Alcohols-buliding-blocks

Electric Literature of 10029-04-6, Adding some certain compound to certain chemical reactions, such as: 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate,molecular formula is C6H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10029-04-6.

Example 1(0189)With reference to FIG. 1, the first generic compound in the synthetic sequence (structure I) is prepared where X is CN, W is H, X? is CO2Et, and L is H.(0190)More specifically, in a 1 liter three-necked flask, alpha(hydroxymethyl)ethylacrylate (260.0 g, 2.0 mol) and 1.1 equivalent of cyanoacetic acid (187.0 g, 2.2 mol) were suspended in toluene (420 mL) with hydroquinone (0.8 g). The mixture was heated at a temperature of 90 C. until the cyanoacetic acid melted, at which point a catalytic amount (two drops) of sulfuric acid was added. The reaction mixture was stirred with heating at a temperature of 125 C. with a Dean-Stark apparatus attached to remove the water.(0191)The reaction mixture was washed with dilute aqueous sodium bicarbonate to remove excess cyanoacetic acid, then with dilute hydrochloric acid and finally with brine. The solvent (toluene) was removed under reduced pressure and the residue with an added 1 g of hydroquinone was distilled (b.p. 130 C. at 0.2 mm Hg) to furnish 197 g of the final product in a yield of 51%. Spectral confirmation is given below.(0192)1H-NMR (60 MHz, CDCl3): delta=1.32 (t, 3H), 3.49 (s, 2H), 4.24 (q, 2H), 4.92 (s, 2H), 5.90 (s, 1H), 6.41 (s, 1H) ppm.(0193)FT-IR (film): 2983.1, 2929.4, 2259.3, 1750.8, 1712.7, 1638.8, 1447.4, 1395.9, 1367.9, 1336.0, 1309.1, 1270.0, 1176.4, 1152.9, 1023.5, 957.7, 879.3, 859.1, 815.9 cm-1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Henkel Ireland Limited; Gherardi, Stefano; McArdle, Ciaran B.; Faimani, Giovanni; Loschen, Christoph; US8399698; (2013); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7735-42-4, name is 1,16-Hexadecanediol, molecular formula is C16H34O2, molecular weight is 258.44, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

The diol 14 (1 .047 g, 4.05 mmol) was dissolved in cyclohexane (30 mL) and vigorously stirred with 48% HBr (0.5 mL, 4.46 mmol, 1.1 eq.). The mixture was refluxed for 6 h, diluted with water (50 mL) and the phases were separated. The aqueous phase was extracted with a mixture of dichloromethane and methanol (v/v, 4:1 3 x 20 mL). The combined organic layer was dried over MgS04. The product was purified by column chromatography with silica gel (6 x 6 cm, cyclohexane/ethyl acetate, 8:1 ) and isolated as a white solid. Yield: 4.598 g (96%). Traces of 1 ,16-dibromohexadecane were also found. 15 M.p.: 65 C (lit. 53-54 C) 1H-NMR (300 MHz, CDCI3) delta [ppm]: 1.26-1.47 (m, 23 H, 4-CH2 to 14-CH2, 1 -OH), 1.51 -1.62 (m, 4 H, 2-CH2, 3-CH2), 1 .85 (m, 2 H, 15-CH2), 3.41 (t, 3JH,H = 6.9 Hz, 2 H, 16-CH2), 3.64 (t, 3JH,H = 6.6 HZ, 2 H, 1 -CH2). 13C-NMR (75 MHz, CDCI3) delta [ppm]: 25.9 (t, C-3), 28.3, 28.9, 29.6, 29.7, 29.8 (t, C-4 to C-14), 33.0 (t, C-2, C-15), 34.3 (t, C-16), 63.3 (t, C-1 ). Refs.: M.p. P. Chuit, J. Hausser, Helv. Chim. Acta 1929, 72,850-859. 1H-NMR spectroscopic data agree with those given by: S. Takanashi, M. Takagi, H. Takikawa; K. Mori, J. Chem. Soc, Perkin Trans. 1 1998, 1603-1606.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7735-42-4, 1,16-Hexadecanediol, and friends who are interested can also refer to it.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; HAUFE, Guenter; LEVKAU, Bodo; SCHAEFERS, Michael; SCHILSON, Stefani Silke; KEUL, Petra; WO2013/26765; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 311-86-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

Adding a moisture content of 4000 ppm in a 50 mL stainless steel autoclave equipped with agitation3,3,3-trifluoropropylene oxide (33.6 g, 0.3 mol), 3-bromo-1,1,1-trifluoro-2-propanol (2.3 g, 12 mol),2,3-dibromo-1,1,1,2,3,3-hexafluoropropane (5.6 g, 18 mol), imidazole (1.6 g, 24 mmol),After sealing, the reactor was replaced twice with CO2, and the stirring was set to a reaction temperature of 120 C.Continuously pass CO2 to maintain the reaction pressure at 2MPa, react for 4h, cool to normal temperature, and slowly releaseTo the excess CO2 gas, 50% water of a molar amount of 3,3,3-trifluoroepoxypropane was added to the reaction solution, and the reaction was stirred at 50 C for about 24 hours to obtain 3,3,3-trifluoro. Crude product of propylene carbonate and 3,3,3-trifluoro-1,2-propanediol, analysis of reaction product distribution by gas chromatography, separation,Refined process to get the target product3,3,3-trifluoropropene carbonate and42.3 g of 3,3,3-trifluoro-1,2-propanediol was used to calculate the yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemical Institute; Lv Jian; Ma Hui; Zhang Wei; Wang Bo; Zeng Jijun; Zhao Bo; Yang Zhiqiang; Qin Yue; Bai Yanbo; Li Fengxian; (10 pag.)CN108178752; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 530-91-6

A solution of alcohol 13 (262 mg, 1.77 mmol, 1 eq.), nosyl chloride (781.5 mg, 3.53 mmol,2.0 eq.), DMAP (73.2 mg, 0.60 mmol, 0.34 eq.) and Et3N (0.74 mL,540.2 mg, 5.34 mmol, 3.0 eq.) in CH2Cl2 (6 mL) wasstirred vigorously for 16 h at rt. 2M NaOH (6 mL) was added and the reactionmixture was extracted with CH2Cl2 (3 x 5 mL). The organiclayer was washed with 2M NaOH (7 mL), dried (Na2SO4),filtered and concentrated in vacuo. The crude product was purified by fc (d = 3cm, l = 13 cm, v = 25 mL, cyclohexane:EtOAc 8:2, Rf = 0.55) to obtain a colorlessoil, yield 380.0 mg (64 %). C16H15NO5S (333.4g/mol). 1H NMR (400 MHz, CDCl3): delta (ppm) = 2.03 – 2.15(m, 2H, 3-CH2), 2.77 – 2.85 (m, 1H, 1-CH2), 2.92 – 3.02(m, 2H, 4-CH2), 3.08 (dd, J = 16.8/4.9 Hz, 1H, 1-CH2),5.10 – 5.15 (m, 1H, 2-CH), 6.95 (dd, J = 7.3/1.5 Hz, 1H,tetraline), 7.05 – 7.16 (m, 3H, tetraline), 8.08 – 8.14 (m, 2H, nos), 8.35 -8.40 (m, 2H, nos).

The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2566-44-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2566-44-1 as follows.

Reaction A : Dissolve oxalyl chloride (9.3 mL, 106.7 mmol) in dichloromethane (140 mL) at ambient temperature, then cool to-78C and add slowly a solution of DMSO (11.22 g, 143.6 mmol) in dichloromethane (20 mL) while venting the mixture and stir the reaction at-78C for 20 minutes. Add 2-cyclopropyl-ethanol (6.11 g, 71.21 mmol) in dichloromethane (20 mL). Warm to 0C and add dichloromethane (25 mL) to assist with stirring and mix for 30 minutes. Dilute this reaction mixture with 100 mL THF and pour into a cold (-78C) solution of Reaction B. Reaction B : Add a solution of tert-butyl acetate (62 mL, 424 mmol) in THF (60 mL) to a cold solution (-78C) of lithium diisopropylamine (2M in heptanes/tetrahydrofuran/ethylbenzene, 180 mL, 360 mmol) in anhydrous THF (700 mL) and stir at-78C for 1.5-2 hours. Add crude Reaction A prepared as described above and rinse with 100 mL anhydrous THF. Stir at-78C for 1.5 hours then add water/diethyl ether and warm to ambient temperature overnight. Separate the layers and extract the aqueous layer with diethyl ether (3x). Dry the combined organic extracts over anhydrous MgS04, filter, and concentrate in vacuo. Purify the reaction on silica gel eluting with 20% EtOAc/hexanes to give 4-cyclopropyl-3-hydroxy-butyric acid tert butyl ester (10. 65 g. 75%).’H NMR (CDC13) 6 4.11-4. 05 (m, 1H), 3. 12 (d, 1H), 2.53 (dd, 1H), 2.38 (dd, 1H), 1. 60- 1.48 (m, 1H), 1.47 (s, 9H), 1.32-1. 23 (m, 1H), 0.80-0. 73 (m, 1H), 0.51-0. 46 (m, 2H), 0. 13-0. 04 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/92835; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 42822-86-6 ,Some common heterocyclic compound, 42822-86-6, molecular formula is C10H20O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: para-Methane-3,8-diol (3, 5.0 g, 0.029 mol) and an appropriatemolar equivalent of acid anhydride were transferred into thereactor concurrently. Both reagents were stirred and heated at60 Cfor 10 minutes. The homogeneous mixture was achievedand 0.3 g of polymer-bound scandium triflate (PS-Sc(OTf)3)catalyst was added into the reaction mixture. The reaction washeated at the appropriate temperature for 24 hours, while followed by sampling at an hourly interval. Upon the completionof the reaction, the catalyst was separated from the product mixture by filtration and the acid byproduct was removed byvacuum distillation. The obtained crude sample was subsequently purified by column chromatography hexane/EtOAc(98:2).Diacetate 9:The reaction was carried out in accordance withthe general procedure using para-menthane-3,8-diol (3, 5.0 g,0.029 mol) and acetic anhydride (5, 7.4 g, 0.073 mol) to givethe title compound 9as viscous colourless oily liquid,bp 288 C, (6.8 g, 91%); 1H NMR (400 MHz, CDCl3, ppm)delta0.78-0.79 (m, 3H), 0.89-1.04 (m, 2H), 1.35 (br d, J= 12 Hz,6H), 1.53-1.60 (m, 3H), 1.72 (d, J= 16 Hz, 1H), 1.82 (d, J= 12Hz, 1H), 1.88 (s, 3H), 1.96 (s, 3H), 2.02-2.08 (m, 1H) and 5.17(br s, 1H); 13C NMR(100 MHz, CDCl3, ppm) delta21.4, 21.9,22.2, 22.3, 24.0, 25.1, 26.6, 34.6, 39.4, 47.3, 69.8, 84.2, 169.9and 170.3; FTIR (cm-1): 2949, 1728, 1180 and 1144; m/z(CI)256 (M+, 1), 197 (78), 137 (71), 95 (62) and 81 (100); GC tR=17.8 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42822-86-6, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mafu, Lubabalo; Zeelie, Ben; Watts, Paul; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2046 – 2054;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 124-68-5, blongs to alcohols-buliding-blocks compound. name: 2-Amino-2-methyl-1-propanol

(1) Acetic acid (5.4 ml) was added to a solution of 2-amino-2-methyl-1-propanol (8.4 g) and benzaldehyde (10 g) in 1,2-dichloroethane (140 ml) under ice-cooling. After 30 minutes of stirring at the same temperature, sodium triacetoxyborohydride (26 g) was added by small portions to the solution over 10 minutes. After 2 hours of stirring at room temperature, the mixture was poured into a solution of sodium hydrogen carbonate (48 g) in water (300 ml). The aqueous layer was separated and adjuster to pH 12 with 24% sodium hydroxide aqueous solution. The alkaline solution was extracted with ethyl acetate 12 times. The extract was dried over sodium sulfate and evaporated under reduced pressure to give colorless crystals of 2-benzylamino-2-methyl-1-propanol (13.2 g). mp: 46.0-47.0 C. IR (Nujol): 3330, 3100, 2900, 1450, 1380, 1355 cm-1 NMR (DMSO-d6, delta): 0.99 (6H, s), 3.23 (2H, d, J=3.9Hz), 3.62 (2H, s), 4.50-4.60 (1H, m), 7.16-7.36 (5H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; MIYAKE, HIROSHI; TAKE, KAZUHIKO; SHIGENAGA, SHINJI; AZAMI, HIDENORI; SASAKI, HIROSHI; EIKYU, YOSHITERU; NAKAI, KAZUO; ISHIDA, JUNYA; MANABE, TAKASHI; KONISHI, NOBUKIYO; TERASAKA, TADASHI; US2003/114668; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 148043-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Into a reactor (internal capacity: 200 mL, made of glass) equipped with a stirrer and a dropping funnel, linear C2F5CH2CH2CH2OH (23.6g), triethylamine (16.1 g) and acetone (80 mL) were put and stirred. Then, by an ice bath, the inner temperature of the reactor was adjusted to be at most 10C, and in a nitrogen atmosphere, a solution of 4-(chloromethyl)benzoic acid chloride (25.0 g) in acetone (15 mL) was dropwise added. Further, the temperature was returned to room temperature, and stirring was continued for 2 hours. The obtained reaction crude liquid was transferred to a separating funnel, dichloropentafluoropropane (tradename: AK-225, manufactured by Asahi Glass Company, Limited) (100 mL) was added, followed by washing three times with distilled water (100 mL), and the solvent in the AK-225 phase was distilled off to obtain 40.2 g of a compound (C-2) (pale yellow liquid) represented by the following structural formula (C-2) and classified into the above compound (C). The yield was 93%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; Asahi Glass Company, Limited; EP2497763; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-95-2, name is 2-Methylbenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Methylbenzyl alcohol

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89-95-2, 2-Methylbenzyl alcohol.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Ethynylbenzyl alcohol a_(l g, 7.57 mmol) was diluted in 20 ml DCM, and cooled to 0¡ã in ice bath. Phosphorus tribromide (4.1 g, 15 mmol) was added dropwise. The reaction was allowed to warm to room temperature gradually, and stirred under nitrogen overnight. The reaction was quenched by addition of H2O in ice bath, extracted by DCM. Combined organic layers were washed with brine, dried over Na2SO4 and concentrated to dryness. The crude material was purified by chromatography (ISCO) using 100percent hexane to give pure 4-ethynylbenzyl bromide b (220 mg). M+H+ 195.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GENENTECH, INC.; WO2008/134679; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts