Category: alcohols-buliding-blocks

Pattanaik, Sandip published the artcileCobalt-Catalyzed Selective Synthesis of Disiloxanes and Hydrodisiloxanes, Recommanded Product: Triethylsilanol, the publication is ACS Catalysis (2019), 9(6), 5552-5561, database is CAplus.

Selective syntheses of sym. siloxanes and cyclotetrasiloxanes are attained from reactions of silanes and dihydrosilanes, resp., with H₂O, and the reactions are catalyzed by a NNN^HtBu Co(II) pincer complex. When phenylsilane was subjected to catalysis with H₂O, a siloxane cage consisting 12 Si and 18 O centers was obtained and remarkably the reaction proceeded with liberation of 3 equiv of H₂ (36 H₂) under mild exptl. conditions. Upon reaction of silane with different silanols, highly selective and controlled syntheses of higher order monohydrosiloxanes and disiloxymonohydrosilanes were achieved by Co catalysis. The liberated H₂ is the only byproduct observed in all of these transformations. Mechanistic studies indicated that the reactions occur via a homogeneous pathway. Kinetic and independent experiments confirmed the catalytic oxidation of silane to silanol, and further dehydrocoupling processes are involved in syntheses of sym. siloxanes, cyclotetrasiloxanes, and siloxane cage compounds, whereas the unsym. monohydrosiloxane syntheses from silanes and silanols proceeded via dehydrogenative coupling reactions. Overall these Co-catalyzed oxidative coupling reactions are based on the Si-H, Si-OH, and O-H bond activation of silane, silanol, and H₂O, resp. Catalytic cycles consisting of Co(II) intermediates probably are operative.

ACS Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cirpan, A. published the artcileConducting polymers of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester, Quality Control of 23351-09-9, the publication is Materials Chemistry and Physics (2004), 85(1), 222-226, database is CAplus.

A dipyrrolyl monomer was synthesized via the reaction between 4-pyrrol-1-yl phenol and decanedioyl dichloride. The electrochem. behavior of this monomer was studied. Polymerization of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester (DAPE) was achieved by chem. and constant current electrolyzes methods. Copolymerization of DAPE with thiophene was performed by constant potential electrolysis in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB), dichloromethane-TBAFB, solvent-electrolyte couples. The chem. structures and properties were investigated by Fourier transform IR spectroscopy, NMR spectroscopy, differential scanning calorimetry and thermal gravimetry anal. The conductivities of the samples were measured by a four-probe technique.

Materials Chemistry and Physics published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Valliant-Saunders, Karine published the artcileOxidation of Tertiary Silanes by Osmium Tetroxide, Product Details of C9H22OSi, the publication is Inorganic Chemistry (2007), 46(13), 5212-5219, database is CAplus and MEDLINE.

In the presence of an excess of pyridine ligand L, osmium tetroxide oxidizes tertiary silanes (Et₃SiH, ⁱPr₃SiH, Ph₃SiH, or PhMe₂SiH) to the corresponding silanols. With L = 4-tert-butylpyridine (^tBupy), OsO₄(^tBupy) oxidizes Et₃SiH and PhMe₂SiH to yield 100 ± 2% of silanol and the structurally characterized osmium(VI) μ-oxo dimer [OsO₂(^tBupy)₂]₂(μ-O)₂ (1a). With L = pyridine (py), only 40-60% yields of R₃SiOH are obtained, apparently because of coprecipitation of osmium(VIII) with [Os(O)₂py₂]₂(μ-O)₂ (1b). Excess silane in these reactions causes further reduction of the Os^VI products, and similar osmium “over-reduction” is observed with PhSiH₃, Bu₃SnH, and boranes. The pathway for OsO₄(L) + R₃SiH involves an intermediate, which forms rapidly at 200 K and decays more slowly to products. NMR and IR spectra indicate that the intermediate is a monomeric Os^VI-hydroxo-siloxo complex, trans-cis-cis-Os(O)₂L₂(OH)(OSiR₃). Mechanistic studies and d. functional theory calculations indicate that the intermediate is formed by the [3 + 2] addition of an Si-H bond across an O:Os:O fragment. This is the first direct observation of a [3 + 2] intermediate in a σ-bond oxidation, though such species have previously been implicated in reactions of H-H and C-H bonds with OsO₄(L) and RuO₄.

Inorganic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C4H10O2, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barua, Harsh published the artcileAn ab initio molecular dynamics method for cocrystal prediction: validation of the approach, COA of Formula: C11H8O3, the publication is CrystEngComm (2019), 21(47), 7233-7248, database is CAplus.

Cocrystals offer exciting opportunities to the scientists, with options of tuning their physicochem., biopharmaceutical, and mech. properties simultaneously, which can expand the solid form diversity of drugs. Herein, for overcoming the need for exhaustive exptl. work and improving the chances of success in the selection of coformers, a computational prediction approach has been developed. In this study, a new cocrystal prediction methodol. employing hydrogen bonding tendency, evaluated with the aid of mol. dynamics, has been utilized. For validation, the exptl. results of 145 coformers with 6 drugs have been used. The method was found to significantly reproduce the exptl. results with attractive features of being a simple, easy-to-use protocol, with short computational time. Further, the developed model was used to predict the formation of cocrystals of nitrofurantoin against a library of new coformers. Three out of the four new cocrystals formed were correctly predicted by the developed prediction methodol. The cocrystal formation of 89 coformers out of a total of 145 coformers was correctly predicted. Thus, the reasonable degree of success obtained in predicting and exptl. generating new cocrystals of nitrofurantoin indicates that the developed computational methodol. can play an important role in screening a large library of coformers in the future.

CrystEngComm published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Hui-Jun published the artcileRapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media, Quality Control of 1043416-40-5, the publication is RSC Advances (2019), 9(23), 13249-13253, database is CAplus and MEDLINE.

A rapid and efficient approach was developed for the synthesis of 2-N-substituted indazolones I [R = H, 5-Br, 6-CF₃, etc.; R¹ = t-Bu, c-pentyl, Bn, etc.] via photochem. cyclization of o-nitrobenzyl alcs. and primary amines in aqueous media at room temperature This straightforward protocol was halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggested a new avenue of great importance to medicinal chem.

RSC Advances published new progress about 1043416-40-5. 1043416-40-5 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Alcohol, name is (4-Fluoro-2-nitrophenyl)methanol, and the molecular formula is C7H6FNO3, Quality Control of 1043416-40-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileSome studies on the tautomerism of heterocyclic and homocyclic compounds, Quality Control of 17236-59-8, the publication is Pure and Applied Chemistry (1987), 59(12), 1577-84, database is CAplus.

The following hydroxy derivatives of heterocyclic compounds have been generated in solution and characterized by ¹H-NMR spectroscopy: 3-hydroxyfuran, 3-hydroxythiophene, 3-hydroxypyrrole, 3-hydroxy-1-methylpyrrole, 3-hydroxybenzofuran, 3-hydroxybenzothiophene, 3-hydroxyindole, 3-hydroxy-1-methylindole, 2-hydroxythiophene, 2-hydroxybenzothiophene, 2,5-dihydroxythiophene. The rate and equilibrium constants for their ketonization have been measured and are discussed. The following hydroxy derivatives of homocyclic compounds were also generated, characterized and investigated: 1-hydroxyindene, 2-hydroxyindene, 1-hydroxycyclohepta-1,3,5-triene, 3-hydroxycyclohepta-1,3,5-triene, hydroxycyclooctatetraene, and 3-hydroxycycloocta-1,3,5-triene. The mechanism of hydrolysis of heterocyclic Me ethers derived from furan, thiophene, 1-methylpyrrole and their benzo-derivatives has been investigated and a change in rate limiting step from C-protonation to nucleophilic attack by water on the intermediate cation detected.

Pure and Applied Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Meilian published the artcileDetermination of ambroxol hydrochloride in human plasma by ultra high performance liquid chromatography-tandem mass spectrometry and bioequivalence evaluation of its preparation, Related Products of alcohols-buliding-blocks, the publication is Sepu (2018), 36(11), 1099-1104, database is CAplus and MEDLINE.

A rapid, simple and sensitive ultra high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) method was developed for the determination of ambroxol hydrochloride in human plasma, and bioequivalence of its preparation was evaluated. The 50 μL-plasma sample was treated with methanol for protein precipitation, while ambroxol-d5 was used as an internal standard (IS). The separation was carried out on a Waters XBridge BEH C18 column (50 mm × 2.1 mm, 2.5 μm) by gradient elution at a flow rate of 0.4 mL/min, with 0.1% (volume/volume) formic acid aqueous solution and methanol containing 0.1% (volume/volume) formic acid as the mobile phases. The analyte was detected using an electrospray ionization source in pos. ion multiple reaction monitoring (MRM) mode. The calibration curves were linear in the range of 2-400 ng/mL (r = 0.998). The intra- and inter-run accuracies were 97.1-108.7%, and the intra- and inter-run precisions were 1.0-5.6%. The method was applied to the determination of the plasma concentration of the six healthy subjects after the oral administration of 30 mg of test and reference preparations The bioavailability was (102.3 ± 14.8)%. The 90% confidence intervals of the test preparation’s pharmacokinetic parameters were 80.0-125.0% of the reference preparation’s corresponding parameters. Thus, it is proved that the test preparation and reference preparation are bioequivalent.

Sepu published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Yi-Wen published the artcileGrowth of Pseudomonas sp. TX1 on a wide range of octylphenol polyethoxylate concentrations and the formation of dicarboxylated metabolites, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2010), 101(8), 2853-2859, database is CAplus and MEDLINE.

Pseudomonas sp. TX1, is able to use octylphenol polyethoxylates (OPEO_n, or Triton X-100; average n = 9.5) as a sole carbon source. It can grow on 0.05-20% of OPEO_n with a specific growth rate of 0.34-0.44 h^-1. High-performance liquid chromatog.-mass spectrometer anal. of OPEO_n degraded metabolites revealed that strain TX1 was able to shorten the ethoxylate chain and produce octylphenol (OP). Furthermore, formation of the short carboxylate metabolites, such as carboxyoctylphenol polyethoxylates (COPEO_n, n = 2, 3) and carboxyoctylphenol polyethoxycarboxylates (COPEC_n, n = 2, 3) began at the log stage, while octylphenol polyethoxycarboxylates (OPEC_n, n = 1-3) was formed at the stationary phase. All the short-ethoxylated metabolites, OPEO_n, OPEC_n, COPEO_n, and COPEC_n, accumulated when the cells were in the stationary phase. This study is the first to demonstrate the formation of COPEO_n and COPEC_n from OPEO_n by an aerobic bacterium.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Shiyang published the artcileRh(I)-Catalyzed Coupling of Azides with Boronic Acids Under Neutral Conditions, Category: alcohols-buliding-blocks, the publication is Organic Letters (2022), 24(30), 5546-5551, database is CAplus and MEDLINE.

A neutral amination reaction using azides RN₃ (R = Ph, 4-nitrophenyl, 4-bromophenyl, etc.) as the nitrogen source and arylboronic acids ArB(OH)₂ (Ar = 4-cyanobutyl, cyclooctyl, Ph, etc.) with a rhodium(I) catalyst to afford alkyl-aryl and aryl-aryl secondary amines RNHAr was presented. Natural products and pharmaceutical derivatives were applied, and gram-scale reactions were performed, which demonstrated the utility. Mechanistic experiments and DFT calculations suggested that the reaction involves a metal-nitrene intermediate.

Organic Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C4H8Cl2S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deng, Xiufeng published the artcileEffect of organic alkali on hydration of GGBS-FA blended cementitious material activated by sodium carbonate, Category: alcohols-buliding-blocks, the publication is Ceramics International (2022), 48(2), 1611-1621, database is CAplus.

Sodium carbonate (SC) activated ground granulated blast-furnace slag (GGBS) and fly ash (FA) is a potential substitute of traditional cement with ultra-low carbon footprint. However, its hydration rate and strength growth are limited, owing to the slow leaching of ions during the activation of weak base. In this work, 60% wet-grinded GGBS and 40% FA were blended as the binder, and two organic alkalis, i.e. triethanolamine (TEA) and triisopropanolamine (TIPA), were adopted to facilitate the ions dissolution and pozzolanic reaction of SC activated GGBS-FA blended cementitious material (SCSF). The compressive strength was tested and the hydration kinetics was studied by hydration heat and chem. shrinkage. Besides, ions leaching behavior was characterized by ICP; hydrates and microstructure were also detected by XRD, TG-DTG and SEM. Results indicated that the addition of TEA or TIPA significantly promoted the ions dissolution 0.05% TEA increased the concentration of leached Ca2+, Al3+ and Fe3+ by 36%, 33% and 1545%, resp. This solubilizing effect was also found in TIPA. Moreover, these two chems. could promote the formation of hydrates, such as C-S(A)-H gel, hydrotalcite, calcite and aragonite, especially at the early period; these also activated the hydration process of SCSF effectively, and the compressive strength of the mortar reached above 40.0 MPa at 7 d and 48.0 MPa at 28 d. The carbon emission of the designed system is 85.9% and 55.9% lower than that of PC and strong base activated GGBS system, resp.

Ceramics International published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts