Category: alcohols-buliding-blocks

Cipriani, Andreza published the artcilePhenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase, Category: alcohols-buliding-blocks, the publication is Natural Product Research (2022), 36(4), 1134-1137, database is CAplus and MEDLINE.

Eugenia involucrata DC. (Myrtaceae), popularly known as “cereja-do-Rio-Grande”, is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), Et acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chem. composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19μg mL-1, for FEA) and α-glucosidase (α-Glu) (best result: IC50 = 31.25 ± 0.15μg mL-1, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ouyang, Mi published the artcileStudy on electrochromic performance of the copolymer based on 4-(1H-pyrrol-1-yl) phenyl 4-(1H-pyrrol-1-yl) butanoate with 3,4-ethylenedioxythiophene, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2011), 335-336(Pt. 2), 929-933, database is CAplus.

A new polypyrrole derivative 4-(1H-pyrrol-1-yl) Ph 4-(1H-pyrrol-1-yl) butanoate (NPB) was synthesized by chem. method and characterized by ¹H and ¹³C NMR spectroscopy. A new copolymer based on NPB and 3,4-ethylenedioxythiophene(EDOT) was electrochem. synthesized. Cyclic voltammogram and spectroelectrochem. characterization showed that the copolymer film had a well-defined reversible redox process as well as electrochromic behavior. Moreover, the copolymer film exhibited a multicolor electrochromism at different potentials, fast switching time of 0.8 s at 365 nm and an optical contrast of 17% at 1100nm.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zasosov, R. V. published the artcileExcretion of naphthamon in the bile of white rats, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1973), 42(5), 557-60, database is CAplus and MEDLINE.

Naphthamon (I) [3818-50-6] (50-1250 mg/kg) was detected in the bile 10 min after it was introduced into the duodenum of rats. The total amount of I excreted in the bile for 24-48 hr was <1% of the dose applied.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C5H11BrO, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsarev, Vasily N. published the artcileP-chiral monodentate diamidophosphites – New and efficient ligands for palladium-catalysed asymmetric allylic substitution, Recommanded Product: 1-Methylcyclobutan-1-ol, the publication is European Journal of Organic Chemistry (2004), 2214-2222, database is CAplus.

Monodentate hexahydropyrrolodiazaphosphole ligands I [R = MeO, Me₂CHO, Me₃CO, (F₃C)₂CHO, 1-Me-1-cyclobutoxy, 1-adamantyloxy, (-)-menthyloxy, PhO, Et₂N, 1-piperidinyl] are prepared and used as ligands for enantioselective allylic substitution and amination reactions of 1,3-diphenylallyl acetate with sodium 4-methylbenzenesulfinate, benzylamine, and di-Me malonate to give substitution products in up to 97% ee. Reaction of alcs. or amines with I (R = Cl) [prepared in one step from (2R)-2-(phenylaminomethyl)pyrrolidine and PCl₃] yields I [R = MeO, Me₂CHO, Me₃CO, (F₃C)₂CHO, 1-Me-1-cyclobutoxy, 1-adamantyloxy, (-)-menthyloxy, PhO, Et₂N, 1-piperidinyl]. I are isolated as mixtures of epimers at phosphorus favoring the (R^P)-configuration. Dinaphthodioxaphosphepines derived from (R)-BINOL are also prepared as nonracemic ligands for comparison. Dimeric rhodium complexes and a monomeric rhodium complexes are prepared from I and [Rh(CO)₂Cl]₂ and characterized by ³¹P NMR. (allyl)palladium complexes derived from I and allylpalladium chloride dimer are prepared as catalysts for allylic substitution and amination reactions; the complexes can also be generated in situ using either allylpalladium chloride dimer or tris(dibenzylideneacetone)dipalladium as precursors, but in some cases the use of in situ generated catalysts gives products with decreased enantioselectivities. The most effective catalysts are those containing phosphine ligands with moderate π-acidity; less π-acidic ligands give decreased enantioselectivities. The enantioselectivity of allylic amination reactions using I and their derived palladium complexes increases as the cone angle of the phosphine increases. Allylic alkylation of (allyl)(methyl)carbonate with a carborane-containing phenylacetic acid ester gives an (allyl)(carboranyl)phenylacetate ester in up to 73% ee, the first direct asym. reaction for a carborane derivative

European Journal of Organic Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C2H2N4O2, Recommanded Product: 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II), Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(9), 1148-1155, database is CAplus and MEDLINE.

New structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives I (R¹ = Me, Ph; R² = H, Me; R³ = H, Ph; R⁴ = H, 4-Me, 4-MeO, etc.) were synthesized for the first time and their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Most of the compounds exhibited good to excellent anticancer activity. In particular, I (R¹ = Me; R², R³ = H; R⁴ = Br), I (R¹, R³ = Ph; R² = H; R⁴ = 4-MeO) and I (R¹, R³ = Ph; R² = H; R⁴ = 4-Br) exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Name: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis of isoxazole moiety containing ferrocene derivatives and preliminarily in vitro anticancer activity, Related Products of alcohols-buliding-blocks, the publication is MedChemComm (2014), 5(7), 968-972, database is CAplus.

Seven isoxazole-ring-containing ferrocene derivatives were synthesized and characterized by ¹H NMR, ¹³C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116, and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, ferrocenecarboxylic acid 3-(2-chlorophenyl)isoxazol-5-ylmethyl ester (3d) exhibited wide spectrum anticancer activity and is the most potent among the isoxazole-ring-containing ferrocene derivatives Compound 3d is more active against A549 and HCT116 cell lines (IC₅₀s: 0.747 and 3.65 nM, resp.) than the reference drug gefitinib (IC₅₀s: 17.90 and 21.55 μM, resp.). 3D can be seen as the best candidate for development of anticancer drugs.

MedChemComm published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jianping published the artcileSynthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II), Quality Control of 438565-33-4, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(10), 1326-1332, database is CAplus and MEDLINE.

Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a∼3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogs) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 M, resp.) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 M, resp.), and which can be regarded as the best candidate for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yong, Jian-Ping published the artcilePotential Anticancer Agents. I. Synthesis of Isoxazole Moiety Containing Quinazoline Derivatives and Preliminarily in vitro Anticancer Activity, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Anti-Cancer Agents in Medicinal Chemistry (2015), 15(1), 131-136, database is CAplus and MEDLINE.

14 New structures of isoxazole-moiety-containing quinazoline derivatives(3a∼3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds showed good to excellent anticancer activity, especially 3d, 3i, 3k and 3m exhibited the more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising drug candidates for development of anticancer drugs.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Ruiting published the artcilePeanut shells-derived biochars as adsorbents for the pipette-tip solid-phase extraction of endocrine-disrupting phenols in water, milk and beverage, Formula: C12H10O4S, the publication is Journal of Chromatography A (2022), 463101, database is CAplus and MEDLINE.

In the present work, a type of biochar materials derived from carbonizing peanut shells were obtained and employed as the adsorbents of pipet-tip solid-phase extraction (PT-SPE) for the enrichment and determination of six endocrine-disrupting phenols (EDPs) in combination with high-performance liquid chromatog. equipped with UV detector (HPLC-UV). Abundant aliphatic and aromatic carbon structures and functional groups from polar heteroatoms (N, O, S) were distributed in the low-cost and eco-friendly peanut shells-derived biochar materials and were favorable for the enrichment of target EDPs. Moreover, the theor. calculation based on d. functional theory (DFT) proved that the effective enrichment of EDPs in aqueous samples benefited from the effective adsorption on the peanut shells-derived biochar materials. The exptl. factors influencing the extraction efficiency were investigated, including adsorbent amount, aspirating/dispensing cycles, the type of elution solvent and elution times, salt addition, sample solution pH and type and volume of washing solvent. Under the optimal conditions, the proposed PT-SPE method exhibited good linear relationship (R2 > 0.993) in the range of 0.5-400μg/L and low limits of detections (LODs) from 0.25 to 2.5μg/L, as well as good precision and accuracy with relative standard deviations (RSDs) of 0.3%-13.2% and recoveries of 83.5%-117.1%. Finally, the biochars-based miniaturized pretreatment method was employed for the determination of six EDPs in bottled water, milk, tea beverage and disposal plastic bag soaked solution with recoveries from 77.5% to 116.5%.

Journal of Chromatography A published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C16H24BF4Ir, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Usta, Hakan published the artcileDithienosilole- and Dibenzosilole-Thiophene Copolymers as Semiconductors for Organic Thin-Film Transistors, Computed Properties of 239075-02-6, the publication is Journal of the American Chemical Society (2006), 128(28), 9034-9035, database is CAplus and MEDLINE.

The synthesis and physicochem. properties of a new class of thiophene/arenesilole-containing π-conjugated polymers are reported. Examples of this new polymer class include the following: poly(2,5-bis(3′,3”-dihexylsilylene-2′,2”-bithieno)thiophene) (TS6T1), poly(2,5′-bis(3”,3”’-dihexylsilylene-2”,2”’-bithieno)bithiophene) (TS6T2), poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)thiophene) (BS8T1), and poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)bithiophene) (BS8T2). Organic field-effect transistors (OFETs) with hole mobilities as high as 0.02-0.06 cm²/V s in air, low turn-on voltages, and current on/off ratios >10⁵-10⁶ are fabricated using solution processing techniques with the above polymers as the active channel layer. OFETs based on this polymer class exhibit excellent ambient operational stability.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C13H17BF3NO2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts