Category: alcohols-buliding-blocks

A common compound: 124-68-5, name is 2-Amino-2-methyl-1-propanol,molecular formula is C4H11NO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 124-68-5

2-Amino-2-methyl-propan-1-ol (53 g, 0.59 mol) and di-tert-butyl dicarbonate (65.0 g, 0.297 mol) were combined in H2O (500 mL) and stirred at 25 C for 1 h. The reaction mixture was extracted with CHCl3 (2 x 250 mL). The organics were dried and concentrated to a white amorphous solid which was recrystallized from hot hexanes to afford desired material (30 g, 53%) as a white solid: 13C NMR (CD3OD, 100 MHz) delta 157.76, 80.135, 70.095, 54.992, 29.247, 24.695.

With the rapid development of chemical substances, we look forward to future research findings about 124-68-5.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99286; (2003); A1;,
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870-72-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 870-72-4, name is Hydroxymethanesulfonic Acid Sodium Salt. This compound has unique chemical properties. The synthetic route is as follows.

175 ml of ethanol and 40 ml of water were added to 32.2 g (0.3 mol) of m-toluidine (manufactured by FUJIFILM Wako Pure Chemical Corporation), and the mixture was stirred at room temperature. To this solution, 48.3 g (0.36 mol) of sodium hydroxymethanesulfonate (manufactured by Tokyo Chemical Industry Co., Ltd.) was added, and the mixture was heated to an external temperature of 100 C. and stirred for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, subjected to filtering, and washed with ethanol. The resulting crystals were dried to obtain 48.8 g of M-1 (yield: 72.8%, white crystals).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt.

Reference:
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6338-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of SL_0498 (120 mg, 177 mumol) in MeCN (15 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (26 mg, 177 mumol) followed by NEt3 (74 muL, 531 mumol). The resulting yellow solution was left at 22 C. for 16 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?10% MeOH/DCM) to provide 106 mg (87% yield) of SL_0503 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.22-7.12 (m, 3H), 5.79 (m, 2H), 4.55 (t, J=5.5, 1H), 4.47-4.43 (m, 4H), 4.04 (t, J=4.8 Hz, 2H), 3.62 (t, J=6.6 Hz, 2H), 3.55 (t, J=4.8 Hz, 2H), 3.52-3.45 (m, 14H), 3.44-3.36 (m, 10H), 3.16-3.06 (m, 6H), 1.70 (p, J=6.7 Hz, 2H), 1.49 (p, J=6.9 Hz, 2H), 1.42-1.25 (m, 4H). MS (ESI+) calc’d for C29H55ClN3O13+ [M+H]+ 688.34, found 688.3

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol.

Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol, the common compound, a new synthetic route is introduced below. 56456-49-6

To a solution of (4-chloro-2-fluorophenyl)methanol (222mg) in MeCN (20ml) was added Mn02 (480mg). The mixture was stirred for 24h. The mixture was filtered over celite, the org. layer was dried over MgS04 and evaporated in vacuo. The crude aldehyde was used without purification in the next step. LC-MS (A): tR = 0.76min; [M+H]+: not visible.

Statistics shows that 56456-49-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-fluorobenzyl alcohol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; KIMMERLIN, Thierry; REMEN, Lubos; SIENDT, Herve; VERCAUTEREN, Magali; WELFORD, Richard; (138 pag.)WO2016/177690; (2016); A1;,
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6338-55-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of SL_0160 (269 mg, 732 mumol) in MeCN (10 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (109 mg, 732 mumol) followed by NEt3 (200 muL, 145 mumol). The resulting yellow solution was left at 22 C. for 24 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?100% EtOAc/hexanes) to provide 220 mg (80% yield) of SL_0483 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.15 (t, J=5.4 Hz, 1H), 5.62 (dt, J=11.4, 5.7 Hz, 1H), 5.49 (dt, J=11.4, 6.5 Hz, 1H), 4.57-4.51 (m, 3H), 4.24 (d, J=5.7 Hz, 2H) 3.51-3.46 (m, 6H), 3.42-3.37 (m, 4H), 3.11 (q, J=5.9 Hz, 2H), 0.87 (s, 9H), 0.05 (s, 6H). MS (ESI+) calc’d for C17H35NaNO6Si+ [M+H]+ 400.21, found 400.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
Alcohol – Wikipedia,
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623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

4-aminobenzyl alcohol (1 g, 8.12 mmol) was dissolved in 5 mL of 5M hydrochloric acid solution,A solution of sodium nitrite (840 mg, 12.18 mmol, dissolved in 20 mL of deionized water) was added dropwise to the solution. The mixture was added dropwise within 30 minutes. The reaction mixture was vigorously stirred in an ice-water bath.Sodium azide (2.1 g, 32.3 mmol) was added portionwise to the reaction system, and the resulting mixture was stirred at room temperature overnight. After the reaction is complete,The residue was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The organic layer was washed with saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated.The crude product was isolated and purified by silica gel column chromatography (EA:PE=1:3, volume ratio) to give 950 mg of a yellow oily liquid in a yield of 78.0%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 623-04-1, (4-Aminophenyl)methanol.

Reference:
Patent; Peking University; Tang Xinjing; Jin Qingqing; (36 pag.)CN107365254; (2017); A;,
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3360-41-6, Adding a certain compound to certain chemical reactions, such as: 3360-41-6, 4-Phenylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3360-41-6, blongs to alcohols-buliding-blocks compound.

General procedure: To 16 (0.6 g, 0.6 mmol) was added dichloromethane (5 mL) in a round-bottom flask. After 10 min, oxalyl chlorideor oxalyl bromide was added (0.6 mmol). The reaction mixture was magnetically stirred at room temperature. Uponcessation of gas evolution, 4 was added (0.5 mmol), and the reaction mixture was heated to reflux. After thereaction was complete according to TLC analysis, the mixture was cooled to room temperature and filtered. Thesolid on the funnel was washed with dichloromethane (3 ¡Á 10 mL), and the filtrate was concentrated under reducedpressure to afford the desired product 5 in an essentially pure state based on 1H and 13C NMR spectroscopicanalyses.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3360-41-6, its application will become more common.

Reference:
Article; Xia, Xuanshu; Toy, Patrick H.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1397 – 1405;,
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440-60-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 440-60-8 as follows.

In a 10 mL round bottom flask, 0.99 g of pentafluorobenzyl alcohol and 2 g of diethylene glycol dimethyl ether were sequentially added.The resulting mixture was subjected to ultrasonic irradiation at 40 kHz/30 W/70 C for 30 minutes in an ultrasonic reaction apparatus. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to obtain 0.89 g of pentafluorobenzoic acid in a yield of 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,440-60-8, its application will become more common.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
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78-69-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78-69-3, name is 3,7-Dimethyloctan-3-ol, molecular formula is C10H22O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Add 2g to the reaction flaskTetraacetyl substituted glucose bromine (chemical formula:), 0.38 g of tetrahydrolinalol (chemical formula:),0.73g of silver carbonate and 10mL of dichloromethane,Reacting at room temperature for 24 hours;The solvent was removed under reduced pressure.Separated by column chromatography,The eluent (a mixture of petroleum ether and ethyl acetate in a mass ratio of 5:1) was washed down with 0.80 g of a white solid.That is, tetrahydrolinalol tetraacetyl glucoside (chemical formula:).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78-69-3, 3,7-Dimethyloctan-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Institute of Technology; Li Hongyi; Pan Xianhua; Chen Yu; Huo Jiyou; Yuan Hongshun; (9 pag.)CN109970826; (2019); A;,
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13826-35-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13826-35-2 as follows.

(3-Phenoxy-phenyl)-methanol (Intermediate 46, 5 g, 25 mmol) was dissolved in DCM (50 mL), cooled to 0 C, and thionyl chloride (4 ml, 50 mmol) was added dropwise followed by a drop of DMF. The reaction mixtre was stirred at room temperature for 12 h and concentrated under reduced pressure to remove solvent. To the resulting residue was added ice and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate, concentrated under reduced pressure and purified by column chromatography (95%, 5.2 g). NMR: 400 MHz, DMSO- d6: delta 7.36-7.43 (m, 3H), 7.13-7.20 (m, 2H), 6.95-7.07 (m, 4H), 4.73 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 13826-35-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian; BRUGGER, Nadia; WO2015/130905; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts