Category: alcohols-buliding-blocks

Huang, Jinshu published the artcileA New Lamellar Biocarbon Catalyst with Enhanced Acidity and Contact Sites for Efficient Biodiesel Production, Product Details of C9H12O, the publication is Waste and Biomass Valorization, database is CAplus.

Biochar is a type of green, biodegradable, sustainable, and cheap carbon material, which is typically prepared by pyrolysis, gasification, and hydrothermal carbonization methods at relatively high temperatures (≤ 180 °C), but generally facing with small sp. surface areas and low acid d. In this study, lignin-derived monomers were explored as carbon sources to prepare porous biochars at a low temperature of 80 °C. The carbonaceous catalyst (PPR-SO₃H-80) was found to be composed of irregular particles accumulated by lamellar carbon, and have a large sp. surface area (165.2 m²/g) and good thermal stability. Meanwhile, PPR-SO3H-80 had a high d. of -SO₃H (3.56 mmol/g), which increases with the degree of carbon defects. Importantly, the co-existence of -OH and -COOH in a certain amount with -SO3H on PPR-SO3H-80 could significantly promote the production of biodiesel (up to 97.1% yield), as optimized by the response surface method (RSM). In addition, PPR-SO3H-80 exhibited good stability and could be recycled 4 times with biodiesel yield slightly decreasing to 90.3%. A new lamellar biochar catalyst with enhanced acidity and large surface area as well as co-existed -SO₃H, -OH and -COOH acidic species was facilely prepared and could efficiently produce biodiesel with a high yield of 97.1%.

Waste and Biomass Valorization published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Joshi, Suraj R. published the artcileConstruction, analysis and validation of co-expression network to understand stress adaptation in Deinococcus radiodurans R1, Related Products of alcohols-buliding-blocks, the publication is PLoS One (2020), 15(6), e0234721, database is CAplus and MEDLINE.

In the current study, we have performed system-level anal. for Deinococcus radiodurans R1 by constructing a gene co-expression network based on several microarray datasets available in the public domain. This condition-independent network was constructed by Weighted Gene Co-expression Network Anal. (WGCNA) with 61 microarray samples from 9 different exptl. conditions. We identified 13 co-expressed modules, of which, 11 showed functional enrichments of one or more pathway/s or biol. process. Comparative anal. of differentially expressed genes and proteins from radiation and desiccation stress studies with our co-expressed modules revealed the association of cyan with radiation response. We obtained 7 TFs for radiation and desiccation responsive modules. The expressions of 3 TFs were validated in response to gamma radiation using qRT-PCR. Along with the TFs, selected close neighbor genes of two important TFs, viz., DR_0997 (CRP) and DR_2287 (AsnC family transcriptional regulator) in the darkgreen module were also validated. In our network, among 13 hub genes associated with 13 modules, the functionality of 5 hub genes which are annotated as hypothetical proteins (hypothetical hub genes) in D. radiodurans genome has been revealed. Overall the study provided a better insight of pathways and regulators associated with relevant DNA damaging stress response in D. radiodurans.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mandrah, Kapil published the artcileA study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography-mass spectrometry based metabolomics, Product Details of C12H10O4S, the publication is Environmental Toxicology and Pharmacology (2022), 103883, database is CAplus and MEDLINE.

The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Anal. indicated that BPS significantly promoted histopathol. disturbance in the kidney, and altered the levels of biomarkers of kidney damage in serum and urine samples of Wistar rats. It is also indicated that BPS altered the expression of kidney damage biomarkers associated with glomerular and tubular injury. Addnl., we determined the perturbation of kidney metabolites in the underlying pathophysiol. response of kidney injury due to BPS exposure. Gas chromatog.-mass spectrometry based untargeted metabolomics exhibited 20 significantly perturbed metabolites. Moreover, metabolic pathway anal. revealed significant disturbance in the TCA cycle and pyruvate metabolism pathways.

Environmental Toxicology and Pharmacology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Gopi published the artcileSimultaneous Estimation of azithromycin and ambroxol hydrochloride in combined dosage form by RP-HPLC method, Formula: C13H19Br2ClN2O, the publication is Journal of Chemical and Pharmaceutical Research (2018), 10(5), 142-147, database is CAplus.

A simple, accurate and precise RP-HPLC method was developed and subsequently validated for simultaneous determination of Azithromycin and Ambroxol Hydrochloride in combined dosage form. The Proposed HPLC method utilizes C18 (250 mm × 4.6 mm × 5 μm) column with mobile phase comprising of KH2PO4 (pH 5.0 adjusted with 1% Orthophosphoric acid: Methanol (60:40% volume/volume) at a flow rate of 1.0 mL/min. Selection of wavelength for determination of Azithromycin (50 μg/mL) and Ambroxol Hydrochloride (15 μg/mL) show reasonably good response at 215 nm. Quantitation was achieved based on peak area with linear calibration curves at concentration ranges 25 – 75 μg/mL for Azithromycin and 7.5 – 22.5 μg/mL for Ambroxol Hydrochloride with Correlation Coefficient of 0.999.The Retention times of Azithromycin and Ambroxol Hydrochloride were found to be 6.73 min and 4.17 min resp. The limit of detection (LOD) was 0.36 and 0.18 for Azithromycin and Ambroxol Hydrochloride resp. The limit of quantification (LOQ) was 1.09 and 0.56 for Azithromycin and Ambroxol Hydrochloride resp. The accuracy was found within the limit. The precision (inter – day, intra – day and repeatability) was found within the limit. The method was validated as per ICH guideline. The method can be successfully employed for simultaneous estimation of Azithromycin and Ambroxol Hydrochloride in combined dosage form.

Journal of Chemical and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vana, Lubomir published the artcileSynthesis of Aza[n]helicenes (n = 4-7) via Photocyclodehydrochlorination of 1-Chloro-N-aryl-2-naphthamides, Quality Control of 86-48-6, the publication is Journal of Organic Chemistry (2022), 87(11), 7150-7166, database is CAplus and MEDLINE.

A series of 5-aza[4]helicene, e.g., I was synthesized using a photocyclodehydrochlorination of 1-chloro-N-aryl-2-naphthamides, e.g., 1-chloro-N-phenyl-2-naphthamide as a general synthetic procedure introducing the nitrogen atom to the third ring of the helicene framework. The effect of the nitrogen presence in the helicene skeleton on the physicochem. properties of the prepared 5-aza[4]helicene was studied and compared to those of the parent carbo-analogs. The insertion of a nitrogen atom into the outer edge of the helicene mol. has a severe impact on certain physicochem. properties such as optical rotation, electrostatic potentials, and intermol. interactions. On the other hand, some other properties such as UV/vis, fluorescence, and phosphorescence spectra remained almost unaffected when compared to the parent carbohelicenes. A nitrogen atom can be also used for further derivatization, which can lead to further modification of helicene properties, as manifested here in the fluorescence changes induced by protonation.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C10H9ClN2O, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jorvekar, Sachin B. published the artcileDetermination of bisphenols and parabens in cow urine distillate from India: implication of human exposure and risk assessment, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Environmental Science and Pollution Research (2022), 29(35), 52507-52519, database is CAplus and MEDLINE.

The exposures of a wide range of endocrine-disrupting chems. to cows have been linked to diseases and are a major concern. In Indian scripts, cow urine is believed to be a treatment for many diseases. Nonetheless, exposure of bisphenols and parabens to cow urine distillates is unknown. Hence, in this study, we determined the concentration of bisphenols and parabens in com. available cow urine distillate collected from India. The mean concentration of total bisphenols and parabens ranges from the limit of quantification (LOQ) to 149.3 ng/mL and 1479.88 ng/mL, resp. Predominant bisphenol-F and bisphenol-A were accounted for 88.6% and 6% of total bisphenol concentration, resp., in marketed cow urine distillate, whereas Me and Pr parabens were dominant and accounted for 33% and 65%, resp. The estimated mean daily intake (EDI) of bisphenol for males and females were 45.94 ng/kg-bw/day and 54.29 ng/kg-bw/day, resp., while for parabens EDI was 455.35ng/kg-bw/day and 538.14 ng/kg-bw/day for males and females, resp. Hazard quotient, to evaluate the potential risk of exposure, showed no risk in the studied samples. Even though the EDI results from the Monte-Carlo risk assessment anal. did not exceed the acceptable daily intake, their estrogenic actions cannot be ignored in general populations. The estrogenic activities contributed by parabens and bisphenol A measured by estradiol equivalency quotient (EEQ) ranged from 0.00033-42 pg/mL and 2.3 pg/mL, resp. Our results revealed higher concentrations of bisphenols and parabens in cow urine distillates; hence, special attention should be given to the quality and safety of cow urine distillates. Moreover, strict guidelines should be enforced for the quality of cow urine distillates.

Environmental Science and Pollution Research published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Shaikh, Aminah Jeza published the artcileBioaugmentation of halophilic consortia for the degradation of petroleum hydrocarbons and petroleum wastewater treatment, Related Products of alcohols-buliding-blocks, the publication is International Journal of Advanced Research in Biological Sciences (2020), 7(9), 97-112, database is CAplus.

The present study, details about a halophilic bacterial consortium enriched from water and sediment samples from Red sea, Jeddah, Saudi Arabia analyzed for PAHs degradation potential under saline condition (40 g/L NaCl concentration). The bacterial consortium was able to growth in halophilic mineral salt medium with PAHs (Polycyclic Aromatic Hydrocarbons) as sole carbon source. Different types of selected LMW (Low Mol. Weight) PAHs such as phenathrene (PHN) and fluorine (FLU) at different concentrations (25, 50, 100, 200, 500 ppm) and pyrene (PY) from HMW(High Mol. Weight) PAH at 50 and 100 ppm concentrations was used in the study under saline condition. The results recorded 90% degradation of phenanthrene and fluoreneupto 500 ppm. HMW pyrene revealed 79% and 69% degradation at 50 ppm and 100 ppm concentration under saline condition by the halophilic consortium. Addition of FLU (100 ppm) along with the PY (50 ppm) recorded 85% of PY degradation in 8 days and 98% degradation in 12 days. Addition of yeast extract during PY degradation recorded complete degradation of PY (50 ppm) in 12 days. Lab Scale reactor study with CSTR (continuous stirred tank reactor) used to investigate the PAHs degradation and petroleum refinery wastewater treatment efficiency of in thehalophilic bacterial consortium. The results recorded 95% COD removal in 32 days with complete degradation of LMW PAHs in 12 days under saline condition. Bacterial strains in the consortium were identified by using mol. techniques such as DNA isolation and next generation sequencing.

International Journal of Advanced Research in Biological Sciences published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Joufi, Fakhria A. published the artcileAnabasis articulata (Forssk.) Moq: A Good Source of Phytochemicals with Antibacterial, Antioxidant, and Antidiabetic Potential, SDS of cas: 90-64-2, the publication is Molecules (2022), 27(11), 3526, database is CAplus and MEDLINE.

Anabasis articulata is medicinally used to treat various diseases. In this study, A. articulata was initially subjected to extraction, and the resultant extracts were then evaluated for their antimicrobial, antioxidant, and antidiabetic potentials. After obtaining the methanolic extract, it was subjected to a silica gel column for separation, and fractions were collected at equal intervals. Out of the obtained fractions (most rich in bioactive compounds confirmed through HPLC), designated as A, B, C, and D as well hexane fraction, were subjected to GC-MS anal., and a number of valuable bioactive compounds were identified from the chromatograms. The preliminary phytochem. tests were pos. for the extracts where fraction A exhibited the highest total phenolic and flavonoid contents. The hexane fraction as antimicrobial agent was the most potent, followed by the crude extract, fraction A, and fraction D. DPPH and ABTS assays were used to estimate the free radical scavenging potential of the extracts Fraction C was found to contain potent inhibitors of both the tested radicals, followed by fraction D. The potential antidiabetic extracts were determined using α-glucosidase and amylase as probe enzymes. The former was inhibited by crude extract, hexane, and A, B, C and D fractions to the extent of 85.32 ± 0.20, 61.14 ± 0.49, 62.15 ± 0.84, 78.51 ± 0.45, 72.57 ± 0.92 and 70.61 ± 0.91%, resp., at the highest tested concentration of 1000 μg/mL with their IC50 values 32, 180, 200, 60, 120 and 140 μg/mL correspondingly, whereas α-amylase was inhibited to the extent of 83.98 ± 0.21, 58.14 ± 0.75, 59.34 ± 0.89, 81.32 ± 0.09, 74.52 ± 0.13 and 72.51 ± 0.02% (IC50 values; 34, 220, 240, 58, 180, and 200 μg/mL, resp.). The observed biol. potentials might be due to high phenolic and flavonoid content as detected in the extracts The A. articulata might thus be considered an efficient therapeutic candidate and could further be investigated for other biol. potentials along with the isolation of pure responsible ingredients.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

White, James D. published the artcileStudies of the Synthesis of Providencin: Construction and Assembly of Two Major Subunits, Application of (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2014), 79(2), 700-710, database is CAplus and MEDLINE.

The “northern” sector of the cembranoid diterpene providencin (I) containing a tetrasubstituted cyclobutane was synthesized from the bis(acetonide) of D-glucose using dicyclopentadienylzirconium(0)-mediated oxygen abstraction from a furanose. Oxidative scission of the vinyl substituent of this cyclobutane gave an aldehyde, which was reacted with an alkynylstannane to provide an allenol (II). Cyclization of the derived allenone with silver nitrate led to a cyclobutylfuran (III) comprising the northern subunit of providencin. The “southern” sector of the cembranoid skeleton containing a trisubstituted iodoalkene attached to an α-phenylselenyl-γ-lactone was synthesized from (R)-glycidol. Negishi carbometalation-iodination established the (E)-iodoalkene, and addition of the lithio dianion of phenylselenoacetic acid to a tosylate generated the substituted lactone (IV). The two sectors were joined via stannylation of the furan of the northern component followed by Stille cross-coupling of the furylstannane with the iodoalkene of the southern subunit. Linkage of the two segments was also made at C12-C13 of providencin using intermol. aldol condensation of the enolate from the selenyl lactone of the southern portion with an acetaldehyde appendage on the cyclobutane of the northern sector. Closure of the providencin macrocycle from these conjoined subunits was unsuccessful.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C15H15OP, Application of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhunia, Susmita published the artcileCatalytic olefin epoxidation over cobalt(II)-containing mesoporous silica by molecular oxygen in dimethylformamide medium, Application In Synthesis of 57044-25-4, the publication is Catalysis Science & Technology (2014), 4(6), 1820-1828, database is CAplus.

A cobalt(II) Schiff base complex has been immobilized onto the surface of Si-MCM-41 to prepare a new catalyst. The amine group-containing organic moiety 3-aminopropyl-triethoxysilane had first been anchored on the surface of Si-MCM-41 via a silicon alkoxide route. Upon condensation with salicylaldehyde, the amine group affords a bidentate Schiff-base moiety in the mesoporous matrix, which is subsequently used for anchoring of cobalt(II) centers. The prepared catalyst has been characterized by UV-vis, IR, EPR spectroscopic and small angle X-ray diffraction (XRD) analyses, and N₂ sorption studies. The catalytic activity was tested in epoxidation reactions of olefinic compounds, including styrene and allyl alc., with mol. oxygen at atm. pressure in DMF medium in the absence of addnl. sacrificial reductant. The reactions seemed to proceed through a radical formation mechanism. The immobilized catalyst showed good activity and epoxide selectivity in the alkene epoxidation Notably, the catalyst can be recovered and reused without any loss of activity.

Catalysis Science & Technology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts