Category: alcohols-buliding-blocks

Sakai, Toshinori published the artcileHemodynamic effects of the new dihydropyridine derivative, (±)-2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate hydrochloride ethanol (NZ-105) in anesthetized dogs, SDS of cas: 111011-76-8, the publication is Oyo Yakuri (1991), 42(1), 43-54, database is CAplus.

The hemodynamic effects of NZ-105 (I) were compared with those of nicardipine in pentobarbital-anesthetized dogs. NZ-105 had a slow onset and prolonged duration of action in decreasing blood pressure. Doses of 10-100 μg/kg i.v. produced a dose-dependent fall in blood pressure but no significant increase in heart rate. The potency of NZ-105 on blood pressure was about half that of nicardipine. However, the duration of action of NZ-105 was longer while the extent of the fall was similar. A small dose of 10 μg/kg of NZ-105 i.v. produced a hypotensive effect, but a large dose of 300 μg/kg i.v. was required to cause prolongation of the P-Q interval in the ECG. In open-chest dogs, NZ-105 (10 and 30 μg/kg i.v.) tended to increase the central venous pressure and transiently increased the left ventricular end-diastolic pressure but produced no significant change in the maximal rate of rise of the left ventricular pressure. NZ-105 (10 and 30 μg/kg i.v.) increased the coronary sinus outflow but caused no significant change in myocardial oxygen consumption. These results suggest that NZ-105 may be a useful agent with a slow onset and long duration of action, vascular selectivity and minimal cardiac effect in the treatment of hypertension.

Oyo Yakuri published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Santonicola, Gabriella M. published the artcileMixtures of n-Octyl-β-D-glucoside and Triethylene Glycol Mono-n-octyl Ether: Phase Behavior and Micellar Structure near the Liquid-Liquid Phase Boundary, Related Products of alcohols-buliding-blocks, the publication is Langmuir (2005), 21(22), 9955-9963, database is CAplus and MEDLINE.

The phase behavior and microstructure of aqueous mixtures of n-octyl-β-D-glucoside (C₈βG₁) and triethylene glycol mono-n-octyl ether (C₈E₃) is presented. C₈βG₁ forms a one-phase micellar solution in water at surfactant concentrations up to 60 wt %, whereas mixtures with C₈E₃ show a liquid-liquid phase transition at low surfactant concentration The position of this phase boundary for mixtures can be rationally shifted in the temperature-composition window by altering the ratio of the two surfactants. Small-angle neutron scattering is used to determine the size and shape of the mixed micelles and to characterize the nature of the fluctuations near the cloud point of the micellar solutions The C₈βG₁/C₈E₃ solutions are characterized by concentration fluctuations that become progressively stronger upon approach to the liquid-liquid phase boundary, whereas micellar growth is negligible. Such observations confirm previous views of the role of the surfactant phase boundary in tuning attractive micellar interactions, which can be used effectively to change the nature and strength of interparticle interactions in colloidal dispersions. Colloidal silica particles were then added to these surfactant mixtures and were found to aggregate at conditions near the cloud point. This finding is relevant to current strategies for protein crystallization

Langmuir published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rapolu, Rajesh Kumar published the artcileShort enantioselective routes to (S)-Dapoxetine, Formula: C19H18O2, the publication is Chemistry & Biology Interface (2013), 3(1), 50-60, database is CAplus.

Two enantioselective approaches involving a stereoselective conjugate addition of a homochiral lithium amide based on (R)-N-(1-phenylethyl)benzylamine and a stereoselective ketone reduction of a prochiral ketone were employed for a chiral synthesis of (S)-dapoxetine. Both routes employ readily and com. viable starting materials and reagents, and suitable for process synthesis of (αS)-N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine (Dapoxetine hydrochloride) (I). The synthesis of the target compound was achieved using 3-chloro-1-phenyl-1-propanone as a starting material.

Chemistry & Biology Interface published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Formula: C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheng, Kuo-Ching published the artcileDelivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo, Computed Properties of 96345-79-8, the publication is European Journal of Immunology (2008), 38(2), 424-436, database is CAplus and MEDLINE.

Antigen mannosylation has been shown to be an effective approach to potentiate antigen immunogenicity, due to the enhanced antigen uptake and presentation by APC. To overcome disadvantages associated with conventional methods used to mannosylate antigens, we have developed a novel mannose-based antigen delivery system that utilizes a polyamidoamine (PAMAM) dendrimer. It is demonstrated that mannosylated dendrimer ovalbumin (MDO) is a potent immune inducer. With a strong binding avidity to DC, MDO potently induced OVA-specific T cell response in vitro. It was found that the immunogenicity of MDO was due not only to enhanced antigen presentation, but also to induction of DC maturation. Mice immunized with MDO generated strong OVA-specific CD4⁺/CD8⁺ T cell and antibody responses. MDO also targeted lymph node DC to cross-present OVA, leading to OTI CD8⁺ T cell proliferation. Moreover, upon challenge with B16-OVA tumor cells, tumors in mice pre-immunized with MDO either did not grow or displayed a much more delayed onset, and had slower kinetics of growth than those of OVA-immunized mice. This mannose-based antigen delivery system was applied here for the first time to the immunization study. With several advantages and exceptional adjuvanticity, we propose mannosylated dendrimer as a potential vaccine carrier.

European Journal of Immunology published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C15H12O8, Computed Properties of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shahar, Or David published the artcileA high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair, Product Details of C28H29NO4, the publication is Nucleic Acids Research (2014), 42(9), 5689-5701, database is CAplus and MEDLINE.

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homol. directed repair (HDR). Identifying novel small mols. that affect HDR is of great importance both for research use and therapy. Mols. that elevate HDR may improve gene targeting, whereas inhibiting mols. can be used for chemotherapy, since some of the cancers are more sensitive to repair impairment. Here, the authors performed a high-throughput chem. screen for FDA approved drugs, which affect HDR in cancer cells. The authors found that HDR frequencies are increased by retinoic acid and Idoxuridine and reduced by the antihypertensive drug Spironolactone. The authors further revealed that Spironolactone impairs Rad51 foci formation, sensitizes cancer cells to DNA damaging agents, to Poly (ADP-ribose) polymerase (PARP) inhibitors and crosslinking agents and inhibits tumor growth in xenografts, in mice. This study suggests Spironolactone as a new candidate for chemotherapy.

Nucleic Acids Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C7H7IN2O, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ye, Juntao published the artcileDirect α-alkylation of primary aliphatic amines enabled by CO₂ and electrostatics, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Nature Chemistry (2018), 10(10), 1037-1041, database is CAplus and MEDLINE.

Primary aliphatic amines are important building blocks in organic synthesis due to the presence of a synthetically versatile NH₂ group. N-functionalization of primary amines is well established, but selective C-functionalization of unprotected primary amines remains challenging. Here, we report the use of CO₂ as an activator for the direct transformation of abundant primary aliphatic amines into valuable γ-lactams under photoredox and hydrogen atom transfer (HAT) catalysis. Exptl. and computational studies suggest that CO₂ not only inhibits undesired N-alkylation of primary amines, but also promotes selective intermol. HAT by an electrostatically accelerated interaction between the in situ-generated neg. charged carbamate and the pos. charged quinuclidinium radical. This electrostatic attraction overwhelms the inherent bond dissociation energies which suggest that HAT should occur unselectively. We anticipate that our findings will open up new avenues for amine functionalizations as well as selectivity control in HAT reactions.

Nature Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H24BNO3, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghiasi, Mina published the artcileConformational Analysis of Topiramate and Related Anion in the Solution and Interaction Between the Most Stable Conformer of Topiramate with Active Center of Carbonic Anhydrase Enzyme, Computed Properties of 20880-92-6, the publication is Journal of Carbohydrate Chemistry (2015), 34(2), 80-102, database is CAplus.

D. functional theory using the B3LYP/6-311++G** method was employed to calculate the details of the electronic structure and electronic energy of the carbonic anhydrase enzyme active center (CA); topiramate, a sulfamate substituted monosaccharide; and the complex between topiramate and CA. The calculated results indicate that topiramate appears to adopt a twist-boat conformation in the solution The conformational anal. around the S-N bond (H-N-S-O dihedral angle) in deprotonated topiramate shows that the conformers with a H-N-S-O torsion of 270, 0, and 180 degrees are the min., transition state, and maximum energy conformers, resp. The deprotonated form of topiramate is coordinated to the Zn²⁺ ion.

Journal of Carbohydrate Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ishimoto, Ryo published the artcileHighly selective oxidation of organosilanes to silanols with hydrogen peroxide catalyzed by a lacunary polyoxotungstate, COA of Formula: C9H22OSi, the publication is Angewandte Chemie, International Edition (2009), 48(47), 8900-8904, S8900/1-S8900/11, database is CAplus and MEDLINE.

Divacant lacunary polyoxotungstate (Bu₄N⁺)₄[γ-SiW₁₀O₃₄(H₂O)₂] (1) is an efficient homogeneous catalyst for highly selective oxidation of organosilanes to silanols with 30-60 % aqueous H₂O₂. Various kinds of silanes, Ph₂MeSiH, Et₃SiH, (C₆H₁₃)₃SiH, ^tBuMe₂SiH, Bu₃SiH, ⁱPr₃SiH, (EtO)₃SiH, (BuO)₃SiH, RMe₂SiH (R = Ph, 4-MeOC₆H₄, 4-MeC₆H₄, 4-CF₃C₆H₄, ClCH₂, PhCC, PhCH:CH) containing aryl, alkyl, alkenyl, alkynyl, and alkoxy groups are chemoselectively converted into the corresponding silanols in high yields with only one equiv of aqueous H₂O₂.

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, COA of Formula: C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nojima, Susumu published the artcileSelective Oxidation with Aqueous Hydrogen Peroxide by [PO₄{WO(O₂)₂}₄]^3- Supported on Zinc-Modified Tin Dioxide, Computed Properties of 597-52-4, the publication is ChemCatChem (2015), 7(7), 1097-1104, database is CAplus.

The supported phosphorus-containing tetranuclear peroxotungstate ([PO₄{WO(O₂)₂}₄]^3-, denoted by PW4) catalysts by using zinc-modified SnO₂ supports with different zinc contents [PW₄-Zn(x)/SnO₂, in which x denotes the zinc content (wt%)] were prepared The supported catalysts, in particular PW4-Zn(0.8)/SnO₂, could act as efficient and reusable heterogeneous catalysts for selective oxidation with aqueous H₂O₂ as the terminal oxidant. The catalytic performance of PW4-Zn(0.8)/SnO₂ was much superior to those of the corresponding homogeneous analog THA₃PW4 (THA = tetra-n-hexylammonium) and the previously reported tungstate-based heterogeneous catalysts such as our W-Zn/SnO₂. In the presence of PW4-Zn(0.8)/SnO₂, various types of organic substrates such as alkenes, amines, silanes, and sulfides could be converted into the corresponding oxygenated products in high to excellent yields by using near-stoichiometric amounts of H₂O₂ with respect to the substrates (typically 1.2 equivalent). The PW4 species interacting with highly dispersed Zn²⁺ species on SnO₂ likely plays an important role in the present oxidation

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shibata, Kentaro published the artcileHomopolymer-block-Alternating Copolymers Composed of Acrylamide Units: Design of Transformable Divinyl Monomers and Sequence-Specific Thermoresponsive Properties, Product Details of C8H5F3O3, the publication is Journal of the American Chemical Society (2022), 144(22), 9959-9970, database is CAplus and MEDLINE.

In this work, we synthesized an acrylamide-based terpolymer that is a block copolymer composed of an AB alternating copolymer and a C homopolymer. The key to the unprecedented achievement is rational design of an acrylate-acrylamide divinyl monomer carrying CF₃-substituted salicylic acid ester bonds (AAm-CF₃) to realize the efficient and selective cyclopolymn. as well as the quant. transformation of the resultant cyclorepeating units. The selectivity in the cyclopolymn. and the pendant transformation ability were evaluated through reactivity ratios of the corresponding model monomers and quant. aminolysis reactions of the model compound The cyclopolymn. via the photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) process with a macrochain-transfer agent and subsequent aminolysis reaction afforded the homopolymer-block-alternating copolymer. The sequence-controlled terpolymer exhibited a very unique thermal response behavior in water that was strikingly different from the corresponding sequence-uncontrolled terpolymers, such as homopolymer-block-statistical copolymers and all statistical terpolymers, despite the fact that the structure cannot be distinguished by ¹H NMR.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C9H10O4, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts