the L_α and the L₃-phase, and the L₃-phase is stable over a wide cosurfactant/surfactant ratio between one and two. In SANS measurements it shows a broad correlation peak that occurs at about the same position as the sharper peak in the L_α-phase. The structure of the L₃-phase is demonstrated by FF-TEM micrographs.

Journal of Physical Chemistry B published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Md, Shadab published the artcileAmbroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells, Synthetic Route of 23828-92-4, the publication is Gels (2021), 7(4), 243, database is CAplus and MEDLINE.

This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, powder x-ray diffractometer, and SEM. The prepared co-precipitate complex was used for the development of the sustained-release formulation to overcome the high metabolic and poor solubility problems associated with ABX. Furthermore, the co-precipitate complex was formulated as a suspension in an aqueous floating gel-forming vehicle of sodium alginate with chitosan, which might be beneficial for targeting the stomach as a good absorption site for ABX. The suspension exhibited rapid floating gel behavior for more than 8 h, thus confirming the gastro-retentive effects. Particle size anal. revealed that the optimum nanosuspension (ABX-NS) had a mean particle size of 332.3 nm. Afterward, the ABX released by the nanoparticles would be distributed to the pulmonary tissue as previously described. Based on extensive pulmonary distribution, the developed nanosuspension-released ABX nanoparticles showed significant cytotoxic enhancement compared to free ABX in A549 lung cancer cells. However, a significant loss of mitochondrial membrane potential (MMP) also occurred. The level of caspase-3 was the highest in the ABX-NS-released particle-treated samples, with a value of 416.6 ± 9.11 pg/mL. Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumor necrosis alpha (NF-kB, IL-6, IL-1β, and TNF-α, resp.) were lower for ABX-NS compared to free ABX (p < 0.05). In caspase-3, Bax, and p53, levels significantly increased in the presence of ABX-NS compared to free ABX. Overall, ABX-NS produced an enhancement of the anticancer effects of ABX on the A549 cells, and the developed sustained-release gel was successful in providing a gastro-retentive effect.

Gels published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Synthetic Route of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts