Category: alcohols-buliding-blocks

Jiang, Ji published the artcileDiscovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(14), 3278-3281, database is CAplus and MEDLINE.

Hydroxyl 1,2-diphenylethanamine analogs were identified as potent inhibitors of cholesterol ester transfer protein (CETP), a therapeutic target to raise HDL cholesterol. In an effort to improve the pharmaceutical properties in the previously disclosed DiPhenylPyridineEthanamine (DPPE) series, polar groups were introduced to the N-linked quaternary center. Optimization of analogs for potency, in vitro liability profile and efficacy led to identification of lead compound 16 which demonstrated robust pharmacodynamic effects in human CETP/apo-B100 dual transgenic mice.

Bioorganic & Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Crozals, Gabriel published the artcileMethylene blue phosphoramidite for DNA labelling, Recommanded Product: 4-(Butylamino)butan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(21), 4458-4461, database is CAplus and MEDLINE.

We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochem. and optical properties of the resulting MB modified oligonucleotides were confirmed. This new mol. is an important breakthrough in the design of new probes labeled with MB.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Recommanded Product: 4-(Butylamino)butan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Enache, Teodor Adrian published the artcileElectrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes, Synthetic Route of 328-90-5, the publication is Combinatorial Chemistry & High Throughput Screening (2010), 13(7), 569-577, database is CAplus and MEDLINE.

The electrochem. behavior of triflusal (TRF) and aspirin (ASA), before and after hydrolysis in water and in alk. medium using two different electrode surfaces, glassy carbon and boron doped diamond, was studied by differential pulse voltammetry over a wide pH range. The hydrolysis products were 2-(hydroxyl)-4-(trifluoromethyl)-benzoic acid (HTB) for triflusal and salicylic acid (SA) for aspirin, which in vivo represent their main metabolites. The hydrolysis processes were also followed by spectrophotometry. The UV results showed complete hydrolysis after one hour for TRF and after two hours for ASA in alk. solution The glassy carbon electrode enables only indirect determination of TRF and ASA through the electrochem. detection of their hydrolysis products HTB and SA, resp. The oxidation processes of HTB and SA are pH dependent and involve different numbers of electrons and protons. Moreover, the difference between the oxidation peak potential of SA and HTB was equal to 100 mV in the studied pH range from 1 to 8 due to the CF₃ of the aromatic ring of HTB mol. Due to its wider oxidation potential range, the boron doped diamond electrode was used to study the direct oxidation of TRF and ASA, as well as of their resp. metabolites HTB and SA.

Combinatorial Chemistry & High Throughput Screening published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afanasyev, Oleg I. published the artcileDirect Reductive Amination of Camphor Using Iron Pentacarbonyl as Stoichiometric Reducing Agent: Features and Limitations, HPLC of Formula: 6346-09-4, the publication is European Journal of Organic Chemistry (2020), 2020(39), 6289-6294, database is CAplus.

The method of direct reductive amination of camphor and fenchone was proposed. The most effective reducing agent is iron pentacarbonyl. No ligands or solvents are needed. The stereochem. of the corresponding products was determined by HMBC, HSQC, and NOESY spectra. The limitations of the method were shown. The reaction of camphor with primary amines led to exclusively exo product, while the reaction of fenchone led to exclusively endo product. The reaction of camphor with cyclic secondary amines led to the mixture of endo and exo isomers.

European Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kinzel, Olaf published the artcileSynthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates, Safety of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Peptide Science (2003), 9(6), 375-385, database is CAplus and MEDLINE.

The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA-binding moieties is described. By a combination of solid- and solution-phase chem. a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described.

Journal of Peptide Science published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Safety of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maharvi, Ghulam M. published the artcileA synthesis of the γ-secretase inhibitor BMS-708163, SDS of cas: 2240-88-2, the publication is Tetrahedron Letters (2010), 51(50), 6542-6544, database is CAplus.

A concise, convergent racemic synthesis of BMS-708163 (I) was reported. Two fragments consisting of N-4-chlorophenylsulfonyl-3,3,3-trifluoropropylglycine and a 1,2,4-oxadiazole derivative of 2-fluorobenzyl alc. were prepared in sep. pots and then coupled together via a Mitsunobu reaction. Since a convenient chiral synthesis of optically pure (D)-3,3,3-trifluoropropyl glycine Me ester was developed using Schoellkopf reagent alkylation, this methodol. can also be adopted for the enantioselective synthesis of BMS-708163.

Tetrahedron Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bennett, Steven H. published the artcileDifunctionalization of C-C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2020), 142(39), 16766-16775, database is CAplus and MEDLINE.

Difunctionalization reactions of C-C σ-bonds have the potential to streamline access to mols. that would otherwise be difficult to prepare However, the development of such reactions is challenging because C-C σ-bonds are typically unreactive. Exploiting the high ring-strain energy of polycyclic carbocycles is a common strategy to weaken and facilitate the reaction of C-C σ-bonds, but there are limited examples of highly strained C-C σ-bonds being used in difunctionalization reactions. We demonstrate that highly strained bicyclo[1.1.0]butyl boronate complexes (strain energy ca. 65 kcal/mol), which were prepared by reacting boronic esters with bicyclo[1.1.0]butyl lithium, react with electrophiles to achieve the diastereoselective difunctionalization of the strained central C-C σ-bond of the bicyclo[1.1.0]butyl unit. The reaction shows broad substrate scope, with a range of different electrophiles and boronic esters being successfully employed to form a diverse set of 1,1,3-trisubstituted cyclobutanes (>50 examples) with high diastereoselectivity. The high diastereoselectivity observed has been rationalized based on a combination of exptl. data and DFT calculations, which suggests that sep. concerted and stepwise reaction mechanisms are operating, depending upon the migrating substituent and electrophile used.

Journal of the American Chemical Society published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boltia, Shereen A. published the artcileFour validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form, Application In Synthesis of 23828-92-4, the publication is Journal of Pharmacy Research (Mohali, India) (2018), 12(4), 446-454, database is CAplus.

The purpose of the present study was to develop and validate spectrophotometric methods for simultaneous determination of a ternary mixture of ambroxol HCl (AMB), guaifenesin (GUA) and theophylline (THEO) in pharmaceutical dosage forms. (a) Direct spectrophotometry (DS), (b) dual wavelength (DW), (c) first derivative of ratio spectra (1DD), and (d) absorption correction (AC). DS method was applied to determine AMB at its λmax (309.0 nm) without any interference of THEO and GUA. Both THEO and GUA were determined as a binary mixture after removal of AMB contribution from the ternary mixture by ratio subtraction technique. DW method was applied to determine GUA by measuring the difference in absorbance at 224.5 nm and 255.0 nm. 1DD was used to determine THEO at 295.4 nm and GUA at 236.5 nm using 14.0μg/mL GUA and 14.5μg/mL THEO as divisors, resp. AC was applied after the second derivative for determination of GUA at 239.5 nm and THEO at 239.5 nm and 266.0 nm. The methods were accurate, specific, and successfully applied for the determination of the three drugs in laboratory prepared mixtures and their combined dosage form.

Journal of Pharmacy Research (Mohali, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bredikhina, Zemfira A. published the artcileFrom racemic epichlorohydrin to a single enantiomer of the drug timolol maleate, Computed Properties of 30165-97-0, the publication is Tetrahedron: Asymmetry (2015), 26(15-16), 797-801, database is CAplus.

The synthesis for a single enantiomer timolol maleate based on an initial Jacobsen hydrolytic kinetic resolution of racemic epichlorohydrin and on the stereochem. of the subsequent chem. transformations has been proposed. The feature of this synthesis is that both products of the kinetic resolution, (R)-epichlorohydrin and (S)-3-chloropropane-1,2-diol, have been utilized in the synthesis of the target, (S)-timolol (I). The mirror stereochem. results can be obtained with the use of (R,R)-salen Co(III) catalyst instead of (S,S)-salen Co(III).

Tetrahedron: Asymmetry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Computed Properties of 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Monsigny, Louis published the artcileEfficient reductive depolymerization of hardwood and softwood lignins with Brookhart’s iridium catalyst and hydrosilanes, Product Details of C15H16O3, the publication is Green Chemistry (2018), 20(9), 1981-1986, database is CAplus.

Efficient catalytic reduction of lignin model mols. and reductive depolymerization of softwood and hardwood lignins is presented with the iridium based Brookhart’s catalyst and hydrosilanes R₃SiH as reductant. This catalyst displays increased stability and selectivity in comparison to the B(C₆F₅)₃/hydrosilane system and it enables a convergent reductive depolymerization of wood lignins to isolable mono-aromatics

Green Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Product Details of C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts