Category: alcohols-buliding-blocks

Salvador-Recatala, Vicenta published the artcileVoltage-gated K⁺ channel block by catechol derivatives: defining nonselective and selective pharmacophores, Application In Synthesis of 1139-46-4, the publication is Journal of Pharmacology and Experimental Therapeutics (2006), 319(2), 758-764, database is CAplus and MEDLINE.

High-throughput screening led to the identification of a 3-norbornyl derivative of catechol called 48F10 (3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol) as a Kv2.1 K⁺ channel inhibitor. By virtue of the involvement of Kv2.1 channels in programmed cell death, 48F10 prevents apoptosis in cortical neurons and enterocytes. This uncharged compound acts with an apparent affinity of 1 μM at the tetraethylammonium (TEA) site at the external mouth of the Kv2.1 channel but is ineffective on Kv1.5. Here we investigated the basis of this selectivity with structure-activity studies. We find that catechol (1,2-benzenediol), unlike 48F10, inhibits Kv2.1 currents with a Hill coefficient of 2 and slows channel activation. Furthermore, this inhibition, which requires millimolar concentrations, is unaffected by external TEA or by mutation of the external tyrosine implicated in channel block by TEA and 48F10. In addition, catechol does not distinguish between Kv2.1 and Kv1.5. Thus, catechol acts at conserved sites that are distinct from 48F10. We also tested 11 catechol derivatives based on hydrocarbon adducts including norbornyl substructures, a 48F10 isomer, and a 48F10 diastereomer. These compounds are more potent than catechol, but none replicated the marked selectivity of 48F10 for Kv2.1 over Kv1.5. We conclude that the targeting of 48F10 to the TEA site at the external mouth of the Kv2.1 pore and away from other sites involved in nonselective Kv channel block by catechol requires the norbornyl group in a unique position and orientation on the catechol ring.

Journal of Pharmacology and Experimental Therapeutics published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application In Synthesis of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirayama, Ryoichi published the artcileThe autorecycling oxidation of benzylamine by synthetic 8-hydroxy-5-deazaflavin derivatives, SDS of cas: 14703-69-6, the publication is Journal of Heterocyclic Chemistry (1989), 26(5), 1255-9, database is CAplus.

8-Hydroxy-5-deazaflavin derivatives I [R = Me, Ph, R¹ = Me, Et, Bu, hexyl, octyl, dodecyl; R = Me, R¹ = (CH₂)_nCO₂H, n = 3, 5] were synthesized as model compounds of coenzyme F₄₂₀. I (R¹ = alkyl) oxidized PhCH₂NH₂ to PhCHO more efficiently than the 8-unsubstituted 5-deazaflavins. I [R¹ = (CH₂)_nCO₂H] showed little oxidizing ability.

Journal of Heterocyclic Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, SDS of cas: 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Erkan, Sultan published the artcileStructural, spectral characterization and molecular docking analyses of mer-ruthenium (II) complexes containing the bidentate chelating ligands, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2020), 117399, database is CAplus and MEDLINE.

The authors analyzed some monofunctional Ru (II) complexes containing chlorine, bromine and fluorine atoms around the central atom. The best calculation level among HF, B3LYP and M062X methods for [Ru (Cl-Ph-tpy)(N-N)X]⁺ (X = F, Cl, Br) was determined in the light of Benchmark anal. and according to this anal. results, the best level is shown as B3LYP-LANL2DZ/6-31G(d). In addition to this, the spectroscopic data (IR, NMR and UV-visible) were also obtained in agreement with exptl. results. The tendency of anticancer activity and structural activity relation (SAR) parameters are predicted with some quantum chem. methods. Surface and contour diagrams, as well as electron densities on mentioned complexes were interpreted through theor. obtained results. Finally, the anticancer activity tendency of the relevant complexes on the human cervical carcinoma cell line (ID: 1 M17) is supported by mol. docking calculations

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ren, Guilin published the artcileStudy of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch, Category: alcohols-buliding-blocks, the publication is Scientific Reports (2022), 12(1), 8153, database is CAplus and MEDLINE.

Volatile oil from traditional Chinese medicine has various biol. activities and has pharmacol. activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clin. practice. However, the development of their clin. applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by phys. adsorption. GC-MS was used to determine the chem. constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chem. constituents were analyzed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analyzed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chem. composition, which was consistent with the theory of flavor. The phys. properties and chem. composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was phys. adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Weihua published the artcileIncorporating Perylene Moiety into Poly(phenothiazine-co-bithiophene) Backbone for Higher Charge Transport, SDS of cas: 239075-02-6, the publication is Journal of Physical Chemistry B (2008), 112(12), 3590-3596, database is CAplus and MEDLINE.

Low band gap π-conjugated polymers composed of phenothiazine, bithiophene, and perylene moieties were prepared in high yields by palladium-catalyzed Suzuki coupling reaction. The polymers were characterized by NMR, gel permeation chromatog., and elemental anal. The characterizations revealed that high-mol. weight (weight-average mol. weight up to 42 400 g/mol) polymers were thermally stable with a decomposition temperature at 338-354° and glass transition temperature (T_g) 124-136°. All polymers demonstrated broad optical absorption in the region of 300-550 nm with efficient blue-green light emission. The absorption was broadened further (for ca. 50 nm) when the perylene moiety was incorporated. Cyclic voltammograms displayed that the p- and n-doping processes of all the polymers were partially reversible and that electrochem. band gaps were as low as -2.30 eV with the incorporation of a perylene moiety. The hole mobility of polymers was evaluated by using the space-charge-limited current model with a PLED device structure of ITO/PEDOT:PSS/polymer/Ca. The incorporation of perylene is beneficial for improving the hole mobility of the conjugated polymers.

Journal of Physical Chemistry B published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C8H7NaO4S, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boehme, Thomas M. published the artcileStructure-Activity Relationships of Dimethindene Derivatives as New M₂-Selective Muscarinic Receptor Antagonists, Quality Control of 101-98-4, the publication is Journal of Medicinal Chemistry (2003), 46(5), 856-867, database is CAplus and MEDLINE.

2,3-Disubstituted indenes, such as I [R = (Me₂CH)₂N, (FCH₂CH₂)MeN; n = 2], analogs of the widely used histamine H₁ receptor antagonist dimethindene, are prepared as potential M₂-selective muscarinic receptor antagonists. (-)-I [R = (Me₂CH)₂N; n = 2] has comparable affinity for M₂ receptors to (S)-dimethindene with 5-275-fold selectivities for the M₂ muscarinic receptor over other muscarinic receptor subtypes and over histamine H₁ receptors. I [R = (FCH₂CH₂)MeN; n = 2] also has high affinity for the muscarinic M₂ receptor and is selective for the M₂ receptor over other muscarinic receptors but possesses high affinity for histamine H₁ receptors. I (R = Me₂N; n = 1) has the highest affinity of the tested indenes for M₂ muscarinic receptors but low selectivity for M₂ muscarinic receptors over other muscarinic receptor subtypes.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bernhardt, Annika published the artcileThe Strong β-CF₃ Shielding Effect in Hexafluoroisopropanol and 100 Other Organic Solvents Revisited with ¹⁷O NMR Spectroscopy, Related Products of alcohols-buliding-blocks, the publication is ChemCatChem (2018), 10(7), 1547-1551, database is CAplus and MEDLINE.

An ¹⁷O NMR spectroscopy survey of more than 100 ubiquitous organic solvents and compounds, including some typical oxofluorinated solvents such as hexafluoroisopropanol, trifluoroethanol, trifluoroacetic acid, and others, is presented with D₂O as a reference A strong alternating α,β-CF₃-substituent chem. shift effect was thus observed This alternating deshielding-shielding effect is suspected to have a role in the exceptional properties of these oxofluorinated solvents, notably in oxidative cross-coupling reactions.

ChemCatChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Chuangxing published the artcileDiscovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer, COA of Formula: C4H9BrO, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(2), 1230-1236, database is CAplus and MEDLINE.

High throughput cell-based screening led to the identification of 3-aryloxy lactams as potent androgen receptor (AR) antagonists. Refinement of these leads to improve the ADME profile and remove residual agonism led to the discovery of 12, a potent full antagonist with greater oral bioavailability. Improvements in the ADME profile were realized by designing more ligand-efficient mols. with reduced mol. weights and lower lipophilicities.

Bioorganic & Medicinal Chemistry Letters published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C4H9BrO, COA of Formula: C4H9BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kennedy, Sean published the artcileSuperacid-promoted synthesis of indolizidine derivatives, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Tetrahedron Letters (2018), 59(20), 1932-1935, database is CAplus.

A series of amido-acetals were reacted with the Bronsted superacid, CF₃SO₃H, to provides indolizidine derives by a cyclization cascade. A mechanism is proposed involving formation of a vinylogous enol which undergoes a 6π-electrocyclization reaction with an adjacent N-acyl iminium ion group. With aryl substituents, there is a strong tendency for the N-acyl iminium ion group to undergo Friedel-Crafts type cyclizations with the aryl group. The synthetic methodol. was used to prepare the alkaloid natural product, ipalbidine.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ahmad, Sufiyan published the artcileQuality by design approach to develop stability indicating reversed-phase high-performance liquid chromatography method development for ambroxol, Quality Control of 23828-92-4, the publication is Asian Journal of Pharmaceutical and Clinical Research (2021), 14(12), 44-49, database is CAplus.

As per requisition of current regulatory requirements, simple, rapid and sensitive method by 33 factorial quality by design approach was established and validated for Ambroxol (AMB) by reversed-phase high-performance liquid chromatog. (RP-HPLC). A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, limit of detection (LOD), limit of quantitation (LOQ), accuracy as per International Conference for Harmonisation guidelines (Q2R1). Statistical data anal. was done for data obtained from different aliquots Runs on Agilent Tech. Gradient System with Auto injector, UV diode-array detection and Gradient Detector. Equipped with Reverse Phase (Agilent) C18 column (4.6 mm x 100 mm; 2.5μm), a 20μl injection loop and UV730D Absorbance detector at 244 nm wave length and running chemstation 10.1 software and drugs along with degradants were separated via Methanol: (0.1% orthophosphoric acid) Water (75:25) of pH 3 as mobile phase setting flow rate 0.7 mL/min at ambient temperature the retention time of AMB were found to be 4.85 min. The industrialized method was found linear over the concentration range of 10-50μg/mL for AMB while the LOD and LOQ of AMB was found to be 0.5174-0.2739μg/mL, anal. method that concluded. There are no interfering peaks underperformed degradation conditions. Therefore, a sensitive, robust, accurate, and stability indicating method was developed with high degree of practical utility.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts