Category: alcohols-buliding-blocks

Clerici, Angelo published the artcileA New One-Pot, Four-Component Synthesis of 1,2-Amino Alcohols: TiCl₃/t-BuOOH-Mediated Radical Hydroxymethylation of Imines, Computed Properties of 101-98-4, the publication is Organic Letters (2008), 10(21), 5063-5066, database is CAplus and MEDLINE.

An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl₃/t-BuOOH system to afford 1,2-amino alcs. in fair to excellent yields.

Organic Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oliveira, Marilene Silva published the artcileMechanism of Photochemical O-Atom Exchange in Nitrosamines with Molecular Oxygen, SDS of cas: 4543-95-7, the publication is Journal of Organic Chemistry (2015), 80(12), 6119-6127, database is CAplus and MEDLINE.

The detection of an oxygen-atom photoexchange process of N-nitrosamines is reported. The photolysis of four nitrosamines (N-nitrosodiphenylamine 1, N-nitroso-N-methylaniline 2, N-butyl-N-(4-hydroxybutyl)nitrosamine 3, and N-nitrosodiethylamine 4) with UV light was examined in an ¹⁸O₂-enriched atm. in solution HPLC/MS and HPLC-MS/MS data show that ¹⁸O-labeled nitrosamines were generated for 1 and 2. But nitrosamines 3 and 4 do not exchange the ¹⁸O label and instead decomposed to amines and/or imines under the conditions. For 1 and 2, the ¹⁸O atom was found not to be introduced by moisture or by singlet oxygen [¹⁸(¹O₂¹Δ_g)] produced thermally by ¹⁸O-¹⁸O labeled endoperoxide of N,N’-di(2,3-hydroxypropyl)-1,4-naphthalene dipropanamide (DHPN¹⁸O₂) or by visible-light sensitization. A d. functional theory study of the structures and energetics of peroxy intermediates arising from reaction of nitrosamines with O₂ is also presented. A reversible head-to-tail dimerization of the O-nitrooxide to the 1,2,3,5,6,7-hexaoxadiazocane (30 kcal/mol barrier) with extrusion of O=¹⁸O accounts for exchange of the oxygen atom label. The unimol. cyclization of O-nitrooxide to 1,2,3,4-trioxazetidine (46 kcal/mol barrier) followed by a retro [2 + 2] reaction is an alternative, but higher energy process. Both pathways would require the photoexcitation of the nitrooxide.

Journal of Organic Chemistry published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, SDS of cas: 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Zhuming published the artcileGut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer, COA of Formula: C3H5F3O, the publication is Journal of Medicinal Chemistry (2021), 64(15), 11570-11596, database is CAplus and MEDLINE.

Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo ¹⁸F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogs that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APC^min/+ mouse model. However, in vitro-in vivo correlation anal. showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is 0, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Truong, Thien published the artcilePromoting crystallization of intrinsic membrane proteins with conjugated micelles, SDS of cas: 85618-21-9, the publication is Scientific Reports (2020), 10(1), 12199, database is CAplus and MEDLINE.

A new technique for promoting nucleation and growth of membrane protein (MP) crystals from micellar environments is reported. It relies on the conjugation of micelles that sequester MPs in protein detergent complexes (PDCs). Conjugation via amphiphilic [metal:chelator] complexes presumably takes place at the micelle/water interface, thereby bringing the PDCs into proximity, promoting crystal nucleation and growth. We have successfully applied this approach to two light-driven proton pumps: bacteriorhodopsin (bR) and the recently discovered King Sejong 1-2 (KS1-2), using the amphiphilic 4,4′-dinonyl-2,2′-dipyridyl (Dinonyl) (0.7 mM) chelator in combination with Zn²⁺, Fe²⁺, or Ni²⁺ (0.1 mM). Crystal growth in the presence of the [metal-chelator] complexes leads to purple, hexagonal crystals (50-75μm in size) of bR or pink, rectangular/square crystals (5-15μm) of KS1-2. The effects of divalent cation identity and concentration, chelator structure and concentration, ionic strength and pH on crystal size, morphol. and process kinetics, are described.

Scientific Reports published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wasson, B. K. published the artcileβ-Adrenergic blocking agents. 3-(3-Substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (1972), 15(6), 651-5, database is CAplus and MEDLINE.

A number of 3-(3-substitute-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles were prepared by 3 general procedures: (a) by condensation of the appropriate 3-hydroxy-4-substituted-1,2,5-thiadiazole with epichlorohydrin, then formation of the epoxide, and condensation with an amine, (b) by treatment of 4-chloro-3-(3-substituted-amino-2-hydroxypropoxy)-1,2,5-thiadiazole with a heterocyclic compound containing a secondary N, or (c) by formation of a bromohydrin of a 3-substituted-4-allyloxy-1,2,5-thiadiazole, followed by treatment with an amine. A number of I containing 4-Cl, 4-Et, or 4-EtO such as (+)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-chloro-1,2,5-thiadiazole-HCl [(+)-I, R = Cl, R1 = H, R2 = tert-Bu] [26791-14-0], 3-(3-isopropylamino-2-hydroxypropoxy)-4-ethyl-1,2,5-thiadiazole-HCl (I, R = Et, R1 = H, R2 = iso-Pr) [26670-38-2] and 3-(3-isopropylamino-2-hydroxypropoxy)-4-ethoxy-1,2,5-thiadiazole-HCl (I, R = EtO, R1 = H, R2 = iso-Pr) [26852-60-8] were potent β-adrenergic blocking agents but short acting (ED50 0.023, 0.04 and 0.035 mg/kg i.v., resp., dose required to inhibit by 50% the cardioaccelerator response to 0.12 mg/kg i.v. isoproterenol in the ganglion-blocked anesthetized rat). A number of 1,2,5-thiadiazoles possessing a bulky group in the 4-position were long acting, the outstanding member being (+-)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole-HCl [(+-)-II -HCl] [26670-02-0] with an ED50 of 0.013. Resolution of (+-)-II showed the bulk of activity resided in the (+)-form, (+)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole hydrogen maleate [(+)-II H maleate] [26839-77-0] the ED50 being 0.0066. The optimal activity in the thiadiazoles was achieved by the presence of an iso-Pr or tert-Bu group in the aminoisopropanoloxy side chain and inclusion of a bulky substituent in the 4 position.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C42H63O3P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Herzog, B. published the artcileSolubility of UV absorbers for sunscreens is essential for the creation of light feel formulations, Computed Properties of 70445-33-9, the publication is SOFW Journal (2013), 139(7), 7-8,10-14, database is CAplus.

The goals of this paper are the comparison of different methods for the determination of solubility, the presentation of some examples of solubility data for solid UV absorbers, and the introduction of a concept using this knowledge to create light feel formulations. UV filters are the key ingredients necessary for the efficacy of sunscreens. Most of the organic UV absorbers are oil-soluble or even oil-miscible compounds and consequently are incorporated into the oil-phase of sunscreen emulsions.

SOFW Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Potawale, Rani S. published the artcileLiquid chromatography tandem-mass spectrometry method development and validation for simultaneous analysis of paracetamol, guaifenesin, phenylephrine hydrochloride, chlorpheniramine maleate, and ambroxol hydrochloride in bulk and in tablet dosage form, HPLC of Formula: 23828-92-4, the publication is Asian Journal of Pharmaceutical and Clinical Research (2018), 11(7), 1-8, database is CAplus.

Objective: The objective is to study liquid chromatog. tandem-mass spectrometry (LC/MS/MS) method for simultaneous quantification of paracetamol (PCM), guaifenesin (GUA), phenylephrine hydrochloride (PE), chlorpheniramine maleate (CPM), and ambroxol hydrochloride (AMB) in tablet dosage form developed and validated as per the International Conference on Harmonization Q2 (R1) guideline. Methods: The chromatograms were developed using a gradient mobile phase of WATER:methanol. Flow rate used was to 0.3 mL/min. Quantitation was performed using multiple reaction monitoring (MRM) mode to study parent to product ion transition, for paracetamol. (m/z 152.0 ≥ 110.0), guaifenesin (m/z 199.0 ≥ 163.0), phenylephrine hydrochloride (m/z 168.0 ≥ 150.0), chlorpheniramine maleate (m/z 275.0 ≥ 230.0) and ambroxol hydrochloride (m/z 379.0 ≥ 263.8). Results: The retention times were found to be 1.76, 1.81, 1.90, 2.10, and 2.33 min for PCM, GUA, PE, CPM, and AMB, resp. The linearity of the method was found to be in the concentration range of 10-200 ng/mL for PCM, GUA, PE, CPM, and AMB. Percentage relative standard deviation values for repeatability and intermediate precision studies were below 2%. Conclusion: Developed method was found to be robust, precise, accurate, rapid and can be used to analyze fixed-dose tablet formulation used in the study.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barzagli, Francesco published the artcileScreening study of different amine-based solutions as sorbents for direct CO₂ capture from air, Product Details of C4H11NO, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(37), 14013-14021, database is CAplus.

Direct air capture (DAC) is an emerging technol. that can help limit the global temperature rises, as it has the potential to contrast the dispersed CO₂ emissions coming from transport and heating that cannot be captured with traditional CCS methods. Although recent improvements are bringing DAC closer to com. feasibility, an obstacle to its diffusion is the high regeneration energy required by the most common liquid sorbents, Na or K hydroxides. In order to develop efficient and more sustainable sorbents, in the present screening study several alkanolamines, particularly those already known for their utilization in CCS, were tested for DAC. The percentage of CO₂ absorbed from compressed air of their 1.5 mol dm^-3 aqueous solutions was evaluated in 24 h capture experiments and the species formed were identified and quantified by means of ¹³C-NMR spectroscopy. For selected amines, their performance in organic diluents was also evaluated. The correlations between aerial CO₂ absorption, chem. structures of the different amine and species formed in solution have shown that a high yield production of amine carbamate is the decisive factor for an effective CO₂ capture, and that aqueous primary unhindered amines are as efficient as aqueous alkali hydroxides, with the potential of a lower regeneration energy.

ACS Sustainable Chemistry & Engineering published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Gurjaspreet published the artcileSelective mercury ion recognition using a methyl red (MR) based silatrane sensor, Safety of Triisopropanolamine, the publication is New Journal of Chemistry (2018), 42(8), 6315-6321, database is CAplus.

A new Methyl red (MR) based silatrane was synthesized in high yield by the transesterification reaction of Methyl red-amidopropyltrimethoxysilane 1 (MR-APTMS) and trisisopropanolamine. Single crystal x-ray diffraction anal. was used to deduce the structure of silatrane 2 which was also supported by NMR (¹H, ¹³C) spectroscopy, mass spectrometry, FTIR, UV-visible and DFT studies. Silatrane 2 when surveyed for cation recognition ability with a library of metal ions in CH₃CN/H₂O (9 : 1, volume/volume) was found to act as an excellent UV-visible probe for the selective recognition of Hg²⁺in vitro. Also, quantum mech. calculations of the interaction complex [MR-APS-Hg]²⁺3 using DFT at the B3LYP level in conjunction with the LanL2DZ basis set determined the geometric and the stability parameters of the surveyed interaction.

New Journal of Chemistry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C8H6ClN, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Delgado, Pete published the artcileUse of Green Solvents in Metallaphotoredox Cross-Electrophile Coupling Reactions Utilizing Lipophilic Modified Dual Ir/Ni Catalyst System, Recommanded Product: (1-Bromocyclopropyl)methanol, the publication is Journal of Organic Chemistry (2021), 86(23), 17428-17436, database is CAplus and MEDLINE.

Facilitating photoredox coupling reactions in process friendly green solvents was achieved by the successful application of the dual Ir/Ni catalyst system with enhanced solubility properties. These photochem. reactions (specifically Br-Br sp²-sp³ cross electrophile coupling) are reported in a head to head comparison to the reactions using standard di-t-Bu bipyridine ligand Ir/Ni catalyst system. This presentation highlights the benefits of altering the solubility properties of the ligands used in the Ir/Ni dual catalyst.

Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Recommanded Product: (1-Bromocyclopropyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts