Category: alcohols-buliding-blocks

Johnston, L. J. published the artcileCharacterization of the triplet excited state of the phenylxanthenium carbocation, Formula: C19H14O2, the publication is Canadian Journal of Chemistry (1992), 70(1), 280-2, database is CAplus.

The triplet excited state of the 9-phenylxanthenium cation is observed directly by both luminescence and transient absorption techniques. The triplet-triplet absorption shows λ_max ≤ 300 nm and decays over a period of several microseconds in the absence of easily oxidized donors. The triplet cation reacts with 9-phenylxanthydrol and biphenyl via electron transfer to give the corresponding radical and radical cation and also reacts rapidly with both oxygen and 1,3-cyclohexadiene.

Canadian Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Formula: C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Safitri, Baiq Firyal Salsabila published the artcileMorphology Modulation in Self-Assembly of Chiral 2-Hydroxy-2-Phenylacetic Acids in Polymeric Diluents, Formula: C8H8O3, the publication is Crystals (2022), 12(6), 807, database is CAplus.

This study focused on the chirality effects that control the lamellar bending sense in self-assembled crystals of chiral 2-hydroxy-2-phenylacetic acids. 2-Hydroxy-2-phenylacetic acid or mandelic acid (MA) was crystallized in the presence of poly(4-vinyl phenol) (PVPh), and its crystalline structures and morphologies were assessed using polarized optical microscopy and SEM . MA of two opposite chiral forms (S- and R-) was crystallized with PVPh as the morphol. modulator; with adjustment of the PVPh content, the morphol. of MA crystals transforms from ring-banded spherulites to highly dendritic spherulites. For MA/PVPh (50/50 weight/weight) blend and neat MA at same T_c, the dendritic spherulites are packed with single crystals where the lamellae bend at a specific direction varying with T_c and chirality. Contrary to conventional thought, the bending senses of the MA lamellae in the dendritic spherulites are not solely governed by the MA mol. chirality (S or R), but also by T_c. Only at high Tc (>65°C) is the lamellar bending direction in dendritic spherulites of (S)-MA or (R)-MA blended with PVPh dictated by the chirality, i.e., displaying counterclockwise and clockwise bending direction for (S)-MA/PVPh and (R)-MA/PVPh, resp. Nevertheless, at low T_c (45°C), the bending sense of dendritic spherulites displays an opposite direction from those at the higher T_c, which is to say that the chirality alone does not control the lamellar bending direction.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dinkloh, A. published the artcileContact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006-2011, Quality Control of 70445-33-9, the publication is Journal of the European Academy of Dermatology and Venereology (2015), 29(6), 1071-1081, database is CAplus and MEDLINE.

Background : Ingredients of leave-on cosmetics and body care products may sensitize. However, not every case of cosmetic intolerance is due to contact sensitization. Objective : To describe the frequency of contact sensitization due to cosmetics in a large clinic population, and a possible particular allergen pattern. Methods : Retrospective anal. of data from the Information Network of Departments of Dermatol., 2006-2011. Results : Of 69 487 patients tested, ‘cosmetics, creams, sunscreens’ was the only suspected allergen source category in 10 124 patients (14.6%). A final diagnosis ‘allergic contact dermatitis’ was stated in 2658 of these patients (26.3%).Compared to a control group, there were significantly more reactions to fragrance mixes I and II, balsam of Peru, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and lanolin alcs. No special pattern of fragrance sensitization could be identified. Among the preservatives, MI was by far the leading allergen, while sensitization to other widely used compounds like parabens or phenoxyethanol was rare. Conclusions : True allergic reactions to cosmetic ingredients are rarer than generally assumed. Limitation of exposure to MI in leave-on cosmetics and body care products is urgently needed.

Journal of the European Academy of Dermatology and Venereology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elslager, Edward F. published the artcileSynthetic schistosomicides. XVI. 5-(Mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds, Formula: C10H13NO2, the publication is Journal of Medicinal Chemistry (1970), 13(3), 370-6, database is CAplus and MEDLINE.

Various 5-(mono- and dialkylamino)-2-nitrosophenols were prepared by nitrosation of the corresponding m-(mono- and dialkylamino)phenols, obtained by heating resorcinol with an excess of the appropriate amine at 200°, or by alkylation of m-aminophenol with an alkyl halide. 5-(Dimethylamino)-2-nitrosophenol, 5-(diethylamino)-2-nitrosophenol (I), 2-nitroso-5-(1-pyrrolidinyl)phenol, and 2-amino-5-(diethylamino)phenol, a potential metabolite of I, displayed strong schistosomicidal activity and effected a 70-100% reduction of adult Schistosoma mansoni in mice at daily doses of 177-568 mg/kg for 14 days. Structure-activity relationship are summarized, and information concerning potential metabolites and the possible mode of action of the nitrosophenols is discussed.

Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheviet, Thomas published the artcileβ-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth, Synthetic Route of 57044-25-4, the publication is Journal of Medicinal Chemistry (2020), 63(15), 8069-8087, database is CAplus and MEDLINE.

Malaria is an infectious disease caused by a parasite of the genus Plasmodium, and the emergence of parasites resistant to all current antimalarial drugs highlights the urgency of having new classes of mols. We developed an effective method for the synthesis of a series of β-modified acyclonucleoside phosphonate (ANP) derivatives, using com. available and inexpensive materials (i.e., aspartic acid and purine heterocycles). Their biol. evaluation in cell culture experiments and SAR revealed that the compounds’ effectiveness depends on the presence of a hydroxyl group, the chain length (four carbons), and the nature of the nucleobase (guanine). The most active derivative I inhibits the growth of Plasmodium falciparum in vitro in the nanomolar range (IC₅₀ = 74 nM) with high selectivity index (SI > 1350). This compound also showed remarkable in vivo activity in P. berghei-infected mice (ED₅₀ ~0.5 mg/kg) when administered by the i.p. route and is, although less efficient, still active via the oral route. It is the first ANP derivative with such potent antimalarial activity and therefore has considerable potential for development as a new antimalarial drug.

Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Synthetic Route of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavanagh, Joseph E. published the artcileOzonation byproducts: identification of bromohydrins from the ozonation of natural waters with enhanced bromide levels, Product Details of C5H11BrO, the publication is Environmental Science and Technology (1992), 26(8), 1658-62, database is CAplus.

Ozonization of 2 surface waters with enhanced levels of Br^– results in the formation of a group of previously unidentified, labile compounds identified as bromohydrins. The compounds are isolated by liquid-liquid extraction and identified by a combination of GC coupled with IR spectroscopy (GC/FT-IR) and GC coupled with mass spectrometry (GC/MS) using electron impact and chem. ionization sources, with 2% NH₃ in CH₄ as the reagent gas. The principal bromohydrin byproduct is 3-bromo-2-methyl-2-butanol, which was confirmed by independent synthesis and comparison of spectral data. At least 6 other bromohydrins are formed during the ozonization/bromination process. These compounds are also formed by reaction of the natural water with aqueous Br, irresp. of prior ozonization, but the nature of their precursors is unknown.

Environmental Science and Technology published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Product Details of C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qureshi, Zafar published the artcileApplication of the Palladium-Catalyzed Norbornene-Assisted Catellani Reaction Towards the Total Synthesis of (+)-Linoxepin and Isolinoxepin, Safety of (R)-Oxiran-2-ylmethanol, the publication is European Journal of Organic Chemistry (2014), 2014(19), 4053-4069, database is CAplus.

The authors’ ongoing effort towards the development of highly selective transition-metal-catalyzed carbon hydrogeb bond (C-H bond) activation processes has led to the expansion of a Catellani reaction. In a Pd⁰/Pd^II/Pd^IV-catalyzed tandem reaction (domino reaction), an aryl iodide, alkyl iodide and tert-Bu acrylate were combined to synthesize a carbon framework of the novel lignan (+)-linoxepin. The enantioselective synthesis highlights the work accomplished in the authors’ group and provides an excellent procedure for a reliable and scalable synthesis of architecturally complex scaffolds. This report outlines the synthetic approaches towards this interesting class of biol. active mols. After a key Catellanireaction/Heck reaction, the synthesis features a Leimeux-Johnson oxidation and a titanium tetrachloride mediated aldol condensation. Finally, a tuneable Mizoroki-Heck reaction was performed to furnish not only the natural product (+)-linoxepin but also its isoform, which we have named isolinoxepin. The synthesis of the target compounds was achieved using 8-[(5-bromo-1,3-benzodioxol-4-yl)methoxy]-3a,4-dihydro-7-(methoxy)naphtho[2,3-c]furan-1(3H)-one as a key intermediate. The title compounds thus formed included (9aR)-9a,10-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [(+)-linoxepin] and 10,12b-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [racemic isolinoxepin].

European Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Safety of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Toelle, Nina published the artcileLight-mediated total synthesis of 17-deoxyprovidencin, COA of Formula: C3H6O2, the publication is Angewandte Chemie, International Edition (2014), 53(15), 3859-3862, database is CAplus and MEDLINE.

An asym. synthesis of the diterpenoid 17-deoxyprovidencin I is described. Key steps include an aldol addition, a base-catalyzed Wipf-type furan formation, a Z-selective ring-closing metathesis for macrocyclization, a photochem. E/Z isomerization to a highly strained and conformationally restricted ring system, and the stereoselective formation of two epoxides on the ring.

Angewandte Chemie, International Edition published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C8H7ClO3, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Berger, R. M. published the artcileStable cation formation and luminescence on inorganic oxide surfaces: 9-phenylxanthenyl cation, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is Chemical Physics Letters (1990), 169(3), 213-17, database is CAplus.

The alc. 9-phenylxanthen-9-ol (I) was adsorbed on silica gel and alumina surfaces. Under room temperature conditions the 9-phenylxanthenyl cation (II) was formed and stabilized on silica gel. Steady state fluorescence studies show II fluoresces with λ_max = 210 nm and that this luminescence occurs via both direct excitation of II as well as adiabatic dehydroxylation of the excited singlet of I. Time-resolved experiments show II has a fluorescence lifetime on silica gel of 37 ± 2 ns and is quenched by oxygen at a rate of 1.5 × 10⁴ torr^-1 s^-1.

Chemical Physics Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karsai, Syrus published the artcileComparison of novel aluminium lactate versus aluminium chloride-based antiperspirant in excessive axillary perspiration: First prospective cohort study, Product Details of C5H12O2, the publication is Dermatologic Therapy (2021), 34(4), e15020, database is CAplus and MEDLINE.

Aluminum chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminum lactate, and a 12.5% aluminum chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminum chloride was more efficacious than aluminum lactate; 22% stated aluminum lactate was more efficacious than aluminum chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminum lactate (p < 0.0001). In this study, aluminum lactate showed significantly greater tolerability than aluminum chloride, although the latter tended to show slightly greater efficacy.

Dermatologic Therapy published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Product Details of C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts