Category: alcohols-buliding-blocks

Pan, Dandan published the artcilePd-Catalyzed Intermolecular Transthiolation of Ar-OTf Using Methyl 3-(Methylthio) Propanoate as a Thiol Surrogate, Application In Synthesis of 4410-99-5, the publication is European Journal of Organic Chemistry (2021), 2021(33), 4616-4619, database is CAplus.

A method for the odorless synthesis of unsym. sulfides ArSR¹ [Ar = naphth-1-yl, 3-NCC₆H₄, 4-F₃CSC₆H₄, etc.; R¹ = Me, Bn, CH₂CH₂Ph, etc.] via Csp²-O and Csp³-S bond activation was presented. Using Me 3-(methylthio) propanoate as a MeSH surrogate, a series of substituted aryl Me sulfides have been obtained in moderate to good yields. This catalytic protocol could also tolerated Me 3-(methylthio)propionate derivatives to afford the corresponding aryl sulfides.

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Shanshan published the artcileDesign and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations, Recommanded Product: 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2020), 112469, database is CAplus and MEDLINE.

SCM-198 (Leonurine) has attracted great attention due to its cardioprotective effects in myocardial infarction (MI). However, no systematic modifications and structure-activity relationship (SAR) studies could be traced so far. In this study, 35 analogs of SCM-198 were designed, synthesized and their cardioprotective effects were evaluated. The cell viability assay on cardiomyocyte cell line H9c2 challenged with H₂O₂ showed that several analogs exhibited more potent cytoprotective effects than SCM-198 at 1μM and 10μM concentrations LDH release level in cells treated with 1μM 14o was comparable with cells treated with 10μM SCM-198. Results of Bcl-2 expression and caspase-3 activation accordingly indicated higher protective activity of 14o than SCM-198. Moreover, in a mouse model of MI, the mice pretreated with 14o had much lower infarct size compared with that of SCM-198. The mechanism study suggested that 14o improved cardiac morphol. and reduced apoptosis of cardiomyocytes in the border zone of infarction, as proved by H&E and TUNEL staining.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Ruiying published the artcileConstruction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes, SDS of cas: 6346-09-4, the publication is European Polymer Journal (2021), 110150, database is CAplus.

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm^-1 at 80°C, which is 25 mS cm^-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm^-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H₂ and O₂ with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated.

European Polymer Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14Cl2S2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Dehua published the artcileMicroporous Aluminophosphate ULM-6: Synthesis, NMR Assignment, and Its Transformation to AlPO₄-14 Molecular Sieve, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry C (2016), 120(22), 11854-11863, database is CAplus.

A pure fluorinated aluminophosphate [Al₈P₈O₃₂F₄·(C₃H₁₂N₂)₂(H₂O)₂] (ULM-6) was synthesized via an aminothermal strategy, in which triisopropanolamine (TIPA) was used as the solvent together with the addition of propyleneurea and HF. The ¹³C NMR spectrum demonstrates that 1,3-diaminopropane, the in situ decomposer of propyleneurea, is the real structure-directing agent (SDA) for ULM-6 crystals. The local Al, P, and F environments of the dehydrated ULM-6 were studied by 1-dimensional and 2-dimensional solid-state NMR spectroscopy. The spatial proximities are extracted from ¹⁹F{²⁷Al}, ¹⁹F{³¹P}, ²⁷Al{¹⁹F}, and ³¹P{¹⁹F} rotational-echo double resonance (REDOR) NMR experiments as well as ¹⁹F → ³¹P heteronuclear correlation (HETCOR) NMR and {³¹P}²⁷Al HMQC NMR experiments, allowing a full assignment of all the ¹⁹F, ²⁷Al, and ³¹P resonances to the corresponding crystallog. sites. Also, the structure of ULM-6 is closely related to that of AlPO₄-14. A combination of high-temperature powder XRD, thermal anal., and ¹⁹F NMR reveals that the removal of F atoms at higher temperature is crucial to the phase transformation of ULM-6 to AlPO₄-14. The calcined product shows high CO₂/CH₄ and CO₂/N₂ selectivity with ratios of 15.5 and 29.1 (101 kPa, 25°), resp.

Journal of Physical Chemistry C published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C38H24F4O4P2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xiaoliang published the artcileDetermination of sucrose and sorbitol in ambroxol hydrochloride oral solution by HPLC-RID, Category: alcohols-buliding-blocks, the publication is Jinri Yaoxue (2021), 31(10), 756-760, database is CAplus.

OBJECTIVE To establish a method for determination of sucrose and sorbitol in ambroxol hydrochloride oral solution and investigated the addition among samples from 21 manufacturers all over the whole country. METHODS The HPLC determination was performed on a HYPERSIL amino column (250 mm×4.6 mm, 5 μm). The mobile phase was consisted of acetonitrile and water (80:20, V/V) at the flow rate of 1.0 mL·min^-1. The column temperature was 35°C and the refractive index detector was used. RESULTS Sucrose and sorbitol could be well separated from ambroxol hydrochloride, and they had good linear relationship (n=6) at the range of 1-10 mg·mL^-1 with sucrose (r=0.9996) and sorbitol (r=0.9999), resp. The limits of quantitation of sucrose and sorbitol were 8.03 and 8.04 μg resp. and the average recoveries (n=9) were 101.0% and 100.9% with the RSD 1.03% and 0.97% resp. The samples from 22 enterprises in the whole country were determined and the determinated results for few individual manufacturers were inconsistent with the production prescription. CONCLUSION The established method is simple, accurate and good repeatability which can lay the foundation for the determination of the addition and quality evaluation of flavor agents in oral solution

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Guang-Bin published the artcilePrediction of Kinetic Isotope Effects for Various Hydride Transfer Reactions Using a New Kinetic Model, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry A (2016), 120(11), 1779-1799, database is CAplus and MEDLINE.

In this work, kinetic isotope effect (KIE_self) values of 68 hydride self-exchange reactions, XH(D) + X⁺ → X⁺ + XH(D), in acetonitrile at 298 K were determined using a new exptl. method. KIE values of 4556 hydride cross transfer reactions, XH(D) + Y⁺ → X⁺ + YH(D), in acetonitrile were estimated from the 68 determined KIE_self values of hydride self-exchange reactions using a new KIE relation formula derived from Zhu’s kinetic equation and the reliability of the estimations was verified using different exptl. methods. A new KIE kinetic model to explain and predict KIE values was developed according to Zhu’s kinetic model using two different Morse free energy curves instead of one Morse free energy curve in the traditional KIE theories to describe the free energy changes of X-H bond and X-D bond dissociation in chem. reactions. The most significant contribution of this paper to KIE theory is to build a new KIE kinetic model, which can be used to not only uniformly explain the various (normal, enormous and inverse) KIE values but also safely predict KIE values of various chem. reactions.

Journal of Physical Chemistry A published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H10N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Juan published the artcileRegulation of pyruvate carboxylase in 3T3-L1 cells, COA of Formula: C18H20N2O12, the publication is Biochemical Journal (1995), 306(1), 205-10, database is CAplus and MEDLINE.

When 3T3-L1 fibroblasts differentiate to adipocytes, the specific activity of pyruvate carboxylase (PC) increases about 25-fold in parallel with its intracellular protein concentration The increase in PC protein concentration is accompanied by a 9-10-fold increase in the relative abundance of 4.2 kb PC mRNA measured by Northern-blot anal. using a cDNA probe encoding a segment of the PC gene of 3T3-L1 adipocytes. The effects of cAMP alone and together with insulin on levels of cellular protein, PC activity, PC protein and on the relative abundance of PC mRNA were examined in mature 3T3-L1 adipocytes. Adipocytes exposed to cAMP for 24 h exhibited a 25% decrease in cellular protein and marked decreases in enzyme activity (88%) and PC mRNA abundance (98%) compared with untreated adipocyte controls. After 48 h of exposure to cAMP, PC activity and PC mRNA diminished to levels approaching their detection limits. When exposed to medium containing cAMP plus insulin, adipocyte enzyme activity and PC mRNA declined more slowly during the first 24 h exposure (about 20% decrease) but after 48 h fell to values comparable with those of adipocytes exposed to cAMP alone. Despite these decreases in enzyme activity, the PC protein content of adipocytes treated with cAMP alone or cAMP plus insulin are nearly identical with that of control adipocytes. The inactivation of PC in cAMP-treated adipocytes does not involve loss of the prosthetic groups from the holoenzyme. Crosslinking experiments suggest that the spatial arrangement of protomers in inactive PC may differ from that in the active tetrameric enzyme. Data presented suggest that, in addition to inducing inactivation, cAMP may also regulate adipocyte PC by decreasing transcription of the PC gene and/or enhancing the rate of degradation of PC mRNA.

Biochemical Journal published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C6H9N3O2S, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiao-Yu published the artcileDual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of Organic Chemistry (2021), 86(13), 8829-8842, database is CAplus and MEDLINE.

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp²)-C(sp³) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chem., under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic mols.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hong, Fengying published the artcileN-terminal strategy (N1-N4) toward high performance liquid crystal materials, Application In Synthesis of 23351-09-9, the publication is Tetrahedron (2016), 72(10), 1285-1292, database is CAplus.

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of mol. design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal mols. through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

Tetrahedron published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Spielmann, Kim published the artcileDirect Conversion of Primary Alcohols to 1,2-Amino Alcohols: Enantioselective Iridium-Catalyzed Carbonyl Reductive Coupling of Phthalimido-Allene via Hydrogen Auto-Transfer, HPLC of Formula: 83706-94-9, the publication is Journal of the American Chemical Society (2019), 141(36), 14136-14141, database is CAplus and MEDLINE.

The first catalytic enantioselective carbonyl (α-amino)allylations are described. Phthalimido-allene and primary alcs. engage in hydrogen auto-transfer-mediated carbonyl reductive coupling by way of (α-amino)allyliridium-aldehyde pairs to form vicinal amino alcs. with high levels of regio-, anti-diastereo-, and enantioselectivity. Reaction progress kinetic anal. and isotopic labeling studies corroborate a catalytic cycle involving turnover-limiting alc. dehydrogenation followed by rapid allene hydrometalation.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C7H13NO2, HPLC of Formula: 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts