Category: alcohols-buliding-blocks

Khammas, A. J. published the artcileSolvent Free Synthesis of N-Substituted Pyrrole Derivatives Catalyzed by Silica Sulfuric Acid, Application of 2-Aminobutan-1-ol, the publication is Russian Journal of General Chemistry (2018), 88(12), 2680-2683, database is CAplus.

Sulfuric acid immobilized on silica gel is used as an efficient catalyst in the synthesis of N-substituted pyrrole derivatives by the Clauson-Kaas pyrrole synthesis. The solvent free reaction mixture is stirred by grinding. Within very short reaction time the process leads to the corresponding products without any decomposition recorded.

Russian Journal of General Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katakawa, Kazuaki published the artcileSelective Synthesis of Benzyl Enol Ethers of β-Dicarbonyl Compounds in Basic Condition and the Application towards Synthesis of Naphthoquinones, Safety of Triisopropylsilanol, the publication is Heterocycles (2014), 88(1), 817-825, database is CAplus.

Selective synthesis of benzyl enol ether of β-tetronic acids and β-dicarbonyl compounds in basic condition was examined The benzylation of α-methyl-β-tetronic acid with benzyl tosylate in the presence of potassium carbonate selectively gave the benzyl enol ether. The reaction of β-tetronic acid and cyclic 1,3-diketones also gave the O-benzyl adducts preferentially over C,O-dibenzylation. The Diels-Alder reactions of furans derived from the benzyl enol ether of α-methylβ-tetronic acid and benzyne gave functionalized naphthoquinones I (R = PhCH₂, H).

Heterocycles published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Safety of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Haisong published the artcileExperimental and Theoretical Study of Oxygen Insertion into Trialkylsilanes by Methyltrioxorhenium Catalyst, Quality Control of 17877-23-5, the publication is Organometallics (1999), 18(23), 4753-4757, database is CAplus.

Among the reactions of H₂O₂ that are catalyzed by methyltrioxorhenium, the oxidation of alkylsilanes is unique. It is not a reaction in which an O atom is added to a substrate, but one featuring a net insertion, R₃Si-H + H₂O₂ → R₃Si-OH + H₂O. Kinetics studies were carried out on 10 compounds Rate constants were determined for the bimol. reaction of the silane with the peroxo compound CH₃Re(O)(η²-O₂)₂(H₂O). The variation of rate constant with the alkyl groups R follows two trends: the values of log(k) are linear functions of (a) the stretching frequency of the Si-H group and (b) the total Taft constant for these substituents. The reactions of Bu₃Si-H and Bu₃Si-D exhibit a kinetic isotope effect of 2.1 at 0°. A model for the transition state was formulated in which O-H and Si-O bond making accompany Si-H bond breaking. Quantum mech. calculations were carried out on the gas-phase reaction between Et₃SiH and CH₃Re(O)₂(η²-O₂). These results support this structure, calculating a structure and energy that are in agreement. The theor. activation energy is 28.5 kcal mol^-1, twice the exptl. value in aqueous MeCN, 12.4 kcal mol^-1. The difference can be attributed to the solvation of the polar transition state in this medium.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C2H8Cl2N4S2, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wakita, Masahiro published the artcileSun protection by new vitamin C derivatives, Category: alcohols-buliding-blocks, the publication is Fragrance Journal (2021), 49(8), 36-41, database is CAplus.

Photoaging is caused by not only UV, but also blue light and near-IR rays. Reactive oxygen species (ROS) is generated inside our skin when the skin is exposed to these lights. As a result, wrinkles and sagging appear on the skin cause due to collagen and elastin reduced. Avoiding light exposure is the best solution against photoaging, but scavenging ROS is also important as the solution Generally, vitamin C is known as a cosmetic ingredient with strong antioxidant effect that eliminates ROS. However, it has problems of stability in itself and formulation. Therefore, author develops a highly stable vitamin C derivative 3-glyceryl ascorbate (3GA). It has a high stability in itself and formulation, in addition, author confirms its anti-photoaging effect improves wrinkles.

Fragrance Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C12H16O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Tian-Yun published the artcileStructure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol, the publication is Bioorganic Chemistry (2021), 104994, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhances the survival rate of patients with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives I (R¹ = H, MeO, R² = MeO, OH, PhCH₂O, EtO, R³ = MeO, OH, EtO, R²R³ = OCH₂O, R⁴ = H, MeO, R⁵ = H, Cl, MeO, PhCH₂O, cyclobutylmethoxy, etc., R⁶ = MeO, OH, R⁷ = MeO, EtO, H) were synthesized and evaluated for their activity on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) anal. revealed that the 2,3-dimethoxy moiety might be beneficial for activity. Among them, I (R¹ = R⁴ = R⁷ = H, R² = R³ = R⁶ = MeO, R⁵ = p-F₃CSC₆H₄CH₂O) (II) displayed the most potent activity with an IC₅₀ value of 9.5 ± 0.5μM, better than that of BBR. Also, it significantly decreased the PCSK9 protein level at the cellular level, as well as in the liver and serum of mice in vivo. Furthermore, II markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of II is targeting HNF1α and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, II might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Bioorganic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jana, Sripati published the artcilePhotoinduced Proton-Transfer Reactions for Mild O-H Functionalization of Unreactive Alcohols, Product Details of C3H5F3O, the publication is Angewandte Chemie, International Edition (2020), 59(14), 5562-5566, database is CAplus and MEDLINE.

Hexafluoroisopropanol is typically considered as an unreactive solvent and not as a reagent in organic synthesis. Herein, we report on a mild and efficient photochem. reaction of aryl diazoacetates with hexafluoroisopropanol that enables, under stoichiometric reaction conditions, the synthesis of fluorinated ethers in excellent yield. Mechanistic studies indicate there is a preorganization of hexafluoroisopropanol and the diazoalkane acts as an unreactive hydrogen-bonding complex. Only after photoexcitation does this complex undergo a protonation-substitution reaction to the reaction product. Investigations on the applicability of this photochem. transformation show that a broad variety of acidic alcs. can be subjected to this transformation and thus demonstrate the feasibility of this concept for O-H functionalization reactions (54 examples, up to 98% yield).

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Strunskaya, E. I. published the artcileElectrochemical Reduction and Oxidation of 3,4-Disubstituted 1,2,5-Thiadiazoles, Category: alcohols-buliding-blocks, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2003), 73(5), 806-815, database is CAplus.

The electron-acceptor N and S atoms in 3,4-disubstituted 1,2,5-thiadiazoles are responsible for much decreased reduction potentials and much increased oxidation potentials of these compounds compared with the corresponding carbocyclic derivatives The thiadiazole ring is resistant to oxidation, and the reversible electron transfer gives rise to fairly stable radical cations. Reductive stability of the heterocycle depends on the nature of its substituents and on the medium: when nucleophile substituents are present, 2-electron transfer in aprotic media results in heterocycle ring opening with iminonitrile formation, whereas in the presence of 2 readily leaving groups, the electron transfer induces cleavage of the complete heterocycle ring into inorganic anions.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H8O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Jing published the artcileEffect of ambroxol hydrochloride lavage with electronic bronchoscope on PCT and CRP levels in elderly patients with pneumonia and respiratory failure, Formula: C13H19Br2ClN2O, the publication is Guizhou Yiyao (2021), 45(3), 380-381, database is CAplus.

The effects of ambroxol hydrochloride lavage with electronic bronchoscope on inflammatory factors procalcitonin (PCT) and C-reactive protein (CRP) in elderly patients with pneumonia complicated with respiratory failure were analyzed. There was no significant difference in the levels of PCT and CRP between the observation group and the control group before treatment. One week after treatment, PCT and CRP in the two groups decreased, and the observer was lower than that in the control group. Studies have shown that ambroxol hydrochloride lavage through electronic bronchoscope can effectively reduce the level of inflammatory factors in elderly patients with pneumonia complicated with respiratory failure, improve pulmonary function and blood gas indexes, and does not increase the rate of adverse reactions or complications. It is a treatment scheme suitable for elderly patients with pneumonia complicated with respiratory failure.

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan journal of pharmaceutical sciences (2018), 31(5(Special)), 2257-2262, database is MEDLINE.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7±65.21) mL and the amount of 24h hemorrhage (308.3±78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4±8.24) mmHg and DBP (79.6±6.21) mmHg in the experimental group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clinical a value.

Pakistan journal of pharmaceutical sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan Journal of Pharmaceutical Sciences (2018), 31(5), 2257-2262, database is CAplus.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7 ± 65.21) mL and the amount of 24h hemorrhage (308.3 ± 78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4 ± 8.24) mmHg and DBP (79.6 ± 6.21) mmHg in the exptl. group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clin. a value.

Pakistan Journal of Pharmaceutical Sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts