Alcohols-buliding-blocks

Synthetic Route of 69605-90-9, Adding some certain compound to certain chemical reactions, such as: 69605-90-9, name is [1,1′-Biphenyl]-3-ylmethanol,molecular formula is C13H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69605-90-9.

Under nitrogen atmosphere, to a stirred mixture of 3-phenylphenyl methanol (0.3 g, 1.63 mmol) in dry CH2C12 (3 mL), Et3N (0.340 mL, 2.44 mmol) and di-2-pyridyl carbonate (0.387 g, 1.79 mmol) were added. The reaction mixture was left at rt for 15h, diluted with CH2C12 and washed first with a saturated NH4C1 solution (3 mL) and subsequently with a saturated NaHC03 solution (3×3 mL). The organic fraction was dried over Na2S04, filtered and concentrated to dryness to afford a dark oil (0.487 g, 98%), as a mixture (ratio 1:3) of 3- phenylphenyl)methyl-2-pyridyl-carbonate and 3-phenylphenyl)methyl-2-oxopyridine 1- carboxylate. The mixture of isomers was not separated and used in the next step without any further purification. MS (ESI) m/z: 328 [M-Na]+, 306 [M-H]+, 262, 167.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 69605-90-9, [1,1′-Biphenyl]-3-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; IIT – ISTITUTO ITALIANO DI TECNOLOGIA; UNIVERSITY DEGLI STUDI DI URBINO; UNIVERSITA DEGLI STUDI DI PARMA; PIOMELLI, Daniele; BANDIERA, Tiziano; MOR, Marco; TARZIA, Giorgio; BERTOZZI, Fabio; PONZANO, Stefano; WO2013/78430; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3279-95-6, 2-(Aminooxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Aminooxy)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(Aminooxy)ethanol

To a solution of 1-(3-(3-(morpholinomethyl)quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethanone hydrochloride (79.3) (23 mg, 0.047 mmol) and 2-(aminooxy)ethanol (10.80 mg, 0.140 mmol) in MeOH (5 ml) was added 2 drops of HCl (2 N) by a 1-ml syringe to reach pH about 3 and the mixture was stirred in a sealed tube at 85 C. for 3 h. The mixture was evaporated to dryness and the residue was dissolved in water. The solution was neutralized by adding solid NaHCO3 until pH reached 9, then extracted by DCM (3×). The combined organic layers were washed by water again, dried over Na2SO4, filtered and evaporated. The residue was purified by preparative base HPLC (gradient eluent NB from 20/80 to 95/5. mobile phase A: NH4OH/CH3CN 0.04%; mobile phase B: NH4OH/H2O 0.04%). The desired fractions were collected, evaporated by BUCHI under 30 mbar at 35 C. to remove CH3CN. The remained solution was lyophilized to afford the title compound (12.2 mg, yield 54.2%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3279-95-6, 2-(Aminooxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue; US2013/245002; (2013); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13330-96-6, name is 4-(Dimethylamino)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-(Dimethylamino)butan-1-ol

Example S. Synthesis of MC4 Ether.[0294] MC4 Ether (Compound 15) having the structure shown below was synthesized as described below.Chemical Fotmuta: Omicron^Eta,, OmicronExact Mass: 627.6Molecular Wteirjit 628.1Bemena And sis: C.8222; K 13.00; N, 2.23; 0.2.55MC4 Ether[0295] A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05g, 9 mmol) and anh. benzene (10 mL) added. Aftereffervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS, INC.; HEYES, James; WOOD, Mark; MARTIN, Alan; WO2011/141705; (2011); A1;,
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Related Products of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

(A) 3-Cyclopentyl-2-(3,4-dichloro-phenyl)-N-pyridin-2-yl-propionamide: A solution of triphenylphosphine (28.80 g, 109.8 mmol) and imidazole (14.9 g, 219.6 mmol) in methylene chloride (160 mL) was cooled to 0 C. and then slowly treated with iodine (27.87 g, 109.8 mmol). The reaction mixture was then treated dropwise with a solution of cyclopentylmethanol (10.0 g, 99.8 mmol) in methylene chloride (10 mL). The resulting reaction mixture was allowed to warm to 25 C., where it was stirred for 4 h. The reaction mixture was then diluted with water (50 mL), and the reaction mixture was further extracted with methylene chloride (3*20 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo at 25 C. The resulting solid was washed with pentane (4*50 mL) and filtered through a silica gel plug. The filtrate was concentrated in vacuo at 25 C. to afford iodomethylcyclopentane (18.48 g, 88%) as a clear colorless liquid: EI-HRMS m/e calcd for C6H11I1 (M+) 209.9906, found 209.9911.

Statistics shows that 3637-61-4 is playing an increasingly important role. we look forward to future research findings about Cyclopentanemethanol.

Reference:
Patent; Bizzarro, Fred Thomas; Corbett, Wendy Lea; Grippo, Joseph Francis; Haynes, Nancy-Ellen; Holland, George William; Kester, Robert Francis; Sarabu, Ramakanth; US2001/39344; (2001); A1;,
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Application of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To the stirred solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.0 g, 7.72 mmol) in water (5 mL) was added HC1 (3.86 mL, 23.15 mmol) at 0 C. To this, sodium nitrite (0.639 g, 9.26 mmol) in water was added drop wise at 0 C and stirred for 1 hour. Potassium iodide (1.922 g, 11.58 mmol) was added and the reaction mixture was stirred at ambient temperature. After completion of the reaction, the aqueous layer was extracted with DCM. The DCM layer was dried over sodium sulphate and evaporated. The crude material obtained was purified by flash column chromatography (silica gel, hexane and ethyl acetate). 1H NMR (DMSO-d6, 300 MHz): oe ppm 8.87(s, 1H), 7.92 (d, J=8.7Hz, 2H), 7.46 (d, J=8.lHz,2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; SAHU, Bichismita; MALI, Sunil, Vasantrao; SINGH, Deepak; KUMAR, Pramod, Bhaskar; DAWANGE, Mahesh; MISTRY, Hitesh; (108 pag.)WO2015/145371; (2015); A1;,
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Electric Literature of 647-42-7, Adding some certain compound to certain chemical reactions, such as: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 647-42-7.

To a mixture of 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol) and succinic anhydride (9.7 g, 49 mmol) and 10ml tetrahydrofuranand stirred at 100C And allowed to react for 60 minutes.Thereafter, the mixture was cooled to 30 DEG C, 100 mL of water was added, and the mixture was further cooled to 15 DEG C, and the precipitated crystals were collected by filtration to obtain carboxylic acid (1-2a). (39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Kato, Syunya; Yoshikawa, Masaru; (58 pag.)KR101634475; (2016); B1;,
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Electric Literature of 505-10-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.505-10-2, name is 3-(Methylthio)propan-1-ol, molecular formula is C4H10OS, molecular weight is 106.19, as common compound, the synthetic route is as follows.

The alcohol 23-a (200 g, 1900 mmol) was dissolved in CH2Cl2 (2000 ml). The mixture was cooled to 0 C. The m-CPBA 85% in water (970 g, 5700 mmol) was added portion wise keeping the temperature between 0 to 5 C. After addition, the mixture was allowed to warm to 25 C. and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether:ethyl acetate=3:1 and then ethyl acetate: methanol=10:1) to yield the intermediate 23-b (75 g, 29%).

Statistics shows that 505-10-2 is playing an increasingly important role. we look forward to future research findings about 3-(Methylthio)propan-1-ol.

Reference:
Patent; Jansen R&D Ireland; Tahri, Abdellah; Jonckers, Tim Hugo Maria; Raboisson, Pierre Jean-Marie Bernard; Vendeville, Sandrine Marie Helene; Hu, Lili; Demin, Samuel Dominique; Cooymans, Ludwig Paul; US2015/111868; (2015); A1;,
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Synthetic Route of 4254-29-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. A new synthetic method of this compound is introduced below.

General procedure: General Procedure C A flame-dried flask with Teflon stir bar was charged with triphenylphosphine (1.2 equiv.) and I2(1.2 equiv.) in CH2Cl2, the mixture was stirred for 10 min at room temperature. Imidazole (1.2equiv.) was added to the resulting mixture. After 10 min of stirring, the corresponding alcohol(1.0 equiv.) was added and the reaction was stirred for additional 5 h at room temperature andwas checked by TLC until completion. The reaction mixture was quenched with Sat. Na2SO3.The mixture was transferred to a separatory funnel using CH2Cl2 and brine to aid the transferand separation. The aqueous and organic layers were separated and the aqueous layer wasextracted by CH2Cl2 (3x). The combined organic layers were washed with brine and dried overNa2SO4, filtered, and concentrated in vacuum. The crude reaction mixture was purified by flashchromatograph on silica gel and evaporated to give the alkyl iodide compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4254-29-9, its application will become more common.

Reference:
Article; Bai, Songlin; Gao, Yadong; Jiang, Chao; Liu, Xiaolei; Qi, Xiangbing; Wang, Jing; Wu, Qingcui; Yang, Chao; Chem; vol. 6; 3; (2020); p. 675 – 688;,
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Synthetic Route of 1113-21-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 5: 5E,9E,13E-Geranylgeranyl Acetone Synthesis[0141] Alternative synthesis of 5-trans Isomer: 5E,9E,13E-Geranylgeranyl acetone 1: The alternative synthesis of 5E,9E,13E-geranylgeranyl acetone 1 can be achieved as shown in the scheme-5.Scheme 5:[0142] The 5E, 9E, 13E-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E- geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in the Carroll rearrangement using Al(OiPr)3 at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA (1) can be prepared by treating geranyl linalool (23) with the Meldrum’s acid 26 in the Carroll rearrangement using Al(OiPr)3 at 160 C. Similarly, the use of tert-butyl acetoacetate (27) with geranyl linalool (23) in the Carroll rearrangement can also give the desired 5E, 9E, 13E-geranyl geranyl acetone (1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1113-21-9, 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; BARRES, Ben A.; NAKAYAMA, Naoki; SERIZAWA, Hiroaki; ARGADE, Ankush B.; WO2012/31028; (2012); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.Formula: C5H10O2

a) [1-[5-Methyl-3-(quinolinyl-8-sulfonyloxy)phenoxy]methyl]-cyclopropylmethanol To 250 mg (0.75 mmol) of 5-methyl-3-(quinolinyl-8-sulfonyloxy)phenol, as prepared in step a of example 15, 170 mg (1.7 mmol) of 1,1-di(hydroxymethyl)cyclopropane (as prepared in US Patent 5472964), and 370 muL (1.49 mmol) of tri-n-butylphosphine in 5 mL of anhydrous tetrahydrofuran was added 378 mg (1.5 mmol) of 1,1′-(azodicarbonyl)dipiperidine. The reaction mixture was stirred at ambient temperature for 2 days. The reaction mixture was diluted with diethyl ether, filtered, and the filtrate concentrated. The residue was purified by flash chromatography (dichloromethane / ethyl acetate (2: 1 to 1: 1)) to give the title compound as a gum (177 mg. 59%). 1H-NMR (300 MHz, CDCl3) delta 9.27 (dd, 1 H, J = 2, 4 Hz), 8.42 (dd, 1 H, J = 1.5,7.5 Hz), 8.30 (dd, 1 H, J = 2, 8 Hz), 7.06 – 7.65 (m, 2 H), 6.56 (s, 1 H), 6.44 – 6.47 (m, 2 H), 3.73 (s, 2 H), 3.56 (d, 2 H, J = 5.5 Hz), 2.17 (s, 3 H), 1.79 (t, 1 H, J = 5.5 Hz), 0.53 – 0.62 (m, 4 H). Mass spectrum (MALDI-TOF, alpha-cyano-4-hydroxycinnamic acid matrix) calcd. for C21H21NO5S: 400.1 (M +H). Found: 399.8.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane, and friends who are interested can also refer to it.

Reference:
Patent; Ortho-McNeil Pharmaceutical, Inc.; EP906091; (2006); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts