Category: alcohols-buliding-blocks

Sorouraddin, Saeed Mohammad published the artcileDeep eutectic solvent-based air-assisted liquid-liquid microextraction of lead in gasoline samples followed by graphite furnace atomic absorption spectrometry, Formula: C8H8O3, the publication is Journal of the Iranian Chemical Society (2022), 19(6), 2591-2599, database is CAplus.

This paper describes determination of lead in gasoline by graphite furnace at. absorption spectrometry after application of an air-assisted liquid-liquid microextraction method using deep eutectic solvent. In this study, for the first time, a ternary deep eutectic solvent was synthesized from menthol, mandelic acid, and glycolic acid and was used as a complexing agent and an extraction solvent, simultaneously. Under optimized conditions, the proposed method made possible the determination of lead in the range of 5-50 ng L^-1 with a good linearity. The obtained detection and quantification limits were 1.6 and 5.0 ng L^-1, resp. Moreover, enrichment factor and extraction recovery values were 166 and 91.3%, resp. The optimized and developed method was successfully used for the determination of lead in various gasoline samples.

Journal of the Iranian Chemical Society published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C17H14F3N3O2S, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lape, Michael published the artcileMolecular determinants of sarco/endoplasmic reticulum calcium ATPase inhibition by hydroquinone-based compounds, Computed Properties of 903-19-5, the publication is Proteins: Structure, Function, and Bioinformatics (2008), 70(3), 639-649, database is CAplus and MEDLINE.

The ion transport activity of the sarco/endoplasmic reticulum calcium ATPase (SERCA) is specifically and potently inhibited by the small mol. 2,5-di-tert-butylhydroquinone (BHQ). In this study, we investigated the relative importance of the nature and position of BHQ’s four substituents for enzyme inhibition by employing a combination of exptl. and computational techniques. The inhibitory potencies of 21 com. available or synthesized BHQ derivatives were determined in ATPase activity assays, and 11 compounds were found to be active. Maximum inhibitory potency was observed in compounds with two para hydroxyl groups, whereas BHQ analogs with only one hydroxyl group were still active, albeit with a reduced potency. The results also demonstrated that two alkyl groups were an absolute requirement for activity, with the most potent compounds having 2,5-substituents with four or five carbon atoms at each position. Using the program GOLD in conjunction with the ChemScore scoring function, the structures of the BHQ analogs were docked into the crystal structure of SERCA mimicking the enzyme’s E₂ conformation. Anal. of the docking results indicated that inhibitor binding to SERCA was primarily mediated by a hydrogen bond between a hydroxyl group and Asp59 and by hydrophobic interactions involving the bulky inhibitor alkyl groups. Attempts to dock BHQ into crystal structures corresponding to the E₁ conformation of the enzyme failed, because the conformational changes accompanying the E₂/E₁ transition severely restricted the size of the binding site, suggesting that BHQ stabilizes the enzyme in its E₂ form. The potential role of Glu309 in enzyme inhibition is discussed in the context of the computational results. The docking scores correlated reasonably well with the measured inhibitory potencies and allowed the distinction between active and inactive compounds, which is a key requirement for future virtual screening of large compound databases for novel SERCA inhibitors.

Proteins: Structure, Function, and Bioinformatics published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Computed Properties of 903-19-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bodor, Nicholas published the artcileImproved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for β-adrenergic blocking agents, Application In Synthesis of 30165-97-0, the publication is Journal of Medicinal Chemistry (1988), 31(1), 100-6, database is CAplus and MEDLINE.

Novel ketoxime analogs, e.g., I and II, of known β-blockers (propranolol, timolol, carteolol) were synthesized and tested as potential site-specific chem. delivery systems. It was assumed that a hydrolysis-reduction sequence could produce the active β-blockers in the iris-ciliary body. Some of these bioprecursors are remarkably active in reducing intraocular pressure in rabbits. I is more effective and a much less irritant than its parent β-blocker. While the ketoximes also displayed activity on isoprenaline-induced tachycardia after i.v. administration, they were void of activity when given orally. Propranolol was found for a prolonged time and in significant concentrations in the rabbit’s eye following topical administration of I; however, the inactive ketoximes apparently were not converted to the corresponding β-blockers in the eye. A correlation was found between the physicochem. properties of the ketoximes and their conversion to the amino alc. and thus their subsequent activity. The results suggest that at least some of the ketoxime precursors could have a use as antiglaucoma agents without systemic side effects.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Application In Synthesis of 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

El-Sayed, A. published the artcileFacile approaches for determination of Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride using Eosin Y, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Annales Pharmaceutiques Francaises, database is CAplus and MEDLINE.

New validated Spectroscopic methods were developed to assay Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride sep. in pure form and pharmaceutical formulations. The spectrophotometric assay (method I) shows complex formation between each of the drugs and Eosin Y at 540 nm at pH 3.6 and 3.4 mL of 4 x 10^-4M Eosin for Bromhexine and Ambroxol. The Spectrofluorimetric assay (method II) depends on quenching eosin native fluorescence by the studied drugs, which measured at 540 nm after excitation at 302 nm. The spectrophotometric absorbance-concentration plot is rectilinear over the ranges (1.0-5.0) and (1.0-10.0) μg/mL for bromhexine and ambroxol with LOD of 0.31 and 0.14 μg/mL and LOQ of 0.94 and 0.42 μg/mL for the two drugs resp. The fluorometric-concentration plot is linear along the range (1.0-5.0) μg/mL and (1-10) μg/mL for the two drugs resp. with LOD of 0.13 μg/mL and 0.22 μg/mL and LOQ of 0.4 μg/mL and 0.65 μg/mL for the two drugs, resp. Developed assays have been validated in agreement with ICH recommendations and they were used in the anal. of com. drug formulations containing the two mucolytic drugs and the results were matching with those obtained by the comparison method.De nouvelles methodes spectroscopiques validees ont etedeveloppes pour doser le chlorhydrate de bromhexine et son metabolite actif, le chlorhydrate d′Ambroxol, sous forme pure et dans des formulations pharmaceutiques. Le dosage spectrophotometrique (methode I) montre la formation d′un complexe entre chacun des medicaments et l′eosine Y a540 nm a pH 3,6 et 3,4 mL d′eosine 4 x 10^-4M pour la bromhexine et l′ambroxol. Le dosage spectrofluorimetrique (methode II) depend de l′extinction de la fluorescence native de l′eosine par les medicaments etudies, qui a ete mesuree a 540 nm apres excitation a 302 nm. Le trace spectrophotometrique. Le trace spectrophotometrique absorbance-concentration est lineaire sur les plages (1,0-5,0) et (1,0-10,0) μg/mL pour la bromhexine et l′ambroxol avec LOD de 0,31 et 0,14 μg/mL et LOQ de 0,94 et 0,42 μg/mL pour les deux medicaments respectivement. Le trace de la concentration fluorometrique est lineaire le long de la plage (1,0-5,0) μg/mL et (1-10) μg/mL pour les deux medicaments respectivement avec LOD de 0,13 μg/mL et 0,22 μg/mL et LOQ de 0,4 μg/ mL et 0,65 μg/mL pour les deux medicaments, respectivement. Les tests developpes ont ete valides en accord avec les recommandations de l′ICH et ils ont ete utilizes dans l′analyze des formulations de medicaments commerciaux contenant les deux medicaments mucolytiques et les resultats correspondaient a ceux obtenus par la methode de comparaison.

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Refaee, Ayaat A. published the artcileNano-bio finishing of cotton fabric with quaternized chitosan Schiff base-TiO₂-ZnO nanocomposites for antimicrobial and UV protection applications, Safety of Triisopropanolamine, the publication is European Polymer Journal (2022), 111040, database is CAplus.

The purpose of this work is to offer a novel approach to designing multifunctional tech. cotton textiles by coating them with smart bio-materials. Two different ternary nanocomposites (NC1, NC2) comprising (ammonium-salicylidene) chitosan Schiff base (ASCSB), TiO₂, and ZnO nanoparticles were in-situ prepared and applied for treating cotton fibers using the facile pad-dry-cure process to impart antimicrobial and UV protection characteristics. Notably, NC1 is TiO₂-rich, while NC2 is rich in ZnO. The physicochem. and visual characteristics of the new nanocomposites and the treated fabrics were investigated by spectral, microscopic, and thermal methods. The as-prepared NC1 exhibited a more homogeneous distribution, higher depositing d. and smaller mean nanoparticle size (48 nm) when compared to NC2 (56 nm). In contrast, NC2-treated fabrics showed a higher depositing d. of nanoparticles than NC1-treated ones. The treated cotton fibers demonstrated strong and sustainable antimicrobial impacts on S. aureus, E. coli, and C. albicans pathogens, with more effective performance for NC2-treated textiles in comparison to NC1-treated fabrics. The NC2-remediated cotton fabrics demonstrated a higher UV protection factor (UPF) value (53) as compared to NC1-coated fabrics (35), indicating that the ZnO-rich nanocomposite endowed cotton fabrics with more UV protection than TiO₂-rich nanocomposite.

European Polymer Journal published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Razek, A. S. published the artcileBioelimination of phenanthrene using degrading bacteria isolated from petroleum soil: safe approach, Safety of 1-Hydroxy-2-naphthoic acid, the publication is Desalination and Water Treatment (2020), 131-140, database is CAplus.

Polyaromatic hydrocarbon contamination is considered as serious pollution resulted from industrial activities. Phys. or chem. methods used for remediation of hydrocarbons might cause the transfer of the remediated compounds from the polluted sites into other clean locations. Our study is concerned by the bioremediation of phenanthrene, using microbial degraders that will eventually, result in the release of non-toxic structures, as end products. Successfully, three bacterial isolates; Enterobacter cloacae, Bacillus sp. and Bacillus thuringiensis with accession numbers; MK559694, MK561601 and MK559693, resp., showed higher phenanthrene biodegradation ability. The examined conditions indicated that the isolates were active in a wide range of temperatures, pH and hydrocarbon concentrations The gas chromatog.-mass spectrum anal. of the formed byproducts showed the existence of intermediate structures with varied carbon values, ranged from C4H8O2 to C12H22O11. However, these byproducts did not show cytotoxic effect against Vero cell lines, compared with the tested undegraded phenanthrene. The obtained results revealed that these bacterial isolates can be used as potent phenanthrene degraders with safe and non-toxic end products, which allow the treated water to be used for non-potable water applications.

Desalination and Water Treatment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Safety of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brody, Gerald published the artcileComparative activity of 29 known anthelmintics under standarized drug-diet and gavage medication regimens against four helminth species in mice, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Journal of Parasitology (1971), 57(5), 1068-77, database is CAplus and MEDLINE.

Of 29 reference anthelmintics (21 aromatic-heterocyclic and 8 organophosphate compounds) tested at an initial concentration of 1000 ppm in the diet of mice for 18 days against 4 mouse helminths, parbendazole (I) [14255-87-9] was the only compound exhibiting activity against all 4 helminths and the effectiveness of I was .sim.100% against the 4 helminths. However, in experiments using the 29 compounds at an initial dose of 200 mg/kg/day by gavage for 3 days, significant differences were observed in the effectiveness of a number of the anthelmintics in the 2 different medication regimens. The data below refers to the effectiveness of the compounds when given in the diet. Against Nematospiroides dubius, I, pyrantel (II) [15686-83-6], dl-tetramisole [5036-02-2], l-tetramisole (III) [14769-73-4], and thiabendazole (IV) [148-79-8] were the most effective. Against Hymenolepis nana (tapeworm), I and Ro-2-9009 (1,4-bis(2-diethylaminoethoxy)anthraquinone-2HCl (V) [18272-48-5] were the most effective. Against Syphacia obvelata, I, II, III, IV, V, dithiazanine (VI) [7187-55-5] (at 250 ppm), pyrvinium (VII) [7187-62-4], stilbazium (VIII) [3784-99-4], coumaphos (IX) [56-72-4], haloxon (X) [321-55-1], mercaptophos (XI) [55-38-9], and Ruelene (XII) [299-86-5] were the most effective. Against Aspiculuris tetraptera, I, II, VI, VII, VIII, IX, X, XI, XII, and dichlorvos [62-73-7] were the most effective.

Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kaufmann, Thomas C. published the artcileA novel method for detergent concentration determination, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Biophysical Journal (2006), 90(1), 310-317, database is CAplus and MEDLINE.

A fast and precise method for detergent concentration determination is presented. A small droplet of the detergent solution is deposited on a piece of Parafilm M and side views are recorded by two orthogonally arranged TV cameras. The droplet contours are then approximated by ellipses to determine the contact angles. Comparison of the observed contact angle values to calibrated standard curves of known detergent concentrations gives the concentration of the detergent assessed. A range of commonly used detergents was studied to demonstrate the reproducibility and precision of this simple method. As a first application, the detergent binding capacity of the Escherichia coli galactose/proton symporter (GalP) was assessed. Aggregation of GalP was observed when <260±5 dodecyl-β-D-maltoside mols. were bound to one GalP mol. These measurements document the efficacy of the drop-shape based detergent concentration determination described.

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wasin, Tuchinda published the artcileFabrication of “Clickable” Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms, Related Products of alcohols-buliding-blocks, the publication is ACS Sensors (2016), 1(6), 766-774, database is CAplus.

“Clickable” nanowires with well-defined and uniform structures made of conjugated polyfluorene polymers were successfully fabricated by single particle nanofabrication technique (SPNT). Poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(9,9′-di-n-octylfluorenyl-2,7-diyl)] (F6E8) and poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(2,2′-bithiophene)] (F6E2T) underwent an efficient crosslinking reaction upon irradiation, resulting in formation of one-dimensional nanostructures with high and desired aspect ratio reaching up to 200. Alkyne groups on the surface of nanowires were functionalized effectively by click reaction with fluorescent 5-TAMRA-PEG3-azide, which was confirmed by confocal microscopy. Substrates functionalized with the nanowires provide dramatic expansion of “clickable” surface area immobilized directly with TAMRA, and the fluorescence resonance energy transfer (FRET) processes between TAMRA and nanowire backbones are demonstrated as biol. sensing platforms.

ACS Sensors published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C6H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Finkel’shtein, E. Sh. published the artcileElectrophilic addition to methylenecyclobutane and bicyclobutylidene, HPLC of Formula: 20117-47-9, the publication is Neftekhimiya (1985), 25(1), 48-57, database is CAplus.

Title reaction of methylenecyclobutane (I) with ROH (R = Me, Et, Bu, 1-methylcyclobutyl, Ph, Ac, ClCH₂CO, FCH₂CO, CCl₃CO, CF₃CO) in the presence or absence of hexane or cyclohexane and/or 80% H₂SO₄ gave the corresponding ethers and esters II. PhOH gave 4-R¹C₆H₄OH (R¹ = 1-methylcyclobutyl) and 2,4,6-R¹₃C₆H₂OH (same R¹) as the major products. Analogous reactions of bicyclobutylidene with ROH (R = H, Me, Ac, CF₃CO, Ph) gave bicyclo[3.3.0]octanes III (R² = OH, OMe, OAc, O₂CCF₃, C₆H₄OH-4, resp.). I reacted with aqueous HCHO under these conditions to give 5,7-dioxaspiro[3.5]nonane, methanolysis which gave diol IV (R = H) (V) and IV (R = Me). Dehydrating V gave 1-vinylcyclobutene . The NMR and mass spectra of the products were interpreted.

Neftekhimiya published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, HPLC of Formula: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts