Category: alcohols-buliding-blocks

Zhou, Jing published the artcileClinical comparative study between Xiao′er feike granules and ambroxol hydrochloride syrup for chronic cough in children, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Xin Zhongyi (2021), 53(5), 120-123, database is CAplus.

Objective: To compare and analyze the clin. application value of Xiao′er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods: A total of 200 children with chronic cough were divided into the study group and the control group, 100 cases each, by digital parity. Based on the routine treatment, the control group was addnl. treated with ambroxol hydrochloride syrup, and the study group was addnl. treated with Xiao′er Feike granules. After two weeks of treatment, the clin. symptoms and signs in the two groups and the clin. effect were evaluated, and the immune function. Results: The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group, which was statistically significant (P<0.05). Before treatment, the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant (P>0.05). After treatment, the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group (P<0.05). The cough relief time and cough disappearance time in the study group were earlier, what were statistically significant, than those in the control group (P<0.05). There was no significant difference before treatment in the comparison of the levels of CD4⁺, CD8⁺, CD4⁺/CD8⁺ between all groups (P>0.05). After treatment, the levels of CD8⁺ in the two groups were increased and the level of the study group was greater than that of the control group;the levels of CD4⁺ and CD4⁺/CD8⁺ were decreased and the level of the study group were greater, which was statistically significant, than those in the control group (P<0.05). Conclusion: Compared with ambroxol hydrochloride syrup, Xiao′er Feike granules is more beneficial to improving the clin. effect, relieving the clin. symptoms and improving the immune resistance of children.

Xin Zhongyi published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C11H10ClNO, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xiao-yan published the artcileEffectiveness and safety of carboprost tromethamine in prevention and treatment of bleeding during cesarean section in high-risk parturients, Quality Control of 58551-69-2, the publication is Zhongguo Fuyou Baojian (2017), 32(22), 5539-5541, database is CAplus.

Objective: The article explored the effectiveness and safety of preventive intrauterine injection of carboprost tromethamine in the prevention and treatment of bleeding during cesarean section in high-risk parturients. Methods: The article selected 381 women with high-risk factors for postpartum hemorrhage during cesarean section admitted to the obstetrics department of Sichuan Provincial Maternity and Child Health Hospital from Jan. 2015 to Dec. 2016 as the research objects. They were divided according to the uterine body injection of uterine contraction drugs. 3 groups, each with 127 cases. Women in the control group were given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered; study group 1 was given 20 IU of oxytocin plus 500mL of compound sodium chloride i.v. infusion immediately after the fetus was delivered 250 μg carprost tromethamine was injected into the uterus; study group 2 immediately after the fetus was delivered, 250 μg carprost tromethamine was injected into the uterus. The article compares the clin. treatment effect, operation time, intraoperative and postoperative blood loss, incidence of postpartum hemorrhage, hemostasis of postpartum hemorrhage and adverse reactions among the three groups of women. Results: The total effective rate of the control group was significantly lower than that of study group 1 and study group 2, and the difference was statistically significant (P < 0.05); the total effective rate of study group 1 and study group 2 was compared, and the difference was not statistically significant (P > 0.05). There was no statistically significant difference in the operation time between the three groups of women (P > 0.05). In the control group, the amount of bleeding and the incidence of postpartum hemorrhage during operation, 2h, 24h after operation were significantly higher than that of study group 1 and study group 2, and the differences were statistically significant (all P < 0.05); study group 1 during operation and 2h after operation Compared with study group 2, the amount of bleeding and the incidence of postpartum hemorrhage at 24h were not statistically significant (P > 0.05). The use of therapeutic uterine contractions in study group 1 and study group 2 was significantly less than that of control group, and the differences were statistically significant (P < 0.05). A total of 29 cases of adverse reactions occurred in all parturients, with an incidence of 22.83%. The incidence of adverse reactions in the control group, study group 1, and study group 2 were 3.94%, 11.18%, and 7.09%, resp. Conclusion: Carprost tromethamine was effective in preventing and treating high-risk parturientsâ€?bleeding during cesarean section, and it was worthy of clin. application.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15ClO3S, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Jin-ling published the artcileEvaluation and analysis of application of carboprost in obstetrics and gynecology, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2013), 24(9), 1993-1994, database is CAplus.

60 Placenta previa lying-in women receiving cesarean section in our hospital in 2012-2013 were randomly divided into observation group and control group. The women in the observation group were given carboprost before placental expulsion, and the women in the control group were given carboprost after placental expulsion. The cesarean operation time and blood loss of the patients of the two groups were comparatively analyzed. Results: The maternal operative time and blood loss of the patients in the observation group were significantly different from those of the control group (P < 0.05), and were statistically significant. Administration of carboprost tromethamine before placental expulsion can shorten operation time, reduce blood loss and has important application value in clin.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C17H16O2, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Yu published the artcileClinical observation of oxytocin combined with hemabate in the treatment of postpartum hemorrhage after cesarean section, SDS of cas: 58551-69-2, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(1), 28-29, database is CAplus.

This article discusses the clin. efficacy of oxytocin combined with hemabate in the treatment of post-cesarean hemorrhage. Oxytocin combined with hemabate treatment can improve the oxidative stress index and coagulation index in patients with post-cesarean hemorrhage, thereby improving the therapeutic effect.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C18H28N2O7, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, M. published the artcileAntioxidant effect of glutathione on promoting 2-keto-L-gulonic acid production in vitamin C fermentation system, HPLC of Formula: 526-98-7, the publication is Journal of Applied Microbiology (2018), 125(5), 1383-1395, database is CAplus and MEDLINE.

The study aims to investigate the antioxidant effect of glutathione on promoting 2-KGA in Vc fermentation system using Ketogulonicigenium vulgare 25B-1 and Bacillus endophyticus ST-1 as the co-culturing microbes. Methods and Results : The activities of antioxidant-related enzymes and qPCR were used to study the antioxidant effect of glutathione addition in Vc fermentation system. The addition of GSH and GSH/GSSG increased 2-KGA production and decreased fermentation time, and the highest 2-KGA production increased by 40·63% and the lowest fermentation time shortened to 60 h when the addition of optimal concentration ratio of GSH/GSSG was 50 : 1. Moreover, the increased production of 2-KGA was accompanied by up-regulated the activities of total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), catalase (CAT) and over-expressed oxidative stress-related genes sod,gst,gr,zwf,gp, which resulted in scavenging reactive oxygen species to reduce oxidative stress in Vc fermentation system. Conclusions : Glutathione showed a significant effect on increasing 2-KGA production and decreasing fermentation time in Vc fermentation system. GSH/GSSG could maintain a dynamic balance with two forms of glutathione and the optimal concentration ratio of GSH/GSSG was 50 : 1. Significance and Impact of the Study : Glutathione is proved to be effective to relieve oxidative stress. The promotion effects of GSSG and GSH on 2-KGA production could help to further explore the optimization of co-culture fermentation process for Vc industrial production

Journal of Applied Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Xin-qi published the artcileNon targeted metabonomics analysis of small molecular substances in fermented cereal drinks, Computed Properties of 86-48-6, the publication is Xiandai Shipin Keji (2021), 37(10), 96-102, 18, database is CAplus.

Millet, glutinous rice and other cereals were used as main raw materials. Two probiotics, L. paracasei L1 and L. casei YQ336, isolated from naturally fermented sweet potato sour liquid and tofu sour liquid were used as fermentation bacteria. Non targeted metabonomics technol. was used to analyze the differences of small mol. substances in cereal drinks before and after fermentation Through principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA), it was found that there were 25 categories and 145 differential metabolites with significant changes (VIP>1 and p<0.05) in beverages before and after fermentation, mainly including 34 organic acids and their derivatives, 21 flavonoids, 20 sugars and their derivatives, 16 alkaloids, 10 nucleotides and their derivatives 10 amino acids and their derivatives The bioactive substances with significantly increased content after fermentation include 36668 times of 1-hydroxy-2-naphthoic acid, 1000 times of dihydroresveratrol, 800 times of 2-hydroxyvaleric acid, 517 times of daidzein, 488 times of vitexin, 238 times of apigenin, 148 times of isoerucic acid, 130 times of genistein, etc. The anal. of KEGG metabolic pathway showed that there were 19 metabolic pathways with significant differences. It is speculated that grain substrate may have certain effects on the synthesis and accumulation of secondary metabolism of L. paracasei L1 and L. casei YQ336. This study will lay a theor. foundation for the fermentation of plant matrix food by lactic acid bacteria and the metabolic mechanism of plant matrix.

Xiandai Shipin Keji published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8N2, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Miao published the artcileClinical research of carboprost tromethamine for preventing and treating postpartum hemorrhage of high risk puerpera undergoing cesarean, HPLC of Formula: 58551-69-2, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(2), 144-145, 205, database is CAplus.

The objective was to observe the effect and security of carboprost tromethamine for preventing and treating postpartum hemorrhage of high risk puerpera undergoing cesarean. The method includes dividing 397 puerpera undergoing cesarean with high risk of postpartum hemorrhage into 3 groups: oxytocin group (injection of 20 IU oxytocin into hyster and i.v. infusion of 20 IU oxytocin, n=131), oxytocin+carboprost tromethamine group (injection of 20 IU oxytocin 20 IU+carboprost tromethamine 250μg into hyster, n=152), and carboprost tromethamine group (injection of carboprost tromethamine 250μg into hyster, n=114), calculating bleeding amount during the cesarean and 2 h after cesarean and the total bleeding amount, and observing the untoward effects. The results show that carboprost tromethamine can significantly reduce the bleeding amount during the cesarean and after cesarean, and the combination of carboprost tromethamine and oxytocin has better effect, and the untoward effect is little.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, HPLC of Formula: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Bai-zhu published the artcileComparison between Hemabate and oxytocin in preventing and treating postpartum hemorrhage in pregnant women with high-risk cesarean section, Related Products of alcohols-buliding-blocks, the publication is Xiandai Zhenduan Yu Zhiliao (2015), 26(20), 4646-4647, database is CAplus.

The clin. data of 106 pregnant women undergoing cesarean section were retrospectively analyzed, and they were randomly divided into control group and observation group with 53 cases each. The control group was given 20U i.v. infusion of oxytocin and 10U uterine muscle injection, and the observation group was given 20U i.v. infusion of oxytocin and 250 μg uterine muscle injection of Hemabate. The bleeding volume and urine volume of the two groups of pregnant women during operation, 2h and 24h postpartum were compared and recorded, and the occurrence of adverse reactions in the two groups was observed The bleeding amount of the control group during surgery, 2h and 24h postpartum was significantly higher than that of the observation group (P < 0.05), and the urine output was lower than that of the observation group (P < 0.05). There were no significant differences in common adverse reactions (such as nausea, vomiting, palpitations, headaches, etc.) between the two groups (P > 0.05). Hemabate has a significant clin. effect compared with oxytocin in preventing and treating postpartum hemorrhage of high-risk cesarean pregnant women, and has fewer adverse reactions and higher safety, which is suitable for clin. use.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Xiangzhan published the artcileSelective Oxidation of Amino Alcohols to Amino Acids over Au Supported on Monoclinic ZrO₂: Dominant Active Sites and Kinetic Study, Safety of 2-Aminobutan-1-ol, the publication is Industrial & Engineering Chemistry Research (2019), 58(19), 8506-8516, database is CAplus.

Au supported on monoclinic ZrO₂ (Au/m-ZrO₂) prepared by deposition-precipitation method showed excellent catalytic performance in the aerobic oxidation of amino alcs. to amino acids, i.e., glycine, alanine, serine, β-alanine, and 2-aminobutyric acid. The Au particle size and valence distribution of the gold species were adjusted by calcination temperature, as demonstrated by XRD, TEM, UV-vis DRS, XPS, and H₂-TPR, which significantly influenced the catalytic activity but not the selectivity of amino acids. Metallic gold atoms on the surface were shown to be the active sites by the correlation between reaction rate per mol of metallic Au and Au particle size. The kinetics of oxidation of monoethanolamine (MEA) was studied in detail, and the results indicated that MEA oxidation is a first-order reaction with an activation energy of 52.8 kJ·mol^-1.

Industrial & Engineering Chemistry Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Zuoyi published the artcileStructural characterisation and antioxidant activity of melanoidins from high-temperature fermented apple, HPLC of Formula: 96-20-8, the publication is International Journal of Food Science and Technology (2021), 56(5), 2471-2480, database is CAplus.

Summary : High-temperature fermented apple is a new fermented product with characteristic black appearance, which is prepared through natural fermentation of whole fresh apple at controlled high temperature (60-90°C) and humidity (relative humidity of 50-90%). In this work, melanoidins from high-temperature fermented apple were obtained by ultrafiltration and subsequent diafiltration. The structural characterization of melanoidins was investigated in the present study. Results showed that the mol. weight of the obtained melanoidins was about 179 kDa and the melanoidins were comprised primarily of furans by pyrolysis-gas chromatog.-mass spectrometry. Antioxidant activities of the high-temperature fermented apple and its melanoidins were evaluated by ABTS, DPPH, hydroxyl radicals, ferric reducing antioxidant power and Fe2+-chelating assays. Both high-temperature fermented apple and its melanoidins showed extremely high antioxidant activities in scavenging hydroxyl radicals. High correlation between the antioxidant activity assayed methods and the physicochem. characteristics of melanoidins was obtained. The contribution of melanoidins to the total antioxidant capacity of high-temperature fermented apple was determined

International Journal of Food Science and Technology published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H8O3, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts