Category: alcohols-buliding-blocks

De Mesmaeker, Alain published the artcileStereoselective carbon-carbon bond formation in carbohydrates by radical cyclization reactions. I, Formula: C4H7BrO, the publication is Tetrahedron Letters (1988), 29(50), 6585-8, database is CAplus.

A 3 step synthesis of α-C(2) branched pyranosides from the glycal I is described. Thus, I was treated with HOCH₂CH₂Cl and BF₃.Et₂O in C₆H₆ to give 92% a mixture of α- and β-glycosides II in the ratio of 89:11 resp. On treatment with Bu₃SnH and AIBN in C₆H₆ II cyclized stereoselectively to give predominately the α-C(2) branched pyranoside III.

Tetrahedron Letters published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Formula: C4H7BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yuming published the artcileTwo-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of alcs., Computed Properties of 4410-99-5, the publication is European Journal of Organic Chemistry (2021), 2021(7), 1179-1183, database is CAplus.

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcs. to afford products containing a C-N, C-S, or C-O bond. In the first step the alc. undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-mol. drugs containing hydroxy-group.

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Feihua published the artcilePalladium-catalyzed ortho-C-H hydroxylation of benzoic acids, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Tetrahedron Letters (2021), 153434, database is CAplus.

A simple Pd(OAc)₂ catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant was explored. This protocol featured relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates was an effective complement to the previous ortho-hydroxylation reaction.

Tetrahedron Letters published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Ling published the artcileAcceptorless Dehydrogenative Cross-Coupling of Primary Alcohols Catalyzed by an N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complex, Safety of Pentane-1,5-diol, the publication is Journal of Organic Chemistry (2022), 87(7), 4550-4559, database is CAplus and MEDLINE.

The acceptorless dehydrogenative cross-coupling of primary alcs. to form cross-esters with the liberation of H₂ gas was enabled using a [RuCl(η⁶-C₆H₆)(κ²-CNP)][PF₆]Cl complex as the catalyst. This sustainable protocol was applicable to a broad range of primary alcs., particularly for the sterically demanding ones, featuring good functional group tolerance and high selectivity. The good catalytic performance can be attributed to the nitrogen-phosphine-functionalized N-heterocyclic carbene (CNP) ligand, which adopted a facial coordination mode as well as the facile dissociation of coordinated benzene.

Journal of Organic Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C8H5F3N4, Safety of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Jia published the artcileAphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant, Name: (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2014), 79(2), 599-607, database is CAplus and MEDLINE.

Aphadilactones A-D isolated from Aphanamixis grandifolia (Meliaceae) are 4 diastereoisomers with an unprecedented carbon skeleton. Their challenging structures and absolute configurations were determined by a combination of spectroscopic data, chem. degradation, fragment synthesis, exptl. CD spectra, and ECD calculations The aphadilactones A-D and their oxidative products were tested for DGAT inhibitory activities in vitro. Aphadilactone C with the 5S,11S,5’S,11’S configuration had potent and selective inhibition against diacylglycerol O-acyltransferase-1 (DGAT-1; IC₅₀ = 0.46 μM; selectivity index >217). Thus, aphadilactone C is the strongest natural DGAT-1 inhibitor discovered to date. The aphadilactones A-D also had significant antimalarial activities against Plasmodium falciparum with in vitro IC₅₀ values of 190, 1350, 170, and 120 nM, resp.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Shuzhou published the artcileDetermination of 26 chemical drugs for the treatment of cough and asthma added illegally in herbal tea by high performance liquid chromatography-tandem mass spectrometry, Quality Control of 23828-92-4, the publication is Jinri Yaoxue (2021), 31(3), 195-199, database is CAplus.

OBJECTIVE To establish a rapid screening method for determination of 26 chem. drugs for the treatment of cough and asthma added illegally in herbal tea. METHODS This method involved liquid chromatog.-tandem mass spectrometry. The samples were extracted with methanol, filtrated by 0.22 μm microporous filters and finally separated on a C₁₈ column (2.1 mm×150 mm, 3.5 μm) by using acetonitrile and water (containing 5 mmol·L^-1 ammonium formate and 0.1% formic acid) as mobile phase. Qual. and quant. anal. were carried out in multiple reaction monitoring (MRM) model. RESULTS The correlative coefficient of 26 chem. drugs were above 0.995. The average recoveries were 61.2% ∼ 115.6%, the relative standard deviations ranged from 1.0% to 2.0% (n=6). CONCLUSION The method is simple, rapid and sensitive. It is suitable for the determination of 26 chem. drugs for the treatment of cough and asthma added illegally in herbal tea.

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C12H15ClO3, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Xiang-Bing published the artcileExploration on applied opportunity and economical efficiency of carboprost tromethamine in cesarean section, HPLC of Formula: 58551-69-2, the publication is Zhongguo Fuyou Baojian (2009), 24(21), 2925-2927, database is CAplus.

The objective of this paper was to explore the applied opportunity and economical efficiency of carboprost tromethamine in cesarean section. 156 Cases were treated by carboprost tromethamine in cesarean section, some of them used carboprost tromethamine for prophylactic treatment before operation, and the others used carboprost tromethamine after operation under different opportunities. All the cases were treated by 20-40 U oxytocin at the same time. Some cases needed more than 250 μg carboprost tromethamine, and 15 min interval between each injection was necessary. The uterus became more harder, the hemorrhage volume became fewer after injection of carboprost tromethamine, 250 μg was ED for 86% of the cases, and 500 μg were ED for 96% of the cases. The adverse reaction included facial blushing, nausea and vomiting. Carboprost tromethamine could prevent and decrease the hemorrhage volume, and the risk of blood transfusion under postpartum hemorrhage.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, HPLC of Formula: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Shi-yun published the artcileSynthesis of related substances for ambroxol hydrochloride glucose injection, Category: alcohols-buliding-blocks, the publication is Huaxue Shiji (2019), 41(10), 1098-1100, database is CAplus.

To perform the quality control of ambroxol hydrochloride glucose injection, related substance 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was prepared 4-(6, 8-Dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was synthesized from ambroxol hydrochloride and formaldehyde by cyclization and oxidation reactions. The structure of 4-(6, 8-dibromo-3, 4-dihydroquinazoline-3-yl)-cyclohexanol was confirmed by IR, ¹HNMR, ¹³CNMR and ESI-MS. The synthetic route designed in this work is simple and the post-processing is convenient, can be used to provide the material foundation for ambroxol hydrochloride related substances 4-(6,8-dibromo-3,4-dihydroquinazoline-3-yl)-cyclohexanol reference substance preparation

Huaxue Shiji published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Klein, Jan J. published the artcileSynthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β-Sheet Aggregation, Formula: C10H15NO, the publication is Organic Letters (2012), 14(1), 330-333, database is CAplus and MEDLINE.

The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.

Organic Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peay, Miya A. published the artcileRed-Shifts upon Metal Binding: A Di-Gold(I)-Substituted Bithiophene, Related Products of alcohols-buliding-blocks, the publication is Organometallics (2011), 30(18), 5071-5074, database is CAplus.

5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene was metalated with (triphenylphosphine)gold(I) at the 5,5′-positions to yield a di-gold(I)-substituted bithiophene. The resulting complex was characterized by X-ray diffraction crystallog., optical spectroscopy, and elemental anal. The digold bithiophene complex emits green, structured luminescence in chloroform. Its absorption profile is red-shifted from those of 2,2′-bithiophene or the boronate ester starting material. D.-functional theory (DFT) calculations indicate that the frontier orbitals of the digold complex concentrate on the bithienyl bridge. Time-dependent DFT calculations find that the LUMO-HOMO promotion mostly accounts for the absorption onset in all three compounds and that CI with vacant orbitals on gold modulates this transition. This interaction contributes to red-shifted absorption profiles of σ-aurated gold(I) organometallics.

Organometallics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts