Category: alcohols-buliding-blocks

Hayashi, Yoshiyuki published the artcilePreparation of tertiary amines having different substituents from quaternary 2-hydroxyethylammonium salts, Related Products of alcohols-buliding-blocks, the publication is Yukagaku (1987), 36(6), 409-12, database is CAplus.

N,N-Disubstituted ethanolamines readily and quant. reacted with alkyl halides to give quaternary 2-hydroxyethylammonium halides. The quaternary salts, when treated with a small excess of KOH at 120°, afforded tertiary amines in high yields, accompanied by the evolution of ethylene oxide. Thus, Me(CH₂)₉NMeCH₂CH₂OH was treated with PhCH₂Cl to give 93% PhCH₂[Me(CH₂)₉]N⁺MeCH₂CH₂OH Cl^–, which was heated at 120° with KOH to give 90% Me(CH₂)₉NMeCH₂Ph. N,N-Dimethylalkylamines were also prepared quant. in a one-pot reaction procedure from N,N-dimethylethanolamine and alkyl halides.

Yukagaku published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salat, Kinga published the artcileThe microglial activation inhibitor minocycline, used alone and in combination with duloxetine, attenuates pain caused by oxaliplatin in mice, Quality Control of 23828-92-4, the publication is Molecules (2021), 26(12), 3577, database is CAplus and MEDLINE.

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition. Since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. To induce neuropathic pain, a single dose (10 mg/kg) of i.p. oxaliplatin was used. The mech. and cold pain thresholds were assessed using mouse von Frey and cold plate tests, resp. On the day of oxaliplatin administration, only duloxetine (30 mg/kg) and minocycline (100 mg/kg) used alone attenuated both tactile allodynia and cold hyperalgesia 1 h and 6 h after administration. Minocycline (50 mg/kg), duloxetine (10 mg/kg) and combined minocycline + duloxetine influenced only tactile allodynia. Seven days after oxaliplatin, tactile allodynia (but not cold hyperalgesia) was attenuated by minocycline (100 mg/kg), duloxetine (30 mg/kg) and combined minocycline and duloxetine. These results indicate a potential usefulness of minocycline used alone or combination with duloxetine in the treatment of oxaliplatin-induced pain.

Molecules published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirano, Tomohiro published the artcileSyndiotactic- and heterotactic-specific radical polymerizations of N-n-propyl-α-fluoroacrylamide and phase-transition behaviors of aqueous solutions of poly(N-n-propyl-α-fluoroacrylamide), Formula: C9H22OSi, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(12), 2471-2483, database is CAplus.

Radical polymerization of N-n-propyl-α-fluoroacrylamide (NNPFAAm) was studied in several solvents at low temperatures in the presence or absence of Lewis bases, Lewis acids, alkyl alcs., silyl alcs., or fluorinated alcs. Different effects of solvents and additives on stereospecificity were observed in the radical polymerizations of NNPFAAm and its hydrocarbon analogs such as N-isopropylacrylamide (NIPAAm) and N-n-propylacrylamide (NNPAAm); for instance, syndiotactic (and heterotactic) specificities were induced in radical polymerization of NNPFAAm in polar solvents (and in toluene in the presence of alkyl and silyl alcs.), whereas isotactic (and syndiotactic) specificities were induced in radical polymerizations of the hydrocarbon analogs under the corresponding conditions. In contrast, heterotactic specificity induced by fluorinated alcs. was further enhanced in radical polymerization of NNPFAAm. The effects of stereoregularity on the phase-transition behaviors of aqueous solutions of poly(NNPFAAm) were also studied. Different tendencies in stereoregularity were observed in aqueous solutions of poly(NNPFAAm)s from those in solutions of the hydrocarbon analogs such as poly(NIPAAm) and poly (NNPAAm). The polymerization behavior of NNPFAAm and the phase-transition behavior of aqueous poly(NNPFAAm) are discussed based on possible fluorine-fluorine repulsion between the monomer and propagating chain-end, and neighboring monomeric units. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Formula: C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Breyton, Cecile published the artcileMicellar and biochemical properties of (hemi)fluorinated surfactants are controlled by the size of the polar head, Category: alcohols-buliding-blocks, the publication is Biophysical Journal (2009), 97(4), 1077-1086, database is CAplus and MEDLINE.

Surfactants with fluorinated and hemifluorinated alkyl chains have yielded encouraging results in terms of membrane protein stability; however, the mols. used hitherto have either been chem. heterogeneous or formed heterogeneous micelles. A new series of surfactants whose polar head size is modulated by the presence of one, two, or three glucose moieties has been synthesized. Anal. ultracentrifugation and small-angle neutron scattering show that fluorinated surfactants whose polar head bears a single glucosyl group form very large cylindrical micelles, whereas those with two or three glucose moieties form small, homogeneous, globular micelles. We studied the homogeneity and stability of the complexes formed between membrane proteins and these surfactants by using bacteriorhodopsin and cytochrome b₆f as models. Homogeneous complexes were obtained only with surfactants that form homogeneous micelles. Surfactants bearing one or two glucose moieties were found to be stabilizing, whereas those with three moieties were destabilizing. Fluorinated and hemifluorinated surfactants with a two-glucose polar head thus appear to be very promising mols. for biochem. applications and structural studies. They were successfully used for cell-free synthesis of the ion channel MscL.

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kiskan, Baris published the artcileSynthesis and characterization of pyrrole and thiophene functional polystyrenes via “click chemistry”, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Polymer Bulletin (Heidelberg, Germany) (2011), 67(4), 609-621, database is CAplus.

Novel side-chain pyrrole or thiophene functional polystyrenes (PS-Py and PS-Th) were synthesized by using “click chem.” strategy. First, approx. 40% of chloro groups of poly(styrene-co-chloromethylstyrene) P(S-co-CMS), prepared by nitroxide mediated radical polymerization (NMRP), were converted to azido groups by using NaN₃ in N,N-dimethylformamide. Propargyl pyrrole was prepared by etherification of 4-(1H-pyrrol-1-yl)phenol prepared by Clauson-Kaas reaction using propargylbromide. Propargyl thiophene was synthesized by heterogeneous esterification reaction between 3-thiophenecarboxylic acid and propargylbromide. Finally, azido-functionalized polystyrene was coupled to these propargyl functional heterocyclics with high efficiency by click chem. The intermediates at various stages and final polymers were characterized by spectral anal. and cyclic voltammetry.

Polymer Bulletin (Heidelberg, Germany) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ojha, Devi Prasan published the artcileGeneration of Hydrogen from Water: A Pd-Catalyzed Reduction of Water Using Diboron Reagent at Ambient Conditions, Application In Synthesis of 25240-59-9, the publication is Organic Letters (2016), 18(19), 5062-5065, database is CAplus and MEDLINE.

Production of hydrogen from renewable sources, particularly from water, is an intensive area of research, which has far-reaching relevance in hydrogen economy. A homogeneous catalytic method is presented for producing clean hydrogen gas from water, in a reaction of water with a diboron compound as the reductant, under ambient reaction conditions. The Pd-catalytic system is stable in water and displays excellent recyclability. Hydroxy analogs such as alcs. are compatible with the Pd/B₂Pin₂ system and generate hydrogen gas efficiently. The B₂Pin₂-H₂O system, in the presence of palladium, is an excellent catalytic system for selective hydrogenation of olefins.

Organic Letters published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Application In Synthesis of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Mingbing published the artcileCopper-Photocatalyzed Hydroboration of Alkynes and Alkenes, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2021), 60(26), 14498-14503, database is CAplus and MEDLINE.

The photocatalytic hydroboration of alkenes and alkynes is reported. The use of newly-designed copper photocatalysts with B₂Pin₂ permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and alkynes. The hydroborated products were isolated in high yields, with excellent diastereoselectivities and a high functional group tolerance under mild conditions. The hydroboration reactions were developed under continuous flow conditions to demonstrate their synthetic utility. The reaction mechanism was studied and suggested an oxidation reaction between an in situ formed borate and the Cu-photocatalyst in its excited state for the boryl radical formation.

Angewandte Chemie, International Edition published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H24S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lewandowska, Aneta published the artcileThiol-ene ionogels based on polymerizable imidazolium ionic liquids, Computed Properties of 111-29-5, the publication is Polymer Chemistry (2022), 13(21), 3154-3170, database is CAplus.

In this work, we report the synthesis of polymerizable ionic liquids (PILs) and the synthesis of ionogels by thiol-ene photopolymerization A series of gemini imidazolium-based bis(trifluoromethylsulfonyl)imide polymerizable ionic liquids with ene functional groups, reactive in thiol-ene polymerization, were synthesized. The obtained polymerizable ionic liquids differ by (i) type of reactive group: vinyl, allyl, (ii) length of hydrocarbon chain spacer (from C2 to C12) between two imidazole rings in cations in the vinyl series of PILs (divinyl-PIL), and (iii) type of substituent (-H or -CH₃) at C(2) position at the imidazole ring in diallyl-PILs. Then ionogel systems on the basis of the prepared PILs used as ene, 1,3,5-trimethylolpropane trimethacrylate (TMPTM), difunctional aliphatic polyester urethane acrylate (DAPU), and tris(3-mercaptobutyloxethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TMTT) were synthesized in 70 wt% of ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMImNTf₂). The mech. properties (tensile strength), ionic conductivity (electrochem. impedance spectroscopy), and thermal properties (differential scanning calorimetry, thermogravimetric anal.) of the prepared ionogels as well as the course of photopolymerization by the photo-DSC method were studied. The resulting ionogels are fully transparent, highly flexible, with no leakage (also at an elevated temperature 80 °C and during mech. testing), all thanks to the presence of PILs in the polymer matrix of ionogels. Interestingly, DSC studies have shown that the ionic liquid EMImNTf₂ does not crystallize in the synthesized ionogels in a broad range of temperatures (-170 – 30 °). The PIL structure influences the polymerization kinetics as well as properties of ionogels. All synthesized ionogels are stable in the temperature range 304 °C-325 °C, and ionogels with allyl-PILs have higher thermal stability than ionogels with vinyl-PILs. The strength (for the ionogels with PILs C2-C6) and Young′s modulus of the obtained ionogels increase with the length of the hydrocarbon chain of the spacer in vinyl-PILs but elongation and ionic conductivity decrease. However, the conductivity of ionogels is greater than 1 mS cm^-1, which allows the use of the obtained materials, e.g., in electrochem. capacitors.

Polymer Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Computed Properties of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dorival-Garcia, Noemi published the artcileIdentification of additives in polymers from single-use bioprocessing bags by accelerated solvent extraction and ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry, Computed Properties of 122-20-3, the publication is Talanta (2020), 121198, database is CAplus and MEDLINE.

Single-use technologies are increasingly used in biopharmaceutical manufacturing Despite their advantages, these plastic assemblies draw concern because they are a potential source of contamination due to extractable and leachable compounds (E&Ls). Characterizing E&Ls from such materials is a necessary step in establishing their suitability for use. Therefore, there is an urgent need for sensitive methods to identify and quant. assess compounds in plastic materials. Accelerated solvent extraction (ASE) is a powerful technique that can be reliably used for this purpose. In this study, ASE followed by liquid chromatog. and Orbitrap-based High Resolution Accurate Mass (HRAM) mass anal. was found to be an efficient and versatile method for the determination of additives in different multilayer polymer systems from single-use bags. ASE optimization was performed using a design of experiments approach. The type of solvent, temperature, swelling agent addition, static time and number of cycles were the selected variables. Optimum conditions were dependent on the type of plastic film. Et acetate and cyclohexane were selected individually as optimum solvents. Optimum temperatures were 90-100°C. Pressure was set at 1500 psi and extraction time was 30 min in 2 cycles. Swelling agent addition was necessary with polar extraction solvents. More than 100 additives and degradation products were confidently identified by HRAM MS. Correlations between the type and levels of identified additives and the type of polymer system were established. In addition, degradation behavior and pathways for some additives can be addressed.

Talanta published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jirasek, Fabian published the artcileSolid-Liquid Equilibrium in the System 2-Keto-L-Gulonic Acid + L-Ascorbic Acid + Water, SDS of cas: 526-98-7, the publication is Chemical Engineering & Technology (2018), 41(12), 2306-2311, database is CAplus and MEDLINE.

The solid-liquid equilibrium (SLE) in the ternary system 2-keto-L-gulonic acid (HKGA) + L-ascorbic acid (vitamin C) + water was investigated exptl. at temperatures between 276 K and 308 K at ambient pressure, i.e., under conditions that are of particular interest for industrial applications. Phase diagrams with one eutonic point were obtained for all temperatures The dissociation constant and the solubility constant of vitamin C were determined as a function of temperature Based on an extended version of the Debye-Hueckel theory, a physicochem. model was developed that describes the SLE in the ternary system. The agreement between exptl. data and results from the model is excellent.

Chemical Engineering & Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, SDS of cas: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts